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  1. Book: Sterben wie im Märchen

    Seifert, Ilja

    Ethik zwischen Embryos und Einäscherung : Essays aus zehn Jahren

    2019  

    Author's details Ilja Seifert
    Keywords A ; Deutschsprachige Literatur 21. Jahrhundert ; Essay ; Ethik ; Gesellschaft ; Gesellschaftskritik ; Menschen mit Behinderung ; Politik ; Sterbehilfe ; Medizinische Ethik
    Subject Ärztliche Ethik ; Klinische Ethik ; Ärztliches Ethos ; Arzt ; Medizin ; Heilberuf ; Medizinethik
    Subject code 800
    Language German
    Size 180 Seiten, 21 cm
    Publisher Karin Fischer Verlag
    Publishing place Aachen
    Publishing country Germany
    Document type Book
    HBZ-ID HT020060725
    ISBN 978-3-8422-4667-6 ; 3-8422-4667-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 A 1314 available for loan (reading room) Lesesaal EG

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  2. Book ; Thesis: Darstellung von Veränderungen der Aderhaut und Netzhaut bei Patienten mit Uveitis posterior mittels Enhanced Depth imaging mit dem Spectralis OCT als Ergänzung zur Fluoreszein- und Indozyaningrünangiographie

    Seifert, Karina

    2014  

    Author's details vorgelegt von Karina Seifert
    Language German
    Size 75 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2014
    HBZ-ID HT018580248
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 E 469 order for loan Magazin

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  3. Article ; Online: [No title information]

    Kobberø, Hanne / Andersen, Karin / Seifert, Rie / Graugaard-Jensen, Charlotte

    Ugeskrift for laeger

    2023  Volume 185, Issue 12

    Abstract: Bladder pain syndrome is rare and leads to increased morbidity and decreased quality of life. The patients are a heterogenous group with different clinical presentations, and little is known of the different aspects of the syndrome. A thorough patient ... ...

    Title translation Bladder pain syndrome.
    Abstract Bladder pain syndrome is rare and leads to increased morbidity and decreased quality of life. The patients are a heterogenous group with different clinical presentations, and little is known of the different aspects of the syndrome. A thorough patient history and specialised diagnostics are required to offer these patients the best possible treatment. This review suggests an algorithm to manage these patients at all levels of the Danish health-care system. It is recommended that final diagnosis and multidisciplinary treatment should be centered at large regional hospitals.
    MeSH term(s) Humans ; Quality of Life ; Cystitis, Interstitial ; Delivery of Health Care ; Syndrome ; Algorithms
    Language Danish
    Publishing date 2023-03-31
    Publishing country Denmark
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 302: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Ua VI Zs.6/30: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  4. Book ; Online ; Thesis: Acinetobacter baumannii RND efflux pump regulators and their impact on antimicrobial susceptibility

    Lucaßen, Kai [Verfasser] / Seifert, Harald [Gutachter] / Schnetz, Karin [Gutachter]

    2022  

    Author's details Kai Lucaßen ; Gutachter: Harald Seifert, Karin Schnetz
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitäts- und Stadtbibliothek Köln
    Publishing place Köln
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  5. Article: Alike but not the same: Psychological profiles of COVID-19 vaccine skeptics.

    Voss, Ursula / Schermelleh-Engel, Karin / Hauser, Leana / Holzmann, Mira / Fichtner, Diana / Seifert, Sonja / Klimke, Ansgar / Windmann, Sabine

    Health psychology open

    2024  Volume 11, Page(s) 20551029241248757

    Abstract: One of the challenges of the SARS-CoV-2 pandemic was a widespread skepticism about vaccination. To elucidate the underlying mental and emotional predispositions, we examined a sample of 1428 participants using latent profile analysis (LPA) on selected ... ...

    Abstract One of the challenges of the SARS-CoV-2 pandemic was a widespread skepticism about vaccination. To elucidate the underlying mental and emotional predispositions, we examined a sample of 1428 participants using latent profile analysis (LPA) on selected personality trait variables, mental health status, and measures of irrational beliefs. LPA revealed five distinct profiles: two classes of non-skeptics and three of skeptics. The smaller non-skeptic class reported the highest rates of mental health problems, along with high levels of neuroticism, hostility, interpersonal sensitivity, and external locus of control. The larger non-skeptic class was psychologically well-balanced. Conversely, the skeptic groups shared strong distrust of COVID-19 vaccination but differed in emotional and mental profiles, leading to graded differences in endorsing extreme conspiracy beliefs. This suggests that vaccine skepticism is not solely a result of mental illness or emotional instability; rather extreme skepticism manifests as a nuanced, graded phenomenon contingent on personality traits and conspirational beliefs.
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2779205-5
    ISSN 2055-1029
    ISSN 2055-1029
    DOI 10.1177/20551029241248757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online ; Thesis: Mobile genetic elements and clonal dynamics of antibiotic-resistant hospital-acquired bacteria

    Xanthopoulou, Kyriaki [Verfasser] / Seifert, Harald [Gutachter] / Schnetz, Karin [Gutachter]

    2021  

    Author's details Kyriaki Xanthopoulou ; Gutachter: Harald Seifert, Karin Schnetz
    Keywords Naturwissenschaften ; Science
    Subject code sg500
    Language English
    Publisher Universitäts- und Stadtbibliothek Köln
    Publishing place Köln
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

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  7. Article: Schlecht hören, schlecht sehen: der Alltag wird schwieriger

    Seifert, Alexander / Huber, Karin

    2017  , Issue 02, Page(s) 14

    Keywords Alter ; Hörschädigung
    Language German
    Document type Article
    ISSN 1664-5154
    Database bibnet.org

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  8. Article ; Online: Structures, targets and recent approaches in anti-leishmanial drug discovery and development.

    Seifert, Karin

    The open medicinal chemistry journal

    2011  Volume 5, Page(s) 31–39

    Abstract: Recent years have seen a significant improvement in available treatment options for leishmaniasis. Two new drugs, miltefosine and paromomycin, have been registered for the treatment of visceral leishmaniasis (VL) in India since 2002. Combination therapy ... ...

    Abstract Recent years have seen a significant improvement in available treatment options for leishmaniasis. Two new drugs, miltefosine and paromomycin, have been registered for the treatment of visceral leishmaniasis (VL) in India since 2002. Combination therapy is now explored in clinical trials as a new treatment approach for VL to reduce the length of treatment and potentially prevent selection of resistant parasites. However there is still a need for new drugs due to safety, resistance, stability and cost issues with existing therapies. The search for topical treatments for cutaneous leishmaniasis (CL) is ongoing. This review gives a brief overview of recent developments and approaches in anti-leishmanial drug discovery and development.
    Language English
    Publishing date 2011-03-09
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2395968-X
    ISSN 1874-1045 ; 1874-1045
    ISSN (online) 1874-1045
    ISSN 1874-1045
    DOI 10.2174/1874104501105010031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development.

    Mead, Timothy J / Bhutada, Sumit / Foulcer, Simon J / Peruzzi, Niccolò / Nelson, Courtney M / Seifert, Deborah E / Larkin, Jonathan / Tran-Lundmark, Karin / Filmus, Jorge / Apte, Suneel S

    Matrix biology : journal of the International Society for Matrix Biology

    2024  

    Abstract: Extracellular matrix remodeling mechanisms are understudied in cardiac development and congenital heart defects. We show that matrix-degrading metalloproteases ADAMTS1 and ADAMTS5, are extensively co-expressed during mouse cardiac development. The mouse ... ...

    Abstract Extracellular matrix remodeling mechanisms are understudied in cardiac development and congenital heart defects. We show that matrix-degrading metalloproteases ADAMTS1 and ADAMTS5, are extensively co-expressed during mouse cardiac development. The mouse mutants of each gene have mild cardiac anomalies, however, their combined genetic inactivation to elicit cooperative roles is precluded by tight gene linkage. Therefore, we coupled Adamts1 inactivation with pharmacologic ADAMTS5 blockade to uncover stage-specific cooperative roles and investigated their potential substrates in mouse cardiac development. ADAMTS5 blockade was achieved in Adamts1 null mouse embryos using an activity-blocking monoclonal antibody during distinct developmental windows spanning myocardial compaction or cardiac septation and outflow tract rotation. Synchrotron imaging, RNA in situ hybridization, immunofluorescence microscopy and electron microscopy were used to determine the impact on cardiac development and compared to Gpc6 and ADAMTS-cleavage resistant versican mutants. Mass spectrometry-based N-terminomics was used to seek relevant substrates. Combined inactivation of ADAMTS1 and ADAMTS5 prior to 12.5 days of gestation led to dramatic accumulation of versican-rich cardiac jelly and inhibited formation of compact and trabecular myocardium, which was also observed in mice with ADAMTS cleavage-resistant versican. Combined inactivation after 12.5 days impaired outflow tract development and ventricular septal closure, generating a tetralogy of Fallot-like defect. N-terminomics of combined ADAMTS knockout and control hearts identified a cleaved glypican-6 peptide only in the controls. ADAMTS1 and ADAMTS5 expression in cells was associated with specific glypican-6 cleavages. Paradoxically, combined ADAMTS1 and ADAMTS5 inactivation reduced cardiac glypican-6 and outflow tract Gpc6 transcription. Notably, Gpc6
    Language English
    Publishing date 2024-05-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1183793-7
    ISSN 1569-1802 ; 0945-053X
    ISSN (online) 1569-1802
    ISSN 0945-053X
    DOI 10.1016/j.matbio.2024.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1694: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: V-pipe: a computational pipeline for assessing viral genetic diversity from high-throughput data.

    Posada-Céspedes, Susana / Seifert, David / Topolsky, Ivan / Jablonski, Kim Philipp / Metzner, Karin J / Beerenwinkel, Niko

    Bioinformatics (Oxford, England)

    2021  Volume 37, Issue 12, Page(s) 1673–1680

    Abstract: Motivation: High-throughput sequencing technologies are used increasingly not only in viral genomics research but also in clinical surveillance and diagnostics. These technologies facilitate the assessment of the genetic diversity in intra-host virus ... ...

    Abstract Motivation: High-throughput sequencing technologies are used increasingly not only in viral genomics research but also in clinical surveillance and diagnostics. These technologies facilitate the assessment of the genetic diversity in intra-host virus populations, which affects transmission, virulence and pathogenesis of viral infections. However, there are two major challenges in analysing viral diversity. First, amplification and sequencing errors confound the identification of true biological variants, and second, the large data volumes represent computational limitations.
    Results: To support viral high-throughput sequencing studies, we developed V-pipe, a bioinformatics pipeline combining various state-of-the-art statistical models and computational tools for automated end-to-end analyses of raw sequencing reads. V-pipe supports quality control, read mapping and alignment, low-frequency mutation calling, and inference of viral haplotypes. For generating high-quality read alignments, we developed a novel method, called ngshmmalign, based on profile hidden Markov models and tailored to small and highly diverse viral genomes. V-pipe also includes benchmarking functionality providing a standardized environment for comparative evaluations of different pipeline configurations. We demonstrate this capability by assessing the impact of three different read aligners (Bowtie 2, BWA MEM, ngshmmalign) and two different variant callers (LoFreq, ShoRAH) on the performance of calling single-nucleotide variants in intra-host virus populations. V-pipe supports various pipeline configurations and is implemented in a modular fashion to facilitate adaptations to the continuously changing technology landscape.
    Availabilityand implementation: V-pipe is freely available at https://github.com/cbg-ethz/V-pipe.
    Supplementary information: Supplementary data are available at Bioinformatics online.
    Language English
    Publishing date 2021-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1422668-6
    ISSN 1367-4811 ; 1367-4803
    ISSN (online) 1367-4811
    ISSN 1367-4803
    DOI 10.1093/bioinformatics/btab015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2374: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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