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  1. Book: Control of communicable diseases manual

    Heymann, David L.

    an official report ot the American Public Health Association

    2022  

    Institution American Public Health Association
    Author's details David L. Heymann editor
    Keywords Communicable Diseases ; Communicable Disease Control ; Communicable diseases/Prevention ; Communicable diseases/Transmission
    Subject code 614.5
    Language English
    Size xxiv, A96, 769 Seiten
    Edition 21st edition
    Publisher APHA Press
    Publishing place Washington, DC
    Publishing country United States
    Document type Book
    HBZ-ID HT021400221
    ISBN 978-0-87553-323-0 ; 0-87553-323-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 A 900 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Identification of MCM4 and PRKDC as new regulators of osteosarcoma cell dormancy based on 3D cell cultures.

    Jubelin, Camille / Muñoz-Garcia, Javier / Ollivier, Emilie / Cochonneau, Denis / Vallette, François / Heymann, Marie-Françoise / Oliver, Lisa / Heymann, Dominique

    Biochimica et biophysica acta. Molecular cell research

    2024  Volume 1871, Issue 3, Page(s) 119660

    Abstract: Dormancy is a potential way for tumors to develop drug resistance and escape treatment. However, the mechanisms involved in cancer dormancy remain poorly understood. This is mainly because there is no in vitro culture model making it possible to ... ...

    Abstract Dormancy is a potential way for tumors to develop drug resistance and escape treatment. However, the mechanisms involved in cancer dormancy remain poorly understood. This is mainly because there is no in vitro culture model making it possible to spontaneously induce dormancy. In this context, the present work proposes the use of three-dimensional (3D) spheroids developed from osteosarcoma cell lines as a relevant model for studying cancer dormancy. MNNG-HOS, SaOS-2, 143B, MG-63, U2OS and SJSA-1 cell lines were cultured in 3D using the Liquid Overlay Technique (LOT). Dormancy was studied by staining cancer cells with a lipophilic dye (DiD), and long-term DiD
    MeSH term(s) Humans ; Methylnitronitrosoguanidine ; Osteosarcoma/genetics ; Cell Culture Techniques, Three Dimensional ; Bone Neoplasms/genetics ; RNA, Small Interfering ; Minichromosome Maintenance Complex Component 4 ; DNA-Activated Protein Kinase ; Ubiquitin-Conjugating Enzymes
    Chemical Substances Methylnitronitrosoguanidine (12H3O2UGSF) ; RNA, Small Interfering ; MCM4 protein, human (EC 3.6.4.12) ; Minichromosome Maintenance Complex Component 4 (EC 3.6.4.12) ; PRKDC protein, human (EC 2.7.11.1) ; DNA-Activated Protein Kinase (EC 2.7.11.1) ; UBE2T protein, human (EC 2.3.2.23) ; Ubiquitin-Conjugating Enzymes (EC 2.3.2.23)
    Language English
    Publishing date 2024-01-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbamcr.2024.119660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Pancreatic enzyme replacement therapy in subjects with exocrine pancreatic insufficiency and diabetes mellitus: a real-life, case-control study.

    Alexandre-Heymann, Laure / Yaker, Fetta / Lassen, Pierre Bel / Dubois-Laforgue, Danièle / Larger, Etienne

    Diabetology & metabolic syndrome

    2024  Volume 16, Issue 1, Page(s) 39

    Abstract: Background: Exocrine pancreatic insufficiency (EPI) can be associated with all types of diabetes. Pancreatic enzyme replacement therapy (PERT) has short and long-term benefits in subjects with EPI, but its effects on diabetes control are uncertain. We ... ...

    Abstract Background: Exocrine pancreatic insufficiency (EPI) can be associated with all types of diabetes. Pancreatic enzyme replacement therapy (PERT) has short and long-term benefits in subjects with EPI, but its effects on diabetes control are uncertain. We aimed to study the effects of PERT initiation on glycemic control in subjects with diabetes and EPI from any cause.
    Methods: In this retrospective study, we compared subjects with EPI and diabetes who were prescribed PERT with subjects with diabetes who had a fecal elastase-1 concentration dosage, but did not receive PERT. The primary outcome was the effect of PERT on hypoglycemia frequency and severity. The secondary outcomes were the effects of PERT on gastro-intestinal disorders, HbA
    Results: 48 subjects were included in each group. Overall, PERT did not have any significant effect on hypoglycemia frequency or severity, but hypoglycemia frequency tended to decrease in subjects with chronic pancreatitis. While 19% of subjects experienced mild hyperglycemia after PERT initiation, we did not report any keto-acidosis or any other severe adverse event. Gastro-intestinal disorders improved in 80% of subjects treated with PERT, versus in 20% of control subjects (p = 0.02). Gastro-intestinal disorders improved in 87% of subjects with recommended dosage of PERT, versus in 50% of subjects with underdosage (NS). HbA
    Conclusions: PERT initiation is safe in subjects with diabetes and EPI. It does not globally decrease hypoglycemia severity of frequency, but is associated with a decrease in gastro-intestinal disorders. Trial registration Retrospectively registered. The database was registered with the Commission Nationale Informatique et Libertés (CNIL), registration number: 2203351v0. The study was approved by the local ethics committee CLEP, registration number: AAA-2023-09047.
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2518786-7
    ISSN 1758-5996
    ISSN 1758-5996
    DOI 10.1186/s13098-024-01265-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Technical report: liquid overlay technique allows the generation of homogeneous osteosarcoma, glioblastoma, lung and prostate adenocarcinoma spheroids that can be used for drug cytotoxicity measurements.

    Jubelin, Camille / Muñoz-Garcia, Javier / Cochonneau, Denis / Ollivier, Emilie / Vallette, François / Heymann, Marie-Françoise / Oliver, Lisa / Heymann, Dominique

    Frontiers in bioengineering and biotechnology

    2023  Volume 11, Page(s) 1260049

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-10-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1260049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: Treatment, prophylaxis and research priorities for developing countries / D. L. Heymann, J. J. Wirima & J. H. Perriens

    Heymann, David L / Wirima, J. J / Perriens, J. H

    1993  

    Keywords AIDS-related opportunistic infections ; HIV infections ; Developing countries ; AIDS and its Control ; drug therapy
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Journal ; Article ; Online: Treatment, prophylaxis and research priorities for developing countries / D. L. Heymann, J. J. Wirima & J. H. Perriens

    Heymann, David L / Wirima, J. J / Perriens, J. H

    1993  

    Keywords AIDS-Related Opportunistic Infections ; HIV Infections ; Developing Countries ; AIDS and its Control ; drug therapy
    Document type Journal ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Book ; Online: Strategies for AIDS prevention and control in Sub-Saharan Africa / D. L. Heymann, K. Edstrom

    Heymann, David L / Edstrom, Karin G

    1991  

    Keywords Acquired immunodeficiency syndrome ; AIDS and its Control ; prevention and control
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Journal ; Article ; Online: Strategies for AIDS prevention and control in Sub-Saharan Africa / D. L. Heymann, K. Edstrom

    Heymann, David L / Edstrom, Karin G

    1991  

    Keywords Acquired Immunodeficiency Syndrome ; AIDS and its Control ; prevention and control
    Document type Journal ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article ; Online: Successful smallpox eradication: what can we learn to control COVID-19?

    Heymann, D L / Wilder-Smith, Annelies

    Journal of travel medicine

    2020  Volume 27, Issue 4

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Disease Eradication/history ; Global Health ; History, 18th Century ; History, 20th Century ; Humans ; International Cooperation ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; Smallpox/physiopathology ; Smallpox/prevention & control ; Smallpox/transmission ; Smallpox Vaccine/history ; Vaccines/immunology
    Chemical Substances Smallpox Vaccine ; Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-05-18
    Publishing country England
    Document type Historical Article ; Journal Article
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/taaa090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4120: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Three-dimensional in vitro culture models in oncology research.

    Jubelin, Camille / Muñoz-Garcia, Javier / Griscom, Laurent / Cochonneau, Denis / Ollivier, Emilie / Heymann, Marie-Françoise / Vallette, François M / Oliver, Lisa / Heymann, Dominique

    Cell & bioscience

    2022  Volume 12, Issue 1, Page(s) 155

    Abstract: Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra- and inter-heterogeneity of malignant tumors make it difficult to develop single targeted approaches. Similarly, their diversity requires various models to ... ...

    Abstract Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra- and inter-heterogeneity of malignant tumors make it difficult to develop single targeted approaches. Similarly, their diversity requires various models to investigate the mechanisms involved in cancer initiation, progression, drug resistance and recurrence. Of the in vitro cell-based models, monolayer adherent (also known as 2D culture) cell cultures have been used for the longest time. However, it appears that they are often less appropriate than the three-dimensional (3D) cell culture approach for mimicking the biological behavior of tumor cells, in particular the mechanisms leading to therapeutic escape and drug resistance. Multicellular tumor spheroids are widely used to study cancers in 3D, and can be generated by a multiplicity of techniques, such as liquid-based and scaffold-based 3D cultures, microfluidics and bioprinting. Organoids are more complex 3D models than multicellular tumor spheroids because they are generated from stem cells isolated from patients and are considered as powerful tools to reproduce the disease development in vitro. The present review provides an overview of the various 3D culture models that have been set up to study cancer development and drug response. The advantages of 3D models compared to 2D cell cultures, the limitations, and the fields of application of these models and their techniques of production are also discussed.
    Language English
    Publishing date 2022-09-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2593367-X
    ISSN 2045-3701
    ISSN 2045-3701
    DOI 10.1186/s13578-022-00887-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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