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Article: Variation in Metal-Support Interaction with TiO

Filip, Mihaela / Anghel, Elena Maria / Rednic, Vasile / Papa, Florica / Somacescu, Simona / Munteanu, Cornel / Aldea, Nicolae / Zhang, Jing / Parvulescu, Viorica

Nanomaterials (Basel, Switzerland)

2023 Volume 13, Issue 10

Abstract: The control of catalytic performance using synthesis conditions is one of the main goals of catalytic research. Two series of Pt-Ti/SBA-15 catalysts with different ... ...

Abstract	The control of catalytic performance using synthesis conditions is one of the main goals of catalytic research. Two series of Pt-Ti/SBA-15 catalysts with different TiO
Language	English
Publishing date	2023-05-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano13101647
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: An ultrasonographic insight into musculoskeletal manifestation in 100 systemic lupus erythematosus patients.

Popov, Ioan Horatiu / Pamfil, Cristina / Tămaș, Maria Magdalena / Onea, Teodor Nicolae / Felea, Ioana / Hălbac, Anca / Rednic, Nicolae / Rednic, Simona

Clinical and experimental rheumatology

2021 Volume 40, Issue 9, Page(s) 1686–1692

Abstract: Objectives: We aimed to investigate the prevalence of US findings in the hand joints and related tendons and explore clinical and laboratory associations in SLE patients of the typical lupus clinic.: Methods: One hundred consecutive SLE patients were ...

Abstract	Objectives: We aimed to investigate the prevalence of US findings in the hand joints and related tendons and explore clinical and laboratory associations in SLE patients of the typical lupus clinic. Methods: One hundred consecutive SLE patients were enrolled in the study. Using B-mode and Doppler US, bilateral wrist, metacarpophalangeal and proximal interphalangeal joints were examined for synovitis and erosions, as well as for signs of hand tenosynovitis. Results: US detected synovitis (grade 1-3) in 75% and erosive changes in 25% of the cohort. We found that clinical examination underestimated grade ≥2 synovitis by 13%, while US detected SH grade ≥2 in 10% of asymptomatic patients. The overall inflammatory burden, reflected by the US score, was associated with disease activity (respectively with CPR, SELENA-2K, MS-BILAG, and hypocomplementemia), as well as the presence of bone erosions. Rhupus patients had higher inflammatory markers, significantly more synovial hypertrophy, more erosions, more grade 3 tenosynovitis, and were more likely to receive methotrexate (p<0.001) than patients with SLE arthritis, while patients with Jaccoud's arthropathy were more likely to accumulate damage. The dominant hand exhibited more inflammatory changes (respectively synovial hypertrophy grade ≥2) at both the wrist and MCP joints; however, handedness was not associated with structural damage. Conclusions: In conclusion: 1. joint involvement in SLE is frequent and underacknowledged; 2. the overall inflammatory burden is associated with systemic disease activity and joint damage; (3) destructive arthritis is more likely to occur in the context of concomitant RA or within an "RA-like" subtype of SLE arthropathy; 4. hand dominance is associated with synovitis, but not structural changes; 5. US assessment may help tailor the management of joint involvement, thus preventing joint damage and disability in SLE patients.
MeSH term(s)	Arthritis/diagnostic imaging ; Arthritis/epidemiology ; Arthritis/etiology ; Humans ; Joint Diseases ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnostic imaging ; Lupus Erythematosus, Systemic/epidemiology ; Methotrexate ; Synovitis/diagnostic imaging ; Synovitis/epidemiology ; Synovitis/etiology ; Tenosynovitis/diagnostic imaging ; Tenosynovitis/epidemiology ; Tenosynovitis/etiology
Chemical Substances	Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2021-12-10
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
DOI	10.55563/clinexprheumatol/am4oj4
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Article: Current Perspectives on Periodontitis in Systemic Sclerosis: Associative Relationships, Pathogenic Links, and Best Practices.

Ciurea, Andreea / Rednic, Nicolae Voicu / Soancă, Andrada / Micu, Iulia Cristina / Stanomir, Alina / Oneț, Diana / Șurlin, Petra / Filipescu, Ileana / Roman, Alexandra / Stratul, Ștefan Ioan / Pamfil, Cristina

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 5

Abstract: Systemic sclerosis is a chronic, autoimmune, multisystemic disease characterized by aberrant extracellular matrix protein deposition and extreme progressive microvasculopathy. These processes lead to damage within the skin, lungs, or gastrointestinal ... ...

Abstract	Systemic sclerosis is a chronic, autoimmune, multisystemic disease characterized by aberrant extracellular matrix protein deposition and extreme progressive microvasculopathy. These processes lead to damage within the skin, lungs, or gastrointestinal tract, but also to facial changes with physiognomic and functional alterations, and dental and periodontal lesions. Orofacial manifestations are common in SSc but are frequently overshadowed by systemic complications. In clinical practice, oral manifestations of SSc are suboptimally addressed, while their management is not included in the general treatment recommendations. Periodontitis is associated with autoimmune-mediated systemic diseases, including systemic sclerosis. In periodontitis, the microbial subgingival biofilm induces host-mediated inflammation with subsequent tissue damage, periodontal attachment, and bone loss. When these diseases coexist, patients experience additive damage, increasing malnutrition, and morbidity. The present review discusses the links between SSc and periodontitis, and provides a clinical guide for preventive and therapeutical approaches in the management of these patients.
Language	English
Publishing date	2023-02-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13050841
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Article: Periodontitis Burden in Diffuse Versus Limited Systemic Sclerosis Subtypes: A Pilot Study.

Stanomir, Alina / Micu, Iulia Cristina / Picoș, Andrei / Roman, Alexandra / Soancă, Andrada / Onet, Diana / Onea, Teodor Nicolae / Rednic, Simona / Ciurea, Andreea / Pamfil, Cristina

Current health sciences journal

2023 Volume 49, Issue 2, Page(s) 280–287

Abstract: Introduction: This study aimed to evaluate the periodontal status of a group of Romanian systemic sclerosis (SSc) patients and to investigate the relationships between periodontitis and SSc subtypes.: Materials and methods: This observational study ... ...

Abstract	Introduction: This study aimed to evaluate the periodontal status of a group of Romanian systemic sclerosis (SSc) patients and to investigate the relationships between periodontitis and SSc subtypes. Materials and methods: This observational study included patients diagnosed with limited SSc (lcSSc) and diffuse SSc (dcSSc). Demographic data were collected from medical records. Each participant underwent a full-mouth periodontal examination including Bleeding on Probing (BoP) index, Oral Hygiene (OH) index, Probing Depth (PD), Gingival Recession (GR), and Clinical Attachment Loss (CAL). The periodontal status was defined according to presently recognised case definition system. Results: The study included 30 patients with lcSSc and 30 patients with dcSSc with a mean age of 52.45±11.75 years. The overall periodontitis frequence in our SSc group was 95%. The frequency of stage III/IV periodontitis was higher in the dcSSc group (90%) than in the lcSSc group (60%). Within the group of SSc patients, significant positive correlations were observed between age, BoP index, OH index, the number of missing teeth, mean PD, mean CAL on one side and periodontitis diagnosis on the other side (r=0.588, p=0.001; r=0.399, p=0.002; r=0.388, p=0.002; r=0.574, p=0.001; r=0.444, p=0.001; r=0.571, p=0.001). A significant positive correlation existed between the diagnostic of periodontitis and SSc subtypes (r=0.327, p <0.001). Conclusions: Periodontitis was highly prevalent in both lcSSc and dcSSc groups. More stage III/IV periodontitis cases were detected dcSSc group of patients.
Language	English
Publishing date	2023-06-30
Publishing country	Romania
Document type	Journal Article
ZDB-ID	2708703-7
ISSN	2069-4032 ; 2067-0656
ISSN (online)	2069-4032
ISSN	2067-0656
DOI	10.12865/CHSJ.49.02.280
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Article ; Online: Current Perspectives on Periodontitis in Systemic Sclerosis

Andreea Ciurea / Nicolae Voicu Rednic / Andrada Soancă / Iulia Cristina Micu / Alina Stanomir / Diana Oneț / Petra Șurlin / Ileana Filipescu / Alexandra Roman / Ștefan Ioan Stratul / Cristina Pamfil

Diagnostics, Vol 13, Iss 841, p

Associative Relationships, Pathogenic Links, and Best Practices

2023 Volume 841

Abstract	Systemic sclerosis is a chronic, autoimmune, multisystemic disease characterized by aberrant extracellular matrix protein deposition and extreme progressive microvasculopathy. These processes lead to damage within the skin, lungs, or gastrointestinal tract, but also to facial changes with physiognomic and functional alterations, and dental and periodontal lesions. Orofacial manifestations are common in SSc but are frequently overshadowed by systemic complications. In clinical practice, oral manifestations of SSc are suboptimally addressed, while their management is not included in the general treatment recommendations. Periodontitis is associated with autoimmune-mediated systemic diseases, including systemic sclerosis. In periodontitis, the microbial subgingival biofilm induces host-mediated inflammation with subsequent tissue damage, periodontal attachment, and bone loss. When these diseases coexist, patients experience additive damage, increasing malnutrition, and morbidity. The present review discusses the links between SSc and periodontitis, and provides a clinical guide for preventive and therapeutical approaches in the management of these patients.
Keywords	periodontitis ; systemic sclerosis ; pathogenesis ; dental biofilm ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Upper gastrointestinal involvement in systemic sclerosis: Findings in a real-life setting.

Petcu, Ana / Ghib, Linda Jessica / Grad, Simona Mihaela / Popovici, Cornelia / Rogojan, Liliana / Rednic, Nicolae Voicu / Rednic, Simona

Experimental and therapeutic medicine

2019 Volume 18, Issue 6, Page(s) 5095–5100

Abstract: Gastrointestinal tract involvement is the most common visceral affectation in systemic sclerosis (SSc), but the manifestations may vary in extension and severity. Endoscopic and histopathological gastroesophageal findings were investigated in patients ... ...

Abstract	Gastrointestinal tract involvement is the most common visceral affectation in systemic sclerosis (SSc), but the manifestations may vary in extension and severity. Endoscopic and histopathological gastroesophageal findings were investigated in patients with SSc. A total of 79 consecutive patients with definite SSc were enrolled in a cross sectional study. Clinical data were collected, upper gastrointestinal endoscopy and biopsies from gastric mucosa were performed in all cases. Fifty-seven (72.1%) out of 79 SSc patients had gastroesophageal symptoms. The most frequent were dysphagia, present in 33 (41.7%) and gastroesophageal reflux symptoms in 23 (29.1%) patients. Out of the 79 patients, 22 were asymptomatic, but in 16 esophageal and gastric mucosa changes were endoscopically detected. Reflux esophagitis was found in 39 (49.3%) patients. The presence of esophageal manifestations was not related to the disease duration or with its other variables. Signs of gastritis were endoscopically described in 47 (59.4%) and confirmed on histopathologic examinations in 45 patients. In 31 patients without any endoscopic changes, 18 (22.7%) showed signs of gastritis on histopathologic examination. No significant statistical differences were found between symptomatic and asymptomatic patients or between those with limited cutaneous SSc and those with diffuse cutaneous SSc in terms of clinical, endoscopic or histopathological findings, except the higher proportion of hiatal hernia in symptomatic patients. The results of this study might suggest that upper gastrointestinal endoscopy should be performed during the early stage of the disease and then periodically in patients diagnosed with SSc, even in the absence of typical symptoms.
Language	English
Publishing date	2019-10-24
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2019.8125
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Article ; Online: Carbamazepine-induced DRESS syndrome

Andrada Luciana Lazar / Olga Hilda Orășan / Corina Baican / Nicolae Voicu Rednic / Adela Sitar-Tăut / Bogdan Man / Vasile Negrean / Nicolae Rednic / Angela Cozma

Journal of Mind and Medical Sciences, Vol 7, Iss 2, Pp 239-

a case report

2020 Volume 244

Abstract: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a potentially life-threatening, idiosyncratic, acute adverse drug reaction. Fever, morbilliform cutaneous eruption, and eosinophilia are essential features for the diagnosis of ... ...

Abstract	Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a potentially life-threatening, idiosyncratic, acute adverse drug reaction. Fever, morbilliform cutaneous eruption, and eosinophilia are essential features for the diagnosis of this syndrome, along with significant multisystem involvement, hepatitis being the most common, followed by nephritis. The pathogenesis of DRESS syndrome is not yet fully understood. Several hypotheses have been proposed which support the involvement of an intricate interplay of multiple factors. We report a clinical case of DRESS syndrome with renal injury, induced by carbamazepine, in a patient with alcohol abstinence syndrome. In order to define the case, the RegiSCAR score and the Japanese Group score, used in the diagnosis of drug-induced hypersensitivity, were applied. DRESS syndrome is a potentially fatal disease, with a mortality that can reach up to 40% of cases. This condition endangers the patient's life by affecting the internal organs, mainly the liver, kidneys, heart, and lungs. Our case attempts to increase awareness among physicians about this serious disease and the importance of early diagnosis, especially since carbamazepine is a commonly used anticonvulsant drug.
Keywords	carbamazepine ; drug hypersensitivity ; eosinophilia ; exanthema ; lymphadenopathy ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Ion Motofei, Carol Davila University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Contrast-enhanced ultrasonography in inflammatory arthritis.

Rednic, Nicolae / Tamas, Maria Magdalena / Rednic, Simona

Medical ultrasonography

2011 Volume 13, Issue 3, Page(s) 220–227

Abstract: The degree of inflammation is the keystone of therapy management in rheumatoid arthritis and other arthritides. The assessment of synovial perfusion using power Doppler ultrasound is an important point in the quantification of the joint inflammation but ... ...

Abstract	The degree of inflammation is the keystone of therapy management in rheumatoid arthritis and other arthritides. The assessment of synovial perfusion using power Doppler ultrasound is an important point in the quantification of the joint inflammation but it is limited by the subjectivity of the vascularization grading and incapacity to detect flows in very small vessels. Contrast agent improves the ultrasound ability to depict and quantify blood flows in synovitis. Contrast-enhanced ultrasonography (CEUS) better differentiates synovitis from collection and distinguishes the active synovitis from inactive fibrotic or necrotic pannus. Quantitative assessment of inflammation is possible analyzing the time-intesity curves and by the correct measurement of the synovial thickness. The additional informations and the diagnostic value of CEUS in arthritides are still controversial but its excellent imaging of synovial vessels open the way for further clinical applications. This review aims to discuss the actual knowledges of CEUS in inflammatory arthritis.
MeSH term(s)	Arthritis/diagnostic imaging ; Contrast Media ; Humans ; Ultrasonography, Doppler, Color
Chemical Substances	Contrast Media
Language	English
Publishing date	2011-09
Publishing country	Romania
Document type	Journal Article ; Review
ZDB-ID	2529623-1
ISSN	2066-8643 ; 1844-4172
ISSN (online)	2066-8643
ISSN	1844-4172
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Article ; Online: Bone status and aortic calcifications in chondrocalcinosis patients

Vele Paulina / Silaghi Ciprian Nicolae / Damian Laura Otilia / Simon Siao-Pin / Craciun Alexandra / Rednic Simona

Romanian Journal of Laboratory Medicine, Vol 28, Iss 2, Pp 195-

2020 Volume 204

Abstract: Aim: We aimed to examine the association between several circulating bone turnover markers [ osteocalcin (OC), osteoprotegerin (OPG), beta-CrossLaps (β-CTx)], hip and spine bone mineral density (BMD) and abdominal aortic calcification (AAC) in patients ... ...

Abstract	Aim: We aimed to examine the association between several circulating bone turnover markers [ osteocalcin (OC), osteoprotegerin (OPG), beta-CrossLaps (β-CTx)], hip and spine bone mineral density (BMD) and abdominal aortic calcification (AAC) in patients with chondrocalcinosis (CC).
Keywords	chondrocalcinosis ; osteocalcin ; osteoprotegerin ; beta cross laps ; abdominal aortic calcifications ; Medicine ; R
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ultrasound assessment for the rapid classification of early arthritis patients.

Tămaş, Maria-Magdalena / Rednic, Nicolae / Felea, Ioana / Rednic, Simona

Journal of investigative medicine : the official publication of the American Federation for Clinical Research

2013 Volume 61, Issue 8, Page(s) 1184–1191

Abstract: Objective: The present study aimed to assess the role of ultrasound (US) in the rapid classification of early rheumatoid arthritis (RA) by investigating whether the US features of inflammation and bone damage in early arthritis overlap with the actual ... ...

Abstract	Objective: The present study aimed to assess the role of ultrasound (US) in the rapid classification of early rheumatoid arthritis (RA) by investigating whether the US features of inflammation and bone damage in early arthritis overlap with the actual clinical concept of classifying and identifying an aggressive disease. Methods: Patients with recent-onset arthritis of at least 1 peripheral joint of the hands and/or the feet were consecutively included in this study. Clinical examination, laboratory tests, the Disease Activity Score 28 (DAS28), and the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for RA were assessed for all patients. Medication with disease-modifying antirheumatic drugs was recorded. Ultrasound assessment was performed at the following anatomical sites: wrists, metacarpophalangeal joints 2 to 5, and metatarsophalangeal joints 2 to 5 for assessing the presence/absence of synovial hypertrophy, the presence/absence of power Doppler signal, and the presence/absence of bone erosions.The US features of inflammation and bone damage were analyzed in comparison with the DAS28, with the presence/absence of rheumatoid factor and anti-cyclic citrullinated peptide, with the fulfillment of the new 2010 ACR/EULAR classification criteria, and with the initiated disease-modifying antirheumatic drug. The prescription of methotrexate was considered a marker of an aggressive disease. Results: The US features of inflammation and bone damage correlated with the activity scores measured by the DAS28. The presence of US bone erosions overlapped with the presence of rheumatoid factor and anti-cyclic citrullinated antibodies. Synovial hypertrophy, intra-articular power Doppler signal, and bone erosions detected in at least 1 anatomical site were seen in patients fulfilling (77.7%) and in patients not fulfilling (72.7%) the 2010 ACR/EULAR classification criteria for RA. Synovial hypertrophy was found in at least 1 site in 83.3% and 58.8% of patients in whom methotrexate was prescribed and in whom methotrexate was not prescribed, respectively (P = 0.01). The US features were not correlated with the initiation of sulfasalazine or hydroxychloroquine. The patients presenting bone erosions received in significantly higher percentages the indication for methotrexate (50%) compared with sulfasalazine (20%), P = 0.03, or hydroxychloroquine (26%), P = 0.05. Conclusions: The US features of inflammation might be of help in classifying early arthritis patients despite the presence of the immune markers for RA. Together with the US features of bone damage, these might be used as an indicator of a more aggressive disease. The absence of correlation between the US findings of RA and the 2010 ACR/EULAR classification criteria indicates a possible independent contribution of US in the understanding of the future evolution of these patients.
MeSH term(s)	Adult ; Arthritis, Rheumatoid/classification ; Arthritis, Rheumatoid/diagnostic imaging ; Early Diagnosis ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Time Factors ; Ultrasonography
Language	English
Publishing date	2013-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1217870-6
ISSN	1708-8267 ; 0009-9279 ; 1081-5589
ISSN (online)	1708-8267
ISSN	0009-9279 ; 1081-5589
DOI	10.2310/JIM.0000000000000005
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