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Article ; Online: Safety, effectiveness, women's experience, and economic costs of outpatient induction in women with uncomplicated pregnancies: A systematic review and meta-analyses.

Sangskär, Heléne / Berglin, Lisa / Sengpiel, Verena / Svanberg, Therese / Svensson, Mikael / Berter, Beatrice / Elden, Helen / Sjögren, Petteri / Strandell, Annika / Carlsson, Ylva

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

2023 Volume 161, Issue 2, Page(s) 343–355

Abstract: Background: Induction of labor is increasing worldwide, and some countries have started to introduce outpatient induction in low-risk women.: Objectives: To assess current knowledge concerning the safety, efficacy, women's experience, and economic ... ...

Abstract	Background: Induction of labor is increasing worldwide, and some countries have started to introduce outpatient induction in low-risk women. Objectives: To assess current knowledge concerning the safety, efficacy, women's experience, and economic costs of outpatient induction compared with inpatient induction. Search strategy: Multiple databases were last searched on October 19, 2021. Studies were selected according to our pre-specified inclusion, selection, and exclusion criteria. Selection criteria: PICO; P-women with low-risk pregnancy planned for induction of labor. I-Outpatient induction C-Inpatient induction O-Outcomes according to the core outcome set for induction of labor (COSIOL). Data collection and analysis: Pooled in meta-analyses. The certainty of evidence was assessed using the GRADE system. Main results: The 20 included studies, including 7956 women, showed an overall low incidence of adverse events and indicated comparable results for inpatient and outpatient induction, but the studies were underpowered for safety-related outcomes. Women's experiences of outpatient induction were mostly positive. Based on three studies, the economic costs consequence is inconclusive. Conclusions: Due to early randomization, heterogenic study design, and underpowered studies regarding safety outcome, the certainty of evidence is very low. It is uncertain whether outpatient induction affects the risk for neonatal and maternal complications.
MeSH term(s)	Pregnancy ; Infant, Newborn ; Female ; Humans ; Oxytocics ; Outpatients ; Ambulatory Care/methods ; Cervical Ripening ; Labor, Induced/adverse effects ; Labor, Induced/methods
Chemical Substances	Oxytocics
Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	80149-5
ISSN	1879-3479 ; 0020-7292
ISSN (online)	1879-3479
ISSN	0020-7292
DOI	10.1002/ijgo.14625
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Zs.A 355: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 183: Show issues

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Article ; Online: Frequent false-negative FIP1L1-PDGFRA FISH analyses of bone marrow samples from clonal eosinophilia at diagnosis.

Olsson-Arvidsson, Linda / Norberg, Anna / Sjögren, Helene / Johansson, Bertil

British journal of haematology

2019 Volume 188, Issue 5, Page(s) e76–e79

MeSH term(s)	Bone Marrow ; Eosinophilia ; Humans ; Oncogene Proteins, Fusion ; Receptor, Platelet-Derived Growth Factor alpha ; mRNA Cleavage and Polyadenylation Factors
Chemical Substances	Oncogene Proteins, Fusion ; mRNA Cleavage and Polyadenylation Factors ; FIP1L1-PDGFRA fusion protein, human (EC 2.7.10.1) ; Receptor, Platelet-Derived Growth Factor alpha (EC 2.7.10.1)
Language	English
Publishing date	2019-12-18
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.16340
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Article: WHO Grade Loses Its Prognostic Value in Molecularly Defined Diffuse Lower-Grade Gliomas.

Carstam, Louise / Corell, Alba / Smits, Anja / Dénes, Anna / Barchéus, Hanna / Modin, Klara / Sjögren, Helene / Ferreyra Vega, Sandra / Bontell, Thomas Olsson / Carén, Helena / Jakola, Asgeir Store

Frontiers in oncology

2022 Volume 11, Page(s) 803975

Abstract: Background: While molecular insights to diffuse lower-grade glioma (dLGG) have improved the basis for prognostication, most established clinical prognostic factors come from the pre-molecular era. For instance, WHO grade as a predictor for survival in ... ...

Abstract	Background: While molecular insights to diffuse lower-grade glioma (dLGG) have improved the basis for prognostication, most established clinical prognostic factors come from the pre-molecular era. For instance, WHO grade as a predictor for survival in dLGG with Material and methods: A total of 253 adults with morphological dLGG, consecutively included between 2007 and 2018, were assessed. Results: There was no survival benefit for patients with WHO grade 2 over grade 3 Conclusion: Our findings suggest that WHO grade is not a robust prognostic factor in molecularly well-defined dLGG. Preoperative tumor size remained a prognostic factor in both
Language	English
Publishing date	2022-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2021.803975
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Article ; Online: Genetic Subtypes and Outcome of Patients Aged 1 to 45 Years Old With Acute Lymphoblastic Leukemia in the NOPHO ALL2008 Trial.

HemaSphere

2023 Volume 7, Issue 5, Page(s) e883

Language	English
Publishing date	2023-05-04
Publishing country	United States
Document type	Journal Article
ISSN	2572-9241
ISSN (online)	2572-9241
DOI	10.1097/HS9.0000000000000883
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Article ; Online: Novel

Deland, Lily / Keane, Simon / Bontell, Thomas Olsson / Fagman, Henrik / Sjögren, Helene / Lind, Anders E / Carén, Helena / Tisell, Magnus / Nilsson, Jonas A / Ejeskär, Katarina / Sabel, Magnus / Abel, Frida

Cancer genomics & proteomics

2022 Volume 19, Issue 6, Page(s) 711–726

Abstract: Background/aim: Although fusion genes involving the proto-oncogene receptor tyrosine kinase ROS1 are rare in pediatric glioma, targeted therapies with small inhibitors are increasingly being approved for histology-agnostic fusion-positive solid tumors.!# ...

Abstract	Background/aim: Although fusion genes involving the proto-oncogene receptor tyrosine kinase ROS1 are rare in pediatric glioma, targeted therapies with small inhibitors are increasingly being approved for histology-agnostic fusion-positive solid tumors. Patient and methods: Here, we present a 16-month-old boy, with a brain tumor in the third ventricle. The patient underwent complete resection but relapsed two years after diagnosis and underwent a second operation. The tumor was initially classified as a low-grade glioma (WHO grade 2); however, methylation profiling suggested the newly WHO-recognized type: infant-type hemispheric glioma. To further refine the molecular background, and search for druggable targets, whole genome (WGS) and whole transcriptome (RNA-Seq) sequencing was performed. Results: Concomitant WGS and RNA-Seq analysis revealed several segmental gains and losses resulting in complex structural rearrangements and fusion genes. Among the top-candidates was a novel TPR::ROS1 fusion, for which only the 3' end of ROS1 was expressed in tumor tissue, indicating that wild type ROS1 is not normally expressed in the tissue of origin. Functional analysis by Western blot on protein lysates from transiently transfected HEK293 cells showed the TPR::ROS1 fusion gene to activate the MAPK-, PI3K- and JAK/STAT- pathways through increased phosphorylation of ERK, AKT, STAT and S6. The downstream pathway activation was also confirmed by immunohistochemistry on tumor tissue slides from the patient. Conclusion: We have mapped the activated oncogenic pathways of a novel ROS1-fusion gene and broadened the knowledge of the newly recognized infant-type glioma subtype. The finding facilitates suitable targeted therapies for the patient in case of relapse.
MeSH term(s)	Humans ; Infant ; Male ; Gene Rearrangement ; Glioma/genetics ; Glioma/pathology ; HEK293 Cells ; Lung Neoplasms/pathology ; Oncogene Proteins, Fusion/genetics ; Phosphatidylinositol 3-Kinases/genetics ; Protein-Tyrosine Kinases/genetics ; Protein-Tyrosine Kinases/metabolism ; Proto-Oncogene Proteins/genetics
Chemical Substances	Oncogene Proteins, Fusion ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; Proto-Oncogene Proteins ; ROS1 protein, human (EC 2.7.10.1)
Language	English
Publishing date	2022-10-31
Publishing country	Greece
Document type	Case Reports ; Journal Article
ZDB-ID	2144517-5
ISSN	1790-6245 ; 1109-6535
ISSN (online)	1790-6245
ISSN	1109-6535
DOI	10.21873/cgp.20354
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Zs.A 5873: Show issues

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Article ; Online: Normal Neurodevelopment and Fertility in Juvenile Male Rats Exposed to Polyethylene Glycol Following Dosing With PEGylated rFIX (Nonacog Beta Pegol, N9-GP): Evidence from a 10-Week Repeat-Dose Toxicity Study.

Jensen, Vivi F H / Schefe, Line H / Jacobsen, Helene / Mølck, Anne-Marie / Almholt, Kasper / Sjögren, Ingrid / Dalsgaard, Charlotte M / Kirk, Rikke K / Benie, Andrew J / Petersen, Bent O / Kyhn, Mette S / Overgaard, Anne J / Bjørnsdottir, Inga / Stannard, Diane R / Offenberg, Hanne K / Egecioglu, Emil

International journal of toxicology

2022 Volume 41, Issue 6, Page(s) 455–475

Abstract: ... N9-GP/ ... ...

Abstract	N9-GP/Rebinyn
MeSH term(s)	Adult ; Animals ; Child ; Factor IX/therapeutic use ; Fertility ; Hemophilia B/drug therapy ; Humans ; Infant ; Male ; Polyethylene Glycols/toxicity ; Rats ; Recombinant Proteins
Chemical Substances	Recombinant Proteins ; nonacog beta pegol (27Y83O992Q) ; Polyethylene Glycols (3WJQ0SDW1A) ; Factor IX (9001-28-9)
Language	English
Publishing date	2022-08-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1379845-5
ISSN	1092-874X ; 1091-5818
ISSN (online)	1092-874X
ISSN	1091-5818
DOI	10.1177/10915818221121054
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Zs.A 1870: Show issues

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Article ; Online: Discovery of a rare

Deland, Lily / Keane, Simon / Olsson Bontell, Thomas / Sjögren, Helene / Fagman, Henrik / Øra, Ingrid / De La Cuesta, Esther / Tisell, Magnus / Nilsson, Jonas A / Ejeskär, Katarina / Sabel, Magnus / Abel, Frida

Cancer biology & therapy

2021 Volume 22, Issue 3, Page(s) 184–195

Abstract: Here we report a case of an 11-year-old girl with an inoperable tumor in the optic chiasm/hypothalamus, who experienced several tumor progressions despite three lines of chemotherapy treatment. Routine clinical examination classified the tumor as ... ...

Abstract	Here we report a case of an 11-year-old girl with an inoperable tumor in the optic chiasm/hypothalamus, who experienced several tumor progressions despite three lines of chemotherapy treatment. Routine clinical examination classified the tumor as a
MeSH term(s)	Adaptor Proteins, Signal Transducing/genetics ; Brain Neoplasms/drug therapy ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Child ; Female ; Glioma/drug therapy ; Glioma/genetics ; Glioma/metabolism ; Humans ; Hypothalamic Diseases ; Membrane Glycoproteins/genetics ; Neoplasm Grading ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Optic Chiasm/pathology ; Protein Kinase Inhibitors/therapeutic use ; Pyrazoles/therapeutic use ; Pyrimidines/therapeutic use ; Receptor, trkB/genetics
Chemical Substances	Adaptor Proteins, Signal Transducing ; Membrane Glycoproteins ; Oncogene Proteins, Fusion ; Protein Kinase Inhibitors ; Pyrazoles ; Pyrimidines ; Receptor, trkB (EC 2.7.10.1) ; tropomyosin-related kinase-B, human (EC 2.7.10.1) ; larotrectinib (PF9462I9HX)
Language	English
Publishing date	2021-04-05
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2146305-0
ISSN	1555-8576 ; 1538-4047
ISSN (online)	1555-8576
ISSN	1538-4047
DOI	10.1080/15384047.2021.1899573
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Zs.A 5887: Show issues

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Article ; Online: Aggregation Behavior of Structurally Similar Therapeutic Peptides Investigated by

Hjalte, Johanna / Hossain, Shakhawath / Hugerth, Andreas / Sjögren, Helen / Wahlgren, Marie / Larsson, Per / Lundberg, Dan

Molecular pharmaceutics

2022 Volume 19, Issue 3, Page(s) 904–917

Abstract: Understanding of peptide aggregation propensity is an important aspect in pharmaceutical development of peptide drugs. In this work, methodologies based on all-atom molecular dynamics (AA-MD) simulations ... ...

Abstract	Understanding of peptide aggregation propensity is an important aspect in pharmaceutical development of peptide drugs. In this work, methodologies based on all-atom molecular dynamics (AA-MD) simulations and
MeSH term(s)	Magnetic Resonance Spectroscopy ; Molecular Dynamics Simulation ; Proton Magnetic Resonance Spectroscopy
Language	English
Publishing date	2022-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.1c00883
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Zs.A 6250: Show issues

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Article ; Online: Investigating thermally induced aggregation of Somatropin- new insights using orthogonal techniques.

Västberg, Amanda / Bolinsson, Hans / Leeman, Mats / Nilsson, Lars / Nylander, Tommy / Sejwal, Kushal / Sintorn, Ida-Maria / Lidayová, Kristina / Sjögren, Helen / Wahlgren, Marie / Elofsson, Ulla

International journal of pharmaceutics

2023 Volume 637, Page(s) 122829

Abstract: Three orthogonal techniques were used to provide new insights into thermally induced aggregation of the therapeutic protein Somatropin at pH 5.8 and 7.0. The techniques were Dynamic Light Scattering (DLS), Asymmetric Flow-Field Flow-Fractionation (AF4), ... ...

Abstract	Three orthogonal techniques were used to provide new insights into thermally induced aggregation of the therapeutic protein Somatropin at pH 5.8 and 7.0. The techniques were Dynamic Light Scattering (DLS), Asymmetric Flow-Field Flow-Fractionation (AF4), and the TEM-based analysis system MiniTEM™. In addition, Differential Scanning Calorimetry (DSC) was used to study the thermal unfolding and stability. DSC and DLS were used to explain the initial aggregation process and aggregation rate at the two pH values. The results suggest that less electrostatic stabilization seems to be the main reason for the faster initial aggregation at pH 5.8, i.e., closer to the isoelectric point of Somatropin. AF4 and MiniTEM were used to investigate the aggregation pathway further. Combining the results allowed us to demonstrate Somatropin's thermal aggregation pathway at pH 7.0. The growth of the aggregates appears to follow two steps. Smaller elongated aggregates are formed in the first step, possibly initiated by partly unfolded species. In the second step, occurring during longer heating, the smaller aggregates assemble into larger aggregates with more complex structures.
MeSH term(s)	Human Growth Hormone ; Dynamic Light Scattering ; Calorimetry, Differential Scanning
Chemical Substances	Human Growth Hormone (12629-01-5)
Language	English
Publishing date	2023-03-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2023.122829
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Zs.A 1409: Show issues

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Article ; Online: Correction: A new GTF2I-BRAF fusion mediating MAPK pathway activation in pilocytic astrocytoma.

Tomić, Tajana Tešan / Olausson, Josefin / Wilzén, Annica / Sabel, Magnus / Truvé, Katarina / Sjögren, Helene / Dósa, Sándor / Tisell, Magnus / Lannering, Birgitta / Enlund, Fredrik / Martinsson, Tommy / Åman, Pierre / Abel, Frida

PloS one

2017 Volume 12, Issue 9, Page(s) e0184715

Abstract: This corrects the article DOI: 10.1371/journal.pone.0175638.]. ...

Abstract	[This corrects the article DOI: 10.1371/journal.pone.0175638.].
Language	English
Publishing date	2017-09-07
Publishing country	United States
Document type	Published Erratum
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0184715
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