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  1. Article ; Online: Clinical and Demographic Characteristics of Herpetic Keratitis Patients-Tertiary Centre Experience.

    Grubešić, Petra / Jurak, Igor / Čaljkušić-Mance, Tea / Belančić, Andrej / Grubešić, Aron

    Medicina (Kaunas, Lithuania)

    2024  Volume 60, Issue 4

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Keratitis, Herpetic/epidemiology ; Keratitis, Herpetic/diagnosis ; Female ; Male ; Middle Aged ; Aged ; Prospective Studies ; Adult ; Visual Acuity ; Aged, 80 and over ; Recurrence ; Tertiary Care Centers/statistics & numerical data ; Demography
    Language English
    Publishing date 2024-03-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60040577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Effects of Multidisciplinary Biopsychosocial Rehabilitation on Short-Term Pain and Disability in Chronic Low Back Pain: A Systematic Review with Network Meta-Analysis.

    Jurak, Ivan / Delaš, Kristina / Erjavec, Lana / Stare, Janez / Locatelli, Igor

    Journal of clinical medicine

    2023  Volume 12, Issue 23

    Abstract: Chronic low back pain (CLBP) is a significant public health issue, with prevalence intensifying due to an ageing global population, amassing approximately 619 million cases in 2020 and projected to escalate to 843 million by 2050. In this study, we ... ...

    Abstract Chronic low back pain (CLBP) is a significant public health issue, with prevalence intensifying due to an ageing global population, amassing approximately 619 million cases in 2020 and projected to escalate to 843 million by 2050. In this study, we analyzed the effects of multidisciplinary biopsychosocial rehabilitation (MBR) on pain and disability. To address this question, we conducted a PRISMA-guided systematic review and random-effect network meta-analysis on studies collected from six electronic databases. The network comprised diverse MBR modalities (behavioral, educational, and work conditioning) alongside exercise therapy (ET), minimal intervention, and usual care, with pain and disability as outcomes. Ninety-three studies were included, encompassing a total of 8059 participants. The NMA substantiated that both ET and MBR modalities were effective in alleviating CLBP, with education-oriented MBR emerging as the most efficacious for pain mitigation (MD = 18.29; 95% CI = 13.70; 22.89) and behavior-focused MBR being the most efficacious for disability reduction (SMD = 0.88; 95% CI = 0.46; 1.30). Nevertheless, the discerned differences amongst the treatments were minimal and uncertain, highlighting that no modality was definitively superior to the others. Given the intricate nature of CLBP, embodying various facets, our findings advocate for a combined therapeutic approach to optimize treatment efficacy.
    Language English
    Publishing date 2023-12-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12237489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Photodynamic Inhibition of Herpes Simplex Virus 1 Infection by Tricationic Amphiphilic Porphyrin with a Long Alkyl Chain.

    Jurak, Igor / Cokarić Brdovčak, Maja / Djaković, Lara / Bertović, Ivana / Knežević, Klaudia / Lončarić, Martin / Jurak Begonja, Antonija / Malatesti, Nela

    Pharmaceutics

    2023  Volume 15, Issue 3

    Abstract: Photodynamic therapy (PDT) is broadly used to treat different tumors, and it is a rapidly developing approach to inactivating or inhibiting the replication of fungi, bacteria, and viruses. Herpes simplex virus 1 (HSV-1) is an important human pathogen and ...

    Abstract Photodynamic therapy (PDT) is broadly used to treat different tumors, and it is a rapidly developing approach to inactivating or inhibiting the replication of fungi, bacteria, and viruses. Herpes simplex virus 1 (HSV-1) is an important human pathogen and a frequently used model to study the effects of PDT on enveloped viruses. Although many photosensitizers (PSs) have been tested for their antiviral properties, analyses are usually limited to assessing the reduction in viral yield, and thus the molecular mechanisms of photodynamic inactivation (PDI) remain poorly understood. In this study, we investigated the antiviral properties of TMPyP3-C
    Language English
    Publishing date 2023-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15030956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effects of Multidisciplinary Biopsychosocial Rehabilitation on Short-Term Pain and Disability in Chronic Low Back Pain

    Ivan Jurak / Kristina Delaš / Lana Erjavec / Janez Stare / Igor Locatelli

    Journal of Clinical Medicine, Vol 12, Iss 23, p

    A Systematic Review with Network Meta-Analysis

    2023  Volume 7489

    Abstract: Chronic low back pain (CLBP) is a significant public health issue, with prevalence intensifying due to an ageing global population, amassing approximately 619 million cases in 2020 and projected to escalate to 843 million by 2050. In this study, we ... ...

    Abstract Chronic low back pain (CLBP) is a significant public health issue, with prevalence intensifying due to an ageing global population, amassing approximately 619 million cases in 2020 and projected to escalate to 843 million by 2050. In this study, we analyzed the effects of multidisciplinary biopsychosocial rehabilitation (MBR) on pain and disability. To address this question, we conducted a PRISMA-guided systematic review and random-effect network meta-analysis on studies collected from six electronic databases. The network comprised diverse MBR modalities (behavioral, educational, and work conditioning) alongside exercise therapy (ET), minimal intervention, and usual care, with pain and disability as outcomes. Ninety-three studies were included, encompassing a total of 8059 participants. The NMA substantiated that both ET and MBR modalities were effective in alleviating CLBP, with education-oriented MBR emerging as the most efficacious for pain mitigation (MD = 18.29; 95% CI = 13.70; 22.89) and behavior-focused MBR being the most efficacious for disability reduction (SMD = 0.88; 95% CI = 0.46; 1.30). Nevertheless, the discerned differences amongst the treatments were minimal and uncertain, highlighting that no modality was definitively superior to the others. Given the intricate nature of CLBP, embodying various facets, our findings advocate for a combined therapeutic approach to optimize treatment efficacy.
    Keywords chronic low back pain ; multidisciplinary biopsychosocial rehabilitation ; exercise therapy ; network meta-analysis ; Medicine ; R
    Subject code 150
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: RNA Editing-Dependent and -Independent Roles of Adenosine Deaminases Acting on RNA Proteins in Herpesvirus Infection-Hints on Another Layer of Complexity.

    Ivanišević, Vlatka / Žilić, Lidia / Čunko, Marina / Fadiga, Hana / Munitić, Ivana / Jurak, Igor

    Viruses

    2023  Volume 15, Issue 10

    Abstract: The Adenosine Deaminases Acting on RNA (ADAR) catalyze the posttranscriptional deamination of adenosine residues to inosine in double-stranded RNAs (dsRNAs, A-to-I editing), preventing the overactivation of dsRNA sensor molecules and interferons. RNA ... ...

    Abstract The Adenosine Deaminases Acting on RNA (ADAR) catalyze the posttranscriptional deamination of adenosine residues to inosine in double-stranded RNAs (dsRNAs, A-to-I editing), preventing the overactivation of dsRNA sensor molecules and interferons. RNA editing is the cornerstone of innate immunity that distinguishes between self and non-self (virus), and it is essential for normal regulation of cellular homeostasis. Although much is already known about the role of ADAR proteins in RNA virus infection, the role of ADAR proteins in herpesvirus infection remains largely unexplored. In this review, we provide several lines of evidence from studies of different herpesviruses for another level of complexity in regulating the already intricate biphasic life cycle of herpesviruses.
    MeSH term(s) Humans ; Adenosine Deaminase/metabolism ; RNA Editing ; RNA, Double-Stranded ; Herpesviridae Infections ; Adenosine/metabolism
    Chemical Substances Adenosine Deaminase (EC 3.5.4.4) ; RNA, Double-Stranded ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2023-09-27
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15102007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Successful sequencing of the first SARS-CoV-2 genomes from Croatian patients.

    Jurak, Igor / Rukavina, Tomislav / Vugrek, Oliver

    Croatian medical journal

    2020  Volume 61, Issue 3, Page(s) 302–303

    Keywords covid19
    Language English
    Publishing date 2020-07-08
    Publishing country Croatia
    Document type Journal Article
    ZDB-ID 1157623-6
    ISSN 1332-8166 ; 0353-9504
    ISSN (online) 1332-8166
    ISSN 0353-9504
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 187: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Herpes Simplex Virus 1 Deregulation of Host MicroRNAs.

    Cokarić Brdovčak, Maja / Zubković, Andreja / Jurak, Igor

    Non-coding RNA

    2018  Volume 4, Issue 4

    Abstract: Viruses utilize microRNAs (miRNAs) in a vast variety of possible interactions and mechanisms, apparently far beyond the classical understanding of gene repression in humans. Likewise, herpes simplex virus 1 (HSV-1) expresses numerous miRNAs and ... ...

    Abstract Viruses utilize microRNAs (miRNAs) in a vast variety of possible interactions and mechanisms, apparently far beyond the classical understanding of gene repression in humans. Likewise, herpes simplex virus 1 (HSV-1) expresses numerous miRNAs and deregulates the expression of host miRNAs. Several HSV-1 miRNAs are abundantly expressed in latency, some of which are encoded antisense to transcripts of important productive infection genes, indicating their roles in repressing the productive cycle and/or in maintenance/reactivation from latency. In addition, HSV-1 also exploits host miRNAs to advance its replication or repress its genes to facilitate latency. Here, we discuss what is known about the functional interplay between HSV-1 and the host miRNA machinery, potential targets, and the molecular mechanisms leading to an efficient virus replication and spread.
    Language English
    Publishing date 2018-11-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2813993-8
    ISSN 2311-553X ; 2311-553X
    ISSN (online) 2311-553X
    ISSN 2311-553X
    DOI 10.3390/ncrna4040036
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  9. Article: Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders.

    De Marchi, Fabiola / Munitic, Ivana / Vidatic, Lea / Papić, Eliša / Rački, Valentino / Nimac, Jerneja / Jurak, Igor / Novotni, Gabriela / Rogelj, Boris / Vuletic, Vladimira / Liscic, Rajka M / Cannon, Jason R / Buratti, Emanuele / Mazzini, Letizia / Hecimovic, Silva

    Biomedicines

    2023  Volume 11, Issue 10

    Abstract: Many potential immune therapeutic targets are similarly affected in adult-onset neurodegenerative diseases, such as Alzheimer's (AD) disease, Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD), as well as in ... ...

    Abstract Many potential immune therapeutic targets are similarly affected in adult-onset neurodegenerative diseases, such as Alzheimer's (AD) disease, Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD), as well as in a seemingly distinct Niemann-Pick type C disease with primarily juvenile onset. This strongly argues for an overlap in pathogenic mechanisms. The commonly researched immune targets include various immune cell subsets, such as microglia, peripheral macrophages, and regulatory T cells (Tregs); the complement system; and other soluble factors. In this review, we compare these neurodegenerative diseases from a clinical point of view and highlight common pathways and mechanisms of protein aggregation, neurodegeneration, and/or neuroinflammation that could potentially lead to shared treatment strategies for overlapping immune dysfunctions in these diseases. These approaches include but are not limited to immunisation, complement cascade blockade, microbiome regulation, inhibition of signal transduction, Treg boosting, and stem cell transplantation.
    Language English
    Publishing date 2023-10-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11102793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia.

    Zubković, Andreja / Gomes, Cristina / Parchure, Adwait / Cesarec, Mia / Ferenčić, Antun / Rokić, Filip / Jakovac, Hrvoje / Whitford, Abigail L / Dochnal, Sara A / Cliffe, Anna R / Cuculić, Dražen / Gallo, Angela / Vugrek, Oliver / Hackenberg, Michael / Jurak, Igor

    Journal of virology

    2023  Volume 97, Issue 10, Page(s) e0073023

    Abstract: Importance: Herpes simplex virus 1 is an important human pathogen that has been intensively studied for many decades. Nevertheless, the molecular mechanisms regulating its establishment, maintenance, and reactivation from latency are poorly understood. ... ...

    Abstract Importance: Herpes simplex virus 1 is an important human pathogen that has been intensively studied for many decades. Nevertheless, the molecular mechanisms regulating its establishment, maintenance, and reactivation from latency are poorly understood. Here, we show that HSV-1-encoded miR-H2 is post-transcriptionally edited in latently infected human tissues. Hyperediting of viral miRNAs increases the targeting potential of these miRNAs and may play an important role in regulating latency. We show that the edited miR-H2 can target ICP4, an essential viral protein. Interestingly, we found no evidence of hyperediting of its homolog, miR-H2, which is expressed by the closely related virus HSV-2. The discovery of post-translational modifications of viral miRNA in the latency phase suggests that these processes may also be important for other non-coding viral RNA in the latency phase, including the intron LAT, which in turn may be crucial for understanding the biology of this virus.
    MeSH term(s) Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Herpesvirus 1, Human/physiology ; Virus Latency/genetics ; Viral Proteins/metabolism ; Ganglia/metabolism ; Trigeminal Ganglion ; Herpes Simplex ; Virus Activation/genetics
    Chemical Substances MicroRNAs ; Viral Proteins
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.00730-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 609: Show issues Location:
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