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  1. Article ; Online: Delving into the adytum of the IL-17 defense pathway.

    Hajishengallis, George

    Cell host & microbe

    2023  Volume 31, Issue 10, Page(s) 1599–1601

    Abstract: Multiple transcription factors are activated in the IL-17 signaling pathway that mediates anti-fungal immunity, although many of them are redundant for protective immunity despite being essential in driving IL-17-mediated autoimmunity. In this issue, ... ...

    Abstract Multiple transcription factors are activated in the IL-17 signaling pathway that mediates anti-fungal immunity, although many of them are redundant for protective immunity despite being essential in driving IL-17-mediated autoimmunity. In this issue, Gaffen and colleagues unveil the IκBζ protein as an indispensable transcription factor in IL-17-activated anti-fungal defense.
    MeSH term(s) Nuclear Proteins/metabolism ; Interleukin-17/metabolism ; Signal Transduction ; Gene Expression Regulation
    Chemical Substances Nuclear Proteins ; Interleukin-17
    Language English
    Publishing date 2023-09-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2023.08.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6578: Show issues Location:
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  2. Article ; Online: Illuminating the oral microbiome and its host interactions: animal models of disease.

    Hajishengallis, George

    FEMS microbiology reviews

    2023  Volume 47, Issue 3

    Abstract: Periodontitis and caries are driven by complex interactions between the oral microbiome and host factors, i.e. inflammation and dietary sugars, respectively. Animal models have been instrumental in our mechanistic understanding of these oral diseases, ... ...

    Abstract Periodontitis and caries are driven by complex interactions between the oral microbiome and host factors, i.e. inflammation and dietary sugars, respectively. Animal models have been instrumental in our mechanistic understanding of these oral diseases, although no single model can faithfully reproduce all aspects of a given human disease. This review discusses evidence that the utility of an animal model lies in its capacity to address a specific hypothesis and, therefore, different aspects of a disease can be investigated using distinct and complementary models. As in vitro systems cannot replicate the complexity of in vivo host-microbe interactions and human research is typically correlative, model organisms-their limitations notwithstanding-remain essential in proving causality, identifying therapeutic targets, and evaluating the safety and efficacy of novel treatments. To achieve broader and deeper insights into oral disease pathogenesis, animal model-derived findings can be synthesized with data from in vitro and clinical research. In the absence of better mechanistic alternatives, dismissal of animal models on fidelity issues would impede further progress to understand and treat oral disease.
    MeSH term(s) Animals ; Humans ; Periodontitis ; Microbiota ; Host Microbial Interactions ; Models, Animal ; Dysbiosis
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 283740-7
    ISSN 1574-6976 ; 0168-6445
    ISSN (online) 1574-6976
    ISSN 0168-6445
    DOI 10.1093/femsre/fuad018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2165: Show issues Location:
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  3. Book: Oral mucosal immunity and microbiome

    Belibasakis, Georgios N. / Hajishengallis, George / Bostanci, Nagihan

    (Advances in experimental medicine and biology ; 1197)

    2019  

    Author's details Georgios N. Belibasakis, George Hajishengallis, Nagihan Bostanci, Michael A. Curtis editors
    Series title Advances in experimental medicine and biology ; 1197
    Collection
    Language English
    Size xii, 189 Seiten, Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT020306017
    ISBN 978-3-030-28523-4 ; 9783030285241 ; 3-030-28523-5 ; 3030285243
    Database Catalogue ZB MED Medicine, Health

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    Zs A 3192 -1197- not available for loan Zeitschriften-Lesesaal

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  4. Article ; Online: Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications.

    Hajishengallis, George

    Periodontology 2000

    2022  Volume 89, Issue 1, Page(s) 9–18

    Abstract: Periodontitis, a microbiome-driven inflammatory disease of the tooth-attachment apparatus, is epidemiologically linked with other disorders, including cardio-metabolic, cognitive neurodegenerative and autoimmune diseases, respiratory infections, and ... ...

    Abstract Periodontitis, a microbiome-driven inflammatory disease of the tooth-attachment apparatus, is epidemiologically linked with other disorders, including cardio-metabolic, cognitive neurodegenerative and autoimmune diseases, respiratory infections, and certain cancers. These associations may, in part, be causal, as suggested by interventional studies showing that local treatment of periodontitis reduces systemic inflammation and surrogate markers of comorbid diseases. The potential cause-and-effect connection between periodontitis and comorbidities is corroborated by studies in preclinical models of disease, which additionally provided mechanistic insights into these associations. This overview discusses recent advances in our understanding of the periodontitis-systemic disease connection, which may potentially lead to innovative therapeutic options to reduce the risk of periodontitis-linked comorbidities.
    MeSH term(s) Humans ; Inflammation ; Microbiota ; Periodontal Diseases/complications ; Periodontal Diseases/epidemiology ; Periodontal Diseases/therapy ; Periodontitis/complications ; Periodontitis/epidemiology ; Periodontitis/therapy
    Language English
    Publishing date 2022-03-04
    Publishing country Denmark
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1200504-6
    ISSN 1600-0757 ; 0906-6713
    ISSN (online) 1600-0757
    ISSN 0906-6713
    DOI 10.1111/prd.12430
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    Zs.A 4046: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Book: Oral microbiology and immunology

    Lamont, Richard J. / Hajishengallis, George N. / Koo, Hyun / Jenkinson, Howard F.

    2019  

    Author's details Richard J. Lamont, George N. Hajishengallis, Hyun (Michel) Koo, Howard F. Jenkinson
    Keywords Mouth Diseases / microbiology ; Tooth Diseases / microbiology ; Mouth / microbiology ; Mouth Diseases / immunology ; Mouth / immunology ; Mouth/Microbiology ; Mouth/Immunology
    Subject code 617/.522
    Language English
    Size xxviii, 565 Seiten, Illustrationen
    Edition Third edition
    Publisher ASM Press
    Publishing place Washington, DC
    Publishing country United States
    Document type Book
    HBZ-ID HT020074001
    ISBN 978-1-55581-998-9 ; 9781555819996 ; 1-55581-998-2 ; 1555819990
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2020 A 45 available for loan (reading room) Lesesaal EG

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  6. Article ; Online: Local destruction from distant action.

    Hajishengallis, George

    Journal of leukocyte biology

    2020  Volume 108, Issue 4, Page(s) 1033–1035

    Abstract: Discussion on the identification of an osteoclast precursor population, which emerges in the bone marrow after systemic infection with a periodontal pathogen. ...

    Abstract Discussion on the identification of an osteoclast precursor population, which emerges in the bone marrow after systemic infection with a periodontal pathogen.
    MeSH term(s) Osteoclasts ; Porphyromonas gingivalis
    Language English
    Publishing date 2020-08-17
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1002/JLB.3CE0720-364R
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    Zs.A 603: Show issues Location:
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  7. Article ; Online: Oral bacteria and leaky endothelial junctions in remote extraoral sites.

    Hajishengallis, George

    The FEBS journal

    2020  Volume 288, Issue 5, Page(s) 1475–1478

    Abstract: Periodontitis and periodontal pathogens have been associated with systemic complications that influence comorbid conditions, such as cardiovascular disease. Using a zebrafish larvae infection model, Farrugia et al. show that Porphyromonas gingivalis ... ...

    Abstract Periodontitis and periodontal pathogens have been associated with systemic complications that influence comorbid conditions, such as cardiovascular disease. Using a zebrafish larvae infection model, Farrugia et al. show that Porphyromonas gingivalis causes vascular damage and increased endothelial permeability by degrading, via its gingipain proteases, platelet endothelial cell adhesion molecule-1, and vascular endothelial cadherin, which are crucial for endothelial junctional integrity. These findings suggest a molecular mechanism whereby this oral pathogen may contribute to endothelial dysfunction and perhaps atherosclerotic cardiovascular disease.
    MeSH term(s) Adhesins, Bacterial ; Animals ; Cysteine Endopeptidases ; Gingipain Cysteine Endopeptidases ; Porphyromonas gingivalis ; Zebrafish
    Chemical Substances Adhesins, Bacterial ; Gingipain Cysteine Endopeptidases ; Cysteine Endopeptidases (EC 3.4.22.-)
    Language English
    Publishing date 2020-08-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.15510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 260: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: New developments in neutrophil biology and periodontitis.

    Hajishengallis, George

    Periodontology 2000

    2020  Volume 82, Issue 1, Page(s) 78–92

    Abstract: Neutrophils have been historically associated with antimicrobial functions in acute infections but are now appreciated as functionally versatile cells with critical roles in chronic inflammation. Recent advances in neutrophil biology have contributed to ... ...

    Abstract Neutrophils have been historically associated with antimicrobial functions in acute infections but are now appreciated as functionally versatile cells with critical roles in chronic inflammation. Recent advances in neutrophil biology have contributed to a better understanding of periodontal disease pathogenesis and, reciprocally, the study of periodontitis has led to important insights into neutrophil regulation and function. Here, the contributions by our group to this field through interdisciplinary collaboration are discussed. The study of leukocyte adhesion deficiency-associated periodontitis has revealed that the connection of neutrophils with destructive inflammation may involve mechanisms beyond the typical bystander injury dogma. In this regard, neutrophils are required for important immunomodulatory functions and their absence from the periodontium leads to dysregulated overproduction of interleukin-17, which drives inflammatory bone loss. We have also discovered that both the production of neutrophils in the bone marrow and their recruitment to peripheral tissues, including the periodontium, are homeostatically regulated by a secreted protein designated developmental endothelial locus-1. However, developmental endothelial locus-1 expression, and hence developmental endothelial locus-1-dependent homeostasis, declines considerably with aging and contributes to an increased susceptibility to periodontitis in old age. Moreover, our work has mechanistically supported the concept that periodontitis is a dysbiotic disease and we have shown that neutrophils become targets of immune subversion by periodontal bacteria in a manner that promotes dysbiosis. The mechanism involves microbial exploitation of key neutrophil receptors (complement C5a receptor-1 and toll-like receptor-2), leading to crosstalk signaling that uncouples neutrophil-mediated killing (which is impaired) from neutrophil-induced inflammation (which is enhanced). These studies have collectively established new mechanisms governing the protective and destructive functions of neutrophils in periodontitis and offered targeted host-modulation approaches for the treatment of periodontal diseases.
    MeSH term(s) Humans ; Inflammation ; Leukocyte Disorders ; Neutrophils ; Periodontitis ; Periodontium
    Language English
    Publishing date 2020-02-18
    Publishing country Denmark
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1200504-6
    ISSN 1600-0757 ; 0906-6713
    ISSN (online) 1600-0757
    ISSN 0906-6713
    DOI 10.1111/prd.12313
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    Zs.A 4046: Show issues Location:
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  9. Book: Current topics in innate immunity / 2

    Lambris, John D. / Hajishengallis, George N.

    (Advances in experimental medicine and biology ; 946 ; Aegean conferences)

    2012  

    Series title Advances in experimental medicine and biology ; 946
    Aegean conferences
    Current topics in innate immunity
    Collection Current topics in innate immunity
    Language English
    Size XVII, 354 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT017039960
    ISBN 978-1-4614-0105-6 ; 9781461401063 ; 1-4614-0105-4 ; 1461401062
    Database Catalogue ZB MED Medicine, Health

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    Zs A 3192 -946- not available for loan Zeitschriften-Lesesaal

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  10. Article ; Online: Inflammatory memory and comorbidities.

    Hajishengallis, George / Chavakis, Triantafyllos

    Clinical and translational medicine

    2022  Volume 12, Issue 7, Page(s) e984

    MeSH term(s) Comorbidity
    Language English
    Publishing date 2022-07-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.984
    Database MEDical Literature Analysis and Retrieval System OnLINE

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