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  1. Article ; Online: Editorial Expression of Concern: Effect of laser‑assisted zona thinning, during assisted reproduction, on pregnancy outcome in women with endometriosis: randomized controlled trial.

    Nada, Adel Mohamed / El-Noury, Amr / Al-Inany, Hesham / Bibars, Mamdouh / Taha, Tamer / Salama, Sameh / Hassan, Fatma / Zein, Eman

    Archives of gynecology and obstetrics

    2023  Volume 309, Issue 5, Page(s) 2257

    Language English
    Publishing date 2023-10-09
    Publishing country Germany
    Document type Expression of Concern
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-023-07236-w
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  2. Article ; Online: A review of the contemporary evidence on rescue cervical cerclage.

    Abu Hashim, Hatem / Al-Inany, Hesham / Kilani, Zaid

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2014  Volume 124, Issue 3, Page(s) 198–203

    Abstract: Background: Rescue cervical cerclage (RCC) is essentially a salvage procedure to prolong pregnancy in women with advanced cervical changes and prolapsed membranes in the second trimester. However, its effectiveness and safety remain controversial.: ... ...

    Abstract Background: Rescue cervical cerclage (RCC) is essentially a salvage procedure to prolong pregnancy in women with advanced cervical changes and prolapsed membranes in the second trimester. However, its effectiveness and safety remain controversial.
    Objectives: To provide a comprehensive review of the contemporary evidence on RCC and evaluate which treatment modalities can be offered to pregnant women based on the best available evidence.
    Search strategy: A PubMed search of published studies on RCC and perinatal outcome was conducted using defined keywords.
    Selection criteria: Clinical studies were included with priority for level I evidence (randomized controlled trials [RCTs]) followed by other evidence levels.
    Data collection and analysis: Abstracts of 141 articles were screened and 40 articles were selected.
    Main results: Evidence from retrospective and nonrandomized prospective trials shows a benefit of RCC. It may prolong pregnancy by an average of 4-5 weeks, with a 2-fold reduction in the chance of preterm birth before 34 weeks. A higher chance of failure is expected if cervical dilatation exceeds 4 cm or if membranes are bulging into the vagina.
    Conclusions: The decision for an RCC should be individualized after comprehensive counseling by a senior obstetrician. Further research in the form of robust RCTs is recommended.
    MeSH term(s) Cerclage, Cervical/methods ; Female ; Humans ; Labor Stage, First ; Pregnancy ; Pregnancy Trimester, Second ; Premature Birth/prevention & control ; Salvage Therapy/methods ; Treatment Outcome ; Uterine Cervical Incompetence/surgery
    Language English
    Publishing date 2014-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1016/j.ijgo.2013.08.021
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  3. Article: Female infertility.

    Al-Inany, Hesham

    Clinical evidence

    2006  , Issue 15, Page(s) 2465–2487

    MeSH term(s) Clomiphene/therapeutic use ; Endometriosis/complications ; Fallopian Tubes/surgery ; Female ; Fertility Agents, Female/therapeutic use ; Fertilization in Vitro ; Gonadotropins/therapeutic use ; Humans ; Infertility, Female/drug therapy ; Infertility, Female/surgery ; Infertility, Female/therapy ; Laparoscopy ; Metformin/therapeutic use ; Ovarian Diseases/drug therapy
    Chemical Substances Fertility Agents, Female ; Gonadotropins ; Clomiphene (1HRS458QU2) ; Metformin (9100L32L2N)
    Language English
    Publishing date 2006-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1495368-7
    ISSN 1462-3846
    ISSN 1462-3846
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  4. Article ; Online: GnRH antagonist for pituitary supression in IVF

    Amr Wahba / Hesham Al-Inany

    Middle East Fertility Society Journal, Vol 16, Iss 4, Pp 256-

    Is it time for a change of practice?

    2011  Volume 258

    Keywords Medicine (General) ; R5-920 ; Reproduction ; QH471-489
    Language English
    Publishing date 2011-12-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Polycystic ovary syndrome.

    Al-Inany, Hesham

    Clinical evidence

    2005  , Issue 14, Page(s) 2343–2351

    MeSH term(s) Cyproterone Acetate/therapeutic use ; Drug Therapy, Combination ; Ethinyl Estradiol/therapeutic use ; Female ; Finasteride/therapeutic use ; Flutamide/therapeutic use ; Humans ; Metformin/therapeutic use ; Polycystic Ovary Syndrome/drug therapy ; Spironolactone/therapeutic use
    Chemical Substances Spironolactone (27O7W4T232) ; Ethinyl Estradiol (423D2T571U) ; Cyproterone Acetate (4KM2BN5JHF) ; Finasteride (57GNO57U7G) ; Flutamide (76W6J0943E) ; Metformin (9100L32L2N)
    Language English
    Publishing date 2005-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1495368-7
    ISSN 1462-3846
    ISSN 1462-3846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Polycystic ovary syndrome.

    Al-Inany, Hesham

    Clinical evidence

    2004  , Issue 12, Page(s) 2678–2688

    MeSH term(s) Androgen Antagonists/therapeutic use ; Cyproterone Acetate/therapeutic use ; Drug Therapy, Combination ; Ethinyl Estradiol/therapeutic use ; Female ; Finasteride/therapeutic use ; Flutamide/therapeutic use ; Hirsutism/drug therapy ; Humans ; Metformin/therapeutic use ; Polycystic Ovary Syndrome/drug therapy ; Spironolactone/therapeutic use
    Chemical Substances Androgen Antagonists ; Spironolactone (27O7W4T232) ; Ethinyl Estradiol (423D2T571U) ; Cyproterone Acetate (4KM2BN5JHF) ; Finasteride (57GNO57U7G) ; Flutamide (76W6J0943E) ; Metformin (9100L32L2N)
    Language English
    Publishing date 2004-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1495368-7
    ISSN 1462-3846
    ISSN 1462-3846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Peritoneal closure vs. non-closure: estimation of pelvic fluid by transvaginal ultrasonography after abdominal hysterectomy.

    Al-Inany, Hesham

    Gynecologic and obstetric investigation

    2004  Volume 58, Issue 4, Page(s) 183–185

    Abstract: Objective: To determine the volume of pelvic fluid and febrile morbidity after hysterectomy in which the peritoneum was or was not closed.: Design: Prospective single-center study.: Participants: Fifty-four women undergoing abdominal hysterectomy ... ...

    Abstract Objective: To determine the volume of pelvic fluid and febrile morbidity after hysterectomy in which the peritoneum was or was not closed.
    Design: Prospective single-center study.
    Participants: Fifty-four women undergoing abdominal hysterectomy were enrolled in the study. Patients were randomized into two groups according to peritoneal closure: group I (n = 28) in which the peritoneum was closed, and group II (n = 26) in which the peritoneum was left open. All participants had early postoperative transvaginal ultrasound.
    Outcome measures: Volume of pelvic fluid accumulated after hysterectomy, total leukocytic count before and after hysterectomy, body temperature over the first 24 h, and wound healing.
    Results: There was a statistically significant difference between both groups regarding the volume of pelvic fluid collection, the duration of the operation and number of ampoules needed (p < 0.05). There was no statistically significant difference regarding body temperature, TLC, and wound complications.
    Conclusion: Peritoneal non-closure does not increase short-term morbidity, however it does cause an increase in peritoneal pelvic fluid. The impact of this on long-term sequelae as adhesions should be investigated.
    MeSH term(s) Ascitic Fluid/diagnostic imaging ; Ascitic Fluid/secretion ; Chi-Square Distribution ; Female ; Fever ; Humans ; Hysterectomy/adverse effects ; Middle Aged ; Pelvis/diagnostic imaging ; Peritoneum/secretion ; Peritoneum/surgery ; Postoperative Complications/diagnostic imaging ; Postoperative Complications/etiology ; Prospective Studies ; Ultrasonography ; Wound Healing
    Language English
    Publishing date 2004
    Publishing country Switzerland
    Document type Clinical Trial ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 800003-7
    ISSN 1423-002X ; 0378-7346
    ISSN (online) 1423-002X
    ISSN 0378-7346
    DOI 10.1159/000079813
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  8. Article ; Online: Are all human-derived follicle-stimulating hormone products the same? A systematic review and meta-analysis using direct and adjusted indirect analyses, to determine whether Fostimon® is more efficient than Metrodin-HP®.

    Al-Inany, Hesham G / Abou-Setta, Ahmed M

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

    2012  Volume 28, Issue 2, Page(s) 94–101

    Abstract: Background: Randomized trials (RCTs) and systematic reviews have challenged the claim for superiority of recombinant follicle-stimulating hormone (recFSH) compared with human-derived FSH (hFSH). Even so, much of the evidence comes from unavailable ... ...

    Abstract Background: Randomized trials (RCTs) and systematic reviews have challenged the claim for superiority of recombinant follicle-stimulating hormone (recFSH) compared with human-derived FSH (hFSH). Even so, much of the evidence comes from unavailable products. If the efficacy of the currently available Fostimon(®) is superior, the off-market Metrodin-HP(®), then data from the latter should not be used, gauge of the former.
    Methods: Electronic/hand searches were performed to identify RCTs comparing Fostimon(®) vs. Metrodin-HP(®) or either product with recFSH. Primary outcomes were live-birth rate (LBR), ongoing pregnancy rate (OPR), and OPR/LBR. Secondary outcomes were clinical pregnancy rate (CPR), multiple pregnancy rate (MPR), ovarian hyperstimulation syndrome (OHSS), abortion rates, and cycle demographics. Data were extracted, allowed for an intention-to-treat analysis, and meta-analyzed using combined direct/adjusted indirect methods.
    Results: Twenty-two RCTs met the inclusion criteria: Fostimon(®) vs. Metrodin-HP(®) (n = 2); Fostimon(®) vs. recFSH (n = 8); and Metrodin-HP(®) vs. recFSH (n = 12). LBR (odds ratio = 1.72; 95% confidence interval = 1.05-2.80), OPR/LBR, and CPR were all significantly higher favoring Fostimon(®). OPR, MPR, OHSS, and miscarriage rates were not significantly different. Pooled results for cycle demographics were not reported due to high heterogeneity. Conclusions. Fostimon(®) is superior to Metrodin-HP(®) regarding clinical outcomes. Therefore, care should be taken not to assume that all hFSH products have the same efficacy.
    MeSH term(s) Female ; Fertilization in Vitro ; Follicle Stimulating Hormone, Human/standards ; Humans ; Pregnancy ; Pregnancy Outcome ; Pregnancy Rate ; Randomized Controlled Trials as Topic ; Sperm Injections, Intracytoplasmic ; Treatment Outcome ; Urofollitropin/standards
    Chemical Substances Follicle Stimulating Hormone, Human ; Urofollitropin
    Language English
    Publishing date 2012-02
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 639237-4
    ISSN 1473-0766 ; 0951-3590
    ISSN (online) 1473-0766
    ISSN 0951-3590
    DOI 10.3109/09513590.2011.569612
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    Zs.MO 608: Show issues

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  9. Article ; Online: Changing attitudes in ovarian stimulation.

    Al-Inany, Hesham / Wahba, Amr / Peitsidis, Panagiotis

    Women's health (London, England)

    2011  Volume 7, Issue 5, Page(s) 505–507

    MeSH term(s) Chorionic Gonadotropin/adverse effects ; Female ; Gonadotropin-Releasing Hormone/agonists ; Gonadotropin-Releasing Hormone/antagonists & inhibitors ; Gonadotropin-Releasing Hormone/standards ; Humans ; Ovarian Hyperstimulation Syndrome/chemically induced ; Ovulation Induction/adverse effects ; Ovulation Induction/methods ; Pregnancy ; Pregnancy Outcome ; Reproductive Control Agents/adverse effects
    Chemical Substances Chorionic Gonadotropin ; Reproductive Control Agents ; Gonadotropin-Releasing Hormone (33515-09-2)
    Language English
    Publishing date 2011-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 2274503-8
    ISSN 1745-5065 ; 1745-5057
    ISSN (online) 1745-5065
    ISSN 1745-5057
    DOI 10.2217/whe.11.51
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  10. Article: GnRH agonist versus antagonist therapy.

    Al-Inany, Hesham

    Human reproduction (Oxford, England)

    2002  Volume 17, Issue 5, Page(s) 1413; author reply 1413–4

    MeSH term(s) Female ; Gonadotropin-Releasing Hormone/agonists ; Gonadotropin-Releasing Hormone/antagonists & inhibitors ; Hormone Antagonists/pharmacology ; Hormones/metabolism ; Humans ; Ovary/drug effects ; Ovary/metabolism
    Chemical Substances Hormone Antagonists ; Hormones ; Gonadotropin-Releasing Hormone (33515-09-2)
    Language English
    Publishing date 2002-05
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 632776-x
    ISSN 1460-2350 ; 0268-1161 ; 1477-741X
    ISSN (online) 1460-2350
    ISSN 0268-1161 ; 1477-741X
    DOI 10.1093/humrep/17.5.1413
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