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  1. Article: Engineering Substrate Channeling in Assembly-Line Terpene Biosynthesis.

    Wenger, Eliott S / Schultz, Kollin / Marmorstein, Ronen / Christianson, David W

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Fusicoccadiene synthase ... ...

    Abstract Fusicoccadiene synthase from
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.25.586617
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Investigating associations between caffeinated beverage consumption and later alcohol consumption among early adolescents.

    Marmorstein, Naomi R

    Addictive behaviors

    2018  Volume 90, Page(s) 362–368

    Abstract: Previous research has demonstrated that caffeinated beverage consumption predicts alcohol consumption among early adolescents. This study aimed to investigate this association in two ways: (1) by examining if this association remained significant once ... ...

    Abstract Previous research has demonstrated that caffeinated beverage consumption predicts alcohol consumption among early adolescents. This study aimed to investigate this association in two ways: (1) by examining if this association remained significant once other established risk factors for alcohol were adjusted for statistically; and (2) by considering three possible moderators of this association: gender, sensation-seeking, and parental monitoring. Data from the Camden Youth Development Study, a longitudinal, community-based study of middle-school students, were used. Youth were initially assessed in 6th and 7th grade and followed-up 16 months later. Self-reports of frequency of energy drink, coffee, and alcohol consumption, as well as sensation-seeking, perceived peer and best friend alcohol use, alcohol expectancies, and parental monitoring, were used. Results indicated that both energy drink and coffee consumption predicted later alcohol consumption, even after adjusting for other risk factors for alcohol consumption. Parental monitoring was a significant moderator of this link, such that youth who consumed energy drinks and reported low parental monitoring were particularly at risk for later alcohol consumption. These findings indicate that the link between earlier caffeine consumption and later alcohol consumption is not simply due to the co-occurrence of caffeine consumption with other risk factors for alcohol use. In addition, risk associated with early energy drink consumption appears to be particularly pronounced for youth in families characterized by low parental monitoring.
    MeSH term(s) Adolescent ; Adolescent Behavior ; Caffeine/administration & dosage ; Child ; Coffee ; Energy Drinks/statistics & numerical data ; Female ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Male ; New Jersey ; Self Report ; Surveys and Questionnaires ; Underage Drinking/statistics & numerical data
    Chemical Substances Coffee ; Caffeine (3G6A5W338E)
    Language English
    Publishing date 2018-11-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 197618-7
    ISSN 1873-6327 ; 0306-4603
    ISSN (online) 1873-6327
    ISSN 0306-4603
    DOI 10.1016/j.addbeh.2018.11.033
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  3. Article ; Online: Reply to: Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase.

    Wei, Xuepeng / Marmorstein, Ronen

    Nature structural & molecular biology

    2021  Volume 28, Issue 8, Page(s) 639–641

    MeSH term(s) ATP Citrate (pro-S)-Lyase/genetics ; Acetyl Coenzyme A ; Adenosine Triphosphate ; Citrate (si)-Synthase ; Multienzyme Complexes ; Oxo-Acid-Lyases
    Chemical Substances Multienzyme Complexes ; Acetyl Coenzyme A (72-89-9) ; Adenosine Triphosphate (8L70Q75FXE) ; Citrate (si)-Synthase (EC 2.3.3.1) ; ATP Citrate (pro-S)-Lyase (EC 2.3.3.8) ; Oxo-Acid-Lyases (EC 4.1.3.-) ; citrate (pro-3S)-lyase (EC 4.1.3.6)
    Language English
    Publishing date 2021-07-22
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2126708-X
    ISSN 1545-9985 ; 1545-9993
    ISSN (online) 1545-9985
    ISSN 1545-9993
    DOI 10.1038/s41594-021-00625-2
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  4. Article ; Online: Preface.

    Marmorstein, Ronen

    Methods in enzymology

    2016  Volume 574, Page(s) xv–xvii

    Language English
    Publishing date 2016
    Publishing country United States
    Document type Editorial
    ISSN 1557-7988 ; 0076-6879
    ISSN (online) 1557-7988
    ISSN 0076-6879
    DOI 10.1016/S0076-6879(16)30150-1
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  5. Article ; Online: Preface.

    Marmorstein, Ronen

    Methods in enzymology

    2016  Volume 573, Page(s) xvii–xix

    Language English
    Publishing date 2016
    Publishing country United States
    Document type Editorial
    ISSN 1557-7988 ; 0076-6879
    ISSN (online) 1557-7988
    ISSN 0076-6879
    DOI 10.1016/S0076-6879(16)30122-7
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  6. Article: Interactions Between Energy Drink Consumption and Sleep Problems: Associations with Alcohol Use Among Young Adolescents.

    Marmorstein, Naomi R

    Journal of caffeine research

    2017  Volume 7, Issue 3, Page(s) 111–116

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2017-07-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2603596-0
    ISSN 2156-5368 ; 2156-5783
    ISSN (online) 2156-5368
    ISSN 2156-5783
    DOI 10.1089/jcr.2017.0007
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  7. Article ; Online: Structure of the prenyltransferase in bifunctional copalyl diphosphate synthase from Penicillium fellutanum reveals an open hexamer conformation.

    Gaynes, Matthew N / Ronnebaum, Trey A / Schultz, Kollin / Faylo, Jacque L / Marmorstein, Ronen / Christianson, David W

    Journal of structural biology

    2024  Volume 216, Issue 1, Page(s) 108060

    Abstract: Copalyl diphosphate synthase from Penicillium fellutanum (PfCPS) is an assembly-line terpene synthase that contains both prenyltransferase and class II cyclase activities. The prenyltransferase catalyzes processive chain elongation reactions using ... ...

    Abstract Copalyl diphosphate synthase from Penicillium fellutanum (PfCPS) is an assembly-line terpene synthase that contains both prenyltransferase and class II cyclase activities. The prenyltransferase catalyzes processive chain elongation reactions using dimethylallyl diphosphate and three equivalents of isopentenyl diphosphate to yield geranylgeranyl diphosphate, which is then utilized as a substrate by the class II cyclase domain to generate copalyl diphosphate. Here, we report the 2.81 Å-resolution cryo-EM structure of the hexameric prenyltransferase of full-length PfCPS, which is surrounded by randomly splayed-out class II cyclase domains connected by disordered polypeptide linkers. The hexamer can be described as a trimer of dimers; surprisingly, one of the three dimer-dimer interfaces is separated to yield an open hexamer conformation, thus breaking the D3 symmetry typically observed in crystal structures of other prenyltransferase hexamers such as wild-type human GGPP synthase (hGGPPS). Interestingly, however, an open hexamer conformation was previously observed in the crystal structure of D188Y hGGPPS, apparently facilitated by hexamer-hexamer packing in the crystal lattice. The cryo-EM structure of the PfCPS prenyltransferase hexamer is the first to reveal that an open conformation can be achieved even in the absence of a point mutation or interaction with another hexamer. Even though PfCPS octamers are not detected, we suggest that the open hexamer conformation represents an intermediate in the hexamer-octamer equilibrium for those prenyltransferases that do exhibit oligomeric heterogeneity.
    MeSH term(s) Humans ; Dimethylallyltranstransferase/genetics ; Penicillium/genetics ; Plant Proteins/genetics ; Alkyl and Aryl Transferases
    Chemical Substances ent-kaurene synthetase A (EC 2.5.1.-) ; Dimethylallyltranstransferase (EC 2.5.1.1) ; Plant Proteins ; Alkyl and Aryl Transferases (EC 2.5.-)
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1032718-6
    ISSN 1095-8657 ; 1047-8477
    ISSN (online) 1095-8657
    ISSN 1047-8477
    DOI 10.1016/j.jsb.2023.108060
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1428: Show issues Location:
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  8. Article: Energy Drink and Coffee Consumption and Psychopathology Symptoms Among Early Adolescents: Cross-Sectional and Longitudinal Associations.

    Marmorstein, Naomi R

    Journal of caffeine research

    2016  Volume 6, Issue 2, Page(s) 64–72

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2016-06-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2603596-0
    ISSN 2156-5368 ; 2156-5783
    ISSN (online) 2156-5368
    ISSN 2156-5783
    DOI 10.1089/jcr.2015.0018
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  9. Article ; Online: Sleep patterns and problems among early adolescents: Associations with alcohol use.

    Marmorstein, Naomi R

    Addictive behaviors

    2016  Volume 66, Page(s) 13–16

    Abstract: Introduction: Sleep and sleep-related problems are associated with alcohol use and related problems among adults. However, existing research on associations between sleep and alcohol use among early adolescents is minimal, and potential individual and ... ...

    Abstract Introduction: Sleep and sleep-related problems are associated with alcohol use and related problems among adults. However, existing research on associations between sleep and alcohol use among early adolescents is minimal, and potential individual and family factors that may affect this association remain largely unexplored. We examined potential associations between frequency of alcohol use and initial insomnia, subjective daytime sleepiness, sleep irregularity, and disturbed sleep among a low-income, ethnic minority sample of early adolescents; we also considered whether psychopathology symptoms and/or parental monitoring accounted for any associations found.
    Methods: 127 youth who participated in the Camden Youth Development Study (64 male; mean age=13.2; 71% Hispanic, 32% African-American) were assessed using self-report measures of sleep, alcohol use, psychopathology symptoms (depressive and conduct disorder), and parental monitoring; in addition, teacher reports of attention-deficit hyperactivity disorder were used.
    Results: Initial insomnia and daytime sleepiness (but not sleep irregularity or disturbed sleep) were associated with frequency of alcohol use. The association between initial insomnia and alcohol use remained significant when each form of psychopathology and parental monitoring were adjusted for.
    Conclusions: Among early adolescents, frequency of alcohol use is associated with initial insomnia, even once symptoms of psychopathology and family environment (parental monitoring) are adjusted for. Longitudinal research investigating the direction of this effect and other possible mediators and moderators would be useful in developing preventative and treatment interventions.
    MeSH term(s) Adolescent ; Attention Deficit Disorder with Hyperactivity/etiology ; Child ; Conduct Disorder/etiology ; Cross-Sectional Studies ; Depression/etiology ; Female ; Humans ; London ; Male ; Parenting ; Self Report ; Sleep/physiology ; Sleep Initiation and Maintenance Disorders/etiology ; Underage Drinking
    Language English
    Publishing date 2016-11-03
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 197618-7
    ISSN 1873-6327 ; 0306-4603
    ISSN (online) 1873-6327
    ISSN 0306-4603
    DOI 10.1016/j.addbeh.2016.11.002
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  10. Article: Interactions Between Internalizing Symptoms and Urgency in the Prediction of Alcohol Use and Expectancies Among Low-Income, Minority Early Adolescents.

    Marmorstein, Naomi R

    Substance abuse : research and treatment

    2016  Volume 9, Issue Suppl 1, Page(s) 59–68

    Abstract: This study examined whether urgency, a disposition to rash action under conditions of strong emotion, moderates associations between internalizing symptoms and alcohol use and related expectancies. Data from the Camden Youth Development Study, a ... ...

    Abstract This study examined whether urgency, a disposition to rash action under conditions of strong emotion, moderates associations between internalizing symptoms and alcohol use and related expectancies. Data from the Camden Youth Development Study, a longitudinal, community-based study of early adolescents (N = 144, mean age at intake = 11.9 years; 65% Hispanic, 30% African-American; 50% male), were used. Self-report questionnaire measures of depressive symptoms, social and generalized anxiety symptoms, urgency, alcohol use, and alcohol expectancies were used. Mixed models were used to examine the effects of internalizing symptoms, urgency, and their interaction on alcohol use and expectancy trajectories over time. Depressive symptoms interacted with urgency such that youth with high levels of both tended to have elevated levels of global positive alcohol expectancies. Social anxiety symptoms interacted with urgency to be associated with increasing levels of social behavior alcohol expectancies such that youth with high levels of both tended to experience particular increases in these expectancies over time. Generalized anxiety was not found to be associated with alcohol-related constructs. Therefore, high levels of urgency combine with depressive and social anxiety symptoms to be associated with particularly increased risk for alcohol expectancies that are associated with later alcohol use and problems, indicating particular risk for youth with these combinations of personality traits and psychopathology symptoms.
    Language English
    Publishing date 2016-08-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1458030-5
    ISSN 1547-0164 ; 1178-2218 ; 0889-7077
    ISSN (online) 1547-0164
    ISSN 1178-2218 ; 0889-7077
    DOI 10.4137/SART.S31438
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