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Article ; Online: Protective effects of Re-yan-ning mixture on

Han, Lizhu / Kou, Jing / Hu, Kunxia / Wang, Yunlan / Tang, Zhishu / Wu, Zhisheng / Song, Xiao

2021 Volume 59, Issue 1, Page(s) 209–221

Abstract: Context: Re-yan-ning mixture (RYNM) is a new national drug approved by China's State ...

Abstract	Context: Re-yan-ning mixture (RYNM) is a new national drug approved by China's State Food and Drug Administration for the treatment of colds, simple pneumonia and acute bronchitis. Objective: To determine the mechanism of action of RYNM in the treatment of bacterial pneumonia. Materials and methods: Using the network pharmacology approach, the multiple components, component candidate targets and multiple therapeutic targets of RYNM were screened and functionally enriched. Also, we established a rat Results: The network pharmacology approach successfully identified 48 bioactive components in RYNM, and 65 potential targets and 138 signal pathways involved in the treatment of Discussion and conclusions: The present study demonstrated the protective effects of RYNM on
MeSH term(s)	Animals ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Inflammation/drug therapy ; Inflammation/microbiology ; Male ; NF-kappa B/metabolism ; Pneumonia, Pneumococcal/microbiology ; Pneumonia, Pneumococcal/prevention & control ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Streptococcus pneumoniae/drug effects ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Drugs, Chinese Herbal ; NF-kappa B ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2021-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2021.1872653
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Article ; Online: Bu-Shen-Ning-Xin decoction inhibits macrophage activation to ameliorate premature ovarian insufficiency-related osteoimmune disorder via FSH/FSHR pathway.

Sun, Hongmei / Qi, Qing / Pan, Xinyao / Zhou, Jing / Wang, Jing / Li, Lisha / Li, Dajing / Wang, Ling

Drug discoveries & therapeutics

2024

Abstract: ... osteoimmune disorder currently. Bu-Shen-Ning-Xin decoction (BSNXD) displayed a favorable role in treating ...

Abstract	Limited studies are associated with premature ovarian insufficiency (POI)-related osteoimmune disorder currently. Bu-Shen-Ning-Xin decoction (BSNXD) displayed a favorable role in treating postmenopausal osteoporosis. However, its impact on the POI-related osteoimmune disorder remains unclear. The study primarily utilized animal experiments and network pharmacology to investigate the effects and underlying mechanisms of BSNXD on the POI-related osteoimmune disorder. First, a 4-vinylcyclohexene dioxide (VCD)-induced POI murine model was conducted to explore the therapeutical action of BSNXD. Second, we analyzed the active compounds of BSNXD and predicted their potential mechanisms for POI-related osteoimmune disorder via network pharmacology, further confirmed by molecular biology experiments. The results demonstrated that VCD exposure led to elevated follicle-stimulating hormone (FSH) levels, a 50% reduction in the primordial follicles, bone microstructure changes, and macrophage activation, indicating an osteoimmune disorder. BSNXD inhibited macrophage activation and osteoclast differentiation but did not affect serum FSH and estradiol levels in the VCD-induced POI model. Network pharmacology predicted the potential mechanisms of BSNXD against the POI-related osteoimmune disorder involving tumor necrosis factor α and MAPK signaling pathways, highlighting BSNXD regulated inflammation, hormone, and osteoclast differentiation. Further experiments identified BSNXD treatment suppressed macrophage activation via downregulating FSH receptor (FSHR) expression and inhibiting the phosphorylation of ERK and CCAAT enhancer binding proteins β. In conclusion, BSNXD regulated POI-related osteoimmune disorder by suppressing the FSH/FSHR pathway to reduce macrophage activation and further inhibiting osteoclastogenesis.
Language	English
Publishing date	2024-04-17
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2568828-5
ISSN	1881-784X ; 1881-784X
ISSN (online)	1881-784X
ISSN	1881-784X
DOI	10.5582/ddt.2024.01006
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Article: Inversion of soil water and salt information based on UAV hyperspectral remote sensing and machine lear-ning.

Wang, Yi-Jing / Ding, Qi-Dong / Zhang, Jun-Hua / Chen, Ruihua / Jia, Keli / Li, Xiao-Lin

Ying yong sheng tai xue bao = The journal of applied ecology

2023 Volume 34, Issue 11, Page(s) 3045–3052

Abstract: Accurate diagnosis of water and salt information in saline agricultural lands is crucial for long-term soil quality improvement and arable land conservation. In this study, we extracted field-scale vegetation canopy spectral information by UAV ... ...

Title translation	基于无人机高光谱遥感和机器学习的土壤水盐信息反演.
Abstract	Accurate diagnosis of water and salt information in saline agricultural lands is crucial for long-term soil quality improvement and arable land conservation. In this study, we extracted field-scale vegetation canopy spectral information by UAV hyperspectral information, transforming the reflectance (R) to standard normal variate transformation (SNV), multiplicative scatter correction (MSC), first derivative of reflectance (FDR) and second derivative of reflectance (SDR). We determined the optimal spectral transformation forms of soil water content (SWC), soil pH, and soil salt content (SSC) by the maximum absolute correlation coefficient (MACC), and extracted the feature bands by competitive adaptive reweighted sampling (CARS). We constructed an inversion model of soil water and salt information by partial least squares regression (PLSR), random forest (RF), and extreme gradient boosting (XGBoost). The results showed that R, FDR and MSC were the best spectral transformation types for soil water content, soil pH, and soil salt content, and the corresponding MACC were 0.730, 0.472 and 0.654, respectively. The CARS algorithm effectively eliminated the irrelevant variables, optimally selecting 16-17 feature bands from 150 spectral bands. Both soil water content and soil pH performed best with XGBoost model, achieving determination coefficient of validation (
MeSH term(s)	Soil/chemistry ; Hyperspectral Imaging ; Water ; Sodium Chloride ; Remote Sensing Technology
Chemical Substances	Soil ; Water (059QF0KO0R) ; Sodium Chloride (451W47IQ8X)
Language	English
Publishing date	2023-11-21
Publishing country	China
Document type	Journal Article
ZDB-ID	2881809-X
ISSN	1001-9332
ISSN	1001-9332
DOI	10.13287/j.1001-9332.202311.012
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Article: Post-marketing safety surveillance and re-evaluaiton of Shu-Xue-Ning injection: a real-world study based on 30,122 cases.

Xinyao, Jin / Yifan, Zhang / Keyi, Wang / Wentai, Pang / Chunyang, Wang / Hui, Wang / Chunxiang, Liu / Yunhua, Xue / Wenke, Zheng

Frontiers in pharmacology

2023 Volume 14, Page(s) 1194367

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2023-11-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1194367
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Article ; Online: Systematic review of randomized controlled trials on Gong Liu Ning as a complimentary therapy in the treatment of uterine fibroids

Lu Fan / Jiahui Hu / Mei Han / Guoyan Yang / Shibo Cong / Min Xiong / Ruiting Wang / Gansheng Zhong

Journal of Traditional Chinese Medical Sciences, Vol 10, Iss 4, Pp 415-

2023 Volume 426

Abstract: Objective: To systematically evaluate the efficacy and safety of Gong Liu Ning as a complimentary ... therapy in treatment for uterine fibroids. Methods: Randomized controlled trials on Gong Liu Ning ... with 1907 patients were analyzed. The meta-analysis results of 15 studies showed that Gong Liu Ning combined ...

Abstract	Objective: To systematically evaluate the efficacy and safety of Gong Liu Ning as a complimentary therapy in treatment for uterine fibroids. Methods: Randomized controlled trials on Gong Liu Ning for uterine fibroids from China National Knowledge Infrastructure, Wanfang, China Science and Technology Journal Database, PubMed, Cochrane Library, Embase, Web of Science, Chinese Clinical Trial Registry, and ClinicalTrials.gov were retrieved from inception to March 20, 2023. The risk of bias tool was used to evaluate the quality of the selected studies after they met inclusion and exclusion criteria. The GRADE tool was used to evaluate the quality of evidence, and the RevMan5.3 software was used for data analysis. Results: Twenty studies with 1907 patients were analyzed. The meta-analysis results of 15 studies showed that Gong Liu Ning combined with mifepristone was more efficacious than those observed in controls taking only Western medicine (risk ratio [RR] = 1.22, 95% confidence interval [CI] = [1.11, 1.33], P < .001). Owing to the large heterogeneity, a random-effects model was used to merge the included studies. Gong Liu Ning combined with mifepristone was better in reducing the volume of uterine fibroids (mean difference [MD] = −4.09 cm3, 95%CI [−5.16, −3.02], P < .001), uterine volume (MD = −23.22 cm3, 95%CI [−29.10, −17.33], P < .001), and the levels of female hormones, including progesterone, estrogen, follicle-stimulating hormone, and luteinizing hormone (all P < .001). Ten studies reported adverse events. The methodological quality of the included studies was not high, and a moderate risk of bias was observed. Conclusion: Compared with conventional Western medicine alone, the combined use of Gong Liu Ning has certain advantages in improving efficacy. It shows a certain advanced tendency to reduce the volume of uterine fibroids, uterine volume, and female hormones; however, more high-quality and rigorously designed studies are required for validation.
Keywords	Gong Liu Ning ; Uterine fibroids ; Chinese patent medicine ; Meta-analysis ; Systematic review ; Miscellaneous systems and treatments ; RZ409.7-999
Subject code	610
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Xin Su Ning-A Review of Basic and Clinical Pharmacology Integrated With Traditional Chinese Medicine Antiarrhythmic Theory.

Wang, Xuan / Wang, Taiyi / Ding, Shuwen / Ma, Yu-Ling

Frontiers in pharmacology

2021 Volume 12, Page(s) 657484

Abstract: Xin Su Ning (XSN) is a patented multicomponent medicine, which was certified in 2005 by the China ...

Abstract	Xin Su Ning (XSN) is a patented multicomponent medicine, which was certified in 2005 by the China State Food and Drug Administration to be produced pharmaceutically and to be used clinically. The XSN capsule was developed from an effective formula composed by Prof. Shuwen Ding of Shandong University of Traditional Chinese Medicine. Through more than 30 years of clinical observation, Prof. Ding concluded that XSN has a significant effect on arrhythmia with phlegm-heat heart-disturbed syndrome according to the traditional Chinese medicine (TCM) diagnosis. XSN, derived from a classical TCM formula Huanglian Wen Dan Decoction, is formulated with 11 Chinese herbal medicines to treat cardiac ventricular arrhythmia. Clinical evidence suggests that it is particularly efficacious for the arrhythmias induced by cardiac ischemia and viral myocarditis without obvious adverse reactions being reported. Cellular electrophysiological studies in ventricular myocytes revealed that XSN prolongs the duration and suppresses the amplitude of the action potential (AP), which is supported by the blockage of sodium and potassium channels indicating the characteristics of class I and III antiarrhythmic drugs. A recently reported double-blind, placebo-controlled, multicenter clinical trial of XSN enrolled 861 patients (ChiCTR-TRC-14004180) and showed that XSN significantly inhibited premature ventricular contraction (PVC). The cellular electrophysiological discoveries provided the mechanistic evidence for the clinical efficacy on inhibition of PVC by XSN as demonstrated in the clinical trial. These studies, for the first time, provided exclusive evidence that multicomponent TCM antiarrhythmic medicine can be evaluated using conventional research methods that have been used for antiarrhythmic drug discoveries for decades. We aimed to give a comprehensive review on XSN including its origin with the support of TCM theory, its pre-licensing clinical use and development, and its pharmacological and clinical study discoveries. The review will be summarized with the discoveries reported in a novel network pharmacological study that introduced a weight coefficient, which made it possible to evaluate the pharmacological properties of the TCM formula with regard to its formation based on TCM theory. Limitations regarding XSN's basic and clinical research and possible future studies are listed. We hope that the advances in how XSN was studied may offer useful guidance on how other TCM could be studied with respect to the integrity of the TCM formulas.
Language	English
Publishing date	2021-11-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.657484
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Article: "Jing-Ning Granules" Can Alleviate Attention Deficit Hyperactivity Disorder in Rats by Modulating Dopaminergic D2/D1-Like Receptor-Mediated Signaling Pathways.

Ding, Jie / Ding, Yiyun / Wu, Jingjing / Deng, Jialin / Yu, Qingyang / Wang, Junhong

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 9139841

Abstract: ... characterized by attention deficit, hyperactivity, and impulsivity. Jing-Ning Granules (JNG) is ...

Abstract	Background: Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by attention deficit, hyperactivity, and impulsivity. Jing-Ning Granules (JNG) is a traditional Chinese medicine (TCM) that can alleviate ADHD. Although JNG is commonly used for the effective treatment of ADHD and has obtained the national invention patent, the exact mechanism of action remains unclear. Objective: In this study, we examined the effect and mechanism of JNG in spontaneously hypertensive rats (SHRs). We hypothesized that JNG affects dopaminergic D2/D1-like receptors and related pathways. Materials and methods: Six rat groups were used in the experiment: Wistar-Kyoto rats (WKY, control group) and five SHR groups, including a model group; atomoxetine (ATX, positive control) group; and low, medium, and high-dose JNG groups. The corresponding treatments were daily administered to each group for 6 weeks. A behavioral test, including a step-down test and open field test (OFT), was carried out at the end of treatment. After the behavioral test, all animals were sacrificed, and the brain tissue was collected and analyzed ex vivo; histopathological analysis was performed to assess the pathological changes of the hippocampus; expression of D1-like and D2-like receptors, sensor protein calmodulin (CaM), protein kinase A (PKA), and calcium/calmodulin-dependent serine/threonine protein kinase (CaMKII) in the striatum and hippocampus was measured by western blot and real-time quantitative PCR (RT-PCR); cyclic adenosine monophosphate (cAMP) levels in the striatum were analyzed using an enzyme-linked immunosorbent assay (ELISA), while the level of Ca Results: Our results showed that ATX or JNG could ameliorate the hyperactive/impulsive behavior and cognitive function of ADHD by promoting neuroprotection. Mechanistically, ATX or JNG could prompt the expressions of Dl-like and D2-like receptors and improve the mRNA and protein levels of cAMP/PKA and Ca Conclusion: These results indicate that JNG can produce therapeutic effects by regulating the balance of D2/D1-like receptor-mediated cAMP/PKA and Ca
Language	English
Publishing date	2022-10-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/9139841
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Article ; Online: Re-Du-Ning injection ameliorates radiation-induced pneumonitis and fibrosis by inhibiting AIM2 inflammasome and epithelial-mesenchymal transition.

Yang, Chenxi / Song, Chenglin / Wang, Yi / Zhou, Wencheng / Zheng, Wei / Zhou, Han / Deng, Guoliang / Li, Haibo / Xiao, Wei / Yang, Zhongqi / Kong, Lingdong / Ge, Huiming / Song, Yaohong / Sun, Yang

Phytomedicine : international journal of phytotherapy and phytopharmacology

2022 Volume 102, Page(s) 154184

Abstract: ... patients, and there is no good medicine to treat it. Re-Du-Ning (RDN) injection is ...

Abstract	Background: Radiation-induced lung injury (RILI) is a common side effect in chest radiotherapy patients, and there is no good medicine to treat it. Re-Du-Ning (RDN) injection is a traditional Chinese medicine that is clinically used to treat upper respiratory tract infections and acute bronchitis. RDN has the advantage of high safety and mild side effects. The mechanism of most traditional Chinese medicine preparations is unknown. Purpose: To illustrate the mechanisms of RDN for the treatment of RILI. Methods: Female C57BL/6 mice were used to establish a RILI model via irradiation, and RDN injection was intraperitoneally administered at doses of 5, 10, and 20 ml/kg. The cytokines were measured by ELISA and qPCR. The data related to Absent in melanoma 2 (AIM2) inflammasome were analyzed via ELISA and a network pharmacological approach. In addition, the data related to epithelial-mesenchymal transition (EMT) were analyzed via immunofluorescence, Western blotting, and a network pharmacological approach. Results: RDN robustly alleviated RILI. Meanwhile, RDN downregulated inflammatory cells' infiltration and the expression of pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α. Next, the potential molecular mechanisms of RDN were predicted through network pharmacology analysis. RDN may ameliorate radiation pneumonitis (RP) by inhibiting AIM2-mediated pyroptosis. Moreover, RDN treatment inhibited EMT and phosphoinositide-3-kinase (PI3K)/protein kinase B (AKT) pathway. The active compounds from Lonicera japonica Thunb. decreased the phosphorylation of Akt. Conclusion: These findings demonstrate that RDN, as a traditional Chinese medicine preparation, will be a candidate drug for treating RILI.
MeSH term(s)	Animals ; Cytokines ; DNA-Binding Proteins ; Epithelial-Mesenchymal Transition ; Female ; Fibrosis ; Humans ; Inflammasomes ; Lung Injury ; Melanoma ; Mice ; Mice, Inbred C57BL ; Pneumonia ; Proto-Oncogene Proteins c-akt/metabolism ; Radiation Injuries/drug therapy ; Radiation Pneumonitis/drug therapy
Chemical Substances	AIM2 protein, human ; Aim2 protein, mouse ; Cytokines ; DNA-Binding Proteins ; Inflammasomes ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2022-05-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2022.154184
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Article ; Online: Qualitative and quantitative analysis of multi-components in Xing-Su-Ning Capsules for quality improvement

Juanning Ren / Rongrong Wang / Wenjing Fan / Tong Li / Pengzhi Dong / Guixiang Pan / Ming Ren / Miaomiao Jiang

Arabian Journal of Chemistry, Vol 15, Iss 6, Pp 103825- (2022)

2022

Abstract: Background: Xin-Su-Ning Capsules (XSNC) is an effective prescription for the treatment ...

Abstract	Background: Xin-Su-Ning Capsules (XSNC) is an effective prescription for the treatment of arrhythmia composed of eleven Chinese herbs. With the wide application of XSNC in clinic, its quality control issues have also received increasing attention. Based on the multi-components characteristics of Chinese herbal compound, there is an urgent need to establish a quality evaluation system. Methods: Gas chromatography-mass spectrometry (GC-MS) and ultra high-performance liquid chromatography quadrupole electrostatic orbitrap high resolution mass spectrometry (UHPLC-Q-Exactive-Orbitrap-MS) were performed to identify the preliminary chemical profile of XSNC. Subsequently, a rapid ultra high-performance liquid chromatography coupled with electrospray ionization triple-quadrupole mass spectrometry (UHPLC-QQQ-MS/MS) method was developed to evaluate the quality of XSNC through a simultaneous determination of 16 components. Results: A total of 21 volatile components and 59 non-volatile compounds were tentatively identified from the XSNC, each identified compound is marked on the corresponding chromatogram. Moreover, sixteen chemical constituents (sophocarpine, matrine, febrifugine, berberine, palmatine, Tangeratin, nobiletin, liensinine, neferine, scopoletin, isoliquiritigenin, liquiritigenin, naringenin, naringin, hesperidin and glycyrrhizic acid) were quantified by the developed UHPLC-QQQ-MS/MS method. The method validation of the sixteen compounds was performed with acceptable linearity (R2, 0.9990-1.0000), precision (RSD, 0.25-2.06%), repeatability (RSD, 0.93-2.90%) and recovery (99.65%-104.03%, RSD≤4.35%). Conclusions: This qualitative analysis method sensitive and reliable for searching the volatile and non-volatile compounds from XSNC. The linearity, accuracy and precision of the quantitative analysis method were satisfactory. It is proposed that the methods described here can be applied for rapid evaluation, quality control and authenticity establishment of XSNC.
Keywords	Xing-Su-Ning Capsules ; Constituent identification ; Quantitative analysis ; UHPLC-Q-Exactive-Orbitrap-MS ; UHPLC-QQQ-MS/MS ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Treatment with Tang-luo-ning altered the microRNA expression profile in rats with diabetic peripheral neuropathy.

Li, Yixiao / Gao, Yanbin / Gong, Yanbing / Guo, Yuxin / Wang, Liying / Liu, Qin / Chen, Feng / Zhang, Taojing

Bioengineered

2020 Volume 11, Issue 1, Page(s) 841–851

Abstract: Tang-luo-ning (TLN) is a traditional Chinese herbal recipe that has been used to treat diabetic ...

Abstract	Tang-luo-ning (TLN) is a traditional Chinese herbal recipe that has been used to treat diabetic peripheral neuropathy (DPN); nevertheless, the underlying mechanism remains unclear. This study was aimed to investigate the microRNA (miRNA) expression profile in diabetic rats treated with TLN, and the target genes were predicted. Male Sprague-Dawley rats were randomly divided into control, diabetes, and TLN-treated diabetes groups. Diabetes was induced with streptozotocin, and TLN (5 g/kg/day) was orally given for eight weeks. Then, the sciatic nerves were harvested for miRNA microarray analyses. The differentially expressed miRNAs and their target genes were analyzed. Compared with the control rats, 24 miRNAs were significantly upregulated, and 59 were downregulated in the sciatic nerves of the diabetic rats by more than two folds (all
MeSH term(s)	Animals ; Cluster Analysis ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/metabolism ; Diabetic Neuropathies/drug therapy ; Diabetic Neuropathies/genetics ; Diabetic Neuropathies/metabolism ; Drugs, Chinese Herbal/therapeutic use ; Male ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Signal Transduction/genetics
Chemical Substances	Drugs, Chinese Herbal ; MicroRNAs
Language	English
Publishing date	2020-07-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2737830-5
ISSN	2165-5987 ; 2165-5979
ISSN (online)	2165-5987
ISSN	2165-5979
DOI	10.1080/21655979.2020.1797282
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