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  1. AU=Kawabe Mayuko
  2. AU="Bacot, Francois"
  3. AU="Abdallah, Hamza Hadj"
  4. AU="Wang, Yanlan"
  5. AU="Regueiro, Benito"
  6. AU="Bar-Nur, Ori"
  7. AU="Hollander, Jonathan A"
  8. AU="Polidoro, Silvia"
  9. AU="Dausset, J"
  10. AU=Eijkholt Marleen
  11. AU=Sousa Braian L A AU=Sousa Braian L A
  12. AU="Fresel, Marielle"
  13. AU="Ilana Babaev"
  14. AU="Tang, Hang"
  15. AU="McBride, Erin"

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  1. Artikel ; Online: Current Status and Perspectives on Recurrent IgA Nephropathy after Kidney Transplantation.

    Kawabe, Mayuko / Yamamoto, Izumi

    Nephron

    2023  Band 147 Suppl 1, Seite(n) 9–13

    Abstract: IgA nephropathy (IgAN) is the most common form of glomerulonephritis worldwide. IgAN progresses to end-stage kidney disease in 20-40% of patients within 20 years of diagnosis. Kidney transplantation is the most effective option for patients with end- ... ...

    Abstract IgA nephropathy (IgAN) is the most common form of glomerulonephritis worldwide. IgAN progresses to end-stage kidney disease in 20-40% of patients within 20 years of diagnosis. Kidney transplantation is the most effective option for patients with end-stage kidney disease caused by IgAN, but recurrence can occur in the transplanted kidney. The IgAN recurrence rate varies from 1% to 10% per year and varies according to the follow-up period, diagnostic modality, and biopsy criteria. Of note, studies based on protocol biopsies have reported a higher incidence of recurrence, which also occurred earlier after transplantation. In addition, recent data show that recurrence of IgAN is a more significant cause of allograft failure than previously believed. Little is known about the pathophysiology of IgAN recurrence, but several potential biomarkers have been investigated. Among them, galactose-deficient IgA1 (Gd-IgA1), IgG anti-Gd-IgA1 antibodies, and soluble CD89 could play a pivotal role in disease activity. This review aims to describe the current status of recurrent IgAN, including the incidence, clinical characteristics, risk factors, and future perspectives, with a focus on the available therapeutic approaches.
    Mesh-Begriff(e) Humans ; Glomerulonephritis, IGA/etiology ; Glomerulonephritis, IGA/surgery ; Glomerulonephritis, IGA/diagnosis ; Kidney Transplantation/adverse effects ; Immunoglobulin A ; Kidney Failure, Chronic/surgery ; Kidney Failure, Chronic/etiology
    Chemische Substanzen galactosyl-deficient IgA1 ; Immunoglobulin A
    Sprache Englisch
    Erscheinungsdatum 2023-03-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000530341
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Challenges Posed by the Banff Classification: Diagnosis and Treatment of Chronic Active T-Cell-Mediated Rejection.

    Yamamoto, Izumi / Kawabe, Mayuko / Hayashi, Ayaka / Kobayashi, Akimitsu / Yamamoto, Hiroyasu / Yokoo, Takashi

    Nephron

    2023  Band 147 Suppl 1, Seite(n) 74–79

    Abstract: The three primary sites of acute T-cell-mediated rejection (TCMR) in transplanted kidneys are the tubular epithelial cells, interstitium, and the vascular endothelial cells. The pathology of acute lesions is characterized by inflammatory cell ... ...

    Abstract The three primary sites of acute T-cell-mediated rejection (TCMR) in transplanted kidneys are the tubular epithelial cells, interstitium, and the vascular endothelial cells. The pathology of acute lesions is characterized by inflammatory cell infiltration; the final diagnosis suggested by the Banff 2019 classification is guided by grading of tubulitis (the t score), interstitial inflammation (the i score), and endarteritis (the v score). Consistent major issues when using the Banff classification are the etiological classifications of interstitial fibrosis and tubular atrophy (IFTA). From 2015 to 2019, technological advances (i.e., genetic analysis in paraffin sections) increased our understanding of IFTA status in patients with smoldering acute TCMR and the roles played by inflammatory cell infiltration (the i-IFTA score) and tubulitis (the t-IFTA score) in IFTA. These two scores were introduced when establishing the diagnostic criteria for chronic active TCMR. Despite the increase in complexity and the lack of a consensus treatment for chronic active TCMR, the Banff classification may evolve as new techniques (i.e., genetic analysis in paraffin sections and deep learning of renal pathology) are introduced. The Banff conference proceeded as follows. First, lesions were defined. Next, working groups were established to better understand the lesions and to derive better classification methods. Finally, the new Banff classification was developed. This approach will continue to evolve; the Banff classification will become a very useful diagnostic standard. This paper overviews the history of TCMR diagnosis using the Banff classification, and the clinical importance, treatment, and prospects for acute and chronic active TCMR.
    Mesh-Begriff(e) Humans ; Kidney Transplantation ; T-Lymphocytes ; Endothelial Cells ; Paraffin ; Kidney/pathology ; Kidney Diseases/pathology ; Graft Rejection/etiology ; Biopsy
    Chemische Substanzen Paraffin (8002-74-2)
    Sprache Englisch
    Erscheinungsdatum 2023-03-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000530158
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  3. Artikel: Higher Soluble ACE2 Levels and Increased Risk of Infection-Related Hospitalization in Patients on Maintenance Hemodialysis.

    Kawabe, Mayuko / Nakashima, Akio / Yamamoto, Izumi / Ohkido, Ichiro / Yokoo, Takashi / Urashima, Mitsuyoshi

    Frontiers in medicine

    2022  Band 9, Seite(n) 791284

    Abstract: Background: Angiotensin-converting enzyme 2 (ACE2) works as an endogenous counter-regulator of the renin-angiotensin system, which has pivotal roles in preventing both cardiovascular disease (CVD) and inflammation. In general populations, higher plasma ... ...

    Abstract Background: Angiotensin-converting enzyme 2 (ACE2) works as an endogenous counter-regulator of the renin-angiotensin system, which has pivotal roles in preventing both cardiovascular disease (CVD) and inflammation. In general populations, higher plasma soluble ACE2 levels were reported to be associated with increased risks of all-cause death and major CVD. Because infections are fatal in patients on maintenance hemodialysis, we aimed to explore whether soluble ACE2 levels are associated with an increased risk of infection-related hospitalization in these patients.
    Methods: Using data from a prospective, multicenter, cohort study conducted in Tokyo, Japan, we performed a
    Results: The soluble ACE2 level (median, 0.16 ng/ml; interquartile range, 0.07-0.57 ng/ml) showed a weak negative association with age. During a median follow-up of 39 months, 106 patients (14.6%) were hospitalized with infectious diseases. Compared with the lower half of soluble ACE2 levels, the higher half was associated with an increased risk of infection-related hospitalization (hazard ratio, 1.57; 95% confidence interval, 1.02-2.41) with adjustment by other risk factors. On the other hand, there were no significant associations between soluble ACE2 and risks of all-cause death and CVD.
    Conclusion: Higher soluble ACE2 levels may associate with an increased risk of infection-related hospitalization in patients on maintenance hemodialysis.
    Sprache Englisch
    Erscheinungsdatum 2022-01-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.791284
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: CASE REPORT: Serial Cases of False-Positive Flow-Cytometry T Cell Crossmatch Associated With Anti-Blood Type Antibodies in Patients Undergoing ABO-Incompatible Kidney Transplantation.

    Hayashi, Ayaka / Yamamoto, Izumi / Kawabe, Mayuko / Kobayashi, Akimitsu / Ito, Makoto / Hotta, Kiyohiko / Shinohara, Nobuo / Tasaki, Tetsunori / Yokoo, Takashi / Iwami, Daiki

    Frontiers in immunology

    2022  Band 13, Seite(n) 862652

    Abstract: Background: A positive flow-cytometry T cell crossmatch (FTXM) has important prognostic implications, even when the complement-dependent cytotoxicity crossmatch is negative. Recent studies have shown that ABO incompatibility is associated with positive ... ...

    Abstract Background: A positive flow-cytometry T cell crossmatch (FTXM) has important prognostic implications, even when the complement-dependent cytotoxicity crossmatch is negative. Recent studies have shown that ABO incompatibility is associated with positive FTXM, but the underlying mechanism remains poorly understood.
    Cases: In five ABO blood type O recipients of kidneys from wives with type B, FTXM was positive but complement-dependent cytotoxicity crossmatch was negative. Application of a solid-phase technique (LABScreen) revealed no case with antibodies to donor-specific human leukocyte antigen. After removal of type B antibodies from patient sera, FTXM was negative for all five patients. In one tested case, the eluate prepared from the donor's T lymphocyte agglutinated only type B red blood cells, implying the existence of blood type B substances on donor T lymphocytes.
    Discussion: False-positive FTXM reflects blood type B substrates bound to T lymphocytes. Repeat FTXM after incubation with donor-type red blood cells (to adsorb anti-ABO antibodies) was negative. This phenomenon explains the discrepancy between FTXM and solid-phase bead assays. Demonstration of type B substances on donor T lymphocytes is necessary before absolute test validity is confirmed.
    Conclusion: False-positive FTXM may be associated with type B antibodies bound to T lymphocytes when a blood type O recipient receives tissue from a type B donor. This phenomenon explains the false-positive FTXM observed in the setting of ABO-incompatible kidney transplantation.
    Mesh-Begriff(e) ABO Blood-Group System ; Anemia, Hemolytic, Autoimmune ; Antibodies ; HLA Antigens ; Histocompatibility Testing/methods ; Humans ; Kidney Transplantation/adverse effects ; Kidney Transplantation/methods ; T-Lymphocytes
    Chemische Substanzen ABO Blood-Group System ; Antibodies ; HLA Antigens
    Sprache Englisch
    Erscheinungsdatum 2022-03-10
    Erscheinungsland Switzerland
    Dokumenttyp Case Reports
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.862652
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Booster effect of the third dose of SARS-CoV-2 mRNA vaccine in Japanese kidney transplant recipients.

    Kawabe, Mayuko / Kuroda, Takafumi / Yamamoto, Izumi / Kobayashi, Akimitsu / Ohki, Yutaro / Hayashi, Ayaka / Urabe, Fumihiko / Miki, Jun / Yamada, Hiroki / Kimura, Takahiro / Matsuo, Nanae / Tanno, Yudo / Horino, Tetsuya / Ohkido, Ichiro / Yamamoto, Hiroyasu / Yokoo, Takashi

    Scientific reports

    2023  Band 13, Heft 1, Seite(n) 9976

    Abstract: The humoral response of kidney transplant recipients (KTR) to the mRNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is generally poor. We evaluated the booster effect of the third dose (D3) of two SARS-CoV-2 mRNA vaccines ... ...

    Abstract The humoral response of kidney transplant recipients (KTR) to the mRNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is generally poor. We evaluated the booster effect of the third dose (D3) of two SARS-CoV-2 mRNA vaccines 6 months after the second dose (D2) in Japanese KTR. The anti-spike (anti-S) antibody titer 1 and 3 months after the D3 was evaluated in 82 Japanese KTR. The primary endpoint was the seropositivity rate, and factors associated with the lack of a response were evaluated in a logistic regression model. Overall, the anti-S antibody seropositivity rate 1 and 3 months after the D3 was 74.7% and 76.0%. The anti-S antibody titers after the first and second doses were higher in patients vaccinated with the mRNA-1273 than with the BNT162b2 vaccine. Among the 38 KTR who were seronegative 5 months after the D2, 18 (47.4%) became seropositive following the D3. Factors associated with a non-response were mycophenolic acid dose, post-transplant duration, hemoglobin, and lymphocyte count. A humoral response 1 and 3 months after the D3 was obtained in ~ 75% of KTR, but 20% were non-responders. Additional studies are needed to clarify the factors hindering a vaccine response.
    Mesh-Begriff(e) Humans ; Antibodies, Viral ; BNT162 Vaccine/administration & dosage ; COVID-19/prevention & control ; East Asian People ; Kidney Transplantation ; Transplant Recipients ; Immunization, Secondary
    Chemische Substanzen Antibodies, Viral ; BNT162 Vaccine
    Sprache Englisch
    Erscheinungsdatum 2023-06-20
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-36998-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Early Recurrence of Immunoglobulin A Nephropathy after Kidney Transplantation in a Patient with Down Syndrome.

    Ohki, Yutaro / Kawabe, Mayuko / Yamamoto, Izumi / Kobayashi, Akimitsu / Kanzaki, Go / Koike, Kentaro / Ueda, Hiroyuki / Tanno, Yudo / Urabe, Fumihiko / Miki, Jun / Yamada, Hiroki / Kimura, Takahiro / Ohkido, Ichiro / Tsuboi, Nobuo / Yamamoto, Hiroyasu / Yokoo, Takashi

    Nephron

    2023  Band 147 Suppl 1, Seite(n) 35–40

    Abstract: A 39-year-old male kidney transplant recipient with Down syndrome (DS) was admitted to our hospital for biopsy. He had proteinuria at age 9, was diagnosed with immunoglobulin A nephropathy (IgAN) at age 22, had a tonsillectomy at age 35, and underwent ... ...

    Abstract A 39-year-old male kidney transplant recipient with Down syndrome (DS) was admitted to our hospital for biopsy. He had proteinuria at age 9, was diagnosed with immunoglobulin A nephropathy (IgAN) at age 22, had a tonsillectomy at age 35, and underwent ABO-compatible kidney transplantation (from his mother) at age 36. His serum creatinine was stable at 2.21 mg/dL 3 months after the kidney transplant, and his urine protein was 0.11 g/day. A protocol biopsy was performed 7 months after the kidney transplant, and there was suspicion of early recurrence of IgAN. One year after the transplant, urine erythrocytes were elevated and proteinuria was 0.41 g/day; at 3 years and 5 months after the kidney transplant, hematuria was evident along with proteinuria (0.74 g/day). Therefore, an episode biopsy was performed. A total of 23 glomeruli were obtained, four of which exhibited global sclerosis; three others showed intra- and extracapillary proliferative glomerulonephritis compatible with IgAN recurrence. Here, we report a rare case of early recurrence of IgAN with disease progression despite tonsillectomy in a patient with DS.
    Mesh-Begriff(e) Male ; Humans ; Child ; Young Adult ; Adult ; Glomerulonephritis, IGA/complications ; Glomerulonephritis, IGA/surgery ; Glomerulonephritis, IGA/diagnosis ; Kidney Transplantation ; Down Syndrome/complications ; Kidney Glomerulus/pathology ; Proteinuria ; Glomerulonephritis, Membranoproliferative ; Recurrence
    Sprache Englisch
    Erscheinungsdatum 2023-06-08
    Erscheinungsland Switzerland
    Dokumenttyp Case Reports
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000530915
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Establishment and Validation of an Ultra-Short-Term Skin Carcinogenicity Bioassay Using Tg-rasH2 Mice

    Kawabe, Mayumi / Urano, Koji / Suguro, Mayuko / Hara, Tomomi / Kageyama, Yasushi / Mera, Yukinori / Tsutsumi, Hideki

    Veterinary Pathology. 2020 Jan., v. 57, no. 1 p.192-199

    2020  

    Abstract: After initiation with 7,12-dimethylbenz[a]anthracene (DMBA), the promoting potential of 12-O-tetradecanoylphorbol-13-acetate (TPA) on skin tumor development can be detected by an ultra-short-term skin carcinogenicity bioassay using Tg-rasH2 mice. In the ... ...

    Abstract After initiation with 7,12-dimethylbenz[a]anthracene (DMBA), the promoting potential of 12-O-tetradecanoylphorbol-13-acetate (TPA) on skin tumor development can be detected by an ultra-short-term skin carcinogenicity bioassay using Tg-rasH2 mice. In the present study, 10 chemicals were assessed using this ultra-short-term bioassay as a first step to validate this practical and easy-to-use skin carcinogenicity bioassay. These chemicals belonged to 4 categories: dermal vehicles (acetone, 99.5% ethanol, anhydrous ethanol, and Vaseline), skin noncarcinogens (oleic acid diethanolamine condensate, benzethonium chloride, and diisopropylcarbodiimide), skin tumor promoters (TPA and benzoyl peroxide), and a skin carcinogen (4-vinyl-1-cyclohexene diepoxide). In a first study, DMBA was used as the initiator at a dose of 50 μg according to previous data, but skin tumors were observed in the no-treatment and vehicle groups. Therefore, the dose of DMBA for skin tumor initiation was reevaluated using 12.5 or 25 μg, with 12.5 μg found to be sufficient for initiation activity. In the ultra-short-term assay, the vehicles and skin noncarcinogens were negative while the skin tumor promoters and the skin carcinogen were positive. The detection of skin tumor promotion and carcinogenicity was feasible in only 8 weeks. In conclusion, this carcinogenicity bioassay may represent a useful tool for the assessment of the carcinogenicity potential of topically applied chemicals.
    Schlagwörter acetone ; animal pathology ; anthracenes ; bioassays ; carcinogenicity ; carcinogens ; chlorides ; condensates ; ethanol ; oleic acid ; skin neoplasms ; topical application ; Tg-rasH2 mouse ; dermal application ; bioassay ; tumor promotion
    Sprache Englisch
    Erscheinungsverlauf 2020-01
    Umfang p. 192-199.
    Erscheinungsort SAGE Publications
    Dokumenttyp Artikel ; Online
    ZDB-ID 188012-3
    ISSN 1544-2217 ; 0300-9858
    ISSN (online) 1544-2217
    ISSN 0300-9858
    DOI 10.1177/0300985819854440
    Datenquelle NAL Katalog (AGRICOLA)

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  8. Artikel ; Online: Booster effect of the third dose of SARS-CoV-2 mRNA vaccine in Japanese kidney transplant recipients

    Mayuko Kawabe / Takafumi Kuroda / Izumi Yamamoto / Akimitsu Kobayashi / Yutaro Ohki / Ayaka Hayashi / Fumihiko Urabe / Jun Miki / Hiroki Yamada / Takahiro Kimura / Nanae Matsuo / Yudo Tanno / Tetsuya Horino / Ichiro Ohkido / Hiroyasu Yamamoto / Takashi Yokoo

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Band 8

    Abstract: Abstract The humoral response of kidney transplant recipients (KTR) to the mRNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is generally poor. We evaluated the booster effect of the third dose (D3) of two SARS-CoV-2 mRNA ... ...

    Abstract Abstract The humoral response of kidney transplant recipients (KTR) to the mRNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is generally poor. We evaluated the booster effect of the third dose (D3) of two SARS-CoV-2 mRNA vaccines 6 months after the second dose (D2) in Japanese KTR. The anti-spike (anti-S) antibody titer 1 and 3 months after the D3 was evaluated in 82 Japanese KTR. The primary endpoint was the seropositivity rate, and factors associated with the lack of a response were evaluated in a logistic regression model. Overall, the anti-S antibody seropositivity rate 1 and 3 months after the D3 was 74.7% and 76.0%. The anti-S antibody titers after the first and second doses were higher in patients vaccinated with the mRNA-1273 than with the BNT162b2 vaccine. Among the 38 KTR who were seronegative 5 months after the D2, 18 (47.4%) became seropositive following the D3. Factors associated with a non-response were mycophenolic acid dose, post-transplant duration, hemoglobin, and lymphocyte count. A humoral response 1 and 3 months after the D3 was obtained in ~ 75% of KTR, but 20% were non-responders. Additional studies are needed to clarify the factors hindering a vaccine response.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-06-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: A Case of Hypokalemia Caused by Left Native Renal Artery Stenosis in a Kidney Transplant Recipient.

    Shiina, Yuki / Kobayashi, Akimitsu / Yamamoto, Izumi / Koda, Nagisa / Miyazawa, Kotaro / Kawabe, Mayuko / Sugano, Naoki / Urabe, Fumihiko / Miki, Jun / Yamada, Hiroki / Kimura, Takahiro / Maruyama, Yukio / Tanno, Yudo / Ohkido, Ichiro / Yamamoto, Hiroyasu / Yokoo, Takashi

    Nephron

    2023  Band 147 Suppl 1, Seite(n) 46–52

    Abstract: A 39-year-old woman with end-stage renal failure of unknown origin was on peritoneal dialysis for 10 years. One year ago, she underwent ABO-incompatible living-donor kidney transplantation from her husband. After the kidney transplantation, her serum ... ...

    Abstract A 39-year-old woman with end-stage renal failure of unknown origin was on peritoneal dialysis for 10 years. One year ago, she underwent ABO-incompatible living-donor kidney transplantation from her husband. After the kidney transplantation, her serum creatinine level remained around 0.7 mg/dL, but her serum potassium level remained low at around 3.5 mEq/L despite potassium supplementation and spironolactone. The patient's plasma renin activity (PRA) and plasma aldosterone concentration (PAC) were markedly elevated (20 ng/mL/h and 868 pg/mL, respectively). A CT angiogram of the abdomen performed 1 year previously suggested stenosis of the left native renal artery, which was considered responsible for the hypokalemia. Renal venous sampling was done on both the native kidneys and the transplanted kidney. Since renin secretion from the left native kidney was significantly elevated, a laparoscopic left nephrectomy was performed. Postoperatively, the renin-angiotensin-aldosterone system was markedly improved (PRA: 6.4 ng/mL/h, PAC: 147.3 pg/mL), and the serum potassium levels also improved. Pathological examination of the removed kidney showed many atubular glomeruli and hyperplasia of the juxtaglomerular apparatus (JGA) in residual glomeruli. In addition, renin staining showed strong positivity in the JGA of these glomeruli. Here, we report a case of hypokalemia caused by left native renal artery stenosis in a kidney transplant recipient. This valuable case study provides histological confirmation of maintained renin secretion in an abandoned native kidney after kidney transplantation.
    Mesh-Begriff(e) Humans ; Female ; Adult ; Renin ; Renal Artery ; Hypokalemia/etiology ; Renal Artery Obstruction/complications ; Kidney Transplantation/adverse effects ; Constriction, Pathologic/complications ; Aldosterone ; Potassium
    Chemische Substanzen Renin (EC 3.4.23.15) ; Aldosterone (4964P6T9RB) ; Potassium (RWP5GA015D)
    Sprache Englisch
    Erscheinungsdatum 2023-03-20
    Erscheinungsland Switzerland
    Dokumenttyp Case Reports
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000530229
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Clinical and Pathological Significance of Mesangial C1q Deposition in Kidney Transplant Recipients with Recurrent IgA Nephropathy and Patients with Native IgA Nephropathy.

    Hayashi, Ayaka / Kawabe, Mayuko / Yamamoto, Izumi / Ohki, Yutaro / Kobayashi, Akimitsu / Ueda, Hiroyuki / Tanno, Yudo / Urabe, Fumihiko / Miki, Jun / Yamada, Hiroki / Kimura, Takahiro / Okido, Ichiro / Tsuboi, Nobuo / Yamamoto, Hiroyasu / Yokoo, Takashi

    Nephron

    2023  Band 147 Suppl 1, Seite(n) 80–88

    Abstract: Introduction: In kidney transplant recipients (KTRs) whose primary disease is IgA nephropathy (IgAN), IgAN recurrence occurs in approximately half of patients by 5 years postoperatively and is associated with graft survival. Although the alternative and ...

    Abstract Introduction: In kidney transplant recipients (KTRs) whose primary disease is IgA nephropathy (IgAN), IgAN recurrence occurs in approximately half of patients by 5 years postoperatively and is associated with graft survival. Although the alternative and lectin pathways are important in the primary pathogenesis of IgAN, the significance of mesangial C1q deposition, which triggers the classical pathway, is unknown. We investigated the clinicopathological significance of mesangial C1q deposition in both recurrent IgAN in KTRs and native IgAN.
    Methods: Between 2000 and 2021, we conducted a 1:2 matched case-control study of 18 KTRs diagnosed with recurrent IgAN, with a group of native IgAN patients as the control. We evaluated the rate and presence/absence of mesangial C1q deposition in terms of pathological findings and kidney outcomes in each group.
    Results: The rate of mesangial C1q deposition was significantly higher in the recurrent IgAN patients in KTRs than in native IgAN patients (11/18 [61.1%] vs. 5/36 [13.9%], p = 0.001). In the former group, the incidence of glomerular crescents was relatively higher in C1q-positive patients. There was no significant difference in the annual rate of estimated glomerular filtration rate decline between C1q-positive and C1q-negative patients in either group.
    Conclusion: Mesangial C1q deposition was more frequent in KTRs with recurrent IgAN than in patients with native IgAN, but we found no difference in kidney outcomes with respect to mesangial C1q deposition. Further large-scale investigations of the importance of mesangial C1q deposition are needed in both KTRs with recurrent IgAN and patients with native IgAN.
    Mesh-Begriff(e) Humans ; Glomerulonephritis, IGA/complications ; Complement C1q ; Kidney Transplantation ; Case-Control Studies ; Glomerular Mesangium/metabolism
    Chemische Substanzen Complement C1q (80295-33-6)
    Sprache Englisch
    Erscheinungsdatum 2023-06-20
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000530916
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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