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Article ; Online: Current status of robotic surgery for hepato-pancreato-biliary malignancies.

Bahra, Marcus / Ossami Saidy, Ramin Raul

2022 Volume 22, Issue 9, Page(s) 939–946

Abstract: Introduction: Robotic surgery is an emerging aspect of gastrointestinal surgery. Hepato-pancreato-biliary surgery is currently being explored for a broad spectrum of indications, entities, and postoperative outcomes. Noninferiority and financial aspects ...

Abstract	Introduction: Robotic surgery is an emerging aspect of gastrointestinal surgery. Hepato-pancreato-biliary surgery is currently being explored for a broad spectrum of indications, entities, and postoperative outcomes. Noninferiority and financial aspects are the focus of studies. In this review, the impact on oncological therapies is assessed. Areas covered: An extensive literature review was conducted, and relevant studies and articles and reviews for robotic surgery in the field of hepato-pancreato-biliary surgery were examined. Special attention was given to the oncological aspects of robotic surgery and its possible impact on the therapy of malignant neoplasms. Expert opinion: Robotic-assisted surgery for oncological indications is promising, in part, an established technique that has already shown its advantages in the last decade, although high-quality studies are missing. Upcoming experience must consider the oncological benefit and putative new indications in a rapidly changing field of anti-neoplastic regimens. Also, robotic surgery may possess the ability to accelerate digitalization and AI-based augmentation in this context.
MeSH term(s)	Humans ; Robotic Surgical Procedures
Language	English
Publishing date	2022-07-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2112544-2
ISSN	1744-8328 ; 1473-7140
ISSN (online)	1744-8328
ISSN	1473-7140
DOI	10.1080/14737140.2022.2105211
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Article ; Online: Fatal course of cutaneous mucormycosis in an immunosuppressed patient.

Solimani, Farzan / Nast, Alexander / Dilling, Amrei / Pahl, Stefan / Graf, Barbara / Gaßner, Joseph / Saidy, Ramin-Raul Ossami / Ghoreschi, Franziska C / Ghoreschi, Kamran / Blume-Peytavi, Ulrike

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

2024

Language	English
Publishing date	2024-04-09
Publishing country	Germany
Document type	Letter
ZDB-ID	2093479-8
ISSN	1610-0387 ; 1610-0379
ISSN (online)	1610-0387
ISSN	1610-0379
DOI	10.1111/ddg.15387
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Book ; Online ; Thesis: Charakteristika der Inflammations- und Resolutionskinetiken im Rückenmark in Abhängigkeit anatomischer Kompartimente nach Induktion einer sterilen Inflammation

Ossami Saidy, Ramin Raul [Verfasser]

2018

Author's details	Ramin Raul Ossami Saidy
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Medizinische Fakultät Charité - Universitätsmedizin Berlin
Publishing place	Berlin
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article: How to Estimate the Probability of Tolerance Long-Term in Liver Transplant Recipients.

Eurich, Dennis / Schlickeiser, Stephan / Ossami Saidy, Ramin Raul / Uluk, Deniz / Rossner, Florian / Postel, Maximilian / Schoening, Wenzel / Oellinger, Robert / Lurje, Georg / Pratschke, Johann / Reinke, Petra / Gruen, Natalie

Journal of clinical medicine

2023 Volume 12, Issue 20

Abstract: Background: Operational tolerance as the ability to accept the liver transplant without pharmacological immunosuppression is a common phenomenon in the long-term course. However, it is currently underutilized due to a lack of simple diagnostic support ... ...

Abstract	Background: Operational tolerance as the ability to accept the liver transplant without pharmacological immunosuppression is a common phenomenon in the long-term course. However, it is currently underutilized due to a lack of simple diagnostic support and fear of rejection despite its recognized benefits. In the present work, we present a simple score based on clinical parameters to estimate the probability of tolerance. Patients and methods: In order to estimate the probability of tolerance, clinical parameters from 82 patients after LT who underwent weaning from the IS for various reasons at our transplant center were extracted from a prospectively organized database and analyzed retrospectively. Univariate testing as well as multivariable logistic regression analysis were performed to assess the association of clinical variables with tolerance in the real-world setting. Results: The most important factors associated with tolerance after multivariable logistic regression were IS monotherapy, male sex, history of hepatocellular carcinoma pretransplant, time since LT, and lack of rejection. These five predictors were retained in an approximate model that could be presented as a simple scoring system to estimate the clinical probability of tolerance or IS dispensability with good predictive performance (AUC = 0.89). Conclusion: In parallel with the existence of a tremendous need for further research on tolerance mechanisms, the presented score, after validation in a larger collective preferably in a multicenter setting, could be easily and safely applied in the real world and already now address all three levels of prevention in LT patients over the long-term course.
Language	English
Publishing date	2023-10-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12206546
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Article: Textbook Outcome after Gastrectomy for Gastric Cancer Is Associated with Improved Overall and Disease-Free Survival.

Çetinkaya-Hosgör, Candan / Seika, Philippa / Raakow, Jonas / Kröll, Dino / Dobrindt, Eva Maria / Maurer, Max Magnus / Martin, Friederike / Ossami Saidy, Ramin Raul / Thuss-Patience, Peter / Pratschke, Johann / Biebl, Matthias / Denecke, Christian

Journal of clinical medicine

2023 Volume 12, Issue 16

Abstract: 1) Background: The complexity of the perioperative outcome for patients with gastric cancer is not well reflected by single quality metrics. To study the effect of the surgical outcome on survival, we have evaluated the relationship between textbook ... ...

Abstract	(1) Background: The complexity of the perioperative outcome for patients with gastric cancer is not well reflected by single quality metrics. To study the effect of the surgical outcome on survival, we have evaluated the relationship between textbook outcome (TO)-a new composite parameter-and oncological outcome. (2) Methods: All patients undergoing total gastrectomy or trans-hiatal extended gastrectomy for gastric cancer with curative intent between 2017 and 2021 at our institution were included. TO was defined by negative resection margins (R0); collection of ≥25 lymph nodes; the absence of major perioperative complications (Clavien-Dindo ≥ 3); the absence of any reintervention; absence of unplanned ICU re-admission; length of hospital stay < 21 days; absence of 30-day readmission and 30-day mortality. We evaluated factors affecting TO by multivariate logistic regression. The correlation between TO and long-term survival was assessed using a multivariate cox proportional-hazards model. (3) Results: Of the patients included in this study, 52 (52.5 %) achieved all TO metrics. Open surgery (
Language	English
Publishing date	2023-08-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12165419
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Article ; Online: Detrimental impact of immunosuppressive burden on clinical course in patients with Cytomegalovirus infection after liver transplantation.

Ossami Saidy, Ramin Raul / Kollar, Stefanie / Czigany, Zoltan / Dittrich, Luca / Raschzok, Nathanael / Globke, Brigitta / Schöning, Wenzel / Öllinger, Robert / Lurje, Georg / Pratschke, Johann / Eurich, Dennis / Uluk, Deniz

Transplant infectious disease : an official journal of the Transplantation Society

2023 Volume 26, Issue 1, Page(s) e14196

Abstract: Introduction: Cytomegalovirus (CMV)-infection and reactivation remain a relevant complication after liver transplantation (LT). The recipient and donor serum CMV-IgG-status has been established for risk stratification when choosing various ... ...

Abstract	Introduction: Cytomegalovirus (CMV)-infection and reactivation remain a relevant complication after liver transplantation (LT). The recipient and donor serum CMV-IgG-status has been established for risk stratification when choosing various pharmaceutical regimens for CMV-prophylaxis in the last two decades. However, factors influencing course of CMV-infection in LT remain largely unknown. In this study, the impact of immunosuppressive regimen was examined in a large cohort of patients. Methods: All patients that underwent primary LT between 2006 and 2018 at the Charité-Universitaetsmedizin, Berlin, were included. Clinical course as well as histological and laboratory findings of patients were analyzed our prospectively maintained database. Univariate and multivariate regression analysis for impact of variables on CMV-occurrence was conducted, and survival was examined using Kaplan-Meier analysis. Results: Overall, 867 patients were included in the final analysis. CMV-infection was diagnosed in 325 (37.5%) patients after transplantation. Significantly improved overall survival was observed in these patients (Log rank = 0.03). As shown by correlation and regression tree classification and regression tree analysis, the recipient/donor CMV-IgG-status with either positivity had the largest influence on CMV-occurrence. Analysis of immunosuppressive burden did not reveal statistical impact on CMV-infection, but statistically significant inverse correlation of cumulative tacrolimus trough levels and survival was found (Log rank < .001). Multivariate analysis confirmed these findings (p = .02). Discussion: CMV-infection remains of clinical importance after LT. Undergone CMV-infection of either recipient or donor requires prophylactic treatment. Additionally, we found a highly significant, dosage-dependent impact of immunosuppression (IS) on long-term outcomes for these patients, underlying the importance of minimization of IS in liver transplant recipients.
MeSH term(s)	Humans ; Liver Transplantation/adverse effects ; Risk Factors ; Cytomegalovirus ; Immunosuppressive Agents/adverse effects ; Cytomegalovirus Infections/epidemiology ; Cytomegalovirus Infections/prevention & control ; Cytomegalovirus Infections/diagnosis ; Immunoglobulin G/therapeutic use ; Disease Progression ; Retrospective Studies ; Antiviral Agents/therapeutic use
Chemical Substances	Immunosuppressive Agents ; Immunoglobulin G ; Antiviral Agents
Language	English
Publishing date	2023-11-27
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1476094-0
ISSN	1399-3062 ; 1398-2273
ISSN (online)	1399-3062
ISSN	1398-2273
DOI	10.1111/tid.14196
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Article ; Online: Successful implementation of preventive measures leads to low relevance of SARS-CoV-2 in liver transplant patients: Observations from a German outpatient department.

Ossami Saidy, Ramin Raul / Globke, Brigitta / Pratschke, Johann / Schoening, Wenzel / Eurich, Dennis

Transplant infectious disease : an official journal of the Transplantation Society

2020 Volume 22, Issue 6, Page(s) e13363

Abstract: Background: Immunosuppressed liver transplant (LT) patients are considered to be at high risk for any kind of infection. What the outbreak of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) means for the transplant cohort is a ... ...

Abstract	Background: Immunosuppressed liver transplant (LT) patients are considered to be at high risk for any kind of infection. What the outbreak of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) means for the transplant cohort is a question that, as of now, cannot easily be answered. Data on prevalence, relevance of the novel virus, and clinical course of the infection in stable LT patients are limited. Methods: Nasopharyngeal swabs were performed in our outpatient department during the shutdown between March and April 2020 in Germany. Results: The prevalence of SARS-CoV-2 was 3%. Three out of a cohort of 101 LT patients were asymptomatic for respiratory diseases. Respiratory complaints were common and not associated with SARS-CoV-2 infection. The overall monthly mortality rate was 0.22% and did not show alterations during the shutdown in Germany. Conclusions: If preventive measures are applied, LT patients do not seem to be at a higher risk for SARS-CoV-2 infection. Telemedicine in the outpatient setting may help to maintain distance and to reduce direct patient contact. However, standard of care must be guaranteed for patients with relevant comorbidities in spite of pandemics, because complications may arise from preexisting conditions.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Ambulatory Care ; Asymptomatic Infections/epidemiology ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/prevention & control ; Cohort Studies ; Communicable Disease Control ; Female ; Germany/epidemiology ; Graft Rejection/prevention & control ; Humans ; Immunosuppressive Agents/therapeutic use ; Infection Control ; Liver Transplantation ; Male ; Middle Aged ; SARS-CoV-2 ; Telemedicine ; Young Adult
Chemical Substances	Immunosuppressive Agents
Keywords	covid19
Language	English
Publishing date	2020-06-22
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1476094-0
ISSN	1399-3062 ; 1398-2273
ISSN (online)	1399-3062
ISSN	1398-2273
DOI	10.1111/tid.13363
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Article ; Online: Clinical and Histological Long-Term Follow-Up of De Novo HBV-Infection after Liver Transplantation.

Ossami Saidy, Ramin Raul / Eurich, Franziska / Postel, Maximilian Paul / Dobrindt, Eva Maria / Feldkamp, Jasper / Schaper, Selina Johanna / Pratschke, Johann / Globke, Brigitta / Eurich, Dennis

Medicina (Kaunas, Lithuania)

2021 Volume 57, Issue 8

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Follow-Up Studies ; Hepatitis B/epidemiology ; Hepatitis B virus ; Humans ; Liver Transplantation ; Retrospective Studies ; Transplants
Language	English
Publishing date	2021-07-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina57080767
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Article ; Online: Discontinuation of Passive Immunization Is Safe after Liver Transplantation for Combined HBV/HDV Infection.

Ossami Saidy, Ramin Raul / Sud, Irina / Eurich, Franziska / Aydin, Mustafa / Postel, Maximilian Paul / Dobrindt, Eva Maria / Pratschke, Johann / Eurich, Dennis

Viruses

2021 Volume 13, Issue 5

Abstract: Patients after LT due to combined HBV/HDV infection are considered to be high-risk patients for recurrence of hepatitis B and D. To date, life-long prophylaxis with hepatitis B immunoglobulin (HBIG) and replication control with nucleos(t)ide analogs (NA) ...

Abstract	Patients after LT due to combined HBV/HDV infection are considered to be high-risk patients for recurrence of hepatitis B and D. To date, life-long prophylaxis with hepatitis B immunoglobulin (HBIG) and replication control with nucleos(t)ide analogs (NA) remains standard. We examined the course of 36 patients that underwent liver transplantation from 1989 to 2020 for combined HBV/HDV-associated end-stage liver disease in this retrospective study. Seventeen patients eventually discontinued HBIG therapy for various reasons. Their graft function, histopathological findings from routine liver biopsies and overall survival were compared with those that received an unaltered NA-based standard regimen combined with HBIG. The median follow-up was 204 and 227 months, respectively. The recurrence of HBV was 25% and did not differ between the groups of standard reinfection prophylaxis NA/HBIG (21.1%) and HBIG discontinuation (29.4%); (
MeSH term(s)	Biomarkers ; Coinfection/epidemiology ; Coinfection/prevention & control ; Female ; Hepatitis B/epidemiology ; Hepatitis B/prevention & control ; Hepatitis B virus/immunology ; Hepatitis D/epidemiology ; Hepatitis D/prevention & control ; Hepatitis Delta Virus/immunology ; Humans ; Immunization, Passive ; Immunohistochemistry ; Liver Transplantation/adverse effects ; Liver Transplantation/statistics & numerical data ; Male ; Postoperative Period ; Prognosis ; Recurrence
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-05-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13050904
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Article: The Role of Immunosuppression for Recurrent Cholangiocellular Carcinoma after Liver Transplantation.

Gül-Klein, Safak / Schmitz, Paulina / Schöning, Wenzel / Öllinger, Robert / Lurje, Georg / Jonas, Sven / Uluk, Deniz / Pelzer, Uwe / Tacke, Frank / Schmelzle, Moritz / Pratschke, Johann / Ossami Saidy, Ramin Raul / Eurich, Dennis

Cancers

2022 Volume 14, Issue 12

Abstract: Liver transplantation (LT) for cholangiocarcinoma (CCA), or biliary tract cancer (BTC), remains controversial regarding high recurrence rates and poor prognosis. Oncological follow-up may benefit from tumor-inhibiting properties of mTOR inhibitors (mTORI) ...

Abstract	Liver transplantation (LT) for cholangiocarcinoma (CCA), or biliary tract cancer (BTC), remains controversial regarding high recurrence rates and poor prognosis. Oncological follow-up may benefit from tumor-inhibiting properties of mTOR inhibitors (mTORI), shown with improved survival for recurrent hepatocellular carcinoma (HCC) patients after LT. The aim of this study was to investigate the recurrence and survival in relation to tumor type and type of immunosuppression (IS). LT patients with CCA or mixed HCC/CCA (mHCC/CCA) (n = 67) were retrospectively analyzed. Endpoints were the time from LT to recurrence (n = 44) and survival after recurrence. Statistically significant impairment in survival for recurrent CCA (rCCA) was shown in patients not eligible for surgical resection (HR 2.46 (CI: 1.2−5.1; p = 0.02). Histological proven grading >1 and N1 status at initial transplantation were associated with impaired survival (HR 0.13 (CI: 0.03−0.58); p < 0.01 and HR 3.4 (CI: 1.0−11.65); p = 0.05). Reduced IS after tumor recurrence improved survival (HR 4.2/CI: 1.3−13.6; p = 0.02). MTORI initiation before recurrence or after had no significant impact on survival. Our data thereby indicate, similar to findings in recurrent HCC after LT, that patients with rCCA after LT benefit from a reduction in IS upon recurrence.
Language	English
Publishing date	2022-06-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14122890
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