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  1. Book ; Thesis: Identifikation MIA inhibierender Medikamente und Peptide

    Barth, Anna

    2018  

    Author's details vorgelegt von Anna Barth
    Language German
    Size 66 Seiten, Illustrationen, Diagramme, 21 cm
    Publishing place Erlangen ; Nürnberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Friedrich-Alexander-Universität Erlangen-Nürnberg, 2018
    HBZ-ID HT019985067
    Database Catalogue ZB MED Medicine, Health

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  2. Book ; Online: Multivariate scaling methods and the reconstruction of social spaces

    Barth, Alice / Leßke, Felix / Atakan, Rebekka / Schmidt, Manuela / Scheit, Yvonne

    Papers in honor of Jörg Blasius

    2023  

    Keywords Social research & statistics ; correspondence analysis;Korrespondenzanalyse;social space;sozialer Raum;Bourdieu;geometric data analysis;geometrische Datenanalyse;categorical data;kategoriale Daten;gentrification;Stadtsoziologie;urban sociology;public space;Raumsoziologie
    Language English
    Size 1 electronic resource (259 pages)
    Publisher Verlag Barbara Budrich
    Document type Book ; Online
    Note English
    HBZ-ID HT030612984
    ISBN 9783847427643 ; 3847427644
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Transfer Queen

    Barth, Patty / Strouse, A.W.

    2018  

    Abstract: ... Barth spy on strangers with a special kind of anonymous intimacy. Transfer Queen is ideal reading ...

    Abstract Cruising the New York City subway, the Transfer Queen is on the prowl! These voyeuristic figure drawings-both poetic and visual-sketch the men of Gotham's transportation system. A.W. Strouse and Patty Barth spy on strangers with a special kind of anonymous intimacy. Transfer Queen is ideal reading material for kinky commuters. But remember: "A crowded subway car is no excuse for unlawful sexual conduct!"
    Keywords Literature (General)
    Size 1 electronic resource (378 p.)
    Publisher punctum books
    Publishing place Verlagsort nicht ermittelbar
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020195518
    ISBN 9781947447639 ; 9781947447646 ; 1947447637 ; 1947447645
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Refining protein amide I spectrum simulations with simple yet effective electrostatic models for local wavenumbers and dipole derivative magnitudes.

    Baronio, Cesare M / Barth, Andreas

    Physical chemistry chemical physics : PCCP

    2024  Volume 26, Issue 2, Page(s) 1166–1181

    Abstract: Analysis of the amide I band of proteins is probably the most wide-spread application of bioanalytical infrared spectroscopy. Although highly desirable for a more detailed structural interpretation, a quantitative description of this absorption band is ... ...

    Abstract Analysis of the amide I band of proteins is probably the most wide-spread application of bioanalytical infrared spectroscopy. Although highly desirable for a more detailed structural interpretation, a quantitative description of this absorption band is still difficult. This work optimized several electrostatic models with the aim to reproduce the effect of the protein environment on the intrinsic wavenumber of a local amide I oscillator. We considered the main secondary structures - α-helices, parallel and antiparallel β-sheets - with a maximum of 21 amide groups. The models were based on the electric potential and/or the electric field component along the CO bond at up to four atoms in an amide group. They were bench-marked by comparison to Hessian matrices reconstructed from density functional theory calculations at the BPW91, 6-31G** level. The performance of the electrostatic models depended on the charge set used to calculate the electric field and potential. Gromos and DSSP charge sets, used in common force fields, were not optimal for the better performing models. A good compromise between performance and the stability of model parameters was achieved by a model that considered the electric field at the positions of the oxygen, nitrogen, and hydrogen atoms of the considered amide group. The model describes also some aspects of the local conformation effect and performs similar on its own as in combination with an explicit implementation of the local conformation effect. It is better than a combination of a local hydrogen bonding model with the local conformation effect. Even though the short-range hydrogen bonding model performs worse, it captures important aspects of the local wavenumber sensitivity to the molecular surroundings. We improved also the description of the coupling between local amide I oscillators by developing an electrostatic model for the dependency of the dipole derivative magnitude on the protein environment.
    MeSH term(s) Amides/chemistry ; Static Electricity ; Models, Molecular ; Proteins/chemistry ; Spectrophotometry, Infrared/methods
    Chemical Substances Amides ; Proteins
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp02018e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Infrared spectroscopy finally sees the light.

    Barth, Andreas

    Nature

    2020  Volume 577, Issue 7788, Page(s) 34–35

    MeSH term(s) Optics and Photonics ; Spectrophotometry, Infrared
    Language English
    Publishing date 2020-01-01
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-019-03866-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Impact of Second-Shell Nucleotides on Ligand Specificity in Cyclic Dinucleotide Riboswitches.

    Barth, Kathryn M / Hiller, David A / Strobel, Scott A

    Biochemistry

    2024  

    Abstract: Ligand specificity is an essential requirement for all riboswitches. Some variant riboswitches utilize a common structural motif, yet through subtle sequence differences, they are able to selectively respond to different small molecule ligands and ... ...

    Abstract Ligand specificity is an essential requirement for all riboswitches. Some variant riboswitches utilize a common structural motif, yet through subtle sequence differences, they are able to selectively respond to different small molecule ligands and regulate downstream gene expression. These variants discriminate between structurally and chemically similar ligands. Crystal structures provide insight into how specificity is achieved. However, ligand specificity cannot always be explained solely by nucleotides in direct contact with the ligand. The cyclic dinucleotide variant family contains two classes, cyclic-di-GMP and cyclic-AMP-GMP riboswitches, that were distinguished based on the identity of a single nucleotide in contact with the ligand. Here we report a variant riboswitch with a mutation at a second ligand-contacting position that is promiscuous for both cyclic-di-GMP and cyclic-AMP-GMP despite a predicted preference for cyclic-AMP-GMP. A high-throughput mutational analysis, SMARTT, was used to quantitatively assess thousands of sites in the first- and second-shells of ligand contact for impacts on ligand specificity and promiscuity. In addition to nucleotides in direct ligand contact, nucleotides more distal from the binding site, within the J1/2 linker and the terminator helix, were identified that impact ligand specificity. These findings provide an example of how nucleotides outside the ligand binding pocket influence the riboswitch specificity. Moreover, these distal nucleotides could be used to predict promiscuous sequences.
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.3c00586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Effects of Early Talent Promotion on Junior and Senior Performance: A Systematic Review and Meta-Analysis.

    Güllich, Arne / Barth, Michael

    Sports medicine (Auckland, N.Z.)

    2023  Volume 54, Issue 3, Page(s) 697–710

    Abstract: Background: Does younger involvement in talent promotion programs (TPPs) facilitate the attainment of higher performance levels? This question is the subject of the present meta-analysis. Many national sport systems have established TPPs such as ... ...

    Abstract Background: Does younger involvement in talent promotion programs (TPPs) facilitate the attainment of higher performance levels? This question is the subject of the present meta-analysis. Many national sport systems have established TPPs such as federations' junior squads (including under-age selection teams) and youth sport academies, and many are making expanding investments in TPPs. TPPs seek to select the most advanced youth high performers at young ages, around puberty or younger, and then strive to further accelerate their performance development. However, studies show 25-55% annual athlete turnover within TPPs. In this context, accelerated biological maturation (puberty, growth spurt), high relative age within one's birth year, and intensified sport-specific childhood/adolescent practice may boost rapid junior performance, but the effects diminish or are reversed by adulthood. Moreover, expanded opportunity costs and risks (time demands, injury, burnout) imposed on young TPP participants may impair their long-term development and even prematurely terminate their career.
    Objective: We aimed to provide robust and generalizable evidence on the effects of early talent promotion on junior and senior performance through a systematic review and meta-analysis.
    Methods: A systematic literature search was conducted 18/03-03/04/2023 in SPORTDiscus, ProQuest, PsycINFO, PubMed, Scopus, WorldCat, and Google Scholar. We searched for original studies that compared athletes across defined higher and lower performance levels within defined types of sports, age categories, and sexes, regarding their age at commencement of TPP involvement and reported effect sizes or data needed to compute effects sizes. Mean meta-analytic Cohen's
    Results: The search yielded k = 51 effect sizes from N = 6233 athletes from a wide range of countries and sports, 82% male and 18% female, from 2009 to 2022. The central finding is that effects on short-term junior performance versus long-term senior performance are opposite, whereby higher-performing junior athletes began TPP involvement at younger ages than lower-performing junior athletes,
    Discussion: The findings are consistent with recent meta-analytic evidence that participation patterns predicting early junior success versus long-term senior success are opposite (starting age, main-sport and other-sports practice amounts, age to reach performance 'milestones'). We discuss theoretical and practical implications of potential selection and 'treatment' effects of TPPs.
    Conclusions: Consistent across different populations, early TPP involvement is positively correlated with short-term junior performance but is negatively correlated with long-term senior performance.
    MeSH term(s) Adolescent ; Humans ; Male ; Female ; Adult ; Child ; Sports ; Athletes ; Team Sports ; Aptitude ; Youth Sports
    Language English
    Publishing date 2023-11-03
    Publishing country New Zealand
    Document type Meta-Analysis ; Systematic Review
    ZDB-ID 605911-9
    ISSN 1179-2035 ; 0112-1642
    ISSN (online) 1179-2035
    ISSN 0112-1642
    DOI 10.1007/s40279-023-01957-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Exploring reading profiles of rural school students.

    Daniel, Johny / Barth, Amy

    Annals of dyslexia

    2023  Volume 73, Issue 2, Page(s) 235–259

    Abstract: This study investigates the reading profiles of rural Grade 5 and 6 students (N = 262), a sample with a high proportion of English language learners. We administered a battery of reading and cognitive assessments to classify students' reading profiles ... ...

    Abstract This study investigates the reading profiles of rural Grade 5 and 6 students (N = 262), a sample with a high proportion of English language learners. We administered a battery of reading and cognitive assessments to classify students' reading profiles and evaluate if performance on cognitive measures predicted membership in particular profiles. Data were analyzed using latent profile analysis. Latent profile analysis showed four distinct reading profiles in our sample: students with severe reading disabilities (< 2%), students at high risk of reading disability (14%), students at some-risk of reading disability (46%), and students who are typical readers (38%). Lower performance on cognitive measures was associated with group membership in the severe reading profile group compared to the group of students at some-risk of reading failure. In contrast, higher performance on cognitive measures was associated with group membership in the typical reader group compared to students at some-risk of reading failure. In keeping with the findings from past studies documenting reader profiles, we found heterogeneity in the reading profiles of rural upper-elementary grade students. We discuss the need for multicomponent interventions that target all areas of reading with some flexibility in the dosage of each reading component dependent on the reader profiles established prior to intervention.
    MeSH term(s) Humans ; Dyslexia/epidemiology ; Reading ; Students/psychology ; Language ; Schools ; Learning Disabilities
    Language English
    Publishing date 2023-01-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 11939-8
    ISSN 1934-7243 ; 0736-9387
    ISSN (online) 1934-7243
    ISSN 0736-9387
    DOI 10.1007/s11881-022-00276-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Lebensmittelassoziierte Mikroorganismen Bakterielle Toxine

    Weiß, Agnes / Barth, Holger / Schmidt, Herbert

    Molekulare Struktur, Funktionsweise und Nachweissysteme

    (Lebensmittelassoziierte Mikroorganismen)

    2018  

    Author's details A. Weiß/H. Barth/H. Schmidt
    Series title Lebensmittelassoziierte Mikroorganismen
    Keywords Bakteriengift ; Molekülstruktur ; Wirkungsmechanismus ; Nachweis
    Subject Test ; Nachweisverfahren ; Nachweismethode ; Molekülbau ; Molekularstruktur ; Molekülgeometrie ; Molekulare Geometrie ; Bakterientoxin ; Bakterielles Toxin
    Language German
    Size X, 80 Seiten, Illustrationen, 21 cm x 14.8 cm, 158 g
    Edition 1. Auflage
    Publisher Behr's Verlag
    Publishing place Hamburg
    Publishing country Germany
    Document type Book
    HBZ-ID HT019929869
    ISBN 978-3-95468-616-2 ; 3-95468-616-3
    Database Catalogue ZB MED Medicine, Health

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  10. Article ; Online: Folding pathway of a discontinuous two-domain protein.

    Agam, Ganesh / Barth, Anders / Lamb, Don C

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 690

    Abstract: It is estimated that two-thirds of all proteins in higher organisms are composed of multiple domains, many of them containing discontinuous folds. However, to date, most in vitro protein folding studies have focused on small, single-domain proteins. As a ...

    Abstract It is estimated that two-thirds of all proteins in higher organisms are composed of multiple domains, many of them containing discontinuous folds. However, to date, most in vitro protein folding studies have focused on small, single-domain proteins. As a model system for a two-domain discontinuous protein, we study the unfolding/refolding of a slow-folding double mutant of the maltose binding protein (DM-MBP) using single-molecule two- and three-color Förster Resonance Energy Transfer experiments. We observe a dynamic folding intermediate population in the N-terminal domain (NTD), C-terminal domain (CTD), and at the domain interface. The dynamic intermediate fluctuates rapidly between unfolded states and compact states, which have a similar FRET efficiency to the folded conformation. Our data reveals that the delayed folding of the NTD in DM-MBP is imposed by an entropic barrier with subsequent folding of the highly dynamic CTD. Notably, accelerated DM-MBP folding is routed through the same dynamic intermediate within the cavity of the GroEL/ES chaperone system, suggesting that the chaperonin limits the conformational space to overcome the entropic folding barrier. Our study highlights the subtle tuning and co-dependency in the folding of a discontinuous multi-domain protein.
    MeSH term(s) Maltose-Binding Proteins ; Entropy ; Fluorescence Resonance Energy Transfer ; Protein Folding ; Research Design
    Chemical Substances Maltose-Binding Proteins
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-44901-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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