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  1. Book ; Online ; E-Book: Interventional Psychiatry

    Quevedo, Joao / Brunoni, André R. / Hamani, Clement

    Road to Novel Therapeutics

    2024  

    Subject code 616.8914
    Language English
    Size 1 online resource (572 pages)
    Edition 1st ed.
    Publisher Elsevier Science & Technology
    Publishing place San Diego
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 9780443184970 ; 9780443184963 ; 0443184976 ; 0443184968
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Neuromodulation in psychiatry

    Hamani, Clement

    2016  

    Author's details Clement Hamani ... ed
    Language English
    Size X, 482 S. : zahlr. Ill., graph. Darst.
    Publisher Wiley
    Publishing place Chichester
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT018719820
    ISBN 978-1-118-80104-8 ; 1-118-80104-0
    Database Catalogue ZB MED Medicine, Health

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  3. Book: Emerging horizons in neuromodulation

    Hamani, Clement

    new frontiers in brain and spine stimulation

    (International review of neurobiology ; 107)

    2012  

    Author's details ed. by Clement Hamani
    Series title International review of neurobiology ; 107
    Collection
    Language English
    Size XIV, 380 S. : Ill., graph. Darst.
    Edition 1. ed.
    Publisher Elsevier AP
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT017514664
    ISBN 978-0-12-404706-8 ; 0-12-404706-8
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Commentary: Awake Deep Brain Stimulation Surgery Without Intraoperative Imaging Is Accurate and Effective: A Case Series.

    Hamani, Clement

    Operative neurosurgery (Hagerstown, Md.)

    2022  Volume 23, Issue 3, Page(s) e201–e202

    MeSH term(s) Anesthesia, General ; Deep Brain Stimulation/methods ; Humans ; Parkinson Disease/therapy ; Wakefulness
    Language English
    Publishing date 2022-07-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2767575-0
    ISSN 2332-4260 ; 2332-4252
    ISSN (online) 2332-4260
    ISSN 2332-4252
    DOI 10.1227/ons.0000000000000334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Preface.

    Hamani, Clement / Polosan, Mircea / Moro, Elena

    International review of neurobiology

    2021  Volume 159, Page(s) xiii–xiv

    MeSH term(s) Humans ; Neurobiology
    Language English
    Publishing date 2021-08-10
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 209876-3
    ISSN 2162-5514 ; 0074-7742
    ISSN (online) 2162-5514
    ISSN 0074-7742
    DOI 10.1016/S0074-7742(21)00080-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Deep brain stimulation as a treatment for depressive disorder.

    Gouveia, Flavia V / Hamani, Clement

    Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

    2020  Volume 42, Issue 4, Page(s) 342–343

    MeSH term(s) Deep Brain Stimulation ; Depressive Disorder, Treatment-Resistant/therapy ; Humans
    Language English
    Publishing date 2020-03-09
    Publishing country Brazil
    Document type Editorial
    ISSN 1809-452X
    ISSN (online) 1809-452X
    DOI 10.1590/1516-4446-2019-0780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Reply: Evaluating the Scope and Safety of Bilateral MRgFUS Thalamotomy for Essential Tremor: A Critical Analysis.

    Scantlebury, Nadia / Rabin, Jennifer S / De Schlichting, Emmanuel / Hamani, Clement / Schwartz, Michael L / Lipsman, Nir / Abrahao, Agessandro

    Movement disorders clinical practice

    2024  Volume 11, Issue 3, Page(s) 320–321

    MeSH term(s) Humans ; Essential Tremor/surgery ; Thalamus/diagnostic imaging ; Magnetic Resonance Imaging ; Psychosurgery
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Letter
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Translational aspects of deep brain stimulation for chronic pain.

    Pagano, Rosana L / Dale, Camila S / Campos, Ana Carolina P / Hamani, Clement

    Frontiers in pain research (Lausanne, Switzerland)

    2023  Volume 3, Page(s) 1084701

    Abstract: The use of deep brain stimulation (DBS) for the treatment of chronic pain was one of the first applications of this technique in functional neurosurgery. Established brain targets in the clinic include the periaqueductal (PAG)/periventricular gray matter ...

    Abstract The use of deep brain stimulation (DBS) for the treatment of chronic pain was one of the first applications of this technique in functional neurosurgery. Established brain targets in the clinic include the periaqueductal (PAG)/periventricular gray matter (PVG) and sensory thalamic nuclei. More recently, the anterior cingulum (ACC) and the ventral striatum/anterior limb of the internal capsule (VS/ALIC) have been investigated for the treatment of emotional components of pain. In the clinic, most studies showed a response in 20%-70% of patients. In various applications of DBS, animal models either provided the rationale for the development of clinical trials or were utilized as a tool to study potential mechanisms of stimulation responses. Despite the complex nature of pain and the fact that animal models cannot reliably reflect the subjective nature of this condition, multiple preparations have emerged over the years. Overall, DBS was shown to produce an antinociceptive effect in rodents when delivered to targets known to induce analgesic effects in humans, suggesting a good predictive validity. Compared to the relatively high number of clinical trials in the field, however, the number of animal studies has been somewhat limited. Additional investigation using modern neuroscience techniques could unravel the mechanisms and neurocircuitry involved in the analgesic effects of DBS and help to optimize this therapy.
    Language English
    Publishing date 2023-01-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2673-561X
    ISSN (online) 2673-561X
    DOI 10.3389/fpain.2022.1084701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: What do we know about astrocytes and the antidepressant effects of DBS?

    Campos, Ana Carolina P / Pagano, Rosana L / Lipsman, Nir / Hamani, Clement

    Experimental neurology

    2023  Volume 368, Page(s) 114501

    Abstract: Treatment-resistant depression (TRD) is a debilitating condition that affects millions of individuals worldwide. Deep brain stimulation (DBS) has been widely used with excellent outcomes in neurological disorders such as Parkinson's disease, tremor, and ... ...

    Abstract Treatment-resistant depression (TRD) is a debilitating condition that affects millions of individuals worldwide. Deep brain stimulation (DBS) has been widely used with excellent outcomes in neurological disorders such as Parkinson's disease, tremor, and dystonia. More recently, DBS has been proposed as an adjuvant therapy for TRD. To date, the antidepressant efficacy of DBS is still controversial, and its mechanisms of action remain poorly understood. Astrocytes are the most abundant cells in the nervous system. Once believed to be a "supporting" element for neuronal function, astrocytes are now recognized to play a major role in brain homeostasis, neuroinflammation and neuroplasticity. Because of its many roles in complex multi-factorial disorders, including TRD, understanding the effect of DBS on astrocytes is pivotal to improve our knowledge about the antidepressant effects of this therapy. In depression, the number of astrocytes and the expression of astrocytic markers are decreased. One of the potential consequences of this reduced astrocytic function is the development of aberrant glutamatergic neurotransmission, which has been documented in several models of depression-like behavior. Evidence from preclinical work suggests that DBS may directly influence astrocytic activity, modulating the release of gliotransmitters, reducing neuroinflammation, and altering structural tissue organization. Compelling evidence for an involvement of astrocytes in potential mechanisms of DBS derive from studies suggesting that pharmacological lesions or the inhibition of these cells abolishes the antidepressant-like effect of DBS. In this review, we summarize preclinical data suggesting that the modulation of astrocytes may be an important mechanism for the antidepressant-like effects of DBS.
    MeSH term(s) Humans ; Deep Brain Stimulation ; Astrocytes/physiology ; Neuroinflammatory Diseases ; Brain ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2023-08-08
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 207148-4
    ISSN 1090-2430 ; 0014-4886
    ISSN (online) 1090-2430
    ISSN 0014-4886
    DOI 10.1016/j.expneurol.2023.114501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Editorial: The Complex Biopsychosocial Interactions That Create Stress Resilience.

    Suchecki, Deborah / Souza-Talarico, Juliana Nery / Hamani, Clement / Olivier, Jocelien D

    Frontiers in behavioral neuroscience

    2021  Volume 15, Page(s) 795312

    Language English
    Publishing date 2021-11-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2452960-6
    ISSN 1662-5153
    ISSN 1662-5153
    DOI 10.3389/fnbeh.2021.795312
    Database MEDical Literature Analysis and Retrieval System OnLINE

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