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Article ; Online: Inhibitors of human bitter taste receptors from the five-flavour berry,

Soh, Ryan / Fu, Lin / Guo, Wei Mei / Seetoh, Wei-Guang / Koay, Ann

2023 Volume 14, Issue 24, Page(s) 10700–10708

Abstract: The human bitter taste 2 receptor member 16 (TAS2R16) is one of 25 class A G-protein-coupled receptors (GPCRs) and responds to a variety of molecules responsible for the bitter taste sensation perceived in humans. TAS2R16 can be activated by β- ... ...

Abstract	The human bitter taste 2 receptor member 16 (TAS2R16) is one of 25 class A G-protein-coupled receptors (GPCRs) and responds to a variety of molecules responsible for the bitter taste sensation perceived in humans. TAS2R16 can be activated by β-glucopyranosides, and its activation can be inhibited by probenecid, a synthetic drug compound used to treat gout. In this study we describe naturally derived compounds which can inhibit the activation of TAS2R16 by salicin
MeSH term(s)	Humans ; Taste ; Schisandra ; Fruit ; Molecular Docking Simulation ; Receptors, G-Protein-Coupled ; Lignans/pharmacology
Chemical Substances	Receptors, G-Protein-Coupled ; Lignans
Language	English
Publishing date	2023-12-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d3fo02303f
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Article: 秸秆还田配施促腐菌剂对土壤团聚体及其养分的影响.

Pei, Ya-Nan / Lyu, Wei-Guang / Guo, Tao / Bai, Na-Ling / Li, Shuang-Xi / Zhang, Juan-Qin / Zhang, Hai-Yun / Zhang, Han-Lin

Ying yong sheng tai xue bao = The journal of applied ecology

2024 Volume 34, Issue 12, Page(s) 3357–3363

Abstract: We analyzed the particle size distribution of soil aggregates in 0-20 and 20-40 cm soil layers of rice-wheat rotation field based on a field plot test with two treatments, conventional straw returning (CK) and straw returning with the addition of straw ... ...

Title translation	Effects of straw-returning combined with application of microbial inoculants on soil aggregates and related nutrients.
Abstract	We analyzed the particle size distribution of soil aggregates in 0-20 and 20-40 cm soil layers of rice-wheat rotation field based on a field plot test with two treatments, conventional straw returning (CK) and straw returning with the addition of straw decomposition promoting microbial inoculants (IT). We evaluated the water stability indices of soil aggregates (the number of soil water stable large aggregates
MeSH term(s)	Soil ; Carbon/analysis ; Agricultural Inoculants ; Nitrogen/analysis ; Nutrients ; Phosphorus ; Water ; Agriculture/methods ; China
Chemical Substances	Soil ; Carbon (7440-44-0) ; Nitrogen (N762921K75) ; Phosphorus (27YLU75U4W) ; Water (059QF0KO0R)
Language	Chinese
Publishing date	2024-03-21
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2881809-X
ISSN	1001-9332
ISSN	1001-9332
DOI	10.13287/j.1001-9332.202312.018
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Article: [Tonglong Kaibi Prescription for the treatment of severe benign prostate hyperplasia: A clinical study].

He, Chao-Ba / Yuan, Shao-Ying / Qin, Zhan / Jin, Ming-Yu / Geng, Li-Guo / Wang, You-Lian / Zhang, Zhao-Lei / Wang, Wei-Guang

Zhonghua nan ke xue = National journal of andrology

2024 Volume 29, Issue 4, Page(s) 342–347

Abstract: Objective: To evaluate the clinical effect of the traditional Chinese medicine (TCM) Tonglong Kaibi Prescription (TKP) in the treatment of severe BPH with kidney deficiency and blood stasis combined with damp heat syndrome.: Methods: We randomly ... ...

Abstract	Objective: To evaluate the clinical effect of the traditional Chinese medicine (TCM) Tonglong Kaibi Prescription (TKP) in the treatment of severe BPH with kidney deficiency and blood stasis combined with damp heat syndrome. Methods: We randomly divided 120 cases of severe BPH with kidney deficiency and blood stasis combined with damp heat syndrome into three groups of equal number, treated with TKP, doxazosin mesylate sustained-release tablets (the DM control), and TKP + DM, all for 8 weeks. We obtained the IPSS, TCM symptoms scores, quality of life (QOL) scores, maximum urinary flow rate (Qmax) and postvoid residual urine volume (PVR) from the patients before and after treatment and compared them among the three groups. Results: After 8 weeks of treatment, the effectiveness rate was significantly higher in the TKP + DM than in the DM control group (P < 0.05). The IPSS, TCM symptoms scores, QOL scores and PVR decreased (P < 0.01), while the Qmax increased dramatically (P < 0.01) in all the three groups. Pairwise comparison showed that the IPSS and QOL scores were lower in the TKP + DM than in the TKP and DM control groups (P < 0.05 or 0.01), and so were the TCM syndrome scores in the TKP + DM and TKP groups than in the DM control (P < 0.01). There were no statistically significant differences in PVR and Qmax among the three groups after treatment (P> 0.05), and no serious adverse events during the treatment. Conclusion: TKP is safe and effective in the treatment of severe BPH, which can improve the TCM symptoms, reduce the IPSS, QOL scores and PVR and increase the Qmax of the patients. TKP is evidently superior to DM alone in improving TCM symptoms of BPH and combined medication of TKP and DM produces even better clinical efficacy.
MeSH term(s)	Humans ; Male ; Hyperplasia ; Prescriptions ; Prostate ; Prostatic Hyperplasia/drug therapy ; Quality of Life ; Syndrome
Language	Chinese
Publishing date	2024-04-10
Publishing country	China
Document type	English Abstract ; Journal Article ; Randomized Controlled Trial
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
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Article ; Online: Enantioselective bioaccumulation, oxidative stress, and thyroid disruption assessment of cis-metconazole enantiomers in zebrafish (Danio rerio).

He, Rujian / Guo, Dong / Lin, Chun / Zhang, Wei-Guang / Fan, Jun

Aquatic toxicology (Amsterdam, Netherlands)

2022 Volume 248, Page(s) 106205

Abstract: Chiral triazole pesticides may cause enantioselectively adverse effects to non-target organisms. In this work, we employed zebrafish as an aquatic organism model to explore stereoselective acute toxicity, bioaccumulation, oxidative stress, and thyroid ... ...

Abstract	Chiral triazole pesticides may cause enantioselectively adverse effects to non-target organisms. In this work, we employed zebrafish as an aquatic organism model to explore stereoselective acute toxicity, bioaccumulation, oxidative stress, and thyroid disruption of cis-metconazole enantiomers. The median lethal concentration values of (1S, 5R)-metconazole, (1R, 5S)-metconazole, and the mixture of them against zebrafish were 4.01, 2.61 and 3.17 mg⋅L
MeSH term(s)	Animals ; Bioaccumulation ; Molecular Docking Simulation ; Oxidative Stress ; Pesticides/metabolism ; Pesticides/toxicity ; Stereoisomerism ; Thyroid Gland ; Triazoles/metabolism ; Water Pollutants, Chemical/toxicity ; Zebrafish/metabolism
Chemical Substances	Pesticides ; Triazoles ; Water Pollutants, Chemical ; metconazole (A2F791945Q)
Language	English
Publishing date	2022-05-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782699-0
ISSN	1879-1514 ; 0166-445X
ISSN (online)	1879-1514
ISSN	0166-445X
DOI	10.1016/j.aquatox.2022.106205
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Article ; Online: Interactions of diclazuril enantiomers with serum albumins: Multi-spectroscopic and molecular docking approaches.

Chen, Ran / He, Ru-Jian / Guo, Dong / Zhang, Zhi-Feng / Zhang, Wei-Guang / Fan, Jun

Journal of molecular recognition : JMR

2022 Volume 35, Issue 4, Page(s) e2948

Abstract: In this work, multi-spectroscopic and molecular docking methods have been conducted in the investigation of enantioselective interactions between diclazuril enantiomers and human/bovine serum albumins (HSA/BSA). The binding constants between serum ... ...

Abstract	In this work, multi-spectroscopic and molecular docking methods have been conducted in the investigation of enantioselective interactions between diclazuril enantiomers and human/bovine serum albumins (HSA/BSA). The binding constants between serum albumins (SAs) and diclazuril enantiomers revealed that SAs exhibited stronger binding affinity for (R)-diclazuril than (S)-enantiomer. In addition, the fluorescence quenching of SAs induced by diclazuril enantiomers was ascribed to static quenching mechanism, in which hydrogen bonds and Van der Waals forces were the main interactions. According to the thermodynamic study, binding of diclazuril enantiomers and SAs was an exothermic process driven by enthalpy change. Then, circular dichroism spectroscopy of SAs with diclazuril enantiomers revealed that the SAs conformation had changed in the presence of diclazuril. Moreover, molecular docking technology was applied in exploration of interactions between SAs and diclazuril enantiomers. The docking energy between SAs and (R)-diclazuril was larger than (S)-diclazuril, which indicated that the affinity of SAs with (R)-diclazuril was stronger than (S)-enantiomer. This work may provide valuable information for explaining differences in pharmacokinetics and residue elimination of diclazuril enantiomers in living organisms.
MeSH term(s)	Binding Sites ; Circular Dichroism ; Humans ; Molecular Docking Simulation ; Nitriles ; Protein Binding ; Serum Albumin/chemistry ; Serum Albumin, Bovine/chemistry ; Serum Albumin, Human/chemistry ; Spectrometry, Fluorescence ; Spectrophotometry, Ultraviolet ; Stereoisomerism ; Thermodynamics ; Triazines
Chemical Substances	Nitriles ; Serum Albumin ; Triazines ; Serum Albumin, Bovine (27432CM55Q) ; diclazuril (K110K1B1VE) ; Serum Albumin, Human (ZIF514RVZR)
Language	English
Publishing date	2022-01-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1015084-5
ISSN	1099-1352 ; 0952-3499
ISSN (online)	1099-1352
ISSN	0952-3499
DOI	10.1002/jmr.2948
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Article ; Online: Evaluation on production trend, compositions, and impact of plastic waste in Chengdu, southwestern China.

Zhao, Xue / Yong, Yi / Du, Cheng-Song / Guo, Wei-Guang / Luo, Da-Peng

Journal of the Air & Waste Management Association (1995)

2022 Volume 72, Issue 12, Page(s) 1454–1462

Abstract: Based on statistical data from 2005 to 2019, we used the back propagation (BP) neural network model to predict the production amount of plastic waste in Chengdu. In addition to the amount of waste produced we wanted to achieve an understanding of its ... ...

Abstract	Based on statistical data from 2005 to 2019, we used the back propagation (BP) neural network model to predict the production amount of plastic waste in Chengdu. In addition to the amount of waste produced we wanted to achieve an understanding of its composition and environmental impacts. Compositions of plastic waste were analyzed by sampling. Particulate matter in the air and greenhouse gas emissions (GHGs) from plastic waste incineration, bisphenol A (BPA) from plastic waste landfills, were also evaluated. Results indicated that (a) economic development, urban construction level, and residents' consumption were pusitively correlated to different degrees to plastic waste production; (b) the production of plastic waste in Chengdu in 2025 and 2030 will reach 865.3 and 931 kilotons (Kt), respectively; (c) high density polyethylene (HDPE) and polypropylene (PP) are the two main components of plastic waste in Chengdu and accounted for 40.17% and 24.96%, respectively; (d) different degrees of environmental impacts occurred during plastic waste incineration and landfill (taking 2019 as an example, the incineration of plastic waste in Chengdu produced between 2874.82 and 4711.73 tons of inhalable particulate matter (PM) and emitted between 725.4 and 867.4 Kt of CO
Language	English
Publishing date	2022-10-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1003064-5
ISSN	2162-2906 ; 0894-0630 ; 1047-3289 ; 1096-2247
ISSN (online)	2162-2906
ISSN	0894-0630 ; 1047-3289 ; 1096-2247
DOI	10.1080/10962247.2022.2126558
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Article ; Online: Earthworm activities enhance taro production by reducing weed infestation through taro–earthworm coculture

Li, Tao / Fan, Jie-Qun / Qian, Hua-Wei / Wei, Ji-Hui / Qian, Zhen-Guan / Guo, Shui-Liang / Lv, Wei-Guang

Agriculture, Ecosystems and Environment. 2023 Aug., v. 352 p.108533-

2023

Abstract: Rapid global population growth increases the human demand for food. Reliance on the high input of agrochemicals in agricultural production has been shown to be unsustainable and cost ineffective. The combination of planting and breeding can maximize the ... ...

Abstract	Rapid global population growth increases the human demand for food. Reliance on the high input of agrochemicals in agricultural production has been shown to be unsustainable and cost ineffective. The combination of planting and breeding can maximize the utilization of agricultural resources. A novel crop–earthworm coculture model has been gradually practiced in urban agriculture in eastern China. We conducted a four-year successive study of taro–earthworm coculture farming to determine the ecological and economic benefits of the model. Our results indicated that earthworm activities in the taro–earthworm coculture system increased taro yield, economic value and net income by depleting the weed seed bank, mitigating weed infestation, and reducing the need for weeding. Compared with those in mono-taro farming, the four-year mean seed bank densities of total weeds, grassy weeds and broadleaf weeds in taro–earthworm farming decreased by 37.1%, 44.4% and 32.2%, respectively; the weed density, biomass, species richness and diversity and need for weeding decreased by 54.1%, 48.3%, 20.8%, 8.2% and 39.7%, respectively; and the taro yield, economic value and net income increased by 19.7%, 19.7% and 50.7%, respectively. Our study suggests that earthworm activities provide ecosystem services in agricultural systems, and the coculture of taro and earthworms enhances crop production by mitigating weed infestation and improving environmental quality.
Keywords	agrochemicals ; biomass ; coculture ; crop production ; earthworms ; economic valuation ; ecosystems ; environment ; environmental quality ; humans ; income ; models ; population growth ; species richness ; taro ; urban agriculture ; weeds ; China ; Earthworm ; Soil weed seed bank ; Weed infestation ; Sustainable agriculture ; Agricultural environment
Language	English
Dates of publication	2023-08
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	602345-9
ISSN	1873-2305 ; 0167-8809
ISSN (online)	1873-2305
ISSN	0167-8809
DOI	10.1016/j.agee.2023.108533
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Enantioselective bioaccumulation, oxidative stress, and thyroid disruption assessment of cis-metconazole enantiomers in zebrafish (Danio rerio)

He, Rujian / Guo, Dong / Lin, Chun / Zhang, Wei-guang / Fan, Jun

Aquatic Toxicology. 2022 July, v. 248 p.106205-

2022

Abstract	Chiral triazole pesticides may cause enantioselectively adverse effects to non-target organisms. In this work, we employed zebrafish as an aquatic organism model to explore stereoselective acute toxicity, bioaccumulation, oxidative stress, and thyroid disruption of cis-metconazole enantiomers. The median lethal concentration values of (1S, 5R)-metconazole, (1R, 5S)-metconazole, and the mixture of them against zebrafish were 4.01, 2.61 and 3.17 mg⋅L⁻¹, respectively. (1R, 5S)-Metconazole was preferentially bioaccumulated in zebrafish than (1S, 5R)-metconazole, and the bioconcentration factor of (1R, 5S)-metconazole was 1.28-fold larger than that of (1S, 5R)-metconazole. Then, the activity order of catalase, superoxide dismutase, and glutathione-S transferase enzymes in zebrafish was expressed as (1S, 5R)-metconazole > the mixture > (1R, 5S)-metconazole, while the order of malondialdehyde content in zebrafish was (1R, 5S)-metconazole > the mixture > (1S, 5R)-metconazole. Moreover, cis-metconazole exhibited enantioselective regulation effects on the levels of triiodothyronine and thyroxine in zebrafish, and (1R, 5S)-metconazole possessed stronger thyroid disruption ability to zebrafish than the others. By virtue of molecular docking methodology, the binding affair and docking energy results supported that interactions between (1R, 5S)-metconazole and thyroid hormone receptors were much stronger than those between (1S, 5R)-metconazole and same receptors. This study of enantioselective evaluation of cis-metconazole in zebrafish can provide favorable information for risk assessments of chiral pesticides toward environment and health of aquatic organisms.
Keywords	Danio rerio ; acute toxicity ; aquatic organisms ; bioaccumulation factor ; catalase ; enantiomers ; enantioselectivity ; energy ; lethal concentration 50 ; malondialdehyde ; models ; oxidative stress ; risk ; superoxide dismutase ; triazoles ; triiodothyronine ; Bioaccumulation ; cis-Metconazole ; Oxidative stress effect ; Thyroid endocrine disruption, zebrafish ; BCFk ; CAT ; GST ; LC50 ; LOD ; LOQ ; MDA ; MEZ ; ROS ; SOD ; T1/2 ; T3 ; T4
Language	English
Dates of publication	2022-07
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	782699-0
ISSN	1879-1514 ; 0166-445X
ISSN (online)	1879-1514
ISSN	0166-445X
DOI	10.1016/j.aquatox.2022.106205
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effects of Rhizophagus intraradices on Plant Growth and the Composition of Microbial Communities in the Roots of Continuous Cropping Soybean at Maturity

Wei-Guang Jie / Yan-Xuan Yao / Na Guo / Ying-Zhi Zhang / Wei Qiao

Sustainability, Vol 13, Iss 6623, p

2021 Volume 6623

Abstract: Soybean is the major food and oil crop in the world. However, soybean continuous cropping can significantly reduce soybean yield. In this study, the effects of Rhizophagus intraradices on soybean growth and the composition of microbial communities in ... ...

Abstract	Soybean is the major food and oil crop in the world. However, soybean continuous cropping can significantly reduce soybean yield. In this study, the effects of Rhizophagus intraradices on soybean growth and the composition of microbial communities in soybean roots under different continuous cropping regimes were investigated at maturity. The results showed that the mycorrhizal colonization rate was affected by R. intraradices and soybean continuous cropping. The mycorrhizal colonization rate was the highest in the inoculated soybean plants under 1 year of continuous cropping. Inoculation of R. intraradices significantly increased soybean plant growth. The greatest biomass parameters were obtained from the soybean plants inoculated with R. intraradices under 0 years of continuous cropping. Bacterial diversity was decreased by soybean continuous cropping, while the opposite result occurred for fungal diversity. Moreover, inoculation of R. intraradices could increase and decrease the diversity of bacteria and fungi in soybean roots, respectively. It also indicated that R. intraradices and soybean continuous cropping had significant effects on the composition of microbial communities in soybean roots. Proteobacteria and Ascomycota were the most dominant bacterial and fungal phylum in all samples, respectively. It would contribute to developing a biocontrol strategy to alleviate the soybean continuous cropping obstacles.
Keywords	arbuscular mycorrhizal fungi ; microbial communities ; soybean ; continuous cropping ; high-throughput sequencing ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	580
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The complete chloroplast genome of

Tan, Cheng-Jiang / Yan, Rong-Rong / Yu, Ping / Lu, Guang-Qin / Wu, Wei / Hu, Guo-Xiong

Mitochondrial DNA. Part B, Resources

2024 Volume 9, Issue 1, Page(s) 24–28

Abstract: Chrysoglossum ... ...

Abstract	Chrysoglossum ornatum
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Journal Article
ISSN	2380-2359
ISSN (online)	2380-2359
DOI	10.1080/23802359.2023.2296920
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