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  1. Book ; Online: Sustainable Development in the Jordan Valley: Final Report of the Regional NGO Master Plan

    Kool, Jeroen

    2016  

    Keywords Environmental economics ; development economics ; water policy ; water governance ; water management ; sustainable development ; conservation
    Size 1 Online-Ressource
    Publisher Springer Nature
    Publishing place Cham
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021029409
    ISBN 9783319300368 ; 3319300369
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Sustainable Development in the Jordan Valley

    Kool, Jeroen

    Final Report of the Regional NGO Master Plan

    (Hexagon Series on Human and Environmental Security and Peace ; 13)

    2016  

    Author's details by Jeroen Kool
    Series title Hexagon Series on Human and Environmental Security and Peace ; 13
    Keywords Environmental management ; Cultural heritage ; Tourism ; Management ; Nature conservation ; Sustainable development ; Development economics
    Subject code 338.9
    Language English
    Size 1 Online-Ressource (XLII, 239 p. 181 illus., 179 illus. in color)
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online
    HBZ-ID HT019138176
    ISBN 978-3-319-30036-8 ; 9783319300351 ; 3-319-30036-9 ; 3319300350
    DOI 10.1007/978-3-319-30036-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Electron activated dissociation - a complementary fragmentation technique to collision-induced dissociation for metabolite identification of synthetic cathinone positional isomers.

    Che, Peng / Davidson, J Tyler / Kool, Jeroen / Kohler, Isabelle

    Analytica chimica acta

    2023  Volume 1283, Page(s) 341962

    Abstract: Over the last decade, a remarkable number of new psychoactive substances (NPS) have emerged onto the drug market, resulting in serious threats to both public health and society. Despite their abundance and potential toxicity, there is little information ... ...

    Abstract Over the last decade, a remarkable number of new psychoactive substances (NPS) have emerged onto the drug market, resulting in serious threats to both public health and society. Despite their abundance and potential toxicity, there is little information available on their metabolism, a crucial piece of information for clinical and forensic purposes. NPS metabolism can be studied using in vitro models, such as liver microsomes, cytosol, hepatocytes, etc. The tentative structural elucidation of metabolites of NPS formed using in vitro models is typically carried out using liquid chromatography combined with high-resolution tandem mass spectrometry (LC-HRMS
    MeSH term(s) Synthetic Cathinone ; Electrons ; Tandem Mass Spectrometry/methods ; Chromatography, Liquid/methods ; Ions/analysis
    Chemical Substances Synthetic Cathinone ; Ions
    Language English
    Publishing date 2023-10-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2023.341962
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Development of a membrane-disruption assay using phospholipid vesicles as a proxy for the detection of cellular membrane degradation.

    Bittenbinder, Mátyás A / Wachtel, Eric / Pereira, Daniel Da Costa / Slagboom, Julien / Casewell, Nicholas R / Jennings, Paul / Kool, Jeroen / Vonk, Freek J

    Toxicon: X

    2024  Volume 22, Page(s) 100197

    Abstract: Snakebite envenoming is a global health issue that affects millions of people worldwide, and that causes morbidity rates surpassing 450,000 individuals annually. Patients suffering from snakebite morbidities may experience permanent disabilities such as ... ...

    Abstract Snakebite envenoming is a global health issue that affects millions of people worldwide, and that causes morbidity rates surpassing 450,000 individuals annually. Patients suffering from snakebite morbidities may experience permanent disabilities such as pain, blindness and amputations. The (local) tissue damage that causes these life-long morbidities is the result of cell- and tissue-damaging toxins present in the venoms. These compounds belong to a variety of toxin classes and may affect cells in various ways, for example, by affecting the cell membrane. In this study, we have developed a high-throughput
    Language English
    Publishing date 2024-04-07
    Publishing country England
    Document type Journal Article
    ISSN 2590-1710
    ISSN (online) 2590-1710
    DOI 10.1016/j.toxcx.2024.100197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Studying Venom Toxin Variation Using Accurate Masses from Liquid Chromatography-Mass Spectrometry Coupled with Bioinformatic Tools.

    Alonso, Luis L / van Thiel, Jory / Slagboom, Julien / Dunstan, Nathan / Modahl, Cassandra M / Jackson, Timothy N W / Samanipour, Saer / Kool, Jeroen

    Toxins

    2024  Volume 16, Issue 4

    Abstract: This study provides a new methodology for the rapid analysis of numerous venom samples in an automated fashion. Here, we use LC-MS (Liquid Chromatography-Mass Spectrometry) for venom separation and toxin analysis at the accurate mass level combined with ... ...

    Abstract This study provides a new methodology for the rapid analysis of numerous venom samples in an automated fashion. Here, we use LC-MS (Liquid Chromatography-Mass Spectrometry) for venom separation and toxin analysis at the accurate mass level combined with new in-house written bioinformatic scripts to obtain high-throughput results. This analytical methodology was validated using 31 venoms from all members of a monophyletic clade of Australian elapids: brown snakes (
    MeSH term(s) Animals ; Computational Biology ; Elapid Venoms/chemistry ; Elapid Venoms/analysis ; Elapidae ; Liquid Chromatography-Mass Spectrometry
    Chemical Substances Elapid Venoms
    Language English
    Publishing date 2024-04-07
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins16040181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Tissue damaging toxins in snake venoms: mechanisms of action, pathophysiology and treatment strategies.

    Bittenbinder, Mátyás A / van Thiel, Jory / Cardoso, Fernanda C / Casewell, Nicholas R / Gutiérrez, José-María / Kool, Jeroen / Vonk, Freek J

    Communications biology

    2024  Volume 7, Issue 1, Page(s) 358

    Abstract: Snakebite envenoming is an important public health issue responsible for mortality and severe morbidity. Where mortality is mainly caused by venom toxins that induce cardiovascular disturbances, neurotoxicity, and acute kidney injury, morbidity is caused ...

    Abstract Snakebite envenoming is an important public health issue responsible for mortality and severe morbidity. Where mortality is mainly caused by venom toxins that induce cardiovascular disturbances, neurotoxicity, and acute kidney injury, morbidity is caused by toxins that directly or indirectly destroy cells and degrade the extracellular matrix. These are referred to as 'tissue-damaging toxins' and have previously been classified in various ways, most of which are based on the tissues being affected (e.g., cardiotoxins, myotoxins). This categorisation, however, is primarily phenomenological and not mechanistic. In this review, we propose an alternative way of classifying cytotoxins based on their mechanistic effects rather than using a description that is organ- or tissue-based. The mechanisms of toxin-induced tissue damage and their clinical implications are discussed. This review contributes to our understanding of fundamental biological processes associated with snakebite envenoming, which may pave the way for a knowledge-based search for novel therapeutic options.
    MeSH term(s) Humans ; Snake Bites/drug therapy ; Snake Venoms/toxicity ; Snake Venoms/therapeutic use ; Extracellular Matrix ; Public Health
    Chemical Substances Snake Venoms
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-024-06019-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Acetylcholine-Binding Protein Affinity Profiling of Neurotoxins in Snake Venoms with Parallel Toxin Identification.

    Palermo, Giulia / Schouten, Wietse M / Alonso, Luis Lago / Ulens, Chris / Kool, Jeroen / Slagboom, Julien

    International journal of molecular sciences

    2023  Volume 24, Issue 23

    Abstract: Snakebite is considered a concerning issue and a neglected tropical disease. Three-finger toxins (3FTxs) in snake venoms primarily cause neurotoxic effects since they have high affinity for nicotinic acetylcholine receptors (nAChRs). Their small ... ...

    Abstract Snakebite is considered a concerning issue and a neglected tropical disease. Three-finger toxins (3FTxs) in snake venoms primarily cause neurotoxic effects since they have high affinity for nicotinic acetylcholine receptors (nAChRs). Their small molecular size makes 3FTxs weakly immunogenic and therefore not appropriately targeted by current antivenoms. This study aims at presenting and applying an analytical method for investigating the therapeutic potential of the acetylcholine-binding protein (AChBP), an efficient nAChR mimic that can capture 3FTxs, for alternative treatment of elapid snakebites. In this analytical methodology, snake venom toxins were separated and characterised using high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS) and high-throughput venomics. By subsequent nanofractionation analytics, binding profiling of toxins to the AChBP was achieved with a post-column plate reader-based fluorescence-enhancement ligand displacement bioassay. The integrated method was established and applied to profiling venoms of six elapid snakes (
    MeSH term(s) Animals ; Neurotoxins/toxicity ; Elapid Venoms/chemistry ; Acetylcholine ; Three Finger Toxins ; Snake Venoms ; Toxins, Biological ; Elapidae/metabolism ; Snake Bites ; Receptors, Nicotinic
    Chemical Substances Neurotoxins ; Elapid Venoms ; Acetylcholine (N9YNS0M02X) ; Three Finger Toxins ; Snake Venoms ; Toxins, Biological ; Receptors, Nicotinic
    Language English
    Publishing date 2023-11-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242316769
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: In vitro metabolism of cathinone positional isomers: does sex matter?

    Che, Peng / Davidson, J Tyler / Still, Kristina / Kool, Jeroen / Kohler, Isabelle

    Analytical and bioanalytical chemistry

    2023  Volume 415, Issue 22, Page(s) 5403–5420

    Abstract: Synthetic cathinones, one of the most prevalent categories of new psychoactive substances, have been posing a serious threat to public health. Methylmethcathinones (MMCs), notably 3-MMC, have seen an alarming increase in their use in the last decade. The ...

    Abstract Synthetic cathinones, one of the most prevalent categories of new psychoactive substances, have been posing a serious threat to public health. Methylmethcathinones (MMCs), notably 3-MMC, have seen an alarming increase in their use in the last decade. The metabolism and toxicology of a large majority of synthetic cathinones, including 3-MMC and 2-MMC, remain unknown. Traditionally, male-derived liver materials have been used as in vitro metabolic incubations to investigate the metabolism of xenobiotics, including MMCs. Therefore, little is known about the metabolism in female-derived in vitro models and the potential sex-specific differences in biotransformation. In this study, the metabolism of 2-MMC, 3-MMC, and 4-MMC was investigated using female rat and human liver microsomal incubations, as well as male rat and human liver microsomal incubations. A total of 25 phase I metabolites of MMCs were detected and tentatively identified using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Seven sex-specific metabolites were detected exclusively using pooled male rat liver microsomal incubations. In addition, the metabolites generated from the sex-dependent in vitro metabolic incubations that were present in both male and female rat liver microsomal incubations showed differences in relative abundance. Yet, neither sex-specific metabolites nor significant differences in relative abundance were observed from pooled human liver microsomal incubations. This is the first study to report the phase I metabolic pathways of MMCs using in vitro metabolic incubations for both male and female liver microsomes, and the relative abundance of the metabolites observed from each sex.
    MeSH term(s) Rats ; Male ; Humans ; Female ; Animals ; Chromatography, Liquid/methods ; Tandem Mass Spectrometry/methods ; Alkaloids/analysis ; Liver/chemistry ; Microsomes, Liver/metabolism
    Chemical Substances cathinone (540EI4406J) ; Alkaloids
    Language English
    Publishing date 2023-07-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-023-04815-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  9. Article ; Online: Metabolome-Based Classification of Snake Venoms by Bioinformatic Tools.

    Alonso, Luis L / Slagboom, Julien / Casewell, Nicholas R / Samanipour, Saer / Kool, Jeroen

    Toxins

    2023  Volume 15, Issue 2

    Abstract: Snakebite is considered a neglected tropical disease, and it is one of the most intricate ones. The variability found in snake venom is what makes it immensely complex to study. These variations are present both in the big and the small molecules found ... ...

    Abstract Snakebite is considered a neglected tropical disease, and it is one of the most intricate ones. The variability found in snake venom is what makes it immensely complex to study. These variations are present both in the big and the small molecules found in snake venom. This study focused on examining the variability found in the venom's small molecules (i.e., mass range of 100-1000 Da) between two main families of venomous snakes-Elapidae and Viperidae-managing to create a model able to classify unknown samples by means of specific features, which can be extracted from their LC-MS data and output in a comprehensive list. The developed model also allowed further insight into the composition of snake venom by highlighting the most relevant metabolites of each group by clustering similarly composed venoms. The model was created by means of support vector machines and used 20 features, which were merged into 10 principal components. All samples from the first and second validation data subsets were correctly classified. Biological hypotheses relevant to the variation regarding the metabolites that were identified are also given.
    MeSH term(s) Animals ; Humans ; Snake Venoms ; Elapidae/metabolism ; Viperidae/metabolism ; Snake Bites ; Mass Spectrometry ; Elapid Venoms/metabolism
    Chemical Substances Snake Venoms ; Elapid Venoms
    Language English
    Publishing date 2023-02-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins15020161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Sustainable development in the Jordan Valley

    Kool, Jeroen

    final report of the regional NGO master plan

    (Hexagon series on human and environmental security and peace ; volume 13)

    2016  

    Author's details Jeroen Kool
    Series title Hexagon series on human and environmental security and peace ; volume 13
    Keywords Nachhaltige Entwicklung ; Regionalplanung ; Regionalpolitik ; Jordantal
    Language Undetermined
    Size xlii, 239 Seiten, Illustrationen
    Publisher Springer Open
    Publishing place Switzerland
    Document type Book
    ISBN 9783319300351 ; 9783319300368 ; 3319300350 ; 3319300369
    Database ECONomics Information System

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