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  1. Article ; Online: New species of Wallabinema Beveridge, 1983 (Nematoda: Strongyloidea) and a redescription of W. gallardi (Johnston & Mawson, 1939) from Australian macropodid marsupials.

    Beveridge, Ian

    Systematic parasitology

    2020  Volume 97, Issue 1, Page(s) 57–67

    Abstract: ... penicillata (J. Gray) and P. inornata Gould, from Queensland, differs from all congeners in having its four ... Macropus dorsalis (J. Gray) and the red-necked pademelon Thylogale thetis (Lesson), also from Queensland ... in the length of the spicules. Wallabinema gallardi (Johnston & Mawson, 1939) is redescribed from T. thetis ...

    Abstract Two new species of Wallabinema Beveridge, 1983 are described from the sacculated fore-stomachs of macropodid marsupials in Australia. Wallabinema petrogale n. sp. from the rock wallabies Petrogale penicillata (J. Gray) and P. inornata Gould, from Queensland, differs from all congeners in having its four sub-median lips subdivided at the base. Wallabinema macropodis n. sp. from the black stripe wallaby Macropus dorsalis (J. Gray) and the red-necked pademelon Thylogale thetis (Lesson), also from Queensland, is most similar to congeners with the nerve-ring encircling the oesophageal isthmus (W. parvispiculare Beveridge, 1983, W. tasmaniense Beveridge, 1983 and W. thylogale Beveridge, 1983), but differs in the length of the spicules. Wallabinema gallardi (Johnston & Mawson, 1939) is redescribed from T. thetis in Queensland and New South Wales, with T. thetis considered to be the type-host.
    MeSH term(s) Animals ; Australia ; Macropodidae/parasitology ; Phylogeny ; Species Specificity ; Stomach/parasitology ; Strongyloidea/anatomy & histology ; Strongyloidea/classification
    Language English
    Publishing date 2020-01-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2018846-8
    ISSN 1573-5192 ; 0165-5752
    ISSN (online) 1573-5192
    ISSN 0165-5752
    DOI 10.1007/s11230-019-09897-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Barriers to Surgical Intervention and Factors Influencing Motor Outcomes in Patients with Severe Peripheral Nerve Injury: A Province Wide Cohort Study.

    Beveridge, Julie C / Beveridge, Allison / Morhart, Michael J / Olson, Jaret L / Tsuyuki, Ross T / Midha, Rajiv / Chan, Christine S M / Wang, Bonnie / Chan, K Ming

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

    2023  , Page(s) 1–9

    Abstract: Introduction: Despite the importance of timing of nerve surgery after peripheral nerve injury, optimal timing of intervention has not been clearly delineated. The goal of this study is to explore factors that may have a significant impact on clinical ... ...

    Abstract Introduction: Despite the importance of timing of nerve surgery after peripheral nerve injury, optimal timing of intervention has not been clearly delineated. The goal of this study is to explore factors that may have a significant impact on clinical outcomes of severe peripheral nerve injury that requires reconstruction with nerve transfer or graft.
    Materials and methods: Adult patients who underwent peripheral nerve transfer or grafting in Alberta were reviewed. Clustered multivariable logistic regression analysis was used to examine the association of time to surgery, type of nerve repair, and patient characteristics on strength outcomes. Cox proportional hazard regression analysis model was used to examine factors correlated with increased time to surgery.
    Results: Of the 163 patients identified, the median time to surgery was 212 days. For every week of delay, the adjusted odds of achieving Medical Research Council strength grade ≥ 3 decreases by 3%. An increase in preinjury comorbidities was associated with longer overall time to surgery (aHR 0.84, 95% CI 0.74-0.95). Referrals made by surgeons were associated with a shorter time to surgery compared to general practitioners (aHR 1.87, 95% CI 1.14-3.06). In patients treated with nerve transfer, the adjusted odds of achieving antigravity strength was 388% compared to nerve grafting; while the adjusted odds decreased by 65% if the injury sustained had a pre-ganglionic injury component.
    Conclusion: Mitigating delays in surgical intervention is crucial to optimizing outcomes. The nature of initial nerve injury and surgical reconstructive techniques are additional important factors that impact postoperative outcomes.
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 197622-9
    ISSN 0317-1671
    ISSN 0317-1671
    DOI 10.1017/cjn.2023.315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Treatment Patterns of Long-Acting Somatostatin Analogs for Neuroendocrine Tumors.

    Clarke, Callisia N / Cockrum, Paul / Beveridge, Thomas J R / Jerry, Michelle / McMorrow, Donna / Tran, Anh Thu / Phan, Alexandria T

    Journal of health economics and outcomes research

    2023  Volume 10, Issue 2, Page(s) 121–131

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-12-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2746906-2
    ISSN 2327-2236 ; 2327-2236
    ISSN (online) 2327-2236
    ISSN 2327-2236
    DOI 10.36469/001c.89300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Investigating the phylogenetic history of toxin tolerance in mushroom-feeding

    Erlenbach, Theresa / Haynes, Lauren / Fish, Olivia / Beveridge, Jordan / Giambrone, Sarah-Ashley / Reed, Laura K / Dyer, Kelly A / Scott Chialvo, Clare H

    Ecology and evolution

    2023  Volume 13, Issue 12, Page(s) e10736

    Abstract: Understanding how and when key novel adaptations evolved is a central goal of evolutionary biology. Within ... ...

    Abstract Understanding how and when key novel adaptations evolved is a central goal of evolutionary biology. Within the
    Language English
    Publishing date 2023-12-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2635675-2
    ISSN 2045-7758
    ISSN 2045-7758
    DOI 10.1002/ece3.10736
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Treatment Patterns of Long-Acting Somatostatin Analogs for Neuroendocrine Tumors

    Callisia N. Clarke / Paul Cockrum / Thomas J.R. Beveridge / Michelle Jerry / Donna McMorrow / Anh Thu Tran / Alexandria T. Phan

    Journal of Health Economics and Outcomes Research (2023)

    2023  

    Abstract: ... using _t_-tests, chi-square/Fisher’s tests, and log-rank tests, respectively. **Results:** The study ...

    Abstract **Background:** Long-acting somatostatin analog therapy (LA-SSA) is recommended as first-line therapy for treatment of unresectable or metastatic neuroendocrine tumors (NETs). Understanding treatment sequencing and dosing patterns of LA-SSA is essential for clinical decision-making to provide value-based management of NETs. **Objective:** To describe treatment patterns of LA-SSA among patients with NETs and subgroups with carcinoid syndrome (CS) in the United States. **Methods:** This retrospective study utilized claims data from MarketScan® databases to identify patients with NETs and newly treated with LA-SSA between January 1, 2015, and October 31, 2020. Patients were stratified by index LA-SSA (lanreotide and octreotide long-acting release \[LAR\]). Reported 28-day doses were based on claim fields for days’ supply/drug quantity or units of service. Dose escalation was defined as increases in quantity or frequency. Continuous variables, categorical variables, and Kaplan-Meier estimated treatment durations were compared using _t_-tests, chi-square/Fisher’s tests, and log-rank tests, respectively. **Results:** The study included 241 lanreotide and 521 octreotide LAR patients. Compared with octreotide LAR patients, treatment duration was longer for lanreotide patients (median, 41.3 vs 26.8 months; log-rank _p_=.004). Fewer lanreotide patients received rescue treatment with short-acting octreotide (7.9% vs 14.4%; _p_=.011), and a first (6.2% vs 27.3%) and second dose escalation (0.8% vs 5.2%; both _p_<.05). Among patients with doses reported, fewer lanreotide patients received above-label doses (2.5% \[5/202\] vs 14.4% \[60/416\]; _p_<.001). Among patients who ended treatment during follow-up, fewer lanreotide patients transitioned to another LA-SSA (18.9% \[17/90\] vs 33.6% \[92/274\]; _p_=.008). Similar treatment patterns were observed in CS subgroups. Results for switched treatment patterns were limited due to insufficient sample sizes. **Discussion:** Real-world treatment patterns of LA-SSA were ...
    Keywords Computer applications to medicine. Medical informatics ; R858-859.7
    Subject code 616 ; 610
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Columbia Data Analytics, LLC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Characteristics of the Inhibition of Brochothrix thermosphacta by Lactobacillus brevis.

    Collins-Thompson, D L / Wood, D S / Beveridge, T J

    Journal of food protection

    2019  Volume 46, Issue 5, Page(s) 403–407

    Abstract: When cultures of Brochothrix thermosphacta and Lactobacillus brevis were grown together or separated by a dialysis membrane (M.W. cut off = 3,500 daltons), the growth of Brochothrix was inhibited. This phenomena occurred under both aerobic and anaerobic ... ...

    Abstract When cultures of Brochothrix thermosphacta and Lactobacillus brevis were grown together or separated by a dialysis membrane (M.W. cut off = 3,500 daltons), the growth of Brochothrix was inhibited. This phenomena occurred under both aerobic and anaerobic conditions and was unaffected by the presence of catalase (412 units/ml). The antagonism appeared to be pH-mediated since it depended on glucose concentration, but low pH (4.5) alone did not directly affect the viability or salt tolerance of singular cultures of B. thermosphacta . Electron microscopy of thin sections of B. thermosphacta after 24 to 48 h of exposure to L. brevis revealed distinct lesions within the peripheral cell wall fabric. These were not seen in control cells of the same age or in cells exposed to 0.01 to 0.1 M acetic acid. Induction of autolysis in B. thermosphacta by cell wall metabolism imbalance was believed to be the cause of the growth inhibition.
    Language English
    Publishing date 2019-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 243284-5
    ISSN 1944-9097 ; 0362-028X
    ISSN (online) 1944-9097
    ISSN 0362-028X
    DOI 10.4315/0362-028X-46.5.403
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Fluorescent Dye Paper-Based Method for Assessment of Pesticide Coverage on Leaves and Trees: A Citrus Grove Case Study.

    Menger, R F / Bontha, M / Beveridge, J R / Borch, T / Henry, C S

    Journal of agricultural and food chemistry

    2020  Volume 68, Issue 47, Page(s) 14009–14014

    Abstract: Crop disease management depends on efficient and adequate pesticide distribution to reduce pest population. Instrument-based methods to evaluate the spatial distribution of pesticides are available, but they are not field-compatible because of instrument ...

    Abstract Crop disease management depends on efficient and adequate pesticide distribution to reduce pest population. Instrument-based methods to evaluate the spatial distribution of pesticides are available, but they are not field-compatible because of instrument size, cost, and extensive sample preparation. The current gold standard of water-sensitive papers is field-compatible; however, these papers often produce false positives due to reaction with water from sources other than the pesticide mixture. Thus, we developed a novel method in which a fluorescent dye is sprayed over a crop with circles of filter paper (samplers) attached to the leaves. After collection, a lightbox is used to take pictures of the samplers, and an algorithm analyzes each image for percent coverage to visualize the pesticide distribution within the crop. Our method produces results quickly and inexpensively compared to current methods and can be applied to any crop to inform best pesticide application strategies.
    MeSH term(s) Agriculture ; Citrus ; Fluorescent Dyes ; Pesticides ; Plant Leaves ; Trees
    Chemical Substances Fluorescent Dyes ; Pesticides
    Language English
    Publishing date 2020-11-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.0c01835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Online crowdfunding for medical expenses related to hidradenitis suppurativa.

    Zheng, D X / Mulligan, K M / Gallo Marin, B / Cullison, C R / Cwalina, T B / Beveridge, M G / Linos, E / Scott, J F

    Clinical and experimental dermatology

    2021  Volume 47, Issue 2, Page(s) 465–467

    MeSH term(s) Adult ; Cost of Illness ; Crowdsourcing ; Female ; Healthcare Financing ; Hidradenitis Suppurativa/economics ; Hidradenitis Suppurativa/surgery ; Humans ; Male ; Social Media ; United States
    Language English
    Publishing date 2021-11-18
    Publishing country England
    Document type Letter
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1111/ced.14955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pain and Post-traumatic Stress Disorder Symptoms: Dyadic Relationships Between Canadian Armed Forces Members/Veterans with Chronic Pain and their Offspring.

    Lund, Tatiana / Bernier, Emily / Roman-Juan, Josep / Kopala-Sibley, Daniel / Soltani, Sabine / Noyek, Samantha / Nania, Cara / Beveridge, Jaimie / Hoppe, Tom / O'Connor, Robert / O'Connor, Christine / Clemens, Jessica / Mychasiuk, Richelle / Asmundson, Gordon / Stinson, Jennifer / Noel, Melanie

    The journal of pain

    2024  

    Abstract: Chronic pain and mental health issues occur at higher rates in Veterans than the general population. One widely recognized mental health issue faced by Veterans is post-traumatic stress disorder (PTSD). Trauma symptoms and pain frequently co-occur and ... ...

    Abstract Chronic pain and mental health issues occur at higher rates in Veterans than the general population. One widely recognized mental health issue faced by Veterans is post-traumatic stress disorder (PTSD). Trauma symptoms and pain frequently co-occur and are mutually maintained due to shared mechanisms. Many Veterans are also parents. Parental physical and mental health issues significantly predict children's chronic pain and related functioning, which can continue into adulthood. Only one US-based study has examined pain in the offspring of Veterans, suggesting heightened risk for pain. Research to date has not examined the associations between trauma and pain, and the dyadic influences of these symptoms, among Veterans and their children. The current study aimed to describe pain characteristics in Canadian Armed Forces (CAF) Members/Veterans with chronic pain and their offspring (youth and adult children aged 9-38). Cross-lagged Panel Models (CLPM) were conducted to examine dyadic relationships between pain interference and trauma symptoms of CAF Members/Veterans and their offspring. Over half of adult offspring and over one quarter of youth offspring reported chronic pain. Results revealed effects between one's own symptoms of PTSD and pain interference. No significant effects of parents on offspring or offspring on parents were found. The findings highlight the interconnection between pain and PTSD consistent with mutual maintenance models, and a lack of significant interpersonal findings suggestive of resiliency in this unique population. PERSPECTIVE: We characterized chronic pain in offspring of Canadian Armed Forces Members/Veterans with chronic pain and examined dyadic relationships between PTSD symptoms and chronic pain interference. Findings revealed that PTSD symptoms and pain interference were related within Veterans and offspring, but no dyadic relationships were found, which could reflect resiliency.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2018789-0
    ISSN 1528-8447 ; 1526-5900
    ISSN (online) 1528-8447
    ISSN 1526-5900
    DOI 10.1016/j.jpain.2024.03.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A2M inhibits inflammatory mediators of chondrocytes by blocking IL-1β/NF-κB pathway.

    Sun, Changqi / Cao, Can / Zhao, Ting / Guo, Hailing / Fleming, Braden C / Owens, Brett / Beveridge, Jillian / McAllister, Scott / Wei, Lei

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society

    2022  Volume 41, Issue 1, Page(s) 241–248

    Abstract: A hallmark of osteoarthritis (OA) is cartilage degeneration, which has been previously correlated with dramatic increases in inflammatory enzymes. Specifically, interleukin-1β (IL-1β) and subsequent upregulation of nuclear factor kappa B (NF-κB) is ... ...

    Abstract A hallmark of osteoarthritis (OA) is cartilage degeneration, which has been previously correlated with dramatic increases in inflammatory enzymes. Specifically, interleukin-1β (IL-1β) and subsequent upregulation of nuclear factor kappa B (NF-κB) is implicated as an important player in the development of posttraumatic osteoarthritis (PTOA). Alpha 2-macroglobulin (A2M) can inhibit this inflammatory pathway, making it a promising therapy for PTOA. Herein, we demonstrate that A2M binds and neutralizes IL-1β, blocking downstream NF-κB-induced catabolism seen in in vitro. Human chondrocytes (cell line C28) were incubated with A2M protein and then treated with IL-1β. A2M was labeled with VivoTag™ 680 to localize the protein postincubation. The degree of binding between A2M and IL-1β was evaluated through immunoprecipitation (IP). Catabolic proteins, including IL-1β and NF-kB, were detected by Western blot. Pro-inflammatory and chondrocyte-related gene expression was examined by qRT-PCR. VivoTag™ 680-labeled A2M was observed in the cytoplasm of C28 human chondrocytes by fluorescence microscopy. IP experiments demonstrated that A2M could bind IL-1β. Additionally, western blot analysis revealed that A2M neutralized IL-1β and NF-κB in a dose-dependent manner. Moreover, A2M decreased levels of MMPs and TNF-α and increased the expression of cartilage protective genes Col2, Type2, Smad4, and aggrecan. Mostly importantly, A2M was shown to directly neutralize IL-1β to downregulate the pro-inflammatory responses mediated by the NF-kB pathway. These results demonstrate a mechanism by which A2M reduces inflammatory catabolic activity and protects cartilage after joint injury. Further in vivo studies are needed to fully understand the potential of A2M as a novel PTOA therapy.
    MeSH term(s) Humans ; Pregnancy ; Female ; NF-kappa B ; Interleukin-1beta ; Inflammation Mediators ; Pregnancy-Associated alpha 2-Macroglobulins ; alpha-Macroglobulins
    Chemical Substances NF-kappa B ; Interleukin-1beta ; Inflammation Mediators ; Pregnancy-Associated alpha 2-Macroglobulins ; A2M protein, human ; alpha-Macroglobulins
    Language English
    Publishing date 2022-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 605542-4
    ISSN 1554-527X ; 0736-0266
    ISSN (online) 1554-527X
    ISSN 0736-0266
    DOI 10.1002/jor.25348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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