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  1. Article: Editorial: Transplant Oncology of Liver Malignancies.

    Ho, Cheng-Maw

    Frontiers in surgery

    2022  Volume 8, Page(s) 811223

    Language English
    Publishing date 2022-01-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2021.811223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Oxygen "therapy" for infection in liver transplant surgery: less is more, enough is enough.

    Ho, Cheng-Maw / Sun, Hsin-Yun

    BMC medicine

    2023  Volume 21, Issue 1, Page(s) 52

    MeSH term(s) Humans ; Liver Transplantation ; Liver ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-02-13
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2131669-7
    ISSN 1741-7015 ; 1741-7015
    ISSN (online) 1741-7015
    ISSN 1741-7015
    DOI 10.1186/s12916-023-02767-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Recovery from antibody-mediated biliary ductopenia and multiorgan inflammation after COVID-19 vaccination.

    Chang, Alan / Jeng, Yung-Ming / Ho, Cheng-Maw / Lee, Po-Huang

    NPJ vaccines

    2024  Volume 9, Issue 1, Page(s) 75

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic has caused significant morbidity and mortality. Spike messenger RNA (mRNA)-based vaccines against severe acute respiratory syndrome coronavirus 2 may contribute to immune-mediated injuries. Here we present ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic has caused significant morbidity and mortality. Spike messenger RNA (mRNA)-based vaccines against severe acute respiratory syndrome coronavirus 2 may contribute to immune-mediated injuries. Here we present a case of a previously healthy 47-year-old man, who developed progressive jaundice 2 weeks after receiving his 3
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-024-00861-9
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  4. Article: Artificial Intelligence in Medical OSCEs: Reflections and Future Developments.

    Soong, Tse Kiat / Ho, Cheng-Maw

    Advances in medical education and practice

    2021  Volume 12, Page(s) 167–173

    Abstract: With the advent of the age of Artificial Intelligence (AI), we seek to consider how AI could shape clinical examinations, specifically Objective Structured Clinical Examinations (OSCEs). OSCEs, whilst having its own limitations, could be further enhanced ...

    Abstract With the advent of the age of Artificial Intelligence (AI), we seek to consider how AI could shape clinical examinations, specifically Objective Structured Clinical Examinations (OSCEs). OSCEs, whilst having its own limitations, could be further enhanced with new technologies like AI to help better assess and prepare our future clinicians. With the everchanging requirements on the modern clinician, we deliberate the strengths and weaknesses of AI, and the need for emphasis on different skills to complement rather than resist the tides of change. In conclusion, we feel that AI has the potential to be a strong driving force in remodelling OSCEs to support future doctors and could serve as a new frontier in medical education and beyond. That being said, we recognize the technology and its applications are still in its infancy, and further study will be needed to eluciate the role of AI in medical education and in the greater landscape of medical practice.
    Language English
    Publishing date 2021-02-18
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2578539-4
    ISSN 1179-7258
    ISSN 1179-7258
    DOI 10.2147/AMEP.S287926
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  5. Article ; Online: Is the Rationale of Anatomical Liver Resection for Hepatocellular Carcinoma Universally Adoptable? A Hypothesis-Driven Review.

    Lin, Young-Jen / Ho, Cheng-Maw

    Medicina (Kaunas, Lithuania)

    2021  Volume 57, Issue 2

    Abstract: Surgical resection is the first-line curative treatment modality for resectable hepatocellular carcinoma (HCC). Anatomical resection (AR), described as systematic removal of a liver segment confined by tumor-bearing portal tributaries, may improve ... ...

    Abstract Surgical resection is the first-line curative treatment modality for resectable hepatocellular carcinoma (HCC). Anatomical resection (AR), described as systematic removal of a liver segment confined by tumor-bearing portal tributaries, may improve survival by reducing the risk of tumor recurrence compared with non-AR. In this article, we propose the rationale for AR and its universal adoption by providing supporting evidence from the advanced understanding of a tumor microenvironment and accumulating clinical experiences of locoregional tumor ablation therapeutics. AR may be advantageous because it completely removes the en-bloc by interrupting tumor vascular supply and thus extirpates the spreading of tumor microthrombi, if they ever exist, within the supplying portal vein. However, HCC is a hypervascular tumor that can promote neoangiogenesis in the local tumor microenvironment, which in itself can break through the anatomical boundary within the liver and even retrieve nourishment from extrahepatic vessels, such as inferior phrenic or omental arteries. Additionally, increasing clinical evidence for locoregional tumor ablation therapies, such as radiofrequency ablation, predominantly performed as a non-anatomical approach, suggests comparable outcomes for surgical resection, particularly in small HCC and colorectal, hepatic metastases. Moreover, liver transplantation for HCC, which can be considered as AR of the whole liver followed by implantation of a new graft, is not universally free from post-transplant tumor recurrence. Overall, AR should not be considered the gold standard among all surgical resection methods. Surgical resection is fundamentally reliant on choosing the optimal margin width to achieve en-bloc tumor niche removal while balancing between oncological radicality and the preservation of postoperative liver function. The importance of this is to liberate surgical resilience in hepatocellular carcinoma. The overall success of HCC treatment is determined by the clearance of the theoretical niche. Developing biomolecular-guided navigation device/technologies may provide surgical guidance toward the total removal of microscopic tumor niche to achieve superior oncological outcomes.
    MeSH term(s) Carcinoma, Hepatocellular/surgery ; Hepatectomy ; Humans ; Liver Neoplasms/surgery ; Neoplasm Recurrence, Local ; Tumor Microenvironment
    Language English
    Publishing date 2021-02-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina57020131
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
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  6. Article ; Online: Comment on "Effect of Remote Ischemic Preconditioning Conducted in Living Liver Donors on Postoperative Liver Function in Donors and Recipients After Liver Transplantation".

    Ho, Cheng-Maw / Hu, Rey-Heng

    Annals of surgery

    2020  Volume 274, Issue 6, Page(s) e821

    MeSH term(s) Humans ; Ischemic Preconditioning ; Liver ; Liver Transplantation ; Living Donors
    Language English
    Publishing date 2020-11-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000004512
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    Uk I Zs.35/1: Show issues Location:
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  7. Article ; Online: Risk factors, patterns, and outcome predictors of late recurrence in patients with hepatocellular carcinoma after curative resection: A large cohort study with long-term follow-up results.

    Hsiao, Chih-Yang / Ho, Cheng-Maw / Ho, Ming-Chih / Cheng, Hou-Ying / Wu, Yao-Ming / Lee, Po-Huang / Hu, Rey-Heng

    Surgery

    2024  

    Abstract: Background: Late recurrence of hepatocellular carcinoma after curative resection significantly influences long-term patient survival outcomes, and yet it remains understudied. This study aims to explore the risk factors and patterns of late recurrence ... ...

    Abstract Background: Late recurrence of hepatocellular carcinoma after curative resection significantly influences long-term patient survival outcomes, and yet it remains understudied. This study aims to explore the risk factors and patterns of late recurrence and predictors of subsequent outcome.
    Methods: This single-center retrospective study analyzed 1,701 consecutive patients who achieved a disease-free survival period exceeding 2 years after curative resection for hepatocellular carcinoma between 2001 and 2018. Univariate and multivariate analyses of factors associated with late recurrence and death after recurrence were conducted using Cox's models.
    Results: The mean age of patients was 60.2 years, with 76.8% being male. During a median follow-up of 8.1 years, 653 patients (38.4%) experienced late recurrence, with median time to recurrence being 4.0 years (interquartile range, 2.7-6.0). Factors such as age >60, chronic hepatitis C, cirrhosis, high albumin-bilirubin grade, absence of family history, multiple tumors, satellite nodules, alpha-fetoprotein levels <400 ng/mL, and minor hepatic resection were identified as risk factors for late recurrence. Among patients with late recurrence, 131 (20.1%) underwent surgical treatment, 272 (41.7%) received radiofrequency ablation, and 27 (4.1%) exhibited extrahepatic lesions. A higher-high albumin-bilirubin grade, recurrent tumor >3 cm, and nonsurgical treatment emerged as predictors of death after late recurrence.
    Conclusion: Over one-third of patients who remain disease-free for more than 2 years postresection will experience late recurrence during subsequent follow-up. For 2-year disease-free survivors, risk factors for late recurrence differ from early recurrence. Treating underlying hepatitis is of paramount importance, given its association with both the risk of late recurrence and survival outcomes post-recurrence.
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2024.02.006
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    Uk I Zs.129: Show issues Location:
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  8. Article ; Online: Longitudinal analysis of liver transplant candidates for hepatocellular carcinoma in a single center.

    Ho, Cheng-Maw / Lee, Po-Huang / Cheng, Hou-Ying / Hsaio, Chih-Yang / Wu, Yao-Ming / Ho, Ming-Chih / Hu, Rey-Heng

    Langenbeck's archives of surgery

    2024  Volume 409, Issue 1, Page(s) 143

    Abstract: Background: Wailitst lost is an critical issue and we investigated the long-term effect of insufficient liver functional reserve at liver transplantation evaluation on waitlist outcomes in patients with hepatocellular carcinoma (HCC).: Methods: ... ...

    Abstract Background: Wailitst lost is an critical issue and we investigated the long-term effect of insufficient liver functional reserve at liver transplantation evaluation on waitlist outcomes in patients with hepatocellular carcinoma (HCC).
    Methods: Clinical data of patients with HCC waitlisted for liver transplantation were retrospectively collected from a single hospital cohort during the period from 2014 to 2021. Parameters of liver reserve, including cirrhosis, Child-Pugh grade, and Model for End-Stage Liver Disease (MELD) scores, were analyzed for patient survival, after adjustment for tumor factors.
    Results: Of 292 eligible patients, 94.2% had cirrhosis, 55.8% had Child-Pugh grade B or C, and the median MELD score was 13.2. The median follow-up time was 2.2 years, with a dropout rate of 62.7%. Eighty-nine candidates (30.5%) eventually received liver transplant, including 67 from live donors. The estimated 1-year mortality rate reached 40.6% in 203 patients who remained on the waitlist without receiving a transplant, of whom 143 died. Most deaths were attributed to liver failure (37.1%) and cancer death (35.7%). After we adjusted for tumor confounders, including alpha fetoprotein, primary HCC stage, tumor number at evaluation, and sequential cancer treatment before and while waiting, hazard ratios (HRs) for patient survival were 1.69 (95% confidence interval, 1.18-2.41) for cirrhotic stage B or C, 1.07 (1.04-1.10) for MELD scores, and 1.14 (1.04-1.25) for tumor size at transplant evaluation. Transplantation was a protective disease modifier with adjusted HR 0.22 (0.14-0.33).
    Conclusion: Insufficient liver functional reserve poses more risk than expected to liver transplant waitlist outcomes with HCC.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/surgery ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/pathology ; Liver Transplantation ; Liver Neoplasms/surgery ; Liver Neoplasms/mortality ; Liver Neoplasms/pathology ; Male ; Female ; Waiting Lists/mortality ; Middle Aged ; Retrospective Studies ; Longitudinal Studies ; Aged ; Adult ; Survival Rate
    Language English
    Publishing date 2024-04-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-024-03336-6
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    Uk I Zs.10: Show issues Location:
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  9. Article ; Online: Comment on "Is It Time to Abandon the Milan Criteria?"

    Ho, Cheng-Maw / Hu, Rey-Heng

    Annals of surgery

    2019  Volume 270, Issue 6, Page(s) e85

    MeSH term(s) Carcinoma, Hepatocellular ; Humans ; Liver Neoplasms ; Liver Transplantation ; Patient Selection ; Time Factors
    Language English
    Publishing date 2019-11-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000003244
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    Uk I Zs.35/1: Show issues Location:
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  10. Article: Appendicitis-mimicking presentation in fishbone induced microperforation of the distal duodenum: A case report.

    Lim, Daniel / Ho, Cheng-Maw

    World journal of gastrointestinal surgery

    2020  Volume 12, Issue 2, Page(s) 77–84

    Abstract: Background: Upper gastrointestinal fishbone microperforations are rare and not commonly reported in medical literature. Despite the increasing use of computer tomography (CT) imaging and the employment of the Alvardo criteria, misdiagnosis of acute ... ...

    Abstract Background: Upper gastrointestinal fishbone microperforations are rare and not commonly reported in medical literature. Despite the increasing use of computer tomography (CT) imaging and the employment of the Alvardo criteria, misdiagnosis of acute appendicitis can still occur. We report the rare case of an elderly Chinese gentleman who had a fish-bone induced microperforation of the duodenum that closely mimicked the symptoms of acute appendicitis.
    Case summary: This 79-year-old man presented with migratory lower abdominal pain that localized at his periumbilical region and right lower quadrant. He had associated pyrexia, general malaise and was noted to have an elevated white cell count. CT investigations initially revealed a distended appendix which was resected laparoscopically but showed no obvious signs of gross inflammation. The patient then deteriorated clinically and had increased oxygen requirements immediately after the surgery. This prompted further investigations. A further review of his CT scan revealed a fine fishbone microperforation in the distal duodenum associated with retroperitoneal abscess formation and seepage extending into the right lower quadrant. He was then started on broad spectrum intravenous antibiotics and subsequently underwent a laparotomy 12 h later to manage the obscure aetiology and to drain the abscess. The post-operative course was uneventful and he was discharged 11 d later including a 2-d stay in the intensive care unit.
    Conclusion: This case offers an insight into a potential mimic of acute appendicitis and the diagnostic difficulties experienced in such presentations.
    Language English
    Publishing date 2020-02-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2573700-4
    ISSN 1948-9366
    ISSN 1948-9366
    DOI 10.4240/wjgs.v12.i2.77
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