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Article ; Online: Analysis of energy storage materials for developments in solar cookers.

Khatri, Rahul / Goyal, Rahul / Sharma, Ravi Kumar

2023 Volume 11, Page(s) 1292

Abstract: Solar energy is accessible freely and can be utilized for many household and industrial applications. The consumption of solar energy for cooking applications has found significant success. Various innovations have been employed in facilitating cooking ... ...

Abstract	Solar energy is accessible freely and can be utilized for many household and industrial applications. The consumption of solar energy for cooking applications has found significant success. Various innovations have been employed in facilitating cooking during off-sunshine hours. Thermal energy storage helps in overcoming the fluctuations in the supply of energy required for cooking during different time periods of the day. This study focuses on the different types of thermal energy storage mediums that are currently utilized in solar cooking. Primarily, oils and pebbles are most commonly used as sensible heat storage (SHS) while organic phase change materials (PCMs) are used as latent heat thermal energy storage materials (LHTES). The properties and performances of various SHS and latent heat storage (LHS) mediums have been compared for their suitable utilization. SHS materials are cost-effective but have lower thermal gradient compared to LHTES materials. The energy storage capability of LHTES is high while degradation with the increasing number of charging and discharging cycles is also considerable. The melting point should be close to the utilization temperature for being used as LHTES as thermal diffusivity of the materials greatly influences the performance of solar cookers. The cooking time is lower for solar cooking systems equipped with energy storage compared to non-equipped cooking systems. It is recognized that the use of energy storage has been proved as a huge advantage to solar cooking systems, however, the design, and heat transfer characteristics of the cooking vessel along with the storage material type and volume must be optimized in order to make this technology more influential.
MeSH term(s)	Humans ; Body Fluids ; Cooking ; Food ; Hot Temperature ; Patient Discharge
Language	English
Publishing date	2023-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2699932-8
ISSN	2046-1402 ; 2046-1402
ISSN (online)	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.126864.2
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Article ; Online: Pancreatic mesenchymal stem cells might protect β-cells.

Khatri, Rahul / Linn, Thomas

Nature reviews. Endocrinology

2022 Volume 18, Issue 12, Page(s) 725–726

MeSH term(s)	Humans ; Mesenchymal Stem Cells ; Insulin-Secreting Cells ; Pancreas ; Pancreatic Neoplasms ; Cell Differentiation
Language	English
Publishing date	2022-11-21
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2489381-X
ISSN	1759-5037 ; 1759-5029
ISSN (online)	1759-5037
ISSN	1759-5029
DOI	10.1038/s41574-022-00763-7
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Zs.A 6336: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Analysis of energy storage materials for developments in solar cookers [version 2; peer review

Rahul Goyal / Ravi Kumar Sharma / Rahul Khatri

F1000Research, Vol

2 approved]

2023 Volume 11

Abstract	Solar energy is accessible freely and can be utilized for many household and industrial applications. The consumption of solar energy for cooking applications has found significant success. Various innovations have been employed in facilitating cooking during off-sunshine hours. Thermal energy storage helps in overcoming the fluctuations in the supply of energy required for cooking during different time periods of the day. This study focuses on the different types of thermal energy storage mediums that are currently utilized in solar cooking. Primarily, oils and pebbles are most commonly used as sensible heat storage (SHS) while organic phase change materials (PCMs) are used as latent heat thermal energy storage materials (LHTES). The properties and performances of various SHS and latent heat storage (LHS) mediums have been compared for their suitable utilization. SHS materials are cost-effective but have lower thermal gradient compared to LHTES materials. The energy storage capability of LHTES is high while degradation with the increasing number of charging and discharging cycles is also considerable. The melting point should be close to the utilization temperature for being used as LHTES as thermal diffusivity of the materials greatly influences the performance of solar cookers. The cooking time is lower for solar cooking systems equipped with energy storage compared to non-equipped cooking systems. It is recognized that the use of energy storage has been proved as a huge advantage to solar cooking systems, however, the design, and heat transfer characteristics of the cooking vessel along with the storage material type and volume must be optimized in order to make this technology more influential.
Keywords	Solar Energy ; Solar Cooker ; Energy Storage ; Sensible Heat ; Latent Heat ; Storage Capacity ; eng ; Medicine ; R ; Science ; Q
Subject code	621
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	F1000 Research Ltd
Document type	Article ; Online
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Book ; Online ; Thesis: Antidiabetic effect of the intrapancreatic application of mesenchymal stem cells through beta-cell regeneration

Khatri, Rahul [Verfasser]

2020

Author's details	Rahul Khatri
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	English
Publisher	Universitätsbibliothek
Publishing place	Gießen
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Current Strategies to Modulate Regulatory T Cell Activity in Allergic Inflammation.

Bellinghausen, Iris / Khatri, Rahul / Saloga, Joachim

Frontiers in immunology

2022 Volume 13, Page(s) 912529

Abstract: Over the past decades, atopic diseases, including allergic rhinitis, asthma, atopic dermatitis, and food allergy, increased strongly worldwide, reaching up to 50% in industrialized countries. These diseases are characterized by a dominating type 2 immune ...

Abstract	Over the past decades, atopic diseases, including allergic rhinitis, asthma, atopic dermatitis, and food allergy, increased strongly worldwide, reaching up to 50% in industrialized countries. These diseases are characterized by a dominating type 2 immune response and reduced numbers of allergen-specific regulatory T (Treg) cells. Conventional allergen-specific immunotherapy is able to tip the balance towards immunoregulation. However, in mouse models of allergy adaptive transfer of Treg cells did not always lead to convincing beneficial results, partially because of limited stability of their regulatory phenotype activity. Besides genetic predisposition, it has become evident that environmental factors like a westernized lifestyle linked to modern sanitized living, the early use of antibiotics, and the consumption of unhealthy foods leads to epithelial barrier defects and dysbiotic microbiota, thereby preventing immune tolerance and favoring the development of allergic diseases. Epigenetic modification of Treg cells has been described as one important mechanism in this context. In this review, we summarize how environmental factors affect the number and function of Treg cells in allergic inflammation and how this knowledge can be exploited in future allergy prevention strategies as well as novel therapeutic approaches.
MeSH term(s)	Allergens ; Animals ; Desensitization, Immunologic/methods ; Inflammation/metabolism ; Mice ; Rhinitis, Allergic ; T-Lymphocytes, Regulatory
Chemical Substances	Allergens
Language	English
Publishing date	2022-05-26
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.912529
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Article ; Online: Thermotolerant methanotrophs belonging to the Methylocaldum genus dominate the methanotroph communities in biogas slurry and cattle dung: A culture-based study from India.

Mohite, Jyoti A / Manvi, Shubha S / Pardhi, Kajal / Khatri, Kumal / Bahulikar, Rahul A / Rahalkar, Monali C

Environmental research

2023 Volume 228, Page(s) 115870

Abstract: Biogas reactors run on various types of waste, with cattle dung and agricultural wastes being the primary sources in India. As biogas contains 50-60% methane, there is a possibility that the reactors harbour methanotrophs or methane-oxidizing bacteria. ... ...

Abstract	Biogas reactors run on various types of waste, with cattle dung and agricultural wastes being the primary sources in India. As biogas contains 50-60% methane, there is a possibility that the reactors harbour methanotrophs or methane-oxidizing bacteria. We set up serial endpoint dilution enrichments for the cultivation of methanotrophs using slurry from a small biogas reactor and cattle dung samples and obtained cultures of Methylocaldum gracile, a thermotolerant methanotroph. The study was expanded by sampling reactors of another small reactor of 20 L capacity and two 1000 L reactors. Dung samples were obtained from two Indian cattle breeds (Tharparkar and Gir). Pulverized rice straw used for feeding the biogas was also used for experiments. All the enrichment bottles were incubated at 39 °C, the reactors' in-situ temperature, and the rumen gut temperature. Our study isolated four pure cultures most related to Methylocaldum gracile VKM-14L
MeSH term(s)	Cattle ; Animals ; Biofuels ; Plant Breeding ; Methane ; Methylococcaceae/genetics ; India
Chemical Substances	Biofuels ; Methane (OP0UW79H66)
Language	English
Publishing date	2023-04-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.115870
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Article ; Online: Piceatannol promotes neuroprotection by inducing mitophagy and mitobiogenesis in the experimental diabetic peripheral neuropathy and hyperglycemia-induced neurotoxicity.

Khan, Islauddin / Preeti, Kumari / Kumar, Rahul / Kumar Khatri, Dharmendra / Bala Singh, Shashi

International immunopharmacology

2023 Volume 116, Page(s) 109793

Abstract: Piceatannol (PCN), a SIRT1 activator, regulates multiple oxidative stress mechanism and has anti-inflammatory potential in various inflammatory conditions. However, its role in Diabetic insulted peripheral neuropathy (DN) remains unknown. Oxidative ... ...

Abstract	Piceatannol (PCN), a SIRT1 activator, regulates multiple oxidative stress mechanism and has anti-inflammatory potential in various inflammatory conditions. However, its role in Diabetic insulted peripheral neuropathy (DN) remains unknown. Oxidative stress and mitochondrial dysfunction are major contributing factors to DN. Myriad studies have proven that sirtuin1 (SIRT1) stimulation convalesce nerve functions by activating mitochondrial functions like mitochondrial biogenesis and mitophagy. Diabetic neuropathy (DN) was provoked by injecting streptozotocin (STZ) at a dose of 55 mg/kg, i.p to male Sprague Dawley (SD) rats. Mechanical, thermal hyperalgesia was evaluated by using water immersion, Vonfrey Aesthesiometer, and Randall Sellito Calipers. Motor, sensory nerve conduction velocity was measured using Power Lab 4sp system whereas The Laser Doppler system was used to evaluate nerve blood flow. To induce hyperglycemia for the in vitro investigations, high glucose (HG) (30 mM) conditions were applied to Neuro2a cells. At doses of 5 and 10 µM, PCN was examined for its role in SIRT1 and Nrf2 activation. HG-induced N2A cells, reactive oxygen exposure, mitochondrial superoxides and mitochondrial membrane potentials were restored by PCN exposure, and their neurite outgrowth was enhanced. Peroxisome proliferator activated receptor-gamma coactivator-1α (PGC-1α) directed mitochondrial biogenesis was induced by increased SIRT1 activation by piceatannol. SIRT1 activation also enhanced Nrf2-mediated antioxidant signalling. Our study results inferred that PCN administration can counteract the decline in mitochondrial function and antioxidant activity in diabetic rats and HG-exposed N2A cells by increasing the SIRT1 and Nrf2 activities.
MeSH term(s)	Rats ; Male ; Animals ; Diabetic Neuropathies/drug therapy ; Rats, Sprague-Dawley ; Neuroprotection ; Mitophagy ; Diabetes Mellitus, Experimental ; Sirtuin 1/metabolism ; NF-E2-Related Factor 2 ; Antioxidants/pharmacology ; Oxidative Stress ; Hyperglycemia/drug therapy ; Neurotoxicity Syndromes
Chemical Substances	3,3',4,5'-tetrahydroxystilbene (6KS3LS0D4F) ; Sirtuin 1 (EC 3.5.1.-) ; NF-E2-Related Factor 2 ; Antioxidants
Language	English
Publishing date	2023-02-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2023.109793
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Article ; Online: Meloxicam emulgel potently suppressed cartilage degradation in knee osteoarthritis: Optimization, formulation, industrial scalability and pharmacodynamic analysis.

Jyothi, Vaskuri Gs Sainaga / Veerabomma, Harithasree / Kumar, Rahul / Khatri, Dharmendra Kumar / Singh, Shashi Bala / Madan, Jitender

Colloids and surfaces. B, Biointerfaces

2023 Volume 228, Page(s) 113399

Abstract: Background and objective: Meloxicam (MLX) is prescribed for the management of pain and inflammation allied with osteoarthritis (OA). However, MLX causes intestinal damage in long term administration. Hence, meloxicam loaded emulgel (MLX-emulgel) was ... ...

Abstract	Background and objective: Meloxicam (MLX) is prescribed for the management of pain and inflammation allied with osteoarthritis (OA). However, MLX causes intestinal damage in long term administration. Hence, meloxicam loaded emulgel (MLX-emulgel) was optimized, formulated and examined under stringent parameters in monosodium-iodoacetate (MIA) induced knee OA in Wistar rats. Methods and results: Nanoemulsion of MLX was fabricated by ultrasonication and microfluidization method with a droplet size of 66.81 ± 5.31-nm and zeta potential of -24.6 ± 0.72-mV. Further, MLX nanoemulsion was optimized with centrifugation, heating-cooling cycles and transmittance parameters in addition to scale-up feasibility with microfluidizer. Post optimization, MLX-nanoemulsion was tailored as emulgel with Carbopol Ultrez 10 NF and assessed for pH, rheology, textural properties, assay and stability features. The in-vitro release study revealed the Korsmeyer-Peppas release kinetics and ex-vivo skin permeation was improved by 6.71-folds. The skin distribution of MLX-emulgel evinced the transfollicular mode of permeation. In-vivo study indicated the protective action of MLX-emulegl expressed in terms of inflammatory cyctokines level, X-ray analysis of knee joints of rats, histopathology and OARSI (Osteoarthritis Research Society International) scoring. MLX-emulgel treated group displayed lower (P < 0.001) level of COX-2 intensity as compared to positive control group. However, it was comparable (P > 0.05) to the normal control group, MLX oral dispersion, i.v. solution and etoricoxib gel groups. MLX-emulgel showcased an alternative to the long term usage of analgesics for relieving the symptoms of knee OA. Conclusion: MLX-emulgel may be a potential candidate for translating in to a clinically viable dosage form in the management of knee OA.
MeSH term(s)	Rats ; Animals ; Meloxicam/pharmacology ; Meloxicam/chemistry ; Meloxicam/metabolism ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Osteoarthritis, Knee/drug therapy ; Osteoarthritis, Knee/metabolism ; Rats, Wistar ; Skin/metabolism
Chemical Substances	Meloxicam (VG2QF83CGL) ; Anti-Inflammatory Agents, Non-Steroidal
Language	English
Publishing date	2023-06-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2023.113399
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Article ; Online: Intrapancreatic MSC transplantation facilitates pancreatic islet regeneration.

Khatri, Rahul / Petry, Sebastian Friedrich / Linn, Thomas

Stem cell research & therapy

2021 Volume 12, Issue 1, Page(s) 121

Abstract: Background: Type 1 diabetes mellitus (T1D) is characterized by the autoimmune destruction of the pancreatic β cells. The transplantation of mesenchymal stromal/stem cells (MSC) was reported to rescue the damaged pancreatic niche. However, there is an ... ...

Abstract	Background: Type 1 diabetes mellitus (T1D) is characterized by the autoimmune destruction of the pancreatic β cells. The transplantation of mesenchymal stromal/stem cells (MSC) was reported to rescue the damaged pancreatic niche. However, there is an ongoing discussion on whether direct physical contact between MSC and pancreatic islets results in a superior outcome as opposed to indirect effects of soluble factors released from the MSC entrapped in the lung microvasculature after systemic administration. Hence, MSC were studied in direct contact (DC) and indirect contact (IDC) with murine pancreatic β cell line MIN6-cells damaged by nitrosourea derivative streptozotocin (STZ) in vitro. Further, the protective and antidiabetic outcome of MSC transplantation was evaluated through the intrapancreatic route (IPR) and intravenous route (IVR) in STZ-induced diabetic NMRI nude mice. Methods: MSC were investigated in culture with STZ-damaged MIN6-cells, either under direct contact (DC) or separated through a semi-permeable membrane (IDC). Moreover, multiple low doses of STZ were administered to NMRI nude mice for the induction of hyperglycemia. 0.5 × 10 Results: The administration of MSC through IPR ameliorated hyperglycemia in contrast to IVR, STZ, and non-diabetic control in a 30-day window. IPR resulted in a higher number of replicating islet cells, number of islets, islet area, growth factor (EGF), and balancing of the Th1/Th2 response in vivo. Physical contact also provided a superior protection to MIN6-cells from STZ through the AKT and ERK pathway in vitro in comparison with IDC. Conclusion: Our study suggests that the physical contact between MSC and pancreatic islet cells is required to fully unfold their protective potential.
MeSH term(s)	Animals ; Diabetes Mellitus, Experimental/therapy ; Insulin ; Islets of Langerhans ; Mesenchymal Stem Cell Transplantation ; Mice ; Mice, Nude ; Streptozocin
Chemical Substances	Insulin ; Streptozocin (5W494URQ81)
Language	English
Publishing date	2021-02-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2548671-8
ISSN	1757-6512 ; 1757-6512
ISSN (online)	1757-6512
ISSN	1757-6512
DOI	10.1186/s13287-021-02173-4
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Article ; Online: Assessment of pollen morphology and hybridization in pomegranate (Punica granatum)

RAHUL SHARMA / VIKAS KUMAR SHARMA / SOM DEV SHARMA / SHIREEN KHATRI

The Indian Journal of Agricultural Sciences, Vol 92, Iss

2022 Volume 11

Abstract: Pollen studies act as a prerequisite for choosing a compatible pollen parent and help plant breeders to achieve successful crossing between different cultivars. An experiment was conducted during 2018–19 at Fruit Research Farm of Regional Horticulture ... ...

Abstract	Pollen studies act as a prerequisite for choosing a compatible pollen parent and help plant breeders to achieve successful crossing between different cultivars. An experiment was conducted during 2018–19 at Fruit Research Farm of Regional Horticulture Research and Training Station Bajaura, Kullu, Himachal Pradesh to evaluate 8 commercial genetically distant pomegranate (Punica granatum L.) cultivars (Chawla, Nabha, P-26, Kandhari Kabuli, G-137, Jodhpur Red, Mridula and Bhagwa) for pollen morphology (shape and size) and viability. Hybridization studies were also carried out to assess the role of cross pollination in fruit set to infuse blood red aril colour and soft seededness in the selected cultivars. The compatibility behaviour was studied by using different cross combinations of cultivars followed by recording their fruit set percentage. It could help breeders understand the performance of cultivars as pollinizers which would ultimately help them in hybridization programs. Pollen viability of the pomegranate germplasm was determined using 2% acetocarmine. Highest pollen viability was recorded in Bhagwa (94.29%) followed by Chawla (91.21%). In hybridization studies, highest fruit set per cent among 16 crosses was observed in Mridula × P-26 (77.80%). The differences in fruit set percentage could be due to varied degree of compatibility between different genotypes, behaviour of pollen with respect to viability percentage, differences in growth rate of pollen tube and might also be due to differences in temperature during bloom period.
Keywords	Cultivars ; Hybridization ; Pomegranate ; Pollen ; Viability ; Agriculture ; S
Subject code	580
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Indian Council of Agricultural Research
Document type	Article ; Online
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