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  1. Article ; Online: Fibrinolytic and functional fibrinogen diagnostics in trauma: a window of opportunity or a bridge to nowhere?

    Barrett, Christopher D / Maginot, Elizabeth R / Kemp, Kevin M

    Journal of thrombosis and haemostasis : JTH

    2023  Volume 21, Issue 10, Page(s) 2705–2707

    MeSH term(s) Humans ; Fibrinogen ; Hemostatics ; Thrombolytic Therapy
    Chemical Substances Fibrinogen (9001-32-5) ; Hemostatics
    Language English
    Publishing date 2023-09-22
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.06.004
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5805: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 295: Show issues

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  2. Article ; Online: Tranexamic acid in trauma: After 3 hours from injury, when is it safe and effective to use again?

    Barrett, Christopher D / Neal, Matthew D / Schoenecker, Jonathan G / Medcalf, Robert L / Myles, Paul S

    Transfusion

    2024  

    Abstract: Tranexamic acid (TXA) has proven mortality benefit if used early after traumatic injury, likely related to a combination of bleeding reduction and other non-bleeding effects. If TXA is given more than 3 h after traumatic injury, there is a significant ... ...

    Abstract Tranexamic acid (TXA) has proven mortality benefit if used early after traumatic injury, likely related to a combination of bleeding reduction and other non-bleeding effects. If TXA is given more than 3 h after traumatic injury, there is a significant and paradoxical increased risk of death due to bleeding. TXA has level 1 evidence for use as a bleeding reduction agent in isolated orthopedic operations, but in polytrauma patients undergoing orthopedic operations, it is not clear if and when TXA is safe or effective once outside the 3-h window of proven trauma efficacy.
    Language English
    Publishing date 2024-03-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.17779
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 284: Show issues Location:
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  3. Article ; Online: The effect of a political crisis on performance of community forests and protected areas in Madagascar.

    Neugarten, Rachel A / Rasolofoson, Ranaivo A / Barrett, Christopher B / Vieilledent, Ghislain / Rodewald, Amanda D

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2963

    Abstract: Understanding the effectiveness of conservation interventions during times of political instability is important given how much of the world's biodiversity is concentrated in politically fragile nations. Here, we investigate the effect of a political ... ...

    Abstract Understanding the effectiveness of conservation interventions during times of political instability is important given how much of the world's biodiversity is concentrated in politically fragile nations. Here, we investigate the effect of a political crisis on the relative performance of community managed forests versus protected areas in terms of reducing deforestation in Madagascar, a biodiversity hotspot. We use remotely sensed data and statistical matching within an event study design to isolate the effect of the crisis and post-crisis period on performance. Annual rates of deforestation accelerated at the end of the crisis and were higher in community forests than in protected areas. After controlling for differences in location and other confounding variables, we find no difference in performance during the crisis, but community-managed forests performed worse in post-crisis years. These findings suggest that, as a political crisis subsides and deforestation pressures intensify, community-based conservation may be less resilient than state protection.
    MeSH term(s) Conservation of Natural Resources ; Madagascar ; Forests ; Biodiversity
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-47318-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: 'Benevolent' patent extensions could raise billions for R&D in poorer countries.

    Barrett, Christopher B

    Nature

    2023  Volume 621, Issue 7980, Page(s) 687–690

    MeSH term(s) Developing Countries/economics ; Drug Industry/economics ; Drug Industry/methods ; Drug Industry/trends ; Patents as Topic/legislation & jurisprudence
    Language English
    Publishing date 2023-09-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-023-02998-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
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    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  5. Article ; Online: Reply: Should We Be for ASCT?: If Yes, Then When?

    Witteles, Ronald M / Barrett, Christopher D

    JACC. Heart failure

    2020  Volume 8, Issue 8, Page(s) 696–697

    MeSH term(s) Amyloidosis ; Heart Failure ; Heart Transplantation ; Humans ; Stem Cell Transplantation ; Transplantation, Autologous
    Language English
    Publishing date 2020-09-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2020.05.008
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  6. Article ; Online: Differentiating Pathologic from Physiologic Fibrinolysis: Not as Simple as Conventional Thrombelastography.

    Moore, Hunter B / Barrett, Christopher D / Moore, Ernest E / Pieracci, Fredric M / Sauaia, Angela

    Journal of the American College of Surgeons

    2024  

    Abstract: Background: Conventional rapid-thrombelastography (rTEG) cannot differentiate fibrinolysis shutdown from hypofibrinolysis, as both of these patient populations have low fibrinolytic activity. Tissue plasminogen activator (tPA) TEG can identify depletion ...

    Abstract Background: Conventional rapid-thrombelastography (rTEG) cannot differentiate fibrinolysis shutdown from hypofibrinolysis, as both of these patient populations have low fibrinolytic activity. Tissue plasminogen activator (tPA) TEG can identify depletion of fibrinolytic inhibitors, and its use in combination with rTEG has the potential to differentiate all three pathologic fibrinolytic phenotypes following trauma. We hypothesize tPA-TEG and rapid TEG (rTEG) in combination can further stratify fibrinolysis phenotypes post-injury to better stratify risk for mortality.
    Study design: Adult trauma patients (n=981) with both rTEG and tPA-TEG performed <2 hours post-injury were included. rTEG LY30 was used to initially define fibrinolysis phenotypes (Hyperfibrinolysis >3%, Physiologic 0.9-3%, Shutdown <0.9%), with Youden Index then used to define pathologic extremes of tPA-TEG LY30 [tPA sensitive (depletion of fibrinolytic inhibitors) versus resistant] resulting in 9 groups that were assessed for risk of death.
    Results: The median NISS was 22, 21% were female, 45% had penetrating injury, and overall mortality was 13%. The tPA-TEG LY30 inflection point for increased mortality was>35.5% (tPA sensitive, OR mortality 9.2 P<0.001) and <0.3% (tPA resistance, OR mortality 6.3 p=0.04). Of the nine potential fibrinolytic phenotypes, five were associated with increased mortality. Overall, the 9 phenotypes provided a significantly better prediction of mortality than rTEG or tPA-TEG alone (AUROC=0.80 vs 0.63 and 0.75, respectively, p<0.0001). These could be condensed to three pathologic phenotypes (true hyperfibrinolysis, early fibrinolysis shutdown, and hypofibrinolysis).
    Conclusions: The combination of rTEG and tPA-TEG increases the ability to predict mortality and suggests patient specific strategies for improved outcome.
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1181115-8
    ISSN 1879-1190 ; 1072-7515
    ISSN (online) 1879-1190
    ISSN 1072-7515
    DOI 10.1097/XCS.0000000000001027
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    Uk I Zs.61: Show issues Location:
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  7. Article ; Online: Rescue Therapy for Severe COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS) with Tissue Plasminogen Activator (tPA) ; A Case Series

    Barrett, Christopher D

    Wolters Kluwer

    2020  

    Abstract: The COVID-19 pandemic has led to unprecedented stresses on modern medical systems, overwhelming the resource infrastructure in numerous countries while presenting a unique series of pathophysiologic clinical findings. Thrombotic coagulopathy is common in ...

    Abstract The COVID-19 pandemic has led to unprecedented stresses on modern medical systems, overwhelming the resource infrastructure in numerous countries while presenting a unique series of pathophysiologic clinical findings. Thrombotic coagulopathy is common in critically ill patients suffering from COVID-19, with associated high rates of respiratory failure requiring prolonged periods of mechanical ventilation. Here we report a case series of five patients suffering from profound, medically refractory COVID-19 associated respiratory failure who were treated with fibrinolytic therapy using tissue plasminogen activator (tPA, Alteplase). All five patients appeared to have an improved respiratory status following tPA administration: one patient had an initial marked improvement that partially regressed after several hours, one patient had transient improvements that were not sustained, and three patients had sustained clinical improvements following tPA administration.
    Keywords Surgery ; Critical Care and Intensive Care Medicine ; covid19
    Subject code 610
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Influence of tranexamic acid on the complement system in trauma.

    Barrett, Christopher D / Yaffe, Michael B

    ANZ journal of surgery

    2020  Volume 90, Issue 4, Page(s) 418–420

    MeSH term(s) Antifibrinolytic Agents ; Hemorrhage ; Humans ; Tranexamic Acid ; Wounds and Injuries/drug therapy
    Chemical Substances Antifibrinolytic Agents ; Tranexamic Acid (6T84R30KC1)
    Language English
    Publishing date 2020-04-27
    Publishing country Australia
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.15538
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    Zs.A 180: Show issues Location:
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  9. Article ; Online: Single-FiO

    Morgan, Thomas J / Scott, Peter H / Langley, Adrian N / Barrett, Robin D C / Anstey, Christopher M

    Journal of clinical monitoring and computing

    2023  Volume 37, Issue 5, Page(s) 1303–1311

    Abstract: We investigated whether machine learning (ML) analysis of ICU monitoring data incorporating volumetric capnography measurements of mean alveolar ... ...

    Abstract We investigated whether machine learning (ML) analysis of ICU monitoring data incorporating volumetric capnography measurements of mean alveolar PCO
    MeSH term(s) Humans ; Ventilation-Perfusion Ratio/physiology ; Capnography ; Computer Simulation ; Lung ; Oxygen ; Pulmonary Gas Exchange/physiology
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-04-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1418733-4
    ISSN 1573-2614 ; 1387-1307 ; 0748-1977
    ISSN (online) 1573-2614
    ISSN 1387-1307 ; 0748-1977
    DOI 10.1007/s10877-023-00996-5
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    Zs.A 2054: Show issues Location:
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  10. Article ; Online: COVID-19: All the wrong moves in all the wrong places.

    Barrett, Christopher D / Yaffe, Michael B

    Science signaling

    2020  Volume 13, Issue 649

    Abstract: In this Editorial, Barrett and Yaffe highlight shortcomings in our collective response to the COVID ...

    Abstract In this Editorial, Barrett and Yaffe highlight shortcomings in our collective response to the COVID-19 pandemic and underscore the need for more basic research into this new disease.
    MeSH term(s) Betacoronavirus ; Cause of Death ; Clinical Laboratory Techniques ; Communicable Disease Control/legislation & jurisprudence ; Communicable Disease Control/methods ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Critical Pathways ; Delivery of Health Care ; Disease Management ; Education, Medical ; Health Policy ; Health Priorities ; Health Services Administration ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Public Health Administration ; Quarantine ; Research ; Research Support as Topic
    Keywords covid19
    Language English
    Publishing date 2020-09-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 2417226-1
    ISSN 1937-9145 ; 1945-0877
    ISSN (online) 1937-9145
    ISSN 1945-0877
    DOI 10.1126/scisignal.abe4242
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