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  1. Book ; Online ; E-Book: Early Detection and Treatment of Head & Neck Cancers

    El Assal, Rami / Gaudilliere, Dyani / Connelly, Stephen Thaddeus

    Theoretical Background and Newly Emerging Research

    2021  

    Abstract: Head and neck cancer (HNC) is a heterogeneous group of cancers that, if combined, represent one of the most common cancer types. Patients with HNC suffer significant morbidity and mortality due to the importance of the structures involved. Over two- ... ...

    Author's details edited by Rami El Assal, Dyani Gaudilliere, Stephen Thaddeus Connelly
    Abstract Head and neck cancer (HNC) is a heterogeneous group of cancers that, if combined, represent one of the most common cancer types. Patients with HNC suffer significant morbidity and mortality due to the importance of the structures involved. Over two-thirds of these patients are diagnosed at a late stage, leading to a poor prognosis. Therefore, advancements in early detection and treatment of HNC are crucial. This second volume provides an up-to-date overview of the theoretical background in the field of head and neck cancer (HNC) as well as of the emerging research that is impacting our understanding of this disease. The book begins with a comprehensive review of the epidemiology, etiology, symptoms, diagnosis, and staging of HNC. Next, it covers the essentials of potentially malignant disorders of the oral cavity, an important variety of HNC. Subsequently, it covers the newly emerging research in the field of HNC. The overall goal is to shift towards precision medicine (discussed in detail in Volume I), which will bring individualized clinical benefit to patients with HNC. This second volume of Early Detection and Treatment of Head & Neck Cancers concludes with the topic of chronic pain associated with HNC, including both the mechanisms of pain and the management strategies, and the emerging oral mucoadhesive drug delivery approach for HNC. All HNC surgeons, scientists, residents, and individuals whose lives have been touched by this disease, will recognize the impact pain has upon a patient’s health and his or her recovery trajectory.
    Keywords Oncology ; Otorhinolaryngology ; Mouth/Surgery ; Oral and Maxillofacial Surgery ; Càncer de cap ; Càncer de coll ; Internal Medicine ; Medical
    Subject code 616.99491
    Language English
    Size 1 online resource (XVI, 224 p. 61 illus., 57 illus. in color.)
    Edition 1st ed. 2021.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-69852-1 ; 3-030-69851-3 ; 978-3-030-69852-2 ; 978-3-030-69851-5
    DOI 10.1007/978-3-030-69852-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Editorial: Saliva used as biological fluid to detect neurodegenerative and neurodevelopmental diseases.

    Tartaglia, Gianluca / Connelly, Stephen

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1141376

    Language English
    Publishing date 2023-02-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1141376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Stephen R. Mackinon y Oris Friesen, China Reporting, an Oral History of American Journalism in the 1930s and 1940s , Berkeley, University of California Press, 1987, 229 pp.

    Marisela Connelly

    Estudios de Asia y África, Vol 24, Iss

    1989  Volume 1

    Abstract: ...

    Abstract -
    Keywords Mackinnon ; Stephen R ; Reseñas ; Conflicto sino-japonés ; 1937-1945 ; Opinión pública extranjera americana ; History of Asia ; DS1-937 ; History of Africa ; DT1-3415 ; Social sciences (General) ; H1-99
    Language Spanish
    Publishing date 1989-01-01T00:00:00Z
    Publisher El Colegio de México, A.C.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Answers in search of questions: what does the comparison of COVID19 data among regions in Northern Italy tell us?

    Connelly, Luke B / Birch, Stephen

    Health economics, policy, and law

    2020  Volume 17, Issue 2, Page(s) 224–226

    Abstract: Since the outbreak of the COVID-19 pandemic, discussions about the capabilities of health and social systems to control and contain infectious diseases have been reignited. In Resilient Managed Competition During Pandemics: Lessons from the Italian ... ...

    Abstract Since the outbreak of the COVID-19 pandemic, discussions about the capabilities of health and social systems to control and contain infectious diseases have been reignited. In Resilient Managed Competition During Pandemics: Lessons from the Italian Experience, Costa-Font, Turatti and Levaggi ask whether or not institutional differences between the managed competition (MC) systems in three of Italy's regions may have affected their performance - and hence, population health outcomes - during the pandemic. Fuchs (2000) previously argued that institutional arrangements not only 'matter', but also sometimes 'matter a great deal' (p. 149, emphasis in original) and this may be particularly true in emergencies.
    MeSH term(s) COVID-19/epidemiology ; Disease Outbreaks ; Humans ; Italy/epidemiology ; Pandemics ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-04
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2214936-3
    ISSN 1744-134X ; 1744-1331
    ISSN (online) 1744-134X
    ISSN 1744-1331
    DOI 10.1017/S1744133120000377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Sustainability of Publicly Funded Health Care Systems: What Does Behavioural Economics Offer?

    Connelly, Luke B / Birch, Stephen

    PharmacoEconomics

    2020  Volume 38, Issue 12, Page(s) 1289–1295

    Abstract: There has been a rapid increase in the use of behavioural economics (BE) as a tool for policy makers to deploy, including in health-related applications. While this development has occurred over the past decade, health care systems have continued to ... ...

    Abstract There has been a rapid increase in the use of behavioural economics (BE) as a tool for policy makers to deploy, including in health-related applications. While this development has occurred over the past decade, health care systems have continued to struggle with escalating costs. We consider the potential role of BE for making improvements to health care system performance and the sustainability of publicly funded health care systems, in particular. We argue that the vast majority of applications in this field have been largely focussed on BE and public health, or the prevailing level of risks to health in populations, and with policy proposals to 'nudge' individual behaviour (e.g. in respect of dietary choices). Yet, improvements in population health may have little, if any, impact on the size, cost or efficiency of health care systems. Few applications of BE have focussed on the management, production, delivery or utilisation of health care services per se. The latter is our focus in this paper. We review the contributions on BE and health care and consider the potential for complementing the considerable work on BE and public health with a clear agenda for behavioural health care economics. This agenda should complement the work of conventional microeconomics in the health care sector.
    MeSH term(s) Administrative Personnel ; Delivery of Health Care ; Economics, Behavioral ; Health Services ; Humans
    Language English
    Publishing date 2020-09-07
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 1100273-6
    ISSN 1179-2027 ; 1170-7690
    ISSN (online) 1179-2027
    ISSN 1170-7690
    DOI 10.1007/s40273-020-00955-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The impact of weather on time allocation to physical activity and sleep of child-parent dyads.

    Nguyen, Ha Trong / Christian, Hayley / Le, Huong Thu / Connelly, Luke / Zubrick, Stephen R / Mitrou, Francis

    The Science of the total environment

    2023  Volume 880, Page(s) 163249

    Abstract: Purpose: Previous studies showed that unfavourable weather conditions discourage physical activity. However, it remains unclear whether unfavourable weather conditions have a differential impact on physical activity in children compared with adults. We ... ...

    Abstract Purpose: Previous studies showed that unfavourable weather conditions discourage physical activity. However, it remains unclear whether unfavourable weather conditions have a differential impact on physical activity in children compared with adults. We aim to explore the differential impact of weather on time allocation to physical activity and sleep by children and their parents.
    Method: We use nationally representative data with time use indicators objectively measured on multiple occasions for >1100 Australian pairs of 12-13-year-old children and their middle-aged parents, coupled with daily meteorological data. We employ an individual fixed effects regression model to estimate the causal impact of weather.
    Results: We find that unfavourable weather conditions, as measured by cold or hot temperatures or rain, cause children to reduce moderate- and vigorous-intensity physical activity time and increase sedentary time. However, such weather conditions have little impact on children's sleep time or the time allocation of their parents. We also find substantial differential weather impact, especially on children's time allocation, by weekdays/weekends and parental employment status, suggesting that these factors may contribute to explaining the differential weather impact that we observed. Our results additionally provide evidence of adaptation, as temperature appears to have a more pronounced impact on time allocation in colder months and colder regions.
    Conclusion: Our finding of a negative impact of unfavourable weather conditions on the time allocated to physical activity by children indicates a need to design policies to encourage them to be more physically active on days with unfavourable weather conditions and hence improve child health and wellbeing. Evidence of a more pronounced and negative impact on the time allocated to physical activity by children than their parents suggests that extreme weather conditions, including those associated with climate change, could make children vulnerable to reduced physical activity.
    MeSH term(s) Adult ; Middle Aged ; Humans ; Child ; Adolescent ; Australia ; Weather ; Exercise ; Rain ; Sleep
    Language English
    Publishing date 2023-04-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.163249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: History of the Thyroid.

    Connelly, Kara J / Park, Julie J / LaFranchi, Stephen H

    Hormone research in paediatrics

    2022  Volume 95, Issue 6, Page(s) 546–556

    Abstract: The history of the thyroid dates from 2697 BCE when the "Yellow Emperor" Hung Ti described the use of seaweed to treat goiter. The English name "thyroid" was coined by Thomas Wharton in 1656 from the Greek word for a shield. Bernard Courtois discovered ... ...

    Abstract The history of the thyroid dates from 2697 BCE when the "Yellow Emperor" Hung Ti described the use of seaweed to treat goiter. The English name "thyroid" was coined by Thomas Wharton in 1656 from the Greek word for a shield. Bernard Courtois discovered iodine in 1811 when he noted a residual purplish ash while burning seaweed. Robert Graves is known for his classic 1835 report of "palpitations, goiter, and exophthalmos" in three women, but Caleb Parry observed the same clinical features in 1786. The clinical syndrome we now recognize as hypothyroidism was characterized as "myxoedema" in 1878 by William Ord at St. Thomas Hospital. In 1891, George Murray reported that injection of thyroid extract from sheep led to improvement in symptoms in a woman with myxedema. Thomas Kocher, who reported that patients with goiter who underwent complete thyroidectomy developed cachexia strumipriva, was awarded the Nobel Prize in Physiology and Medicine in 1909. Edward Kendall discovered "thyroxin" on Christmas day in 1914. Studies by David Marine that iodine treatment prevented endemic goiter led to salt iodination, which has largely eradicated endemic cretinism. In 1973, Jean Dussault reported detection of congenital hypothyroidism by screening newborn populations.
    MeSH term(s) Female ; Male ; Animals ; Humans ; Sheep ; Goiter ; Thyroidectomy ; Hypothyroidism/drug therapy ; Myxedema ; Iodine
    Chemical Substances Iodine (9679TC07X4)
    Language English
    Publishing date 2022-11-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2537278-6
    ISSN 1663-2826 ; 1663-2818
    ISSN (online) 1663-2826
    ISSN 1663-2818
    DOI 10.1159/000526621
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Condylar Position is Maintained in Maxillomandibular Advancement Surgery Utilizing Custom Cutting Guides and Plates.

    Dai, Zachary / Connelly, Stephen T / Silva, Rebeka / Gupta, Rishi Jay

    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

    2022  Volume 81, Issue 2, Page(s) 156–164

    Abstract: Purpose: The objective of this study is to compare virtual surgical planned (VSP) and postoperative condylar positioning outcomes in patients who underwent maxillomandibular advancement surgery with custom mandibular cutting guides and osteosynthesis ... ...

    Abstract Purpose: The objective of this study is to compare virtual surgical planned (VSP) and postoperative condylar positioning outcomes in patients who underwent maxillomandibular advancement surgery with custom mandibular cutting guides and osteosynthesis plates to establish reliability and effectiveness using these forms of technology.
    Methods: An ambispective case series was performed by obtaining preoperative and postoperative computed tomography (CT) scans of obstructive sleep apnea patients who underwent maxillomandibular advancement surgery with VSP and custom printed mandibular cutting guides and plates at the San Francisco Veterans Affairs Healthcare System from February 2019 to October 2021. The primary predictor variables were the use of custom guides and plates compared to VSP over the course of a year. The outcome variable was the maintained condylar position, defined as the mean differences between the VSP and postoperative positioning. The comparison group was the preoperative VSP position. Covariates were planned surgical movements, age, and gender. Measurements were taken bilaterally in sagittal CT sections measuring the condylar positioning within the posterior space, superior space, and anterior space of the glenoid fossae. Similarly, coronal CT section measurements were taken to measure the condylar positioning within the coronal lateral space, coronal central space, and coronal medial space. A Wilcoxon signed rank test was used.
    Results: This study included 6 male participants (n = 6) aged 32 to 57 years (mean 46.5). The median differences for the posterior space, superior space, and anterior space planned versus postoperative position were 0.25 (0.40), 0.40 (0.35), and 0.40 (0.55) mm, respectively. The median differences for the coronal lateral space, coronal central space, and coronal medial space planned versus postoperative position were 0.30 (0.30), 0.78 (0.70), and 0.40 (0.30) mm, respectively. There was no statistically significant difference in the planned and postoperative condylar position (Wilcoxon signed rank test, P > .5). A qualitative analysis showed little to no displacement or rotation of the condyle in the virtually planned and postoperative condylar positions.
    Conclusions: Qualitative and quantitative comparisons of the preoperative virtual surgical planned and the postoperative condylar position with the use of custom-printed mandibular cutting guides and plates support the null hypothesis that there is no difference between planned and postoperative positioning.
    MeSH term(s) Humans ; Male ; Mandibular Condyle/diagnostic imaging ; Mandibular Condyle/surgery ; Reproducibility of Results ; Imaging, Three-Dimensional/methods ; Mandible/surgery ; Orthognathic Surgical Procedures
    Language English
    Publishing date 2022-10-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 392404-x
    ISSN 1531-5053 ; 0278-2391
    ISSN (online) 1531-5053
    ISSN 0278-2391
    DOI 10.1016/j.joms.2022.10.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Spinoza, Right and Absolute Freedom

    Connelly, Stephen

    (Birkbeck Law Press)

    2015  

    Abstract: Against jurisprudential reductions of Spinoza's thinking to a kind of eccentric version of Hobbes, this book argues that Spinoza's theory of natural right contains an important idea of absolute freedom, which would be inconceivable within Hobbes' own ... ...

    Series title Birkbeck Law Press
    Abstract Against jurisprudential reductions of Spinoza's thinking to a kind of eccentric version of Hobbes, this book argues that Spinoza's theory of natural right contains an important idea of absolute freedom, which would be inconceivable within Hobbes' own schema. Spinoza famously thought that the universe and all of the beings and events within it are fully determined by their causes. This has led jurisprudential commentators to believe that Spinoza has no room for natural right - in the sense that whatever happens by definition has a 'right' to happen. But, although this book demonstrates how Spin
    Language English
    Size Online-Ressource (257 p)
    Publisher Taylor and Francis
    Publishing place Hoboken
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9781138826892 ; 1138826898
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Article: Answers in search of questions: what does the comparison of COVID19 data among regions in Northern Italy tell us?

    Connelly, Luke B / Birch, Stephen

    Health Econ Policy Law

    Abstract: Since the outbreak of the COVID-19 pandemic, discussions about the capabilities of health and social systems to control and contain infectious diseases have been reignited. In Resilient Managed Competition During Pandemics: Lessons from the Italian ... ...

    Abstract Since the outbreak of the COVID-19 pandemic, discussions about the capabilities of health and social systems to control and contain infectious diseases have been reignited. In Resilient Managed Competition During Pandemics: Lessons from the Italian Experience, Costa-Font, Turatti and Levaggi ask whether or not institutional differences between the managed competition (MC) systems in three of Italy's regions may have affected their performance - and hence, population health outcomes - during the pandemic. Fuchs (2000) previously argued that institutional arrangements not only 'matter', but also sometimes 'matter a great deal' (p. 149, emphasis in original) and this may be particularly true in emergencies.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #744337
    Database COVID19

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