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Article ; Online: Potential role of GcMAF in suppressing the severity of COVID-19-induced immune responses: Lesson learned from HIV.

Spadera, Lucrezia / Spadera, Maria

2020 Volume 144, Page(s) 110293

MeSH term(s)	COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/therapy ; DNA-Binding Proteins/genetics ; Estrogens/metabolism ; HIV Infections/epidemiology ; HIV Infections/immunology ; HIV Infections/therapy ; Humans ; Immune System ; Immunotherapy ; Italy/epidemiology ; Macrophage-Activating Factors/immunology ; Models, Theoretical ; Neoplasms/immunology ; Pandemics ; Polymorphism, Genetic ; Transcription Factors/genetics ; Vitamin D/genetics ; Vitamin D-Binding Protein/immunology ; COVID-19 Drug Treatment
Chemical Substances	DBP protein, human ; DNA-Binding Proteins ; Estrogens ; Macrophage-Activating Factors ; Transcription Factors ; Vitamin D-Binding Protein ; vitamin D-binding protein-macrophage activating factor ; Vitamin D (1406-16-2)
Language	English
Publishing date	2020-09-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	193145-3
ISSN	1532-2777 ; 0306-9877
ISSN (online)	1532-2777
ISSN	0306-9877
DOI	10.1016/j.mehy.2020.110293
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Article: Potential Role of GcMAF in suppressing the severity of COVID-19-induced immune responses: lesson learned from HIV

Spadera, Lucrezia / Spadera, Maria

Medical Hypotheses

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #793570
Database	COVID19

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Article ; Online: Potential role of GcMAF in suppressing the severity of COVID-19-induced immune responses

Spadera, Lucrezia / Spadera, Maria

Medical Hypotheses

Lesson learned from HIV

2020 Volume 144, Page(s) 110293

Keywords	General Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	193145-3
ISSN	1532-2777 ; 0306-9877
ISSN (online)	1532-2777
ISSN	0306-9877
DOI	10.1016/j.mehy.2020.110293
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Article ; Online: Adjunctive use of oral MAF is associated with no disease progression or mortality in hospitalized patients with COVID-19 pneumonia: The single-arm COral-MAF1 prospective trial.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 169, Page(s) 115894

Abstract: Based on a growing body of evidence that a dysregulated innate immune response mediated by monocytes/macrophages plays a key role in the pathogenesis of COVID-19, a clinical trial was conducted to investigate the therapeutic potential and safety of oral ... ...

Abstract	Based on a growing body of evidence that a dysregulated innate immune response mediated by monocytes/macrophages plays a key role in the pathogenesis of COVID-19, a clinical trial was conducted to investigate the therapeutic potential and safety of oral macrophage activating factor (MAF) plus standard of care (SoC) in the treatment of hospitalized patients with COVID-19 pneumonia. Ninety-seven hospitalized patients with confirmed COVID-19 pneumonia were treated with oral MAF and a vitamin D3 supplement, in combination with SoC, in a single-arm, open label, multicentre, phase II clinical trial. The primary outcome measure was a reduction in an intensive care unit transfer rate below 13% after MAF administration. At the end of the study, an additional propensity score matching (PSM) analysis was performed to compare the MAF group with a control group treated with SoC alone. Out of 97 patients treated with MAF, none needed care in the ICU and/or intubation with mechanical ventilation or died during hospitalization. Oxygen therapy was discontinued after a median of nine days of MAF treatment. The median length of viral shedding and hospital stay was 14 days and 18 days, respectively. After PSM, statistically significant differences were found in all of the in-hospital outcomes between the two groups. No mild to serious adverse events were recorded during the study. Notwithstanding the limitations of a single-arm study, which prevented deﬁnitive conclusions, a 21-day course of MAF treatment plus SoC was found to be safe and promising in the treatment of hospitalized adult patients with COVID-19 pneumonia. Further research will be needed to confirm these preliminary findings.
MeSH term(s)	Adult ; Humans ; COVID-19 ; Disease Progression ; Hospitalization ; Length of Stay ; Prospective Studies ; SARS-CoV-2 ; Treatment Outcome
Language	English
Publishing date	2023-11-21
Publishing country	France
Document type	Clinical Trial ; Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115894
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Article ; Online: Symptom improvement after transtympanic tube placement in Ménière's disease: preliminary observations.

Marcelli, Vincenzo / Spadera, Lucrezia / De Bernardo, Erica / Barba, Giuseppe / Martino, Eugenio / Gentile, Marcello / Tortoriello, Giuseppe

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

2021 Volume 41, Issue 5, Page(s) 467–473

Abstract: Objective: The treatment of choice for Ménière disease (MD) aims at preventing severity and frequency of vertigo attacks. The purpose of this study was to evaluate the effectiveness of ventilation tube (VT) placement on vertigo control in patients ... ...

Abstract	Objective: The treatment of choice for Ménière disease (MD) aims at preventing severity and frequency of vertigo attacks. The purpose of this study was to evaluate the effectiveness of ventilation tube (VT) placement on vertigo control in patients affected by MD with no response to standard medical therapy. Methods: 76 consecutive outpatients diagnosed with definite MD who failed medical therapy received VT insertion at the Department of Otolaryngology Head and Neck Surgery, "Ospedale del Mare", Naples, Italy, with a 3-year follow up. Results: Over the long term, VT placement was effective in controlling vertigo in 61.8% of patients. In the control group treated with standard preventive care (SPC) alone, all patients continued to experience recurrent vertigo during the entire study. Comparison of survival curves by using the log-rank test shows that significant differences in survival exist between subjects treated with VT placement and the control sample (p = 0.001). Conclusions: Our long-term follow-up confirms that VT placement is an effective and safe management option in intractable definite MD, especially in the elderly or in those refusing more invasive treatments.
MeSH term(s)	Aged ; Animals ; Dizziness ; Female ; Horses ; Humans ; Italy ; Meniere Disease ; Middle Ear Ventilation ; Vertigo
Language	English
Publishing date	2021-11-25
Publishing country	Italy
Document type	Journal Article
ZDB-ID	604898-5
ISSN	1827-675X ; 0392-100X
ISSN (online)	1827-675X
ISSN	0392-100X
DOI	10.14639/0392-100X-N1705
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Article ; Online: Carotid artery disease and stroke in patients with peripheral arterial disease. The role of inflammation

Giusy Sirico / Lucrezia Spadera / Mario De Laurentis / Gregorio Brevetti

Monaldi Archives for Chest Disease, Vol 72, Iss

2016 Volume 1

Abstract: Although during the last decade there have been great advances in our knowledge of the epidemiology and pathophysiology of multi-district atherosclerotic disease, little is known about the association between peripheral arterial disease and carotid ... ...

Abstract	Although during the last decade there have been great advances in our knowledge of the epidemiology and pathophysiology of multi-district atherosclerotic disease, little is known about the association between peripheral arterial disease and carotid artery disease. This review was conceived to cast some light on this topic, paying special attention to inflammation which plays a pivotal role in atherosclerosis. An aspect of pathophysiologic and clinical relevance is that the coexistence of carotid disease is more frequent in peripheral arterial disease than in coronary artery disease, not only in terms of carotid stenosis, but also with respect to the presence of hypoechoic unstable plaque. These latter plaques present a large infiltration of macrophages and are associated to high levels of inflammatory markers. In particular, the greater prevalence of hypoechoic carotid plaques in peripheral arterial disease compared to patients with carotid artery disease was poorly related to classic risk factors, but showed an independent association with an increased number of leukocyte and neutrophil cells, which are reliable markers of inflammation. The greater prevalence of hypoechoic unstable carotid plaques could explain why peripheral arterial disease portends higher risk of stroke than coronary artery disease.
Keywords	peripheral arterial disease ; carotid artery disease ; stroke ; polyvascular disease ; inflammation ; Medicine ; R
Subject code	610
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The role of endogenous Antisecretory Factor (AF) in the treatment of Ménière's Disease: A two-year follow-up study. Preliminary results.

Viola, Pasquale / Pisani, Davide / Scarpa, Alfonso / Cassandro, Claudia / Laria, Carla / Aragona, Teodoro / Ciriolo, Marco / Spadera, Lucrezia / Ralli, Massimo / Cavaliere, Michele / Iengo, Maurizio / Chiarella, Giuseppe

American journal of otolaryngology

2020 Volume 41, Issue 6, Page(s) 102673

Abstract: Purpose: To evaluate the effects of increased endogenous Antisecretory Factor (AF) synthesis using specially processed cereals (SPC) in a sample of patients with defined unilateral Meniere's disease (MD), compared to the results of a treatment protocol ... ...

Abstract	Purpose: To evaluate the effects of increased endogenous Antisecretory Factor (AF) synthesis using specially processed cereals (SPC) in a sample of patients with defined unilateral Meniere's disease (MD), compared to the results of a treatment protocol of intravenous glycerol and dexamethasone. Materials and methods: Twenty-six patients with unilateral MD were divided in 2 groups and treated with SPC and with intravenous glycerol and dexamethasone for 24 months. Audio-vestibular evaluation was performed before (T0) and every six months. The number of vertigo spells were evaluated before and after therapy and the Efficacy Index (EI) was calculated. Questionnaires for hearing loss, tinnitus and quality of life were administered. Results: EI decreased in the SPC group after 18 (T18) (p = .0017) and 24 (T24) months of therapy (p = .0111). There was a significant reduction for tinnitus score in the SPC group at T24 (p = .0131). No significant differences were found between the two groups at T0 (p = .4723), while a significant difference was found at T24 (p = .0027). Quality of life showed a significant improvement in daily activities in the SPC group (p = .0033) compared to the infusion therapy group. No statistically significant changes in PTA thresholds were found in both groups between T0 and T24. Conclusion: The preliminary results of our study show a significant reduction of vertigo spells and a positive effect on tinnitus severity and on quality of life in patients with unilateral MD treated with SPC and when compared to patients treated with intravenous glycerol and dexamethasone. No effects on hearing thresholds were noted in both groups.
MeSH term(s)	Adult ; Aged ; Dexamethasone/administration & dosage ; Edible Grain ; Female ; Follow-Up Studies ; Foods, Specialized ; Glycerol/administration & dosage ; Hearing ; Humans ; Infusions, Intravenous ; Male ; Meniere Disease/diet therapy ; Meniere Disease/drug therapy ; Meniere Disease/physiopathology ; Middle Aged ; Neuropeptides/biosynthesis ; Patient Outcome Assessment ; Quality of Life ; Surveys and Questionnaires ; Time Factors
Chemical Substances	Neuropeptides ; antisecretory factor ; Dexamethasone (7S5I7G3JQL) ; Glycerol (PDC6A3C0OX)
Language	English
Publishing date	2020-08-11
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	604541-8
ISSN	1532-818X ; 0196-0709
ISSN (online)	1532-818X
ISSN	0196-0709
DOI	10.1016/j.amjoto.2020.102673
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Article ; Online: Sudden olfactory loss as an early marker of COVID-19: a nationwide Italian survey.

Spadera, Lucrezia / Viola, Pasquale / Pisani, Davide / Scarpa, Alfonso / Malanga, Donatella / Sorrentino, Gerardo / Madini, Enrico / Laria, Carla / Aragona, Teodoro / Leopardi, Gianluca / Maggiore, Giandomenico / Ciriolo, Marco / Boccuto, Luigi / Pizzolato, Raffaella / Abenavoli, Ludovico / Cassandro, Claudia / Ralli, Massimo / Cassandro, Ettore / Chiarella, Giuseppe

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2020 Volume 278, Issue 1, Page(s) 247–255

Abstract: Purpose: The presence of many asymptomatic COVID-19 cases may increase the risks of disease dissemination, mainly for physicians. There are numerous reports on the frequent findings of sudden anosmia or hyposmia, before or at the same time of the ... ...

Abstract	Purpose: The presence of many asymptomatic COVID-19 cases may increase the risks of disease dissemination, mainly for physicians. There are numerous reports on the frequent findings of sudden anosmia or hyposmia, before or at the same time of the typical COVID-19 symptoms onset. The aim of this study was to verify the association of olfactory impairment and COVID-19, providing a basis for subsequent research in the field of COVID-19 clinical heterogeneity. Methods: We developed a 15-item online questionnaire on "Sudden Olfactory Loss (SOL) and COVID-19" that was administered during March 2020 to Italian general practitioners registered to a social media group. Results: One hundred and eighty responses were received. SOL was identified as a significant sign of infection in COVID-19 patients, mainly aged between 30 and 40 years, even in the absence of other symptoms. SOL was present as an initial symptom in 46.7% of subjects, and in 16.7%, it was the only symptom. Among the COVID-19 confirmed cases, SOL occurred as the only symptom in 19.2% of patients. Conclusion: SOL could represent a possible early symptom in otherwise asymptomatic COVID-19 subjects. Subjects affected by SOL should be considered as potential COVID-19 cases. Level of evidence: 4.
MeSH term(s)	Adult ; Anosmia/diagnosis ; Anosmia/epidemiology ; Anosmia/etiology ; Biomarkers ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; Female ; Humans ; Italy/epidemiology ; Male ; Middle Aged ; Olfaction Disorders/diagnosis ; Olfaction Disorders/epidemiology ; Olfaction Disorders/etiology ; SARS-CoV-2 ; Surveys and Questionnaires
Chemical Substances	Biomarkers
Keywords	covid19
Language	English
Publishing date	2020-08-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-020-06252-9
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Article ; Online: Sudden olfactory loss as an early marker of COVID-19

European Archives of Oto-Rhino-Laryngology ; ISSN 0937-4477 1434-4726

a nationwide Italian survey

2020

Keywords	Otorhinolaryngology ; General Medicine ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
DOI	10.1007/s00405-020-06252-9
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Chronic aortic dissection: still a challenge.

Giugliano, Giuseppe / Spadera, Lucrezia / De Laurentis, Mario / Brevetti, Gregorio

Acta cardiologica

2009 Volume 64, Issue 5, Page(s) 653–663

Abstract: Chronic aortic dissections are complex lesions with a fairly predictable natural history depending on factors such as baseline aortic diameter, the degree of false lumen thrombosis, the presence of a persistent communication, an underlying connective ... ...

Abstract	Chronic aortic dissections are complex lesions with a fairly predictable natural history depending on factors such as baseline aortic diameter, the degree of false lumen thrombosis, the presence of a persistent communication, an underlying connective tissue disorder, and the control of hypertension. Medical management with antihypertensive therapy including beta-blockers is the treatment of choice for all stable chronic aortic dissections. Repair is indicated in the case of complications: aortic rupture, malperfusion syndromes, symptomatic dissections, asymptomatic dissections becoming significantly aneurysmal or demonstrating a rapid growth rate. In this regard, serial imaging of the aorta is crucial to detect unstable lesions requiring surgery or an endovascular intervention. As endograft technologies improve endovascular approach may become the future standard of care.
MeSH term(s)	Adrenergic beta-Antagonists/therapeutic use ; Aneurysm, Dissecting/diagnosis ; Aneurysm, Dissecting/etiology ; Aneurysm, Dissecting/therapy ; Antihypertensive Agents/therapeutic use ; Aortic Aneurysm/diagnosis ; Aortic Aneurysm/etiology ; Aortic Aneurysm/therapy ; Chronic Disease ; Diagnostic Imaging/methods ; Humans ; Hypertension/complications ; Prognosis ; Vascular Surgical Procedures/methods
Chemical Substances	Adrenergic beta-Antagonists ; Antihypertensive Agents
Language	English
Publishing date	2009-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	390197-x
ISSN	0001-5385
ISSN	0001-5385
DOI	10.2143/AC.64.5.2042696
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