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Article ; Online: The role of intravenous immunoglobulin in the treatment of community - Acquired West Nile virus encephalitis after liver transplantation.

Lauterio, Andrea / De Carlis, Riccardo / Centonze, Leonardo / Merli, Marco / Valsecchi, Mila / Monti, Gianpaola / Puoti, Massimo / Fumagalli, Roberto / De Carlis, Luciano

Transplant infectious disease : an official journal of the Transplantation Society

2023 Volume 25, Issue 3, Page(s) e14025

MeSH term(s)	Humans ; West Nile virus ; Immunoglobulins, Intravenous/therapeutic use ; Liver Transplantation/adverse effects ; West Nile Fever/drug therapy ; Antibodies, Viral
Chemical Substances	Immunoglobulins, Intravenous ; Antibodies, Viral
Language	English
Publishing date	2023-02-07
Publishing country	Denmark
Document type	Letter
ZDB-ID	1476094-0
ISSN	1399-3062 ; 1398-2273
ISSN (online)	1399-3062
ISSN	1398-2273
DOI	10.1111/tid.14025
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Zs.A 5100: Show issues

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Article ; Online: The impact of postoperative complications on oncological outcomes of liver transplantation for hepatocellular carcinoma: A competing risk analysis.

Incarbone, Niccolò / De Carlis, Riccardo / Centonze, Leonardo / Bernasconi, Davide Paolo / Valsecchi, Maria Grazia / Lauterio, Andrea / De Carlis, Luciano

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

2023 Volume 55, Issue 12, Page(s) 1690–1698

Abstract: Objective: To investigate the influence of postoperative complications on tumor-related (TRD), disease-free survival (DFS) and overall survival (OS) in patients undergoing liver transplant (LT) for hepatocellular carcinoma (HCC).: Methods: We ... ...

Abstract	Objective: To investigate the influence of postoperative complications on tumor-related (TRD), disease-free survival (DFS) and overall survival (OS) in patients undergoing liver transplant (LT) for hepatocellular carcinoma (HCC). Methods: We retrospectively evaluated 425 LTs for HCC from 2010 to 2019. Postoperative complications were classified according to Comprehensive Complication Index (CCI) and the posttransplant risk of TRD assessed through Metroticket 2.0 calculator. The population was stratified into high-risk and low-risk cohorts based on the predicted TRD risk of 80%. In a second step, we re-evaluated TRD, DFS and OS of both cohorts according to a further stratification based on 47.3 points of CCI cut-off. Results: In the low-risk cohort, we observed a significantly better DFS (84% vs. 46%, p<0.001), TRD (3% vs. 26%, p<0.001) and OS (89% vs. 62%, p<0.001) in the group with CCI < 47.3. In the high-risk cohort, patients with CCI < 47.3 had significantly better DFS (50% vs. 23%, p = 0.003) and OS (68% vs. 42%, p = 0.02) and a comparable TRD (22% vs. 31%, p = 0.142). Conclusions: A complicated postoperative course negatively influenced long-term survival. This poorer oncological outcome associated with in-hospital postoperative complications suggests that every effort should be made to improve the early posttransplant course in HCC patients, including a careful donor-to recipient match and use of new perfusion technologies.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/pathology ; Liver Transplantation/adverse effects ; Liver Neoplasms/pathology ; Retrospective Studies ; Risk Assessment ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Neoplasm Recurrence, Local/epidemiology
Language	English
Publishing date	2023-06-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1459373-7
ISSN	1878-3562 ; 1125-8055
ISSN (online)	1878-3562
ISSN	1125-8055
DOI	10.1016/j.dld.2023.05.026
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Zs.A 1134: Show issues

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Article ; Online: Computed Tomography and Magnetic Resonance Imaging Signs of Chronic Liver Rejection: A Case-Control Study.

Asmundo, Luigi / Rizzetto, Francesco / Sgrazzutti, Cristiano / Carbonaro, Luca A / Mazzarelli, Chiara / Centonze, Leonardo / Rutanni, Davide / De Carlis, Luciano / Vanzulli, Angelo

Journal of computer assisted tomography

2023 Volume 48, Issue 1, Page(s) 26–34

Abstract: Objective: In liver transplantation, chronic rejection is still poorly studied. This study aimed to investigate the role of imaging in its recognition.: Methods: This study is a retrospective observational case-control series. Patients with ... ...

Abstract	Objective: In liver transplantation, chronic rejection is still poorly studied. This study aimed to investigate the role of imaging in its recognition. Methods: This study is a retrospective observational case-control series. Patients with histologic diagnosis of chronic liver transplant rejection were selected; the last imaging examination (computed tomography or magnetic resonance imaging) before the diagnosis was evaluated. At least 3 controls were selected for each case; radiological signs indicative of altered liver function were analyzed. χ 2 Test with Yates correction was used to compare the rates of radiologic signs in the case and control groups, also considering whether patients suffered chronic rejection within or after 12 months. Statistical significance was set at P < 0.050. Results: A total of 118 patients were included in the study (27 in the case group and 91 in the control group). Periportal edema was appreciable in 19 of 27 cases (70%) and in 6 of 91 controls (4%) ( P < 0.001); ascites and hepatomegaly were present in 14 of 27 cases (52%) and 12 of 27 cases (44%), respectively, and in 1 of 91 controls (1%) ( P < 0.001); splenomegaly was present in 13 of 27 cases (48%) and in 8 of 91 controls (10%) ( P < 0.001); and biliary tract dilatation was present in 13 of 27 cases (48%) and in 11 of 91 patients controls (5%) ( P < 0.001). In the controls, periportal edema was significantly less frequent beyond 12 months after transplant (1% vs 11%; P = 0.020); the other signs after 12 months were not significant. Conclusions: The identification of periportal edema, biliary dilatation, ascites, and hepatosplenomegaly can serve as potential warning signs of ongoing chronic liver rejection. It is especially important to investigate periportal edema if it is present 1 year or more after orthotopic liver transplantation.
MeSH term(s)	Humans ; Case-Control Studies ; Retrospective Studies ; Ascites ; Liver Diseases ; Tomography, X-Ray Computed/methods ; Magnetic Resonance Imaging ; Edema
Language	English
Publishing date	2023-07-07
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	80392-3
ISSN	1532-3145 ; 0363-8715
ISSN (online)	1532-3145
ISSN	0363-8715
DOI	10.1097/RCT.0000000000001511
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Zs.A 1388: Show issues

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Article ; Online: Successful Liver Transplantation From a Deceased Donor With Vaccine-Induced Thrombotic Thrombocytopenia Causing Cerebral Venous Sinus and Hepatic Veins Thrombosis After ChAdOx1 nCov-19 Vaccination.

Centonze, Leonardo / Lauterio, Andrea / De Carlis, Riccardo / Ferla, Fabio / De Carlis, Luciano

Transplantation

2021 Volume 105, Issue 10, Page(s) e144–e145

MeSH term(s)	Adult ; Aged ; COVID-19 Vaccines/adverse effects ; Cerebral Veins ; ChAdOx1 nCoV-19 ; Female ; Hepatic Veins ; Humans ; Liver Transplantation ; Thrombocytopenia/complications ; Vaccination/adverse effects ; Venous Thrombosis/mortality
Chemical Substances	COVID-19 Vaccines ; ChAdOx1 nCoV-19 (B5S3K2V0G8)
Language	English
Publishing date	2021-06-23
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000003875
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Article ; Online: Discovery of a Rare Variant of the Arc of Bühler During Liver Procurement.

Incarbone, Niccolò / De Carlis, Riccardo / Centonze, Leonardo / Lauterio, Andrea / De Carlis, Luciano

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

2021 Volume 19, Issue 12, Page(s) 1345–1347

Abstract: We report a rare variant of the hepatic arterial supply observed during liver procurement from a 71-year-old female donor for whom an ischemic stroke caused brain death. Preoperative computed tomography showed a partially obliterated celiac trunk and an ... ...

Abstract	We report a rare variant of the hepatic arterial supply observed during liver procurement from a 71-year-old female donor for whom an ischemic stroke caused brain death. Preoperative computed tomography showed a partially obliterated celiac trunk and an atypical arterial branch that coursed in a retropancreatic plane away from its origin at the superior mesenteric artery to anastomose with the common hepatic artery at the origin of the proper hepatic artery. The gastroduodenal artery and the dorsal pancreatic artery are the 2 conventional anastomotic arcades between the celiac trunk and the superior mesenteric artery. However, another potential anastomotic route is a rare physiological phenomenon known as the arc of Bühler, which, if present, connects the superior mesenteric artery with the celiac trunk or one of its branches. Although the arc of Bühler is known to occur in less than 3% of the general population, it could serve as a crucial anastomotic option in the case of median arcuate ligament syndrome or atheromatous obliteration of the celiac trunk. In our case, we were able to dissect and preserve the entire anastomotic arc from the donor. For arterial reconstruction during liver transplant, we anastomosed the arc of Bühler to the recipient's hepatic artery at the origin of the gastroduodenal artery. The postoperative course was uneventful, and the recipient was in good health at the 6-month follow-up. The arc of Bühler, when present, is an important anastomotic option in hepatobiliary surgery to avoid potential damage to the arterial supply of the liver.
MeSH term(s)	Aged ; Celiac Artery/diagnostic imaging ; Celiac Artery/surgery ; Female ; Hepatic Artery/diagnostic imaging ; Hepatic Artery/surgery ; Humans ; Liver ; Mesenteric Artery, Superior ; Treatment Outcome
Language	English
Publishing date	2021-11-10
Publishing country	Turkey
Document type	Case Reports
ZDB-ID	2396778-X
ISSN	2146-8427 ; 1304-0855
ISSN (online)	2146-8427
ISSN	1304-0855
DOI	10.6002/ect.2021.0302
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Zs.A 6632: Show issues

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Article ; Online: Portal Steal Syndrome From a Large Linton's Splenorenal Shunt after Liver Transplantation: Successful Endovascular Management Through Off-Label Application of a 30 mm Amplatzer Cardiac Plug.

Centonze, Leonardo / Vella, Ivan / Morelli, Francesco / Checchini, Giuliana / De Carlis, Riccardo / Rampoldi, Antonio / Lauterio, Andrea / Andorno, Enzo / De Carlis, Luciano

Vascular and endovascular surgery

2022 Volume 56, Issue 3, Page(s) 308–311

Abstract: A 34-year-old patient underwent liver transplantation for progressive hepatic failure in the setting of congenital hepatic fibrosis. In past medical history, the patient had undergone splenectomy with proximal Linton's splenorenal surgical shunt creation ...

Abstract	A 34-year-old patient underwent liver transplantation for progressive hepatic failure in the setting of congenital hepatic fibrosis. In past medical history, the patient had undergone splenectomy with proximal Linton's splenorenal surgical shunt creation for symptomatic portal hypertension with hypersplenism. The patient developed an early allograft dysfunction, with radiologic evidence of a reduced portal flow associated to portal steal from the patent surgical shunt. The patient was successfully treated through endovascular placement of a 30 mm Amplatzer cardiac plug at the origin of the splenic vein.
MeSH term(s)	Adult ; Endovascular Procedures/adverse effects ; Humans ; Liver Transplantation/adverse effects ; Off-Label Use ; Portal Vein/diagnostic imaging ; Portal Vein/surgery ; Splenorenal Shunt, Surgical ; Treatment Outcome
Language	English
Publishing date	2022-01-03
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2076272-0
ISSN	1938-9116 ; 1538-5744
ISSN (online)	1938-9116
ISSN	1538-5744
DOI	10.1177/15385744211068614
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Zs.A 622: Show issues

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Article ; Online: Current practice of normothermic regional perfusion and machine perfusion in donation after circulatory death liver transplants in Italy.

De Carlis, Riccardo / Lauterio, Andrea / Centonze, Leonardo / Buscemi, Vincenzo / Schlegel, Andrea / Muiesan, Paolo / De Carlis, Luciano

Updates in surgery

2022 Volume 74, Issue 2, Page(s) 501–510

Abstract: Background: Normothermic regional perfusion (NRP) and machine perfusion (MP) are variously used in many European centers to improve the outcomes after liver transplantation from donation after circulatory death (DCD). In Italy, a combination of NRP and ... ...

Abstract	Background: Normothermic regional perfusion (NRP) and machine perfusion (MP) are variously used in many European centers to improve the outcomes after liver transplantation from donation after circulatory death (DCD). In Italy, a combination of NRP and subsequent MP has been used since the start of the activity. While NRP is mandatory for every DCD recovery, the subsequent use of MP is left to each center. Methods: We have designed a national survey to investigate practices and policies of these techniques. The questionnaire included 46 questions and was distributed to all the 21 Italian centers using an online form between June and July 2021. Results: The overall response rate was 100%. A local NRP program for controlled Maastricht type 3 DCD was active in 11/21 (52.4%) centers. Organization and availability of personnel were perceived as the main difficulties in starting such a program. Between 2015 and 2020, 119 DCD livers were transplanted, with an overall utilization rate of 69.2%. Pump flow and gross aspect were considered the most reliable parameters in liver selection during NRP. Eight (72.7%) centers adopted subsequent hypothermic MP, 1 (9.1%) center normothermic MP, and the remaining 2 (18.2%) used both MP types. Conclusion: This first snapshot survey shows that NRP with subsequent MP is the most used protocol in Italy for DCD livers, although some heterogeneity exists in the type and purpose of MP between centers. Overall, this policy ensures a high utilization rate, considering the high risk of the DCD donor population in Italy.
MeSH term(s)	Graft Survival ; Humans ; Liver Transplantation/methods ; Organ Preservation/methods ; Perfusion/methods ; Tissue Donors
Language	English
Publishing date	2022-02-28
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2572692-4
ISSN	2038-3312 ; 2038-131X
ISSN (online)	2038-3312
ISSN	2038-131X
DOI	10.1007/s13304-022-01259-9
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Article: Selection of Hepatocellular Carcinoma Patients for Liver Transplantation: Should the Threshold for Expected Oncological Survival Be Lowered?

Giacomoni, Alessandro / Centonze, Leonardo / Famularo, Simone / Tripepi, Matteo / DeCarlis, Luciano

Transplantation direct

2019 Volume 5, Issue 6, Page(s) e459

Language	English
Publishing date	2019-05-29
Publishing country	United States
Document type	Journal Article
ISSN	2373-8731
ISSN	2373-8731
DOI	10.1097/TXD.0000000000000904
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Article ; Online: Clinical Impact of Spontaneous Portosystemic Shunts in Liver Transplantation: A Comprehensive Assessment Through Total Shunt Area Measurement.

Centonze, Leonardo / Gorga, Giovanna / De Carlis, Riccardo / Bernasconi, Davide / Lauterio, Andrea / Carbonaro, Luca / Vella, Ivan / Sgrazzutti, Cristiano / Incarbone, Niccolò / Rizzetto, Francesco / Valsecchi, Maria Grazia / Vanzulli, Angelo / De Carlis, Luciano

Transplantation

2023 Volume 107, Issue 4, Page(s) 913–924

Abstract: Background: The impact of spontaneous portosystemic shunts (SPSSs) on natural history of cirrhotic patients was recently evaluated through the measurement of total shunt area (TSA), a novel tool that allows a comprehensive assessment of SPSSs extension, ...

Abstract	Background: The impact of spontaneous portosystemic shunts (SPSSs) on natural history of cirrhotic patients was recently evaluated through the measurement of total shunt area (TSA), a novel tool that allows a comprehensive assessment of SPSSs extension, identifying a direct correlation of higher TSA with lower patient survival. The role of SPSSs in liver transplant (LT) is still debated: we sought to investigate the clinical impact of TSA on the development of early allograft dysfunction (EAD), acute kidney injury (AKI), postoperative complications, and graft and patient survival following LT. Methods: Preoperative imaging of 346 cirrhotic patients undergoing primary LT between 2015 and 2020 were retrospectively revised, recording the size and anatomy of each SPSS to calculate TSA. The impact of TSA and selected patient and donor characteristics on the development of EAD, AKI, and clinically relevant complications was evaluated through univariate and multivariate logistic regression, whereas their effect on graft and patient survival was investigated through Cox regression analysis. Results: A TSA exceeding 78.54 mm 2 resulted as an independent risk factor for the development of EAD (odds ratio [OR]: 2.327; P = 0.003), grade 3 AKI (OR: 2.093; P = 0.041), and clinically relevant complications (OR: 1.962; P = 0.015). Moreover, higher TSA was significantly related to early graft and patient survivals, emerging as an independent risk factor for 12-mo graft loss (hazard ratio: 3.877; P = 0.007) and patient death (hazard ratio: 2.682; P = 0.018). Conclusions: Higher TSA emerged as a significant risk factor for worse postoperative outcomes following LT, supporting the need for careful hemodynamic assessment and management of patients presenting multiple/larger shunts.
MeSH term(s)	Humans ; Liver Transplantation/adverse effects ; Portasystemic Shunt, Transjugular Intrahepatic/adverse effects ; Retrospective Studies ; Graft Survival ; Risk Factors ; Liver Cirrhosis ; Acute Kidney Injury/etiology
Language	English
Publishing date	2023-03-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000004391
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Robotic Versus Laparoscopic Donor Nephrectomy: A Retrospective Bicentric Comparison of Learning Curves and Surgical Outcomes From 2 High-volume European Centers.

Centonze, Leonardo / Di Bella, Caterina / Giacomoni, Alessandro / Silvestre, Cristina / De Carlis, Riccardo / Frassoni, Samuele / Franchin, Barbara / Angrisani, Marco / Tuci, Francesco / Di Bello, Marianna / Bagnardi, Vincenzo / Lauterio, Andrea / Furian, Lucrezia / De Carlis, Luciano

Transplantation

2023 Volume 107, Issue 9, Page(s) 2009–2017

Abstract: Background: Although laparoscopic donor nephrectomy (LDN) represents the gold-standard technique for kidney living donation, robotic donor nephrectomy (RDN) settled as another appealing minimally invasive technique over the past decades. A comparison ... ...

Abstract	Background: Although laparoscopic donor nephrectomy (LDN) represents the gold-standard technique for kidney living donation, robotic donor nephrectomy (RDN) settled as another appealing minimally invasive technique over the past decades. A comparison between LDN and RDN outcomes was performed. Methods: RDN and LDN outcomes were compared, focusing on operative time and perioperative risk factors affecting surgery duration. Learning curves for both techniques were compared through spline regression and cumulative sum models. Results: The study analyzed 512 procedures (154 RDN and 358 LDN procedures) performed between 2010 and 2021 in 2 different high-volume transplant centers. The RDN group presented a higher prevalence of arterial variations (36.2 versus 22.4%; P = 0.001) compared with the LDN cohort. No open conversions occurred; operative time (210 versus 195 min; P = 0.011) and warm ischemia time (WIT; 230 versus 180 s; P < 0.001) were longer in RDN. Postoperative complication rate was similar (8.4% versus 11.5%; P = 0.49); the RDN group showed shorter hospital stay (4 versus 5 d; P < 0.001). Spline regression models depicted a faster learning curve in the RDN group ( P = 0.0002). Accordingly, cumulative sum analysis highlighted a turning point after about 50 procedures among the RDN cohort and after about 100 procedures among the LDN group.Higher body mass index resulted as an independent risk factor for longer operative time for both techniques; multiple arteries significantly prolonged operative time in LDN, whereas RDN was longer in right kidney procurements; both procedures were equally shortened by growing surgical experience. Conclusions: RDN grants a faster learning curve and improves multiple vessel handling. Incidence of postoperative complications was low for both techniques.
MeSH term(s)	Humans ; Retrospective Studies ; Learning Curve ; Robotic Surgical Procedures/adverse effects ; Nephrectomy/adverse effects ; Nephrectomy/methods ; Kidney Transplantation/adverse effects ; Kidney Transplantation/methods ; Living Donors ; Kidney/surgery ; Tissue and Organ Harvesting/adverse effects ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Treatment Outcome
Language	English
Publishing date	2023-08-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000004618
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