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Article ; Online: A case of repeated Kounis syndrome after anaphylactic shock: A note for disease management.

Kawaguchi, Satoshi / Kuroshima, Tatsuki / Namba, Ryo / Satou, Hiroki / Kashiwagi, Riku / Abe, Ai / Okada, Motoi

2024 Volume 11, Issue 1, Page(s) e908

Abstract: Background: Kounis syndrome (KS) is an underdiagnosed disease. The management of the disease remains elusive because of its infrequency.: Case presentation: A 78-year-old man with anaphylactic shock was admitted to our hospital 2 h after multiple bee ...

Abstract	Background: Kounis syndrome (KS) is an underdiagnosed disease. The management of the disease remains elusive because of its infrequency. Case presentation: A 78-year-old man with anaphylactic shock was admitted to our hospital 2 h after multiple bee stings. After recovering from an anaphylactic reaction, he presented with chest pain with ST elevation. We diagnosed him with KS. After a continuous intravenous infusion of vasodilators, his chest pain and ST elevation improved. However, chest pain with ST-segment elevation recurred the next day. Coronary angiography revealed severe stenosis in the middle left anterior descending coronary artery, and drug-eluting stents were implanted. The patient was discharged on foot after treatment for heart failure. Conclusion: KS, in which anaphylaxis and acute coronary syndrome occur simultaneously, can recur repeatedly after an initial anaphylactic reaction; however, it could be delayed or it could present simultaneously with the anaphylactic reaction. Therefore, long-term observation is important.
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Case Reports
ZDB-ID	2751184-4
ISSN	2052-8817 ; 2052-8817
ISSN (online)	2052-8817
ISSN	2052-8817
DOI	10.1002/ams2.908
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of problem-based learning tutor seniority on medical students' emotions: an equivalence study.

Nomura, Osamu / Abe, Tatsuki / Soma, Yuki / Tomita, Hirofumi / Kijima, Hiroshi

BMC medical education

2023 Volume 23, Issue 1, Page(s) 419

Abstract: Background: The effectiveness of peer learning has been recognized and discussed by many scholars, and implemented in the formal curriculums of medical schools internationally. However, there is a general dearth of studies in measuring the objective ... ...

Abstract	Background: The effectiveness of peer learning has been recognized and discussed by many scholars, and implemented in the formal curriculums of medical schools internationally. However, there is a general dearth of studies in measuring the objective outcomes in learning. Methods: We investigated the objective effect of near-peer learning on tutee's emotions and its equivalence within the formal curriculum of a clinical reasoning Problem Based Learning session in a Japanese medical school. Fourth-year medical students were assigned to the group tutored by 6 Results: Of the 143 eligible participant students, 90 were allocated to the peer tutor group and 53 were allocated to the faculty group. There was no significant difference between the groups. The 95% confidence interval of the mean score difference for positive activating emotions (-0.22 to 0.15), positive deactivating emotions (-0.35 to 0.18), negative activating emotions (-0.20 to 0.22), negative deactivating emotions (-0.20 to 0.23), and self-efficacy (-6.83 to 5.04) were withing the predetermined equivalence margins for emotion scores, meaning that equivalence was confirmed for these variables. Conclusions: Emotional outcomes were equivalent between near-peer PBL sessions and faculty-led sessions. This comparative measurement of the emotional outcomes in near-peer learning contributes to understanding PBL in the field of medical education.
MeSH term(s)	Humans ; Problem-Based Learning ; Students, Medical/psychology ; Education, Medical, Undergraduate ; Curriculum ; Emotions
Language	English
Publishing date	2023-06-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-023-04416-9
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Article ; Online: Effect of problem-based learning tutor seniority on medical students’ emotions

Osamu Nomura / Tatsuki Abe / Yuki Soma / Hirofumi Tomita / Hiroshi Kijima

BMC Medical Education, Vol 23, Iss 1, Pp 1-

an equivalence study

2023 Volume 7

Abstract: Abstract Background The effectiveness of peer learning has been recognized and discussed by many scholars, and implemented in the formal curriculums of medical schools internationally. However, there is a general dearth of studies in measuring the ... ...

Abstract	Abstract Background The effectiveness of peer learning has been recognized and discussed by many scholars, and implemented in the formal curriculums of medical schools internationally. However, there is a general dearth of studies in measuring the objective outcomes in learning. Methods We investigated the objective effect of near-peer learning on tutee’s emotions and its equivalence within the formal curriculum of a clinical reasoning Problem Based Learning session in a Japanese medical school. Fourth-year medical students were assigned to the group tutored by 6th-year students or by faculties. The positive activating emotion, positive deactivating emotion, negative activating emotion, negative deactivating emotion, Neutral emotion were measured using the Japanese version of the Medical Emotion Scale (J-MES), and self-efficacy scores were also assessed. We calculated the mean differences of these variables between the faculty and the peer tutor groups and were statistically analyzed the equivalence of these scores. The equivalence margin was defined as a score of 0.4 for J-MES and 10.0 for the self-efficacy score, respectively. Results Of the 143 eligible participant students, 90 were allocated to the peer tutor group and 53 were allocated to the faculty group. There was no significant difference between the groups. The 95% confidence interval of the mean score difference for positive activating emotions (–0.22 to 0.15), positive deactivating emotions (–0.35 to 0.18), negative activating emotions (–0.20 to 0.22), negative deactivating emotions (–0.20 to 0.23), and self-efficacy (–6.83 to 5.04) were withing the predetermined equivalence margins for emotion scores, meaning that equivalence was confirmed for these variables. Conclusions Emotional outcomes were equivalent between near-peer PBL sessions and faculty-led sessions. This comparative measurement of the emotional outcomes in near-peer learning contributes to understanding PBL in the field of medical education.
Keywords	Near-peer learning ; Emotions ; Emotional outcomes ; Control-Value Theory ; Medical education ; Problem-based learning ; Special aspects of education ; LC8-6691 ; Medicine ; R
Subject code	370
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Properties of INDETERMINATE DOMAIN Proteins from

Khan, Saiful Islam / Yamada, Ren / Shiroma, Ryoichi / Abe, Tatsuki / Kozaki, Akiko

Genes

2023 Volume 14, Issue 6

Abstract: INDETERMINATE DOMAIN (IDD) proteins are plant-specific transcription factors that interact with GRAS proteins, such as DELLA and SHORT ROOT (SHR), to regulate target genes. The combination of IDD and DELLA proteins regulates genes involved in gibberellic ...

Abstract	INDETERMINATE DOMAIN (IDD) proteins are plant-specific transcription factors that interact with GRAS proteins, such as DELLA and SHORT ROOT (SHR), to regulate target genes. The combination of IDD and DELLA proteins regulates genes involved in gibberellic acid (GA) synthesis and GA signaling, whereas the combination of IDD with the complex of SHR and SCARECROW, another GRAS protein, regulates genes involved in root tissue formation. Previous bioinformatic research identified seven
MeSH term(s)	Arabidopsis/genetics ; Arabidopsis/metabolism ; Transcription Factors/metabolism ; Plants/genetics ; Signal Transduction/physiology ; Bryopsida/genetics ; DNA/metabolism
Chemical Substances	Transcription Factors ; DNA (9007-49-2)
Language	English
Publishing date	2023-06-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14061249
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Article ; Online: Absolute local conformation of poly(methyl methacrylate) chains adsorbed on a quartz surface.

Kawaguchi, Daisuke / Sasahara, Kazuki / Inutsuka, Manabu / Abe, Tatsuki / Yamamoto, Satoru / Tanaka, Keiji

The Journal of chemical physics

2023 Volume 159, Issue 24

Abstract: Polymer chains at a buried interface with an inorganic solid play a critical role in the performance of polymer nanocomposites and adhesives. Sum frequency generation (SFG) vibrational spectroscopy with a sub-nanometer depth resolution provides valuable ... ...

Abstract	Polymer chains at a buried interface with an inorganic solid play a critical role in the performance of polymer nanocomposites and adhesives. Sum frequency generation (SFG) vibrational spectroscopy with a sub-nanometer depth resolution provides valuable information regarding the orientation angle of functional groups at interfaces. However, in the case of conventional SFG, since the signal intensity is proportional to the square of the second-order nonlinear optical susceptibility and thereby loses phase information, it cannot be unambiguously determined whether the functional groups face upward or downward. This problem can be solved by phase-sensitive SFG (ps-SFG). We here applied ps-SFG to poly(methyl methacrylate) (PMMA) chains in direct contact with a quartz surface, shedding light on the local conformation of chains adsorbed onto the solid surface. The measurements made it possible to determine the absolute orientation of the ester methyl groups of PMMA, which were oriented toward the quartz interface. Combining ps-SFG with all-atomistic molecular dynamics simulation, the distribution of the local conformation and the driving force are also discussed.
Language	English
Publishing date	2023-12-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0184315
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Article ; Online: Neuralgic Amyotrophy After COVID-19 Vaccination in an Adolescent: Successful Intravenous Immunoglobulin Treatment.

Fukahori, Kyoko / Saito, Naka / Abe, Yu / Ikuse, Tatsuki / Tohyama, Jun / Saitoh, Akihiko

Pediatric neurology

2022 Volume 140, Page(s) 50–51

MeSH term(s)	Humans ; Adolescent ; Immunoglobulins, Intravenous ; COVID-19 Vaccines ; Brachial Plexus Neuritis/therapy ; COVID-19 ; Vaccination
Chemical Substances	Immunoglobulins, Intravenous ; COVID-19 Vaccines
Language	English
Publishing date	2022-11-26
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	639164-3
ISSN	1873-5150 ; 0887-8994
ISSN (online)	1873-5150
ISSN	0887-8994
DOI	10.1016/j.pediatrneurol.2022.11.014
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Article ; Online: Properties of INDETERMINATE DOMAIN Proteins from Physcomitrium patens: DNA-Binding, Interaction with GRAS Proteins, and Transcriptional Activity

Khan, Saiful Islam / Yamada, Ren / Shiroma, Ryoichi / Abe, Tatsuki / Kozaki, Akiko

Genes (Basel). 2023 June 11, v. 14, no. 6

2023

Abstract	INDETERMINATE DOMAIN (IDD) proteins are plant-specific transcription factors that interact with GRAS proteins, such as DELLA and SHORT ROOT (SHR), to regulate target genes. The combination of IDD and DELLA proteins regulates genes involved in gibberellic acid (GA) synthesis and GA signaling, whereas the combination of IDD with the complex of SHR and SCARECROW, another GRAS protein, regulates genes involved in root tissue formation. Previous bioinformatic research identified seven IDDs, two DELLA, and two SHR genes in Physcomitrium patens, a model organism for non-vascular plants (bryophytes), which lack a GA signaling pathway and roots. In this study, DNA-binding properties and protein–protein interaction of IDDs from P. patens (PpIDD) were analyzed. Our results showed that the DNA-binding properties of PpIDDs were largely conserved between moss and seed plants. Four PpIDDs showed interaction with Arabidopsis DELLA (AtDELLA) proteins but not with PpDELLAs, and one PpIDD showed interaction with PpSHR but not with AtSHR. Moreover, AtIDD10 (JACKDAW) interacted with PpSHR but not with PpDELLAs. Our results indicate that DELLA proteins have modified their structure to interact with IDD proteins during evolution from moss lineage to seed plants, whereas the interaction of IDD and SHR was already present in moss lineage.
Keywords	Arabidopsis ; Corvus monedula ; Physcomitrium ; bioinformatics ; evolution ; gibberellic acid ; mosses and liverworts ; protein-protein interactions ; transcription (genetics)
Language	English
Dates of publication	2023-0611
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14061249
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Efficacy and Safety of Platinum Rechallenge in Patients With Platinum-resistant Ovarian, Fallopian Tube or Primary Peritoneal Cancer: A Multicenter Retrospective Study.

Tatsuki, Shunsuke / Shoji, Tadahiro / Abe, Marina / Tomabechi, Hidetoshi / Takatori, Eriko / Kaido, Yoshitaka / Nagasawa, Takayuki / Kagabu, Masahiro / Aida, Takeshi / Baba, Tsukasa

Anticancer research

2022 Volume 42, Issue 9, Page(s) 4603–4610

Abstract: Background/aim: Ovarian cancer diagnosed with platinum-resistant recurrence has very poor prognosis and single-agent chemotherapy with no cross-resistance to prior chemotherapy is recommended for its treatment. In this study, we retrospectively ... ...

Abstract	Background/aim: Ovarian cancer diagnosed with platinum-resistant recurrence has very poor prognosis and single-agent chemotherapy with no cross-resistance to prior chemotherapy is recommended for its treatment. In this study, we retrospectively evaluated the efficacy and safety of platinum rechallenge therapy for once diagnosed with platinum-resistant ovarian cancer who had a platinum-free interval (PFI) of at least 6 months. Patients and methods: The study included 49 patients who received platinum rechallenge therapy for ovarian, fallopian tube or primary peritoneal cancer who were once diagnosed with platinum-resistant recurrence between January 2010 and March 2021 and evaluated the efficacy and safety of this treatment. In addition, patient background factors were identified, and independent prognostic factors for progression-free survival (PFS) and overall survival (OS) were investigated. Results: A complete response was noted in 7 cases, partial response in 21, stable disease in 9, and progressive disease in 10. The response and disease control rates were 55% and 76%, respectively. The median PFS and OS were 8.5 months and 35.8 months, respectively. The independent prognostic factor was PFI for OS, and there was no independent prognostic factor for PFS. Seven patients discontinued chemotherapy owing to serious adverse events, including one patient with treatment-related death. Conclusion: Platinum rechallenge therapy for patients with platinum-resistant recurrence did not cause previously unreported adverse events, and the adverse events were manageable. In addition, high response and disease control rates were observed, as well as long-term OS. Platinum rechallenge therapy for platinum-resistant ovarian cancer may be a viable treatment option.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Ovarian Epithelial/drug therapy ; Drug Resistance, Neoplasm ; Fallopian Tube Neoplasms/drug therapy ; Fallopian Tubes ; Female ; Humans ; Neoplasm Recurrence, Local/chemically induced ; Neoplasm Recurrence, Local/drug therapy ; Ovarian Neoplasms/drug therapy ; Peritoneal Neoplasms/drug therapy ; Platinum/adverse effects ; Retrospective Studies
Chemical Substances	Platinum (49DFR088MY)
Language	English
Publishing date	2022-08-29
Publishing country	Greece
Document type	Journal Article ; Multicenter Study
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.15964
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Article: [A Case of Appendiceal Carcinoma with BRAF V600E Mutation and Microsatellite Instability-High].

Inagaki, Tatsuki / Tajima, Yosuke / Shimada, Yoshifumi / Nakano, Mae / Nakano, Masato / Abe, Kaoru / Yamai, Daisuke / Ozeki, Hikaru / Muneoka, Yusuke / Ishikawa, Hirosuke / Kano, Yosuke / Ichikawa, Hiroshi / Takizawa, Kazuyasu / Sakata, Jun / Wakai, Toshifumi

Gan to kagaku ryoho. Cancer & chemotherapy

2024 Volume 50, Issue 13, Page(s) 1584–1586

Abstract: A 75-year-old woman presented to our hospital with abdominal pain and melena. Colonoscopy revealed an ulcer at the appendiceal orifice. Histopathological examination of biopsy specimens revealed adenocarcinoma. Computed tomography showed an appendiceal ... ...

Abstract	A 75-year-old woman presented to our hospital with abdominal pain and melena. Colonoscopy revealed an ulcer at the appendiceal orifice. Histopathological examination of biopsy specimens revealed adenocarcinoma. Computed tomography showed an appendiceal mass of 11.8×6.7 cm in size involving the cecum and terminal ileum without any distant metastatic findings. Ileocecal resection with regional lymph node dissection to the root of the ileocolonic artery was performed. Histopathological examination of the specimen revealed appendiceal adenocarcinoma. Molecular subtype of the tumor was BRAF V600E mutation and microsatellite instability-high(MSI-H). The pathological stage was pT4bpN1bcM0, pStage ⅢC. She received 8 courses of CapeOX as adjuvant chemotherapy and no recurrence was noted 12 months following the surgery. The establishment of standard treatment strategies including surgery, chemotherapy, and immunotherapy for carcinoma of the appendix with BRAF V600E mutation and/or MSI-H is needed.
MeSH term(s)	Female ; Humans ; Aged ; Proto-Oncogene Proteins B-raf/genetics ; Microsatellite Instability ; Appendiceal Neoplasms/genetics ; Appendiceal Neoplasms/surgery ; Appendiceal Neoplasms/pathology ; Appendix ; Adenocarcinoma ; Carcinoma ; Mutation
Chemical Substances	Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; BRAF protein, human (EC 2.7.11.1)
Language	Japanese
Publishing date	2024-02-01
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Intergenerational Theater Workshops as Unique Recreational Activities among Older Adults in Japanese Care Facilities: A Qualitatively Driven Mixed-Methods Multiple-Case Study Design.

Abe, Michiko / Gyo, Ren / Shibata, Junro / Okazaki, Kentaro / Inoue, Rumiko / Oishi, Tatsuki / Inoue, Machiko

International journal of environmental research and public health

2022 Volume 19, Issue 18

Abstract: Intergenerational theater activities have been recently employed in recreation for older adults. We held a series of four intergenerational theater workshops in two older adults' care facilities in Japan and sought the experiences of older participants, ... ...

Abstract	Intergenerational theater activities have been recently employed in recreation for older adults. We held a series of four intergenerational theater workshops in two older adults' care facilities in Japan and sought the experiences of older participants, younger participants, and the facility managers. With a qualitatively driven mixed-methods multiple-case study design, we obtained data from field observation, interviews with participants, and preworkshop and postworkshop changes on a well-being scale (Ikigai-9) among older participants, and the results of the two sites were compared. "Immediate effects" were seen in older adults because they responded actively and demonstrated surprising faculties during the workshop. Facility staff members and younger participants received "extended effects" because they gained new ideas regarding the remaining skills of older participants and a sense of reuniting with old neighbors through the exercise. In the Ikigai-9 scale, the items measuring "present happiness" significantly improved at Site 1 but not at Site 2. Better results at Site 1 might have been caused by the lower care needs of participants and the inclusion of children. Less support from facility staff members during the activities also might have promoted the voluntary participation of older adults. Involving children and engaging the facility staff in preparation could enhance the quality of activities.
MeSH term(s)	Aged ; Child ; Happiness ; Humans ; Japan ; Research Design
Language	English
Publishing date	2022-09-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph191811474
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