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Article ; Online: Structural basis for the inhibition of coronaviral main proteases by ensitrelvir.

Lin, Cheng / Jiang, Haihai / Li, Wenwen / Zeng, Pei / Zhou, Xuelan / Zhang, Jin / Li, Jian

Structure (London, England : 1993)

2023 Volume 31, Issue 9, Page(s) 1016–1024.e3

Abstract: Main protease ( ... ...

Abstract	Main protease (M
MeSH term(s)	Humans ; SARS-CoV-2/metabolism ; COVID-19 ; Protease Inhibitors/chemistry ; Antiviral Agents/chemistry ; Peptide Hydrolases
Chemical Substances	ensitrelvir (PX665RAA3H) ; Protease Inhibitors ; Antiviral Agents ; Peptide Hydrolases (EC 3.4.-)
Language	English
Publishing date	2023-07-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1213087-4
ISSN	1878-4186 ; 0969-2126
ISSN (online)	1878-4186
ISSN	0969-2126
DOI	10.1016/j.str.2023.06.010
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Article ; Online: Crystal structure of SARS-CoV-2 main protease (M

Jiang, Haihai / Zou, Xiaofang / Zhou, Xuelan / Zhang, Jin / Li, Jian

Biochemical and biophysical research communications

2023 Volume 692, Page(s) 149352

Abstract: SARS-CoV-2 constantly circulates and evolves worldwide, generating many variants and posing a menace to global health. It is urgently needed to discover effective medicines to treat the disease caused by SARS-CoV-2 and its variants. An established target ...

Abstract	SARS-CoV-2 constantly circulates and evolves worldwide, generating many variants and posing a menace to global health. It is urgently needed to discover effective medicines to treat the disease caused by SARS-CoV-2 and its variants. An established target for anti-SARS-CoV-2 drug discovery is the main protease (M
MeSH term(s)	Humans ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; COVID-19 ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; Protease Inhibitors/chemistry ; Viral Nonstructural Proteins/chemistry ; Molecular Docking Simulation
Chemical Substances	2-(benzotriazol-1-yl)-N-((3-chlorophenyl)methyl)-N-(4-(1H-imidazol-4-yl)phenyl)acetamide ; 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Antiviral Agents ; Protease Inhibitors ; Viral Nonstructural Proteins
Language	English
Publishing date	2023-12-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2023.149352
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Zs.A 116: Show issues

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Article ; Online: Structural Basis for the Inhibition of SARS-CoV-2 M

Zhao, Zhenyu / Zhu, Qinyao / Zhou, Xuelan / Li, Wenwen / Yin, Xiushan / Li, Jian

Viruses

2023 Volume 16, Issue 1

Abstract: Preventing the spread of SARS-CoV-2 and its variants is crucial in the fight against COVID-19. Inhibition of the main protease ( ... ...

Abstract	Preventing the spread of SARS-CoV-2 and its variants is crucial in the fight against COVID-19. Inhibition of the main protease (M
MeSH term(s)	Lactams ; Leucine ; Naphthoquinones/pharmacology ; Nitriles ; SARS-CoV-2/drug effects ; SARS-CoV-2/genetics ; Coronavirus 3C Proteases/antagonists & inhibitors
Chemical Substances	Lactams ; Leucine (GMW67QNF9C) ; Naphthoquinones ; Nitriles ; shikonin (3IK6592UBW) ; Coronavirus 3C Proteases (EC 3.4.22.28) ; 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-)
Language	English
Publishing date	2023-12-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v16010065
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Article ; Online: Effect of Sodium Selenite on the Metabolite Profile of Epichloë sp. Mycelia from Festuca sinensis in Solid Culture.

Zhou, Lianyu / Jiao, Lu / Ju, Jiasheng / Ma, Xuelan

Biological trace element research

2022 Volume 200, Issue 11, Page(s) 4865–4879

Abstract: Selenium (Se) is an essential micronutrient with many beneficial effects for humans and other living organisms. Numerous microorganisms in culture systems enrich and convert inorganic selenium to organic selenium. In this study, Epichloë sp. from Festuca ...

Abstract	Selenium (Se) is an essential micronutrient with many beneficial effects for humans and other living organisms. Numerous microorganisms in culture systems enrich and convert inorganic selenium to organic selenium. In this study, Epichloë sp. from Festuca sinensis was exposed to increasing Na
MeSH term(s)	Agar ; Antioxidants/pharmacology ; Cellobiose ; Epichloe/chemistry ; Epichloe/metabolism ; Fatty Acids ; Festuca/metabolism ; Glucose ; Glutathione ; Humans ; Isomaltose ; Lysine ; Maltose ; Micronutrients ; Palmitic Acids ; Selenious Acid ; Selenium/metabolism ; Selenium/pharmacology ; Sodium Selenite/metabolism ; Sodium Selenite/pharmacology ; Stearic Acids ; Sucrose ; Tyrosine ; Uridine
Chemical Substances	Antioxidants ; Fatty Acids ; Micronutrients ; Palmitic Acids ; Stearic Acids ; Cellobiose (16462-44-5) ; Tyrosine (42HK56048U) ; Sucrose (57-50-1) ; Isomaltose (67I334IX2M) ; Maltose (69-79-4) ; Agar (9002-18-0) ; Selenious Acid (F6A27P4Q4R) ; Glutathione (GAN16C9B8O) ; Selenium (H6241UJ22B) ; Sodium Selenite (HIW548RQ3W) ; Glucose (IY9XDZ35W2) ; Lysine (K3Z4F929H6) ; Uridine (WHI7HQ7H85)
Language	English
Publishing date	2022-01-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-021-03054-w
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Article ; Online: Crystal structures of main protease (M

Jiang, Haihai / Zou, Xiaofang / Zeng, Pei / Zeng, Xiangyi / Zhou, Xuelan / Wang, Jie / Zhang, Jin / Li, Jian

Molecular biomedicine

2023 Volume 4, Issue 1, Page(s) 23

Abstract: There is an urgent need to develop effective antiviral drugs to prevent the viral infection caused by constantly circulating SARS-CoV-2 as well as its variants. The main protease ( ... ...

Abstract	There is an urgent need to develop effective antiviral drugs to prevent the viral infection caused by constantly circulating SARS-CoV-2 as well as its variants. The main protease (M
Language	English
Publishing date	2023-08-03
Publishing country	Singapore
Document type	Journal Article
ISSN	2662-8651
ISSN (online)	2662-8651
DOI	10.1186/s43556-023-00134-2
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Article: Effect of Sodium Selenite on the Metabolite Profile of Epichloë sp. Mycelia from Festuca sinensis in Solid Culture

Zhou, Lianyu / Jiao, Lu / Ju, Jiasheng / Ma, Xuelan

Biological trace element research. 2022 Nov., v. 200, no. 11

2022

Abstract	Selenium (Se) is an essential micronutrient with many beneficial effects for humans and other living organisms. Numerous microorganisms in culture systems enrich and convert inorganic selenium to organic selenium. In this study, Epichloë sp. from Festuca sinensis was exposed to increasing Na₂SeO₃ concentrations (0, 0.1, 0.2, 0.3, and 0.4 mmol/L) in Petri dishes with potato dextrose agar (PDA) for 8 weeks. Epichloë sp. mycelia were immediately collected after mycelial diameters were measured at 4, 5, 6, 7, and 8 weeks of cultivation, respectively. Gas chromatography-mass spectrometer (GC-MS) analysis was performed on different groups of Epichloë sp. mycelia. Different changes were observed as Epichloë sp. was exposed to different selenite conditions and cultivation time. The colony diameter of Epichloë sp. decreased in response to increased selenite concentrations, whereas the inhibitory effects diminished over time. Seventy-two of the 203 identified metabolites did not differ significantly across selenite treatments within the same time point, while 82 compounds did not differ significantly between multiple time points of the same Se concentration. However, the relative levels of 122 metabolites increased the most under selenite conditions. Specifically, between the 4th and 8th weeks, there were increases in 2-keto-isovaleric acid, uridine, and maltose in selenite treatments compared to controls. Selenium increased glutathione levels and exhibited antioxidant properties in weeks 4, 5, and 7. Additionally, we observed that different doses of selenite could promote the production of carbohydrates such as isomaltose, cellobiose, and sucrose; fatty acids such as palmitoleic acid, palmitic acid, and stearic acid; and amino acids such as lysine and tyrosine in Epichloë sp. mycelia. Therefore, Epichloë sp. exposed to selenite stress may benefit from increased levels of some metabolite compounds.
Keywords	Festuca sinensis ; antioxidants ; cellobiose ; culture media ; gas chromatography ; glutathione ; isomaltose ; lysine ; maltose ; metabolites ; mycelium ; palmitic acid ; palmitoleic acid ; research ; selenium ; sodium selenite ; spectrometers ; stearic acid ; sucrose ; tyrosine ; uridine
Language	English
Dates of publication	2022-11
Size	p. 4865-4879.
Publishing place	Springer US
Document type	Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-021-03054-w
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Structural Basis for Coronaviral Main Proteases Inhibition by the 3CLpro Inhibitor GC376.

Lin, Cheng / Zhu, Zhimin / Jiang, Haihai / Zou, Xiaofang / Zeng, Xiangyi / Wang, Jie / Zeng, Pei / Li, Wenwen / Zhou, Xuelan / Zhang, Jin / Wang, Qisheng / Li, Jian

Journal of molecular biology

2024 Volume 436, Issue 6, Page(s) 168474

Abstract: The main protease ( ... ...

Abstract	The main protease (M
MeSH term(s)	Humans ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Coronavirus/drug effects ; Coronavirus/enzymology ; Lactams/pharmacology ; Leucine/analogs & derivatives ; SARS-CoV-2/enzymology ; Sulfonic Acids/pharmacology ; Coronavirus 3C Proteases/antagonists & inhibitors ; Coronavirus 3C Proteases/chemistry
Chemical Substances	Antiviral Agents ; GC376 (H1NMJ5XDG5) ; Lactams ; Leucine (GMW67QNF9C) ; Sulfonic Acids ; Coronavirus 3C Proteases (EC 3.4.22.28)
Language	English
Publishing date	2024-02-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80229-3
ISSN	1089-8638 ; 0022-2836
ISSN (online)	1089-8638
ISSN	0022-2836
DOI	10.1016/j.jmb.2024.168474
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Zs.A 867: Show issues

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Article ; Online: Alleviation effect of conjugated linoleic acid on estradiol benzoate induced fatty liver hemorrhage syndrome in Hy-line male chickens.

Wang, Anqi / Zhang, Kexin / Fu, Chunyan / Zhou, Changming / Yan, Zhengui / Liu, Xuelan

Journal of animal science

2023 Volume 101

Abstract: The purpose of this study was to explore whether conjugated linoleic acid (CLA) could alleviate fatty liver hemorrhagic syndrome (FLHS) induced by estradiol benzoate intramuscular injection in laying hens. One hundred male Hy-Line white chickens were ... ...

Abstract	The purpose of this study was to explore whether conjugated linoleic acid (CLA) could alleviate fatty liver hemorrhagic syndrome (FLHS) induced by estradiol benzoate intramuscular injection in laying hens. One hundred male Hy-Line white chickens were randomly divided into two groups, namely, the control (CON) and estradiol benzoate (E) groups, and both groups were fed the same basal diet. After injections of estradiol benzoate at 2 mg/kg every two days for a total of 7 times, chickens in the E group showed FLHS symptoms, including liver enlargement, hemorrhage, and steatosis. Then half of the chickens in the E group received an additional diet containing 5000 mg/kg CLA for 8 weeks. The results of morphological observations, hematoxylin and eosin staining, and Oil Red O staining showed that CLA alleviated liver enlargement, hemorrhage, and lipid accumulation in FLHS chickens. In addition, we measured liver function and lipid metabolism indicators, including ALT, AST, TG, TCH, HDL-C, and LDL-C, which further suggested that CLA mitigated the disturbance of serum and liver metabolism in FLHS chickens. Mechanistically, CLA inhibited hepatic de novo lipogenesis, cholesterol synthesis, and TG accumulation and increased TG hydrolysis in FLHS chickens by regulating the gene expression of CD36, ACC, FAS, SCD 1, DGAT2, LIPE, ATGL, CPT1A, SREBP-1c, SREBP-2, PPARγ, and PPARα. Furthermore, CLA ameliorated hepatic oxidative stress and inhibited NF-κB signaling pathway-mediated inflammation in FLHS chickens. In conclusion, CLA regulated lipid metabolism, thus further alleviating oxidative stress and inflammation to alleviate FLHS induced by estrogen in chickens.
MeSH term(s)	Male ; Animals ; Female ; Chickens/physiology ; Linoleic Acids, Conjugated/metabolism ; Fatty Liver/veterinary ; Liver/metabolism ; Hemorrhage/genetics ; Hemorrhage/metabolism ; Hemorrhage/veterinary ; Inflammation/metabolism ; Inflammation/veterinary
Chemical Substances	estradiol 3-benzoate (1S4CJB5ZGN) ; Linoleic Acids, Conjugated
Language	English
Publishing date	2023-02-07
Publishing country	United States
Document type	Randomized Controlled Trial, Veterinary ; Journal Article
ZDB-ID	390959-1
ISSN	1525-3163 ; 0021-8812
ISSN (online)	1525-3163
ISSN	0021-8812
DOI	10.1093/jas/skad045
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Article ; Online: Effects of Environmental Factors on Bird Communities in Different Urbanization Grades: An Empirical Study in Lishui, a Mountainous Area of Eastern China

Wenwen / Zhou, Ying / Fang, Xuelan / Zhao, Shengjun / Wu, Yi / Zhang, Haonan / Cui, Liangwei / Cui, Peng

Animals. 2023 Feb. 28, v. 13, no. 5

2023

Abstract: The rapid development of urbanization has changed landscape patterns and biological habitats severely and, therefore, affected biodiversity. In this study, we selected 75 townships in Lishui, a mountainous area in eastern China, to conduct bird surveys ... ...

Abstract	The rapid development of urbanization has changed landscape patterns and biological habitats severely and, therefore, affected biodiversity. In this study, we selected 75 townships in Lishui, a mountainous area in eastern China, to conduct bird surveys for two years. We analyzed the birds’ composition characters in townships with different levels of development in order to identify the effects on bird diversity of the urban development level, land cover pattern, landscape pattern, and other factors. In total, 296 bird species from 18 orders and 67 families were recorded between December 2019 and January 2021. A total of 166 species of birds belonged to Passeriformes (56.08%). The seventy-five townships were divided into three grades by K-means cluster analysis. The average number of bird species, richness index, and diversity index were higher in G-H (highest urban development level) compared with the other grades. At the township level, landscape diversity and landscape fragmentation were the key factors that positively affected the bird species number, diversity index, and richness index. Landscape diversity had a greater effect than landscape fragmentation, particularly on the Shannon–Weiner diversity index. The diversity and heterogeneity of urban landscapes could be improved by constructing biological habitats in future urban development planning to maintain and increase biodiversity. The results obtained in this study provide a theoretical basis for urban planning in mountainous areas, and a reference for policymakers to formulate biodiversity conservation strategies, construct reasonable biodiversity patterns, and solve practical biodiversity conservation problems.
Keywords	Passeriformes ; biodiversity ; biodiversity conservation ; birds ; cluster analysis ; empirical research ; habitat fragmentation ; land cover ; landscapes ; mountains ; urbanization ; China
Language	English
Dates of publication	2023-0228
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13050882
Database	NAL-Catalogue (AGRICOLA)

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Article: The Protective Effect of Ethyl Acetate and

Luan, Ruqiao / Sun, Linlin / Zhang, Xuelan / Zhao, Pan / Zhou, Qiao / Zhang, Zhihui

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 6512242

Abstract: Ligustri Lucidi Fructus (LLF), the dry and ripe fruit ... ...

Abstract	Ligustri Lucidi Fructus (LLF), the dry and ripe fruit of
Language	English
Publishing date	2021-10-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/6512242
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