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  1. Article ; Online: Substituting Angiotensin-(1-7) to Prevent Lung Damage in SARS-CoV-2 Infection?

    Peiró, Concepción / Moncada, Salvador

    Circulation

    2020  Volume 141, Issue 21, Page(s) 1665–1666

    MeSH term(s) Angiotensin I/physiology ; Angiotensin-Converting Enzyme 2 ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/prevention & control ; Humans ; Lung/virology ; Lung Injury/prevention & control ; Pandemics/prevention & control ; Peptide Fragments/physiology ; Peptidyl-Dipeptidase A/physiology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2
    Chemical Substances Peptide Fragments ; Angiotensin I (9041-90-1) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; angiotensin I (1-7) (IJ3FUK8MOF)
    Keywords covid19
    Language English
    Publishing date 2020-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.120.047297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.60: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Mechanisms of endothelial activation, hypercoagulation and thrombosis in COVID-19: a link with diabetes mellitus.

    Valencia, Inés / Lumpuy-Castillo, Jairo / Magalhaes, Giselle / Sánchez-Ferrer, Carlos F / Lorenzo, Óscar / Peiró, Concepción

    Cardiovascular diabetology

    2024  Volume 23, Issue 1, Page(s) 75

    Abstract: Early since the onset of the COVID-19 pandemic, the medical and scientific community were aware of extra respiratory actions of SARS-CoV-2 infection. Endothelitis, hypercoagulation, and hypofibrinolysis were identified in COVID-19 patients as subsequent ... ...

    Abstract Early since the onset of the COVID-19 pandemic, the medical and scientific community were aware of extra respiratory actions of SARS-CoV-2 infection. Endothelitis, hypercoagulation, and hypofibrinolysis were identified in COVID-19 patients as subsequent responses of endothelial dysfunction. Activation of the endothelial barrier may increase the severity of the disease and contribute to long-COVID syndrome and post-COVID sequelae. Besides, it may cause alterations in primary, secondary, and tertiary hemostasis. Importantly, these responses have been highly decisive in the evolution of infected patients also diagnosed with diabetes mellitus (DM), who showed previous endothelial dysfunction. In this review, we provide an overview of the potential triggers of endothelial activation related to COVID-19 and COVID-19 under diabetic milieu. Several mechanisms are induced by both the viral particle itself and by the subsequent immune-defensive response (i.e., NF-κB/NLRP3 inflammasome pathway, vasoactive peptides, cytokine storm, NETosis, activation of the complement system). Alterations in coagulation mediators such as factor VIII, fibrin, tissue factor, the von Willebrand factor: ADAMST-13 ratio, and the kallikrein-kinin or plasminogen-plasmin systems have been reported. Moreover, an imbalance of thrombotic and thrombolytic (tPA, PAI-I, fibrinogen) factors favors hypercoagulation and hypofibrinolysis. In the context of DM, these mechanisms can be exacerbated leading to higher loss of hemostasis. However, a series of therapeutic strategies targeting the activated endothelium such as specific antibodies or inhibitors against thrombin, key cytokines, factor X, complement system, the kallikrein-kinin system or NETosis, might represent new opportunities to address this hypercoagulable state present in COVID-19 and DM. Antidiabetics may also ameliorate endothelial dysfunction, inflammation, and platelet aggregation. By improving the microvascular pathology in COVID-19 and post-COVID subjects, the associated comorbidities and the risk of mortality could be reduced.
    MeSH term(s) Humans ; COVID-19/complications ; Post-Acute COVID-19 Syndrome ; Pandemics ; SARS-CoV-2 ; Thrombophilia/diagnosis ; Thrombophilia/drug therapy ; Thrombosis ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/epidemiology ; Endothelium
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2093769-6
    ISSN 1475-2840 ; 1475-2840
    ISSN (online) 1475-2840
    ISSN 1475-2840
    DOI 10.1186/s12933-023-02097-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Substituting Angiotensin-(1-7) to Prevent Lung Damage in SARS-CoV-2 Infection?

    Peiró, Concepción / Moncada, Salvador

    Circulation

    2020  Volume 141, Issue 21, Page(s) 1665–1666

    Keywords Physiology (medical) ; Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/circulationaha.120.047297
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.60: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Onion and Apple Functional Ingredients Intake Improves Antioxidant and Inflammatory Status and Vascular Injury in Obese Zucker Rats.

    Balderas, Claudia / Angulo, Javier / Sevilleja-Ortiz, Alejandro / Peiró, Concepción / Vallejo, Susana / Dongil, Pilar / Ancos, Begoña de / Sánchez-Moreno, Concepción

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 10

    Abstract: The objective of this study was to investigate the effects of onion and apple functional ingredients in homozygous (fa/fa) obese Zucker rats. Rodents were fed three diets: standard diet [obese control (OC) group], standard diet containing 10% onion [ ... ...

    Abstract The objective of this study was to investigate the effects of onion and apple functional ingredients in homozygous (fa/fa) obese Zucker rats. Rodents were fed three diets: standard diet [obese control (OC) group], standard diet containing 10% onion [obese onion 10% (OO) group] and standard diet containing 10% apple [obese apple 10% (OA) group] for 8 weeks. Food intake and body weight gain were higher in obese than in lean rats. Food efficiency was lower in OO and AO groups compared with OC group. Within the obese groups, total cholesterol, LDL-cholesterol, triacylglycerols, glucose, insulin and triglyceride-glucose index were lower in OO group than in OC group, and HDL-cholesterol was higher in OO group than in OC group. In general, antioxidant activity (ABTS
    Language English
    Publishing date 2022-09-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11101953
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Substituting Ang-(1-7) to prevent lung damage in SARS-CoV2 infection?

    Peiró, Concepción / Moncada, Salvador

    2020  

    Abstract: CP is supported by a grant from Plan Nacional de I+D (SAF2017- 84776-R) ...

    Abstract CP is supported by a grant from Plan Nacional de I+D (SAF2017- 84776-R)
    Keywords angiotensin receptor blockers ; angiotensins ; ards ; human ; lung inflammation ; sars coronavirus ; treatment ; vascular endothelial cells ; COVID-19 ; Medicina ; covid19
    Language English
    Publishing date 2020-07-27T08:51:36Z
    Publisher American Heart Association
    Publishing country es
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Polyphenols Attenuate Highly-Glycosylated Haemoglobin-Induced Damage in Human Peritoneal Mesothelial Cells.

    Sánchez-Rodríguez, Carolina / Peiró, Concepción / Rodríguez-Mañas, Leocadio / Nevado, Julián

    Antioxidants (Basel, Switzerland)

    2020  Volume 9, Issue 7

    Abstract: We investigated the cytoprotective role of the dietary polyphenols on putative damage induced by Amadori adducts in Human Peritoneal Mesothelial Cells (HPMCs). Increased accumulation of early products of non-enzymatic protein glycation-Amadori adducts-in ...

    Abstract We investigated the cytoprotective role of the dietary polyphenols on putative damage induced by Amadori adducts in Human Peritoneal Mesothelial Cells (HPMCs). Increased accumulation of early products of non-enzymatic protein glycation-Amadori adducts-in the peritoneal dialysis fluid due to their high glucose, induces severe damage in mesothelial cells during peritoneal dialysis. Dietary polyphenols reportedly have numerous health benefits in various diseases and have been used as an efficient antioxidant in the context of several oxidative stress-related pathologies. HPMCs isolated from different patients were exposed to Amadori adducts (highly glycated haemoglobin, at physiological concentrations), and subsequently treated with several polyphenols, mostly presented in our Mediterranean diet. We studied several Amadori-induced effects in pro-apoptotic and oxidative stress markers, as well as the expression of several pro-inflammatory genes (nuclear factor-kappaB, NF-kB; inducible Nitric Oxide synthetase, iNOS), different caspase-activities, level of P53 protein or production of different reactive oxygen species in the presence of different polyphenols. In fact, cytoprotective agents such as dietary polyphenols may represent an alternate approach to protect mesothelial cells from the cytotoxicity of Amadori adducts. The interference with the Amadori adducts-triggered mechanisms could represent a therapeutic tool to reduce complications associated with peritoneal dialysis in the peritoneum, helping to maintain peritoneal membrane function longer in patients undergoing peritoneal dialysis.
    Language English
    Publishing date 2020-07-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox9070572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Correction: SARS-CoV-2 S protein activates NLRP3 inflammasome and deregulates coagulation factors in endothelial and immune cells.

    Villacampa, Alicia / Alfaro, Enrique / Morales, Cristina / Díaz-García, Elena / López-Fernández, Cristina / Bartha, José Luis / López-Sánchez, Francisco / Lorenzo, Óscar / Moncada, Salvador / Sánchez-Ferrer, Carlos F / García-Río, Francisco / Cubillos-Zapata, Carolina / Peiró, Concepción

    Cell communication and signaling : CCS

    2024  Volume 22, Issue 1, Page(s) 64

    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2126315-2
    ISSN 1478-811X ; 1478-811X
    ISSN (online) 1478-811X
    ISSN 1478-811X
    DOI 10.1186/s12964-024-01491-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: NLRP3 Inflammasome in Vascular Disease: A Recurrent Villain to Combat Pharmacologically.

    González-Moro, Ainara / Valencia, Inés / Shamoon, Licia / Sánchez-Ferrer, Carlos Félix / Peiró, Concepción / de la Cuesta, Fernando

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 2

    Abstract: Despite the great advances in medicine, mortality from cardiovascular diseases keeps on growing. This tendency is not likely to change considering the pandemic proportions of obesity and diabetes. Besides, the global population is more aged as life ... ...

    Abstract Despite the great advances in medicine, mortality from cardiovascular diseases keeps on growing. This tendency is not likely to change considering the pandemic proportions of obesity and diabetes. Besides, the global population is more aged as life expectancy increases, and vascular aging plays a key role in the increased risk of vascular disease. In light of recent trials, namely the CANTOS study, showing the enormous potential of anti-inflammatory therapies and in particular those targeted to IL-1β, a change in therapeutical management of cardiovascular diseases is coming about. The NLRP3 inflammasome is a multiprotein complex that assembles to engage the innate immune defense by processing the maturation of pro-inflammatory cytokines IL-1β and IL-18. Substantial evidence has positioned the NLRP3 inflammasome at the center of vascular disease progression, with a particular significance in the context of aging and the low-grade chronic inflammation associated (inflammaging). Therefore, pharmacological blockade of the NLRP3 inflammasome and its end products has arisen as an extremely promising tool to battle vascular disease. In this review, we discuss the mechanisms by which the NLRP3 inflammasome contributes to vascular disease, with particular attention to the consequences of aging, and we enumerate the therapeutic options available to combat this recurrent villain.
    Language English
    Publishing date 2022-01-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11020269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: SARS-CoV-2 S protein activates NLRP3 inflammasome and deregulates coagulation factors in endothelial and immune cells.

    Villacampa, Alicia / Alfaro, Enrique / Morales, Cristina / Díaz-García, Elena / López-Fernández, Cristina / Bartha, José Luis / López-Sánchez, Francisco / Lorenzo, Óscar / Moncada, Salvador / Sánchez-Ferrer, Carlos F / García-Río, Francisco / Cubillos-Zapata, Carolina / Peiró, Concepción

    Cell communication and signaling : CCS

    2024  Volume 22, Issue 1, Page(s) 38

    Abstract: Background: Hyperinflammation, hypercoagulation and endothelial injury are major findings in acute and post-COVID-19. The SARS-CoV-2 S protein has been detected as an isolated element in human tissues reservoirs and is the main product of mRNA COVID-19 ... ...

    Abstract Background: Hyperinflammation, hypercoagulation and endothelial injury are major findings in acute and post-COVID-19. The SARS-CoV-2 S protein has been detected as an isolated element in human tissues reservoirs and is the main product of mRNA COVID-19 vaccines. We investigated whether the S protein alone triggers pro-inflammatory and pro-coagulant responses in primary cultures of two cell types deeply affected by SARS-CoV-2, such are monocytes and endothelial cells.
    Methods: In human umbilical vein endothelial cells (HUVEC) and monocytes, the components of NF-κB and the NLRP3 inflammasome system, as well as coagulation regulators, were assessed by qRT-PCR, Western blot, flow cytometry, or indirect immunofluorescence.
    Results: S protein activated NF-κB, promoted pro-inflammatory cytokines release, and triggered the priming and activation of the NLRP3 inflammasome system resulting in mature IL-1β formation in both cell types. This was paralleled by enhanced production of coagulation factors such as von Willebrand factor (vWF), factor VIII or tissue factor, that was mediated, at least in part, by IL-1β. Additionally, S protein failed to enhance ADAMTS-13 levels to counteract the pro-coagulant activity of vWF multimers. Monocytes and HUVEC barely expressed angiotensin-converting enzyme-2. Pharmacological approaches and gene silencing showed that TLR4 receptors mediated the effects of S protein in monocytes, but not in HUVEC.
    Conclusion: S protein behaves both as a pro-inflammatory and pro-coagulant stimulus in human monocytes and endothelial cells. Interfering with the receptors or signaling pathways evoked by the S protein may help preventing immune and vascular complications driven by such an isolated viral element. Video Abstract.
    MeSH term(s) Humans ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; COVID-19 Vaccines ; NF-kappa B/metabolism ; von Willebrand Factor ; COVID-19 ; SARS-CoV-2 ; Human Umbilical Vein Endothelial Cells/metabolism ; Interleukin-1beta/metabolism ; Spike Glycoprotein, Coronavirus
    Chemical Substances Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; spike protein, SARS-CoV-2 ; COVID-19 Vaccines ; NF-kappa B ; von Willebrand Factor ; Interleukin-1beta ; Spike Glycoprotein, Coronavirus
    Language English
    Publishing date 2024-01-15
    Publishing country England
    Document type Video-Audio Media ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126315-2
    ISSN 1478-811X ; 1478-811X
    ISSN (online) 1478-811X
    ISSN 1478-811X
    DOI 10.1186/s12964-023-01397-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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