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Book ; Online: Everybody’s a victim?

Akay, Alpaslan / Bargain, Olivier / Elsayed, Ahmed

global terror, well-being and political attitudes

(Working papers in economics ; no. 733)

2018

Author's details	Alpaslan Akay, Olivier Bargain and Ahmed Elsayed
Series title	Working papers in economics ; no. 733
Language	English
Size	1 Online-Ressource (circa 49 Seiten), Illustrationen
Document type	Book ; Online
Database	ECONomics Information System

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Article ; Online: Dermatoscopic and Mucoscopic Features of Lesions in Patients with Behcet’s Disease

S. Zahra Ghodsi / Negar Bahrololoumi Bafruee / Chyda Chams Davatchi / Cliff Rosendahl / Bengu Nisa Akay / Fereydoun Davatchi / Hormoz Chams / Farhad Shahram / Abdolhadi Nadji / Massoomeh Akhlaghi / Tahereh Faezi / Hoda Kavosi

Acta Reumatológica Portuguesa, Vol 2019, Iss 3, Pp 225-

2019 Volume 231

Abstract: ... patterns, we set this study to find if there is any characteristic pattern in the dermatoscopy of Behcet’s ... dermatoscopic features of Behcet’s mucocutaneous lesions. Fifty six consecutive patients presenting ... Objective: Behcet's disease (BD), as a vasculitis, can affect small and large vessels ...

Abstract	Objective: Behcet's disease (BD), as a vasculitis, can affect small and large vessels. As dermatoscopy has been shown to improve the accuracy in diagnosis of various skin lesions especially vascular patterns, we set this study to find if there is any characteristic pattern in the dermatoscopy of Behcet’s mucocutaneous lesions. Methods: This prospective cross-sectional observational study designed to evaluate dermatoscopic features of Behcet’s mucocutaneous lesions. Fifty six consecutive patients presenting at the outpatient clinic of the BD Research Unit were included. If present, for each patient one oral, one skin and one genital lesion were evaluated by dermatoscopy. When indicated, pathergy test was performed according to a standard protocol and the results were evaluated by dermatoscopy. Results: A total of 40 oral, 8 genital, 14 skin lesions and 14 pathergy tests were evaluated by dermatoscopy. While vascular component was the most prominent feature in oral aphthae, this component was less prominent in genital lesions. Dot vessels were the most common form of vessels in both oral and skin lesions. All the oral lesions were characterized by a central white structureless area. Skin lesions were characterized by a red structureless background. In pathergy tests, negative pricks showed absence of specific features while positive pricks were characterized by a structureless background in pink, purple or red. No obvious vascular component was detected in any of the pricks. Conclusion: It seems that these findings have no specific clues for the diagnosis of BD, but our study is the first study in this field and the findings may give way to further investigations.
Keywords	behçet's disease ; Internal medicine ; RC31-1245 ; Immunologic diseases. Allergy ; RC581-607
Subject code	610
Language	English
Publishing date	2019-07-01T00:00:00Z
Publisher	Sociedade Portuguesa de Reumatologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effectiveness of participatory women’s groups scaled up by the public health system to improve birth outcomes in Jharkhand, eastern India

Hassan Haghparast-Bidgoli / Audrey Prost / Andrew Copas / Amit Kumar / Rajkumar Gope / Vikash Nath / Nirmala Nair / Vasudha Chakravarthy / Tanja AJ Houweling / Shibanand Rath / Suchitra Rath / Prasanta K Tripathy / Hemanta Pradhan / Parabita Basu / Amit Ojha / Akay Minz / Pradeep Baskey / Manir Ahmed / Riza Mahanta

BMJ Global Health, Vol 6, Iss

a pragmatic cluster non-randomised controlled trial

2021 Volume 11

Keywords	Medicine (General) ; R5-920 ; Infectious and parasitic diseases ; RC109-216
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of the COVID-19 Pandemic on Children’s Eating Patterns and Parents’ Anxiety Levels

Çocuk ve Gençlik Ruh Sağlığı Dergisi, Vol 28, Iss 1, Pp 14-

A Multi- Center Study

2021 Volume 18

Abstract: ... respectively).Conclusion:The COVID-19 epidemic has affected both parents’ anxiety and children’s eating ...

Abstract	Objectives:Our study aimed to evaluate the eating patterns of children as well as parental anxiety on virus transmission along with associated factors in the first month of the Coronavirus disease-2019 (COVID-19) pandemic and to compare the results to pre-epidemic patterns.Materials and Methods:This study was planned as a multi-center (n=8), cross-sectional study. Informed consent forms and questionnaires were sent to the parents of the children between the ages of 6 and 18 years who applied to the study centers and accepted study participation via e-mail or instant messaging applications.Results:During the study period, 893 children with a mean age of 11.1 years (standard deviation=3.4) were enrolled. More than half (50.7%, n=453) were girls. The majority of families reported no change in eating patterns of their children in the first month of the pandemic (63.6%, n=568). More than one-fifth (21.4%, n=191) reported an improvement in eating patterns while 15.0% reported worsening. A significant minority of parents (40.0%) reported feeling “very anxious” for potential risk of transmission to themselves or their children. Parents with higher levels of anxiety were significantly younger and had lower levels of education (p<0.001, p=0.001, respectively).Conclusion:The COVID-19 epidemic has affected both parents’ anxiety and children’s eating patterns. The association of younger parental age and lower levels of education with elevated levels of anxiety related to transmission risk may be important for protective interventions in mental health.
Keywords	covid-19 outbreak ; child ; eating ; parental anxiety ; Medicine ; R ; Psychiatry ; RC435-571
Subject code	360
Language	Turkish
Publishing date	2021-04-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: PICALM Rescues Endocytic Defects Caused by the Alzheimer’s Disease Risk Factor APOE4

Priyanka Narayan / Grzegorz Sienski / Julia M. Bonner / Yuan-Ta Lin / Jinsoo Seo / Valeriya Baru / Aftabul Haque / Blerta Milo / Leyla A. Akay / Agnese Graziosi / Yelena Freyzon / Dirk Landgraf / William R. Hesse / Julie Valastyan / M. Inmaculada Barrasa / Li-Huei Tsai / Susan Lindquist

Cell Reports, Vol 33, Iss 1, Pp 108224- (2020)

2020

Abstract: ... including late-onset Alzheimer’s disease (AD). We investigate the cellular consequences of APOE4 in human ...

Abstract	Summary: The ε4 allele of apolipoprotein E (APOE4) is a genetic risk factor for many diseases, including late-onset Alzheimer’s disease (AD). We investigate the cellular consequences of APOE4 in human iPSC-derived astrocytes, observing an endocytic defect in APOE4 astrocytes compared with their isogenic APOE3 counterparts. Given the evolutionarily conserved nature of endocytosis, we built a yeast model to identify genetic modifiers of the endocytic defect associated with APOE4. In yeast, only the expression of APOE4 results in dose-dependent defects in both endocytosis and growth. We discover that increasing expression of the early endocytic adaptor protein Yap1802p, a homolog of the human AD risk factor PICALM, rescues the APOE4-induced endocytic defect. In iPSC-derived human astrocytes, increasing expression of PICALM similarly reverses endocytic disruptions. Our work identifies a functional interaction between two AD genetic risk factors—APOE4 and PICALM—centered on the conserved biological process of endocytosis.
Keywords	apolipoprotein E ; Alzheimer's disease ; genetic risk factors ; PICALM ; endocytosis ; trafficking ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The local and global mental health effects of the Covid-19 pandemic.

Akay, Alpaslan

Economics and human biology

2022 Volume 45, Page(s) 101095

Abstract: ... where we match the previous day's confirmed pandemic cases to a four-month panel of individual mental health ...

Abstract	This paper investigates the mental health effects of the local and global level Covid-19 pandemic among the UK population. To identify the effect, we use a high-quality dataset and an original strategy where we match the previous day's confirmed pandemic cases to a four-month panel of individual mental health information observed during the interview next day. The approach suggested in this paper aims to identify the average mental health effect on the overall population for the first and second waves of the pandemic. Using a linear fixed-effects model specification, we report robust findings that the average mental health in the UK is substantially reduced by the local and global pandemic. The total reduction in the average mental health of the UK population during our sampling period (April - June, 2020) is about 1.5% for the local and 2.4% for the global cases, which sum up to a 3.9% reduction. Extrapolating the total reduction in average mental health during the first wave of the pandemic (February - September, 2020) sums up to 2.8% while the effect is as large as 9.6% for the first and second waves together, which covers roughly a year since the start. An extensive robustness check suggests that the findings are stable with respect to alternative pandemic datasets, measures, estimators, functional forms, and time functions. The characteristics of the most vulnerable individuals (e.g., elderly, chronic illness, and job security concerns) and their household conditions (e.g., living alone and no private space) are explored. The paper discusses on the implications of the results.
MeSH term(s)	Aged ; COVID-19/epidemiology ; Humans ; Mental Health ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2022-01-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2099749-8
ISSN	1873-6130 ; 1570-677X
ISSN (online)	1873-6130
ISSN	1570-677X
DOI	10.1016/j.ehb.2021.101095
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Hydrogen, Ammonia and Symbiotic/Smart Fertilizer Production Using Renewable Feedstock and CO 2 Utilization through Catalytic Processes and Nonthermal Plasma with Novel Catalysts and In Situ Reactive Separation

Galip Akay

Catalysts, Vol 13, Iss 1287, p

A Roadmap for Sustainable and Innovation-Based Technology

2023 Volume 1287

Abstract: ... symbiotic and smart fertilizers (S-fertilizers), synthesis of plasma interactive supported catalysts ...

Abstract	This multi-disciplinary paper aims to provide a roadmap for the development of an integrated, process-intensified technology for the production of H 2 , NH 3 and NH 3 -based symbiotic/smart fertilizers (referred to as target products) from renewable feedstock with CO 2 sequestration and utilization while addressing environmental issues relating to the emerging Food, Energy and Water shortages as a result of global warming. The paper also discloses several novel processes, reactors and catalysts. In addition to the process intensification character of the processes used and reactors designed in this study, they also deliver novel or superior products so as to lower both capital and processing costs. The critical elements of the proposed technology in the sustainable production of the target products are examined under three-sections: (1) Materials: They include natural or synthetic porous water absorbents for NH 3 sequestration and symbiotic and smart fertilizers (S-fertilizers), synthesis of plasma interactive supported catalysts including supported piezoelectric catalysts, supported high-entropy catalysts, plasma generating-chemical looping and natural catalysts and catalysts based on quantum effects in plasma. Their performance in NH 3 synthesis and CO 2 conversion to CO as well as the direct conversion of syngas to NH 3 and NH 3 —fertilizers are evaluated, and their mechanisms investigated. The plasma-generating chemical-looping catalysts (Catalysts, 2020, 10, 152; and 2016, 6, 80) were further modified to obtain a highly active piezoelectric catalyst with high levels of chemical and morphological heterogeneity. In particular, the mechanism of structure formation in the catalysts BaTi 1−r M r O 3−x−y {#} x N z and M 3 O 4−x−y {#} x N z /Si = X was studied. Here, z = 2y/3, {#} represents an oxygen vacancy and M is a transition metal catalyst. (2) Intensified processes: They include, multi-oxidant (air, oxygen, CO 2 and water) fueled catalytic biomass/waste gasification for the generation of hydrogen-enriched ...
Keywords	ammonia ; black/piezoelectric barium titanate ; CO 2 splitting ; CO 2 utilization ; Havnes effect ; hydrogen ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Subject code	290
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Recent Advances in Antibacterial Coatings to Combat Orthopedic Implant-Associated Infections.

Akay, Seref / Yaghmur, Anan

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 5

Abstract: Implant-associated infections (IAIs) represent a major health burden due to the complex structural features of biofilms and their inherent tolerance to antimicrobial agents and the immune system. Thus, the viable options to eradicate biofilms embedded on ...

Abstract	Implant-associated infections (IAIs) represent a major health burden due to the complex structural features of biofilms and their inherent tolerance to antimicrobial agents and the immune system. Thus, the viable options to eradicate biofilms embedded on medical implants are surgical operations and long-term and repeated antibiotic courses. Recent years have witnessed a growing interest in the development of robust and reliable strategies for prevention and treatment of IAIs. In particular, it seems promising to develop materials with anti-biofouling and antibacterial properties for combating IAIs on implants. In this contribution, we exclusively focus on recent advances in the development of modified and functionalized implant surfaces for inhibiting bacterial attachment and eventually biofilm formation on orthopedic implants. Further, we highlight recent progress in the development of antibacterial coatings (including self-assembled nanocoatings) for preventing biofilm formation on orthopedic implants. Among the recently introduced approaches for development of efficient and durable antibacterial coatings, we focus on the use of safe and biocompatible materials with excellent antibacterial activities for local delivery of combinatorial antimicrobial agents for preventing and treating IAIs and overcoming antimicrobial resistance.
MeSH term(s)	Humans ; Anti-Bacterial Agents/pharmacology ; Biofilms ; Prostheses and Implants ; Biofouling ; Postoperative Complications ; Coated Materials, Biocompatible/chemistry ; Titanium/chemistry
Chemical Substances	Anti-Bacterial Agents ; Coated Materials, Biocompatible ; Titanium (D1JT611TNE)
Language	English
Publishing date	2024-03-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29051172
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Article ; Online: The distribution of HLA-DRB1 alleles in patients with hashimoto’s thyroiditis

Turkan Patiroglu / H. Haluk Akar / Abdurrahman Akay / Engin Ok

Şişli Etfal Hastanesi Tip Bülteni, Vol 49, Iss

2015 Volume 4

Abstract: Objective: Hashimoto’s thyroiditis (HT) is an autoimmune thyroid disease resulting from complex ...

Abstract	Objective: Hashimoto’s thyroiditis (HT) is an autoimmune thyroid disease resulting from complex interactions between genetic and environmental factors. The Human Leukocyte Antigen (HLA) genes have been found to be involved in the susceptibility to HT. In this retrospective study, we aimed to investigate the associations between HLA-DRB1 alleles and patients with HT. Material and Methods: Forty eight patients with HT were included in this study. We analyzed HLA-DRB1 by polymerase chain reaction with sequence specific oligonucleotide probes (PCR-SSOP), and compared them with 126 unrelated healthy controls. Results: The HLA-DRB103 allele was higher in the HT patients than in the controls (p=0.006). Also, the HLA-DRB101 allele was lower in the HT patients than in the controls (p=0.021). Conclusion: The susceptible and protectable alleles were found as HLA-DRB103 and HLA-DRB101 alleles respectively in patients with HT in the Kayseri Turkish population, in Turkey. Further studies with a larger cohort are required to confirm the role of HLA-DRB1 alleles in the development of HT in the Turkish population.
Keywords	Hashimoto’s thyroiditis ; HLA-DRB1 alleles ; thyroid gland ; Medicine (General) ; R5-920 ; Medicine ; R
Subject code	610
Language	Turkish
Publishing date	2015-01-01T00:00:00Z
Publisher	Yerkure Tanitim ve Yayincilik Hizmetleri A.S.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dermatoscopic Profiling of Inverted Follicular Keratosis in Differing Skin Phenotypes.

Demirdağ, Hatice Gamze / Akay, Bengü Nisa

Clinical and experimental dermatology

2024

Abstract: ... primarily in Fitzpatrick's phototypes 4 and 5. The incidence of a pink, structureless area and blood spots ...

Abstract	Background: Inverted follicular keratosis is a rare benign tumor of the follicular infundibulum. Due to its similarity to other benign and malignant cutaneous lesions, it poses a diagnostic challenge. There is limited information regarding the dermatoscopic characteristics of inverted follicular keratosis, and the majority of cases have been reported in patients with fair skin types. Objective: To describe the prevalent dermatoscopic features of inverted follicular keratosis, especially in patients with skin of color. Methods: We retrospectively analysed 35 histopathologically verified cases of inverted follicular keratosis fom a single university hospital in Turkiye. Results: With respect to Fitzpatrick skin phototype, 2 (5.7%), 12 (34.3%), 16 (45.7%) and 5 (14.3%) patients had phototypes 2,3,4, and 5, respectively. Clinically, the majority of inverted follicular keratoses were hypopigmented or nonpigmented (82.9%). Pink-white structureless areas (54.3%), ulceration (54.3%), central keratin mass (42.9%), and blood spots on keratin mass (42.9%) were the most frequent dermatoscopic findings. Pigmented structures were observed as blue-grey structureless areas in 12 lesions and as blue-grey clods in 5 lesions, primarily in Fitzpatrick's phototypes 4 and 5. The incidence of a pink, structureless area and blood spots on ulceration was found to be statistically significantly higher in individuals with fair skin types, while a greater prevalence of blue-grey coloration was observed in those with skin of color (p < 0.05). Conclusion: Although our study presents some dermatoscopic distinctions of inverted follicular keratosis, the diagnosis is generally confirmed by histopathology, as the clinical appearance and dermatoscopic findings may not be sufficient to differentiate it from other tumors, especially squamous cell carcinoma or keratoacanthoma. The dermatoscopic characteristics of dark skin are comparable to those of pale skin; however, hyperpigmentation can be more noticeable in skin of color.
Language	English
Publishing date	2024-01-06
Publishing country	England
Document type	Journal Article
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1093/ced/llae008
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