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Article ; Online: Harmonic field extension for QSM with reduced spatial coverage using physics-informed generative adversarial network.

Jung, Siyun / Jeon, Soohyun / Gho, Sung-Min / Lee, Ho-Joon / Jung, Kyu-Jin / Kim, Dong-Hyun

2024 Volume 288, Page(s) 120528

Abstract: Quantitative susceptibility mapping (QSM) is frequently employed in investigating brain iron related to brain development and diseases within deep gray matter (DGM). Nonetheless, the acquisition of whole-brain QSM data is time-intensive. An alternative ... ...

Abstract	Quantitative susceptibility mapping (QSM) is frequently employed in investigating brain iron related to brain development and diseases within deep gray matter (DGM). Nonetheless, the acquisition of whole-brain QSM data is time-intensive. An alternative approach, focusing the QSM specifically on areas of interest such as the DGM by reducing the field-of-view (FOV), can significantly decrease scan times. However, severe susceptibility value underestimations have been reported during QSM reconstruction with a limited FOV, largely attributable to artifacts from incorrect background field removal in the boundary region. This presents a considerable barrier to the clinical use of QSM with small spatial coverages using conventional methods alone. To mitigate the propagation of these errors, we proposed a harmonic field extension method based on a physics-informed generative adversarial network. Both quantitative and qualitative results demonstrate that our method outperforms conventional methods and delivers results comparable to those obtained with full FOV. Furthermore, we demonstrate the versatility of our method by applying it to data acquired prospectively with limited FOV and to data from patients with Parkinson's disease. The method has shown significant improvements in local field results, with QSM outcomes. In a clear illustration of its feasibility and effectiveness in real clinical environments, our proposed method addresses the prevalent issue of susceptibility underestimation in QSM with small spatial coverage.
MeSH term(s)	Humans ; Image Processing, Computer-Assisted/methods ; Magnetic Resonance Imaging/methods ; Algorithms ; Brain/diagnostic imaging ; Brain Mapping/methods
Language	English
Publishing date	2024-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2024.120528
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Article ; Online: Comparative study between biliary covered self-expandable metal stent and conventional endoscopic bile drainage treatment in endoscopic retrograde cholangiopancreatography-related Stapfer type II retroperitoneal perforations.

Heo, Jun / Jung, Min Kyu / Lee, Jieun / Lee, Dong Wook / Cho, Chang Min / Cha, Jung Guen

PloS one

2024 Volume 19, Issue 3, Page(s) e0300029

Abstract: Background: Perforation is one of the most serious complications of endoscopic retrograde cholangiopancreatography (ERCP). Conventional nonsurgical endoscopic treatments including intravenous antibiotic administration and plastic endoscopic biliary ... ...

Abstract	Background: Perforation is one of the most serious complications of endoscopic retrograde cholangiopancreatography (ERCP). Conventional nonsurgical endoscopic treatments including intravenous antibiotic administration and plastic endoscopic biliary drainage are generally approved for the treatment of ERCP-related Stapfer type II perforation (perivaterian type). Biliary covered metal stent placement has recently been reported to have favorable outcomes in ERCP-related Stapfer type II perforations. We aimed to compare the outcomes of conventional endoscopic bile drainage and biliary covered self-expandable metal stent (SEMS) insertion in patients with Stapfer type II perforation. Methods: Medical records of patients who underwent ERCP at Kyungpook National University Hospital in Daegu from 2011 to 2022 were retrospectively reviewed. Results: A total of 8,402 ERCP procedures were performed in our hospital. Sixty-six ERCP-related perforations (0.78%) were identified. Among them, 37 patients (56.1%) who had Stapfer type II perforations were enrolled. Thirteen and twenty-four patients received biliary covered SEMS insertion and conventional endoscopic bile drainage treatments, respectively. No significant differences were observed in the clinical success rate (92.3% vs. 91.7%, p = 1.000), hospital stay (9.46 ± 5.97 vs. 13.9 ± 13.2 days, p = 0.258), and post-ERCP-related fasting time (5.4 ± 3.4 vs 4.3 ± 3.0 days, p = 0.305). Complications including bleeding, post-ERCP pancreatitis, fever, and death were not significantly different between the two groups. The conventional endoscopic bile drainage group took less time for ERCP than the SEMS group (11.5 ± 5.2 vs. 18.5 ± 11.2 min, p = 0.013). Conclusions: Compared with the conventional endoscopic bile drainage treatment method, biliary covered SEMS did not improve patient outcomes in ERCP-related Stapfer type II perforations.
MeSH term(s)	Humans ; Cholangiopancreatography, Endoscopic Retrograde ; Bile ; Retrospective Studies ; Stents ; Drainage/methods ; Treatment Outcome
Language	English
Publishing date	2024-03-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0300029
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Article ; Online: Clinical value of deep vein thrombosis density on lower-extremity CT venography: prediction of pulmonary thromboembolism.

Jung, Jae Hyeop / Kim, Jin Kyem / Kim, Taeho / Kim, Dong Kyu

Current medical imaging

2023

Abstract: Aim: Diagnosis of pulmonary thromboembolism (PTE) can be delayed if the signs and symptoms of patients are nonspecific.: Introduction: To assess the clinical value of deep vein thrombosis (DVT) density on computed tomography (CT) venography for ... ...

Abstract	Aim: Diagnosis of pulmonary thromboembolism (PTE) can be delayed if the signs and symptoms of patients are nonspecific. Introduction: To assess the clinical value of deep vein thrombosis (DVT) density on computed tomography (CT) venography for predicting PTE. Method: From 2016 to 2021, patients with DVT diagnosed on lower-extremity CT venography were included. Of these patients, those without PTE were classified into 'DVT-only group' and those with PTE were classified into the 'DVT with PTE group'. The DVT Hounsfield unit (HU) density was measured by drawing free-hand region-of-interests within the thrombus at the most proximal filling defect level. The risk factors associated with PTE were identified by using multivariate logistic regression analysis. A receiver operating characteristic (ROC) analysis was used to evaluate the value of DVT density for predicting the risk of PTE. Results and discussion: This study included 177 patients with a mean age of 41.7 ± 10.3 years (DVT-only group: 105 patients; DVT with PTE group: 72 patients). DVT density was significantly higher in DVT with the PTE group than DVT-only group (66.8HU ± 8.7 vs. 57.9HU ± 11.1, p < 0.001). The ROC analysis revealed that the area under the curve (AUC), sensitivity, and specificity for predicting the risk of PTE were 0.737, 72.2%, and 66.7%, respectively, at a DVT density cutoff of 63.0 HU. On univariate and multivariate analysis, DVT density was the only significant risk factor associated with PTE. Conclusion: Higher DVT density was a significant risk factor for PTE. In addition, DVT density could be a predictive factor for PTE.
Language	English
Publishing date	2023-04-05
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	1573-4056
ISSN (online)	1573-4056
DOI	10.2174/1573405620666230405104312
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Article ; Online: Thrombus volume and Hounsfield unit density as a predictor of pulmonary embolism in patients with deep vein thrombosis.

Yu, Min Hyuk / Jung, Jae Hyeop / Kim, Taeho / Kim, Dong Kyu

Acta radiologica (Stockholm, Sweden : 1987)

2023 Volume 64, Issue 6, Page(s) 2198–2204

Abstract: Background: There is a lack of studies evaluating the association between thrombus volume and density of deep vein thrombosis (DVT) and pulmonary embolism (PE).: Purpose: To assess the clinical value of thrombus volume and density for prediction of ... ...

Abstract	Background: There is a lack of studies evaluating the association between thrombus volume and density of deep vein thrombosis (DVT) and pulmonary embolism (PE). Purpose: To assess the clinical value of thrombus volume and density for prediction of PE in patients with DVT. Material and methods: Among the patients with DVT, those without PE were classified as the "DVT-only group" and those with PE were classified as the "DVT-PE group." Thrombus volume and Hounsfield unit (HU) density of DVT was measured by drawing free-hand volume of interests within the thrombus. Multivariate regression and receiver operating characteristic (ROC) analysis was used to evaluate the predictive value of thrombus volume and density for PE. Results: Of the included 145 patients (mean age=41.7 ± 10.3 years), there were 87 patients in the DVT-only group and 58 patients in the DVT-PE group. The DVT-PE group showed a significantly higher DVT density (67.4 ± 8.6 HU vs. 57.3 ± 10.4 HU; Conclusion: Though the results of our study should be considered within the limitations, DVT density could be a predictor for acute PE. Further studies are needed to clarify the clinical value of quantitative features of DVT including thrombus volume as an imaging biomarker for PE.
MeSH term(s)	Humans ; Adult ; Middle Aged ; Venous Thrombosis/complications ; Venous Thrombosis/diagnostic imaging ; Pulmonary Embolism/complications ; Pulmonary Embolism/diagnostic imaging ; Thrombosis ; Acute Disease ; Regression Analysis ; Risk Factors
Language	English
Publishing date	2023-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	105-3
ISSN	1600-0455 ; 0284-1851 ; 0349-652X
ISSN (online)	1600-0455
ISSN	0284-1851 ; 0349-652X
DOI	10.1177/02841851231165921
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Article ; Online: Treatment outcomes for idiopathic sudden sensorineural hearing loss in dialysis patients.

Kim, Seonju / Lee, Dong Kyu / Kim, Hae-Rim / Park, Jung Mee / Kim, Soon Bae / Yu, Hoon

Scientific reports

2024 Volume 14, Issue 1, Page(s) 360

Abstract: Idiopathic sudden sensorineural hearing loss (ISSNHL) is challenging for both nephrologists and otolaryngologists treating patients undergoing dialysis. This single-center, retrospective, observational study investigated the treatment outcomes of ... ...

Abstract	Idiopathic sudden sensorineural hearing loss (ISSNHL) is challenging for both nephrologists and otolaryngologists treating patients undergoing dialysis. This single-center, retrospective, observational study investigated the treatment outcomes of patients with ISSNHL undergoing dialysis, enrolling 700 patients (47 undergoing and 653 not undergoing dialysis) diagnosed with ISSNHL between January 2005 and December 2021 at Asan Medical Center, Republic of Korea. To balance pre-existing clinical characteristics, 1:5 propensity score matching (PSM) was performed with the patients who were not undergoing dialysis. Treatment included high-dose systemic steroid therapy or intra-tympanic steroid injections. The pure tone average of the groups was compared before and 2 weeks and 2 months after treatment. The hearing-improvement degree was evaluated using Siegel's criteria. Before PSM, age, prevalence of diabetes or hypertension, initial hearing threshold at each frequency level (0.5, 1, 2, and 4 kHz), and treatment strategies exhibited significant between-group differences. However, in the PS-matched cohort, none of the confounders showed significant between-group differences. Two months after steroid treatment, the non-dialysis patient group demonstrated significantly higher average improvement in pure tone audiometry (P = 0.029) and greater percentage of complete response according to Siegel's criteria. This study suggests that treatment outcomes for ISSNHL are significantly poorer for patients undergoing than for those not undergoing dialysis.
MeSH term(s)	Humans ; Renal Dialysis ; Treatment Outcome ; Hearing Loss, Sensorineural/diagnosis ; Hearing Loss, Sudden/drug therapy ; Hearing Loss, Sudden/diagnosis ; Steroids/therapeutic use ; Retrospective Studies ; Audiometry, Pure-Tone ; Glucocorticoids/therapeutic use
Chemical Substances	Steroids ; Glucocorticoids
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-49306-8
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Article ; Online: Correction: TNF-α promotes α-synuclein propagation through stimulation of senescence-associated lysosomal exocytosis.

Bae, Eun-Jin / Choi, Minsun / Kim, Jeong Tae / Kim, Dong-Kyu / Jung, Min Kyo / Kim, Changyoun / Kim, Tae-Kyung / Lee, Jun Sung / Jung, Byung Chul / Shin, Soo Jean / Rhee, Ka Hyun / Lee, Seung-Jae

Experimental & molecular medicine

2024

Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1328915-9
ISSN	2092-6413 ; 1226-3613 ; 0378-8512
ISSN (online)	2092-6413
ISSN	1226-3613 ; 0378-8512
DOI	10.1038/s12276-024-01215-0
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Article ; Online: Smoking behavior change and the risk of pneumonia hospitalization among smokers with diabetes mellitus.

Han, Dong-Woo / Jung, Wonyoung / Lee, Kyu Na / Han, Kyungdo / Lee, Sei Won / Shin, Dong Wook

Scientific reports

2023 Volume 13, Issue 1, Page(s) 14189

Abstract: Smoking patients with diabetes mellitus (DM) are at greater risk of developing pneumonia. How smoking behavior changes affect the risk of pneumonia hospitalization, however, remains unclear. Therefore, we investigated the association between smoking ... ...

Abstract	Smoking patients with diabetes mellitus (DM) are at greater risk of developing pneumonia. How smoking behavior changes affect the risk of pneumonia hospitalization, however, remains unclear. Therefore, we investigated the association between smoking behavior change and the risk of pneumonia hospitalization in patients with DM. From January 1, 2009 and December 31, 2018, we investigated the association between smoking behavior change and the risk of pneumonia hospitalization in patients with DM. A total of 332,798 adult patients with DM from the Korean National Health Insurance System database who underwent health screening examination between 2009 and 2012, and were smokers at the first health examination were included. During a mean follow-up of 4.89 years, 14,598 (4.39%) incident pneumonia hospitalization cases were identified. Reducers had a slightly increased risk of pneumonia hospitalization (aHR 1.06, 95% CI 1.01-1.10) compared to sustainers. Quitters did not have a significant association with incidence of pneumonia hospitalization. However, increasers had 13% higher risk of pneumonia hospitalization (aHR 1.13, 95% CI 1.07-1.18), regardless of whether initial smoking was light, moderate, or heavy. Our study showed that an increase in smoking intensity was associated with an increased risk of pneumonia hospitalization in people with DM. However, a protective effect of smoking reduction or cessation on pneumonia risk was not demonstrated.
MeSH term(s)	Adult ; Humans ; Smoking/adverse effects ; Smokers ; Diabetes Mellitus/epidemiology ; Hospitalization ; Pneumonia/epidemiology
Language	English
Publishing date	2023-08-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-40658-9
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Article: Analysis of the Incidence of Type 2 Diabetes, Requirement of Insulin Treatment, and Diabetes-Related Complications among Patients with Cancer.

Lee, Su Jung / Kim, Chulho / Yu, Hyunjae / Kim, Dong-Kyu

Cancers

2023 Volume 15, Issue 4

Abstract: This retrospective nationwide population-based cohort study used a dataset collected from the Korean National Health Insurance Service. We evaluated incident type 2 diabetes, insulin requirements, and diabetes-associated complications during a 10-year ... ...

Abstract	This retrospective nationwide population-based cohort study used a dataset collected from the Korean National Health Insurance Service. We evaluated incident type 2 diabetes, insulin requirements, and diabetes-associated complications during a 10-year follow-up period using the log-rank test and Cox proportional hazards regression models. In total, 8114 and 16,228 individuals with and without cancer, respectively, were enrolled. We found a higher incidence rate and an increased adjusted hazard ratio (HR) for new cases of type 2 diabetes in patients with cancer, compared with those without cancer. Additionally, patients with cancer had a higher risk of insulin requirement than patients without cancer (adjusted HR 1.43, 95% confidence interval [CI], 1.14-1.78). Although there was no significant association between diabetes-associated complications and overall cancer diagnosis, specific cancer types (pancreas, bladder, and prostate) showed an increased risk of subsequent diabetic nephropathy. Therefore, clinicians should closely monitor patients with cancer for the early detection of type 2 diabetes and related morbidities.
Language	English
Publishing date	2023-02-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15041094
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Article: Effects of Ankle Stabilization Exercises Using Sonic Balance Pad on Proprioception and Balance in Subjects with Ankle Instability.

Uygun, Merve Nur / Yang, Dong-Kyu / Moon, Jung-Su / Park, Dae-Sung

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 18

Abstract: Sound waves generate acoustic resonance energy that penetrates deeply and safely into body areas normal mechanical vibrations cannot reach. The sonic balance pad utilizes these sound waves to create an optimal musculoskeletal response. The purpose of ... ...

Abstract	Sound waves generate acoustic resonance energy that penetrates deeply and safely into body areas normal mechanical vibrations cannot reach. The sonic balance pad utilizes these sound waves to create an optimal musculoskeletal response. The purpose of this study was to investigate the effects of a 4-week ankle stabilization exercise program using a sonic balance pad on proprioceptive sense and balance ability in individuals with ankle instability. This study was conducted as a randomized control-group pre-and post-test design in 30 participants (21 females and 9 males) who had experienced an ankle fracture or sprain within the last 5 years or who scored 11 points or more on The Identification of Functional Ankle Instability. The ankle stabilization exercise program was conducted for 4 weeks in the experimental group (
Language	English
Publishing date	2023-09-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11182544
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Article ; Online: Relationship of Depression, Anxiety, and Bipolar Disease with Burning Mouth Syndrome: A Nationwide Cohort Study.

Lee, Su Jung / Kim, Chulho / Yu, Hyunjae / Kim, Dong-Kyu

International journal of environmental research and public health

2023 Volume 20, Issue 4

Abstract: Burning mouth syndrome (BMS) is a chronic, painful condition of the oral mucosa. Although the pathogenesis remains unclear, psychological and neuroendocrine factors are considered the major contributors. Few longitudinal studies have investigated the ... ...

Abstract	Burning mouth syndrome (BMS) is a chronic, painful condition of the oral mucosa. Although the pathogenesis remains unclear, psychological and neuroendocrine factors are considered the major contributors. Few longitudinal studies have investigated the effects of psychological factors on the occurrence of BMS. Therefore, we evaluated the risk of BMS in patients with affective disorders using a nationwide population-based cohort dataset. We identified patients with depression, anxiety, and bipolar disorder and then selected comparison participants using the 1:4 propensity score-matching method. We investigated the incidence of BMS events during the follow-up period using survival analysis, the log-rank test, and Cox proportional hazards regression models. After adjusting for other contributing conditions, the adjusted hazard ratio (HR) for developing BMS was 3.37 (95% confidence interval [CI]: 1.67-6.80) for depression and 5.09 (95% CI: 2.19-11.80) for anxiety; however, bipolar disorder showed no significant risk. Specifically, female patients with depression and anxiety had an increased risk of BMS. Moreover, patients with anxiety showed an increased adjusted HR of BMS events during the first 4 years after diagnosis, whereas patients with depression did not. In conclusion, depression and anxiety disorders are significantly associated with the risk of BMS. Additionally, female patients showed a significantly higher risk of BMS than male patients, and anxiety showed increased BMS events earlier than depression. Therefore, clinicians should consider the risk of BMS when treating patients with depression or anxiety.
MeSH term(s)	Humans ; Male ; Female ; Bipolar Disorder ; Depression/psychology ; Cohort Studies ; Burning Mouth Syndrome/psychology ; Anxiety/psychology ; Anxiety Disorders/complications
Language	English
Publishing date	2023-02-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20043391
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