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  1. Article: Rowell Syndrome: A Diagnostic Challenge.

    Gallo, Lucia / Megna, Matteo / Festa, Bianca / Stellato, Pio / di Pinto, Rosita / Fabbrocini, Gabriella / Ferrillo, Maria

    The Journal of clinical and aesthetic dermatology

    2020  Volume 13, Issue 4, Page(s) 40–42

    Abstract: BACKGROUND: ...

    Abstract BACKGROUND:
    Language English
    Publishing date 2020-04-01
    Publishing country United States
    Document type Case Reports
    ISSN 1941-2789
    ISSN 1941-2789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Blinatumomab in Children and Adolescents with Relapsed/Refractory B Cell Precursor Acute Lymphoblastic Leukemia: A Real-Life Multicenter Retrospective Study in Seven AIEOP (Associazione Italiana di Ematologia e Oncologia Pediatrica) Centers.

    Beneduce, Giuliana / De Matteo, Antonia / Stellato, Pio / Testi, Anna M / Bertorello, Nicoletta / Colombini, Antonella / Putti, Maria C / Rizzari, Carmelo / Cesaro, Simone / Cellini, Monica / Barisone, Elena / Petruzziello, Fara / Menna, Giuseppe / Parasole, Rosanna

    Cancers

    2022  Volume 14, Issue 2

    Abstract: Five-year event-free survival in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) currently exceeds 80-85%. However, 15-20% of patients still experience a relapsed/refractory disease. From 1 January 2015 to 31 December 2020, thirty-nine ... ...

    Abstract Five-year event-free survival in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) currently exceeds 80-85%. However, 15-20% of patients still experience a relapsed/refractory disease. From 1 January 2015 to 31 December 2020, thirty-nine patients, 0-21 years old with r/r BCP-ALL were treated with blinatumomab with the aim of inducing remission (
    Language English
    Publishing date 2022-01-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14020426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Specific lncRNA signatures discriminate childhood acute leukaemias: a pilot study.

    Buono, Lorena / Iside, Concetta / De Matteo, Antonia / Stellato, Pio / Beneduce, Giuliana / de Vera d'Aragona, Roberta Penta / Parasole, Rosanna / Salvatore, Marco / Smaldone, Giovanni / Mirabelli, Peppino

    Cancer cell international

    2022  Volume 22, Issue 1, Page(s) 373

    Abstract: Background: Long non-coding RNAs are RNAs longer than 200 bps that do not encode any proteins and are able to alter gene expression by acting on different steps of regulation, including DNA methylation and chromatin structure. They represent a class of ... ...

    Abstract Background: Long non-coding RNAs are RNAs longer than 200 bps that do not encode any proteins and are able to alter gene expression by acting on different steps of regulation, including DNA methylation and chromatin structure. They represent a class of biomarkers of crescent interest in the hematologic and oncologic fields. Recent studies showed that the expression levels of specific lncRNAs correlate with the prognosis of paediatric patients with Acute Lymphoblastic Leukaemia.
    Methods: We used NGS approaches to analyse the transcriptome of 9 childhood B-ALL patients and 6 childhood T-ALL patients, in comparison with B and T healthy lymphocytes from cord blood. We validate our findings both ex vivo, in a different cohort of 10 B-ALL and 10 T-ALL patients, and in silico using public datasets.
    Results: We characterised the lncRNA landscape for B-ALL, T-ALL, healthy B, and T cell progenitors. From the characterised signature, we selected candidate lncRNAs able to discriminate not only B-ALL and T-ALL from healthy subjects but also between the two types of leukaemia, and subsequently validated their potential as a diagnostic tool in an additional cohort of paediatric patients. We confirmed our finding with open access transcriptomic data, comparing ALL lncRNAs with AML lncRNA landscape as well. Finally, expression correlation analyses of T-ALL selected lncRNA biomarkers suggested a possible role in lymphocyte activation and the β-catenin signalling pathway for AC247036.1 and involvement in hedgehog signalling for HHIP-AS1.
    Conclusions: Our work identified a lncRNA signature discriminating paediatric B-ALL and T-ALL from healthy subjects, between them and from AML. This study provides the keystone to future clinical studies determining the theragnostic value of the characterised long non coding transcriptome panorama in a clinical setting for childhood patient management.
    Language English
    Publishing date 2022-11-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091573-1
    ISSN 1475-2867
    ISSN 1475-2867
    DOI 10.1186/s12935-022-02789-3
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  4. Article ; Online: Successful management plan of COVID-19 in a pediatric hemato-oncology department: a single-centre experience.

    Stellato, Pio / Granata, Annalisa / De Matteo, Antonia / Capelli, Carlo / Paparo, Matteo / Parasole, Rosanna / Ricciardi, Immacolata / Tambaro, Francesco Paolo / Leone, Ornella / Quaglietta, Lucia / Menna, Giuseppe / Silvestri, Nicola

    BMJ paediatrics open

    2020  Volume 4, Issue 1, Page(s) e000818

    Abstract: COVID-19 pandemic raised concern about management of patients with paediatric cancer. We present the operating system that the Hemato-Oncology Department of the Santobono-Pausilipon Hospital applied. We divided our department in three zones: surveillance ...

    Abstract COVID-19 pandemic raised concern about management of patients with paediatric cancer. We present the operating system that the Hemato-Oncology Department of the Santobono-Pausilipon Hospital applied. We divided our department in three zones: surveillance and screening; quarantine and COVID free, in order to screen admitted patients and to reduce the risk of cross infection. From 3 April until 29 May 2020 (56 days), 662 patients and caregivers underwent rapid serological tests for a total of 1397 assays. No patient or parent with SARS-CoV2 infection was found, demonstrating the effectiveness of COVID-19 screening process.
    Language English
    Publishing date 2020-09-15
    Publishing country England
    Document type Journal Article
    ISSN 2399-9772
    ISSN (online) 2399-9772
    DOI 10.1136/bmjpo-2020-000818
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  5. Article ; Online: Current practices for nutritional evaluation and care during the treatment of pediatric oncology patients: a survey among AIEOP centers.

    Venturelli, Francesco / Leardini, Davide / Baccelli, Francesco / Gottardi, Francesca / Barat, Veronica / Vendemini, Francesca / Folsi, Veronica Maria / Meazza, Cristina / Marinoni, Maddalena / Bernardo, Maria Ester / Tumino, Manuela / Brugiolo, Alessandra / Pizzato, Cristina / Battisti, Laura / Bertolini, Patrizia / Pancaldi, Alessia / Rinieri, Simona / Pericoli, Roberta / Coccia, Paola /
    Onofrillo, Daniela / Fabozzi, Francesco / Bianchi, Simona / Rizzo, Daniela / Daniele, Rosa Maria / Stellato, Pio / Prete, Arcangelo / Masetti, Riccardo / Muratore, Edoardo

    European journal of pediatrics

    2023  Volume 183, Issue 3, Page(s) 1137–1144

    Abstract: Nutritional status plays a crucial role in the mortality rates of the pediatric oncology patients. However, there is a lack of systematic approaches for nutritional assessment in this population. This study aims to assess the current practice for ... ...

    Abstract Nutritional status plays a crucial role in the mortality rates of the pediatric oncology patients. However, there is a lack of systematic approaches for nutritional assessment in this population. This study aims to assess the current practice for nutritional assessment and care of pediatric cancer patients in Italy. A 25-items web-based, nation-wide questionnaire was circulated as of January 9, 2023 among physicians within the AIEOP network, composed of 49 national centers, out of which 21 routinely perform HCT. This survey examined the practices of 21 Italian pediatric oncology centers, revealing significant heterogeneity in nutritional practices. Only half of the centers routinely assessed all patients, utilizing different clinical and biochemical parameters. The use of neutropenic diets remained prevalent after chemotherapy or stem cell transplantation.
    Conclusion: This study underscores the pressing need for unified recommendations to improve nutritional care and potentially enhance outcomes for pediatric cancer patients.
    What is known: • The assessment and support of nutrition are gaining interest in the overall care of children with cancer. • The assessment and management of nutritional needs in pediatric cancer patients, including those undergoing hematopoietic cell transplantation, currently lack a systematic approach.
    What is new: • There is considerable variability in the nutritional assessment and support among Italian centers treating pediatric patients with cancer. • To enhance nutritional assessment and support for pediatric cancer patients, it is essential to establish shared national and international guidelines.
    MeSH term(s) Humans ; Child ; Nutrition Assessment ; Medical Oncology ; Nutritional Support ; Surveys and Questionnaires ; Neoplasms/complications ; Neoplasms/therapy ; Neoplasms/epidemiology
    Language English
    Publishing date 2023-12-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 194196-3
    ISSN 1432-1076 ; 0340-6199 ; 0943-9676
    ISSN (online) 1432-1076
    ISSN 0340-6199 ; 0943-9676
    DOI 10.1007/s00431-023-05368-4
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    Um IV Zs.75: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Collateral effects of COVID-19 pandemic in pediatric hematooncology: Fatalities caused by diagnostic delay.

    Parasole, Rosanna / Stellato, Pio / Conter, Valentino / De Matteo, Antonia / D'Amato, Luigia / Colombini, Antonella / Pecoraro, Carmine / Bencivenga, Carmela / Raimondo, Marta / Silvestri, Susanna / Tipo, Vincenzo / Annicchiarico Petruzzelli, Luigi / Giagnuolo, Giovanna / Curatolo, Agostino / Biondi, Andrea / Menna, Giuseppe

    Pediatric blood & cancer

    2020  Volume 67, Issue 8, Page(s) e28482

    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; Child ; Coronavirus Infections/complications ; Coronavirus Infections/mortality ; Coronavirus Infections/virology ; Delayed Diagnosis/statistics & numerical data ; Hematologic Neoplasms/diagnosis ; Hematologic Neoplasms/mortality ; Hematologic Neoplasms/virology ; Humans ; Pandemics ; Pediatrics/standards ; Pneumonia, Viral/complications ; Pneumonia, Viral/mortality ; Pneumonia, Viral/virology ; Practice Guidelines as Topic/standards ; SARS-CoV-2 ; Survival Rate
    Keywords covid19
    Language English
    Publishing date 2020-06-11
    Publishing country United States
    Document type Letter
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.28482
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    Zs.A 1131: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Presymptomatic Diagnosis of Celiac Disease in Predisposed Children: The Role of Gene Expression Profile.

    Galatola, Martina / Cielo, Donatella / Panico, Camilla / Stellato, Pio / Malamisura, Basilio / Carbone, Lorenzo / Gianfrani, Carmen / Troncone, Riccardo / Greco, Luigi / Auricchio, Renata

    Journal of pediatric gastroenterology and nutrition

    2017  Volume 65, Issue 3, Page(s) 314–320

    Abstract: Objective: The prevalence of celiac disease (CD) has increased significantly in recent years, and risk prediction and early diagnosis have become imperative especially in at-risk families. In a previous study, we identified individuals with CD based on ... ...

    Abstract Objective: The prevalence of celiac disease (CD) has increased significantly in recent years, and risk prediction and early diagnosis have become imperative especially in at-risk families. In a previous study, we identified individuals with CD based on the expression profile of a set of candidate genes in peripheral blood monocytes. Here we evaluated the expression of a panel of CD candidate genes in peripheral blood mononuclear cells from at-risk infants long time before any symptom or production of antibodies.
    Methods: We analyzed the gene expression of a set of 9 candidate genes, associated with CD, in 22 human leukocyte antigen predisposed children from at-risk families for CD, studied from birth to 6 years of age. Nine of them developed CD (patients) and 13 did not (controls). We analyzed gene expression at 3 different time points (age matched in the 2 groups): 4-19 months before diagnosis, at the time of CD diagnosis, and after at least 1 year of a gluten-free diet. At similar age points, controls were also evaluated.
    Results: Three genes (KIAA, TAGAP [T-cell Activation GTPase Activating Protein], and SH2B3 [SH2B Adaptor Protein 3]) were overexpressed in patients, compared with controls, at least 9 months before CD diagnosis. At a stepwise discriminant analysis, 4 genes (RGS1 [Regulator of G-protein signaling 1], TAGAP, TNFSF14 [Tumor Necrosis Factor (Ligand) Superfamily member 14], and SH2B3) differentiate patients from controls before serum antibodies production and clinical symptoms. Multivariate equation correctly classified CD from non-CD children in 95.5% of patients.
    Conclusions: The expression of a small set of candidate genes in peripheral blood mononuclear cells can predict CD at least 9 months before the appearance of any clinical and serological signs of the disease.
    MeSH term(s) Case-Control Studies ; Celiac Disease/blood ; Celiac Disease/diagnosis ; Celiac Disease/genetics ; Child, Preschool ; Female ; Gene Expression Profiling ; Genetic Markers ; Genetic Predisposition to Disease ; Genetic Testing/methods ; Genotyping Techniques ; Humans ; Infant ; Leukocytes, Mononuclear ; Longitudinal Studies ; Male ; Multivariate Analysis ; Transcriptome
    Chemical Substances Genetic Markers
    Language English
    Publishing date 2017-08-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603201-1
    ISSN 1536-4801 ; 0277-2116
    ISSN (online) 1536-4801
    ISSN 0277-2116
    DOI 10.1097/MPG.0000000000001519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1728: Show issues Location:
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  8. Article: Collateral effects of COVID-19 pandemic in pediatric hematooncology: Fatalities caused by diagnostic delay

    Parasole, Rosanna / Stellato, Pio / Conter, Valentino / De Matteo, Antonia / D039, / Amato, Luigia / Colombini, Antonella / Pecoraro, Carmine / Bencivenga, Carmela / Raimondo, Marta / Silvestri, Susanna / Tipo, Vincenzo / Annicchiarico Petruzzelli, Luigi / Giagnuolo, Giovanna / Curatolo, Agostino / Biondi, Andrea / Menna, Giuseppe

    Pediatr Blood Cancer

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #593666
    Database COVID19

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  9. Article ; Online: Collateral effects of COVID‐19 pandemic in pediatric hematooncology

    Parasole, Rosanna / Stellato, Pio / Conter, Valentino / De Matteo, Antonia / D'Amato, Luigia / Colombini, Antonella / Pecoraro, Carmine / Bencivenga, Carmela / Raimondo, Marta / Silvestri, Susanna / Tipo, Vincenzo / Annicchiarico Petruzzelli, Luigi / Giagnuolo, Giovanna / Curatolo, Agostino / Biondi, Andrea / Menna, Giuseppe

    Pediatric Blood & Cancer

    Fatalities caused by diagnostic delay

    2020  Volume 67, Issue 8

    Keywords Pediatrics, Perinatology, and Child Health ; Oncology ; Hematology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.28482
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1131: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article: Successful management plan of COVID-19 in a pediatric hemato-oncology department: a single-centre experience

    Stellato, Pio / Granata, Annalisa / De Matteo, Antonia / Capelli, Carlo / Paparo, Matteo / Parasole, Rosanna / Ricciardi, Immacolata / Tambaro, Francesco Paolo / Leone, Ornella / Quaglietta, Lucia / Menna, Giuseppe / Silvestri, Nicola

    BMJ Paediatrics Open

    Abstract: COVID-19 pandemic raised concern about management of patients with paediatric cancer We present the operating system that the Hemato-Oncology Department of the Santobono-Pausilipon Hospital applied We divided our department in three zones: surveillance ... ...

    Abstract COVID-19 pandemic raised concern about management of patients with paediatric cancer We present the operating system that the Hemato-Oncology Department of the Santobono-Pausilipon Hospital applied We divided our department in three zones: surveillance and screening;quarantine and COVID free, in order to screen admitted patients and to reduce the risk of cross infection From 3 April until 29 May 2020 (56 days), 662 patients and caregivers underwent rapid serological tests for a total of 1397 assays No patient or parent with SARS-CoV2 infection was found, demonstrating the effectiveness of COVID-19 screening process
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #831771
    Database COVID19

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