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  1. Article: 18

    Peters, Lynn / Jiang, Wanjie / Eberhardt, Nina / Hagemann, Jürgen Benjamin / Grüner, Beate / Tappe, Dennis

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 8

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-08-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12081041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Suffocating in the eye of the storm: attempting to breathe at the epicentre of New York's COVID-19 pandemic.

    Jiang, Lynn / Flores, Stefan

    Emergency medicine journal : EMJ

    2020  Volume 37, Issue 6, Page(s) 330–331

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/psychology ; Emergency Medicine/organization & administration ; Humans ; New York City/epidemiology ; Pandemics ; Physicians/psychology ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/psychology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-03
    Publishing country England
    Document type Editorial
    ZDB-ID 2040124-3
    ISSN 1472-0213 ; 1472-0205
    ISSN (online) 1472-0213
    ISSN 1472-0205
    DOI 10.1136/emermed-2020-209825
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1941: Show issues Location:
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  3. Article ; Online: Multiple Fibroblast Subtypes Contribute to Matrix Deposition in Pulmonary Fibrosis.

    Liu, Xue / Dai, Kristy / Zhang, Xuexi / Huang, Guanling / Lynn, Heather / Rabata, Anas / Liang, Jiurong / Noble, Paul W / Jiang, Dianhua

    American journal of respiratory cell and molecular biology

    2023  Volume 69, Issue 1, Page(s) 45–56

    Abstract: Progressive pulmonary fibrosis results from a dysfunctional tissue repair response and is characterized by fibroblast proliferation, activation, and invasion and extracellular matrix accumulation. Lung fibroblast heterogeneity is well recognized. With ... ...

    Abstract Progressive pulmonary fibrosis results from a dysfunctional tissue repair response and is characterized by fibroblast proliferation, activation, and invasion and extracellular matrix accumulation. Lung fibroblast heterogeneity is well recognized. With single-cell RNA sequencing, fibroblast subtypes have been reported by recent studies. However, the roles of fibroblast subtypes in effector functions in lung fibrosis are not well understood. In this study, we incorporated the recently published single-cell RNA-sequencing datasets on murine lung samples of fibrosis models and human lung samples of fibrotic diseases and analyzed fibroblast gene signatures. We identified and confirmed the novel fibroblast subtypes we reported recently across all samples of both mouse models and human lung fibrotic diseases, including idiopathic pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and coronavirus disease (COVID-19). Furthermore, we identified specific cell surface proteins for each fibroblast subtype through differential gene expression analysis, which enabled us to isolate primary cells representing distinct fibroblast subtypes by flow cytometry sorting. We compared matrix production, including fibronectin, collagen, and hyaluronan, after profibrotic factor stimulation and assessed the invasive capacity of each fibroblast subtype. Our results suggest that in addition to myofibroblasts, lipofibroblasts and Ebf1
    MeSH term(s) Humans ; Mice ; Animals ; COVID-19/metabolism ; Fibroblasts/metabolism ; Lung/pathology ; Idiopathic Pulmonary Fibrosis/pathology ; Fibrosis ; Membrane Proteins/metabolism
    Chemical Substances Membrane Proteins
    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2022-0292OC
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2851: Show issues Location:
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  4. Article ; Online: Association of Clinical Factors and Degree of Early Background Parenchymal Enhancement on Contrast-Enhanced Mammography.

    Wang, Simin / Sun, Yuqi / You, Chao / Jiang, Tingting / Yang, Meng / Shen, Xigang / Qian, Min / Duan, Shaofeng / Lynn, Henry S / Li, Ruimin / Gu, Yajia

    AJR. American journal of roentgenology

    2023  Volume 221, Issue 1, Page(s) 45–55

    Abstract: BACKGROUND. ...

    Abstract BACKGROUND.
    MeSH term(s) Female ; Humans ; Middle Aged ; Retrospective Studies ; Contrast Media ; Magnetic Resonance Imaging/methods ; Mammography/methods ; Breast Neoplasms/diagnostic imaging
    Chemical Substances Contrast Media
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.22.28769
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Book ; Online: Suffocating in the eye of the storm

    Jiang, Lynn / Flores, Stefan

    attempting to breathe at the epicentre of New Yorks COVID-19 pandemic

    2020  

    Keywords The view from here ; covid19
    Language English
    Publishing date 2020-06-01 00:00:00.0
    Publisher BMJ Publishing Group Ltd
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Preparedness and response at long-term care facilities following Hurricane Sandy: A qualitative analysis of experiences and attitudes among staff and administrators.

    Jiang, Lynn / Tedeschi, Christopher M

    Journal of emergency management (Weston, Mass.)

    2020  Volume 18, Issue 5, Page(s) 383–398

    Abstract: Background: In late 2012, Hurricane Sandy struck the eastern United States. Healthcare infrastructure in New York City-including long-term care facilities (LTCFs)-was affected significantly. The authors examined the impact of the storm on LTCFs 2 years ... ...

    Abstract Background: In late 2012, Hurricane Sandy struck the eastern United States. Healthcare infrastructure in New York City-including long-term care facilities (LTCFs)-was affected significantly. The authors examined the impact of the storm on LTCFs 2 years after the event, using a qualitative approach consisting of a semistructured interview focused on preparedness and response. Important insights regarding preparedness and response may be lost by quantitative analysis or outcome measurement alone. During Sandy, individuals at LTCFs experienced the event in important subjective ways that, in aggregate, could lead to valuable insights about how facilities might mitigate future risks. The authors used data from a semistructured interview to generate hypotheses regarding the preparation and response of LTCFs. The interview tool was designed to help develop theories to explain why LTCF staff and administrators experienced the event in the way they did, and to use that data to inform future policy and research.
    Methods: Representatives from LTCFs located in a heavily affected area of New York City were approached for participation in a semistructured interview. Interviews were digitally recorded and transcribed. Recurrent themes were coded based on time period (before, during, or after the storm) and content. A grounded theory approach was used to identify important themes related to the participants' experiences.
    Results: A total of 21 interviews were conducted. Several overarching themes were identified, including a perception that facilities had not prepared for an event of such magnitude, of inefficient communication and logistics during evacuation, and of lack of easily identifiable or appropriate resources after the event. Access to electrical power emerged as a key identifier of recovery for most facilities. The experience had a substantial psychological impact on LTCF staff regardless of whether they evacuated or sheltered in place during the storm.
    Conclusion: Representatives from LTCFs affected by Sandy experienced the preparation, response, and recovery phases of the event with a unique perspective. Their insights offer evidence which can be used to generate testable hypothesis regarding similar events in the future, and can inform policy makers and facility administrators alike as they prepare for extreme weather events in similar settings. Results specifically suggest that LTCFs develop plans which carefully address the unique qualities of extreme weather events, including communication with local officials, evacuation and transfer needs in geographic areas with multiple facilities, and plans for the safe transfer of residents. Emergency managers at LTCFs should consider electrical power needs with the understanding that in extreme weather events, power failures can be more protracted than in other types of emergencies.
    MeSH term(s) Administrative Personnel/psychology ; Attitude ; Cyclonic Storms ; Humans ; Long-Term Care ; New York City ; Nursing Homes ; United States
    Language English
    Publishing date 2020-11-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2799989-0
    ISSN 1543-5865
    ISSN 1543-5865
    DOI 10.5055/jem.2020.0487
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  8. Article ; Online: Large Mammals Have More Powerful Antibacterial Defenses Than Expected from Their Metabolic Rates.

    Downs, Cynthia J / Schoenle, Laura A / Goolsby, Eric W / Oakey, Samantha J / Ball, Ray / Jiang, Rays H Y / Martin, Lynn B

    The American naturalist

    2023  Volume 201, Issue 2, Page(s) 287–301

    Abstract: AbstractTerrestrial mammals span seven orders of magnitude in body size, ranging from the <2-g Etruscan pygmy shrew ( ...

    Abstract AbstractTerrestrial mammals span seven orders of magnitude in body size, ranging from the <2-g Etruscan pygmy shrew (
    MeSH term(s) Animals ; Mammals/physiology ; Body Size
    Language English
    Publishing date 2023-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207092-3
    ISSN 1537-5323 ; 0003-0147
    ISSN (online) 1537-5323
    ISSN 0003-0147
    DOI 10.1086/722504
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    In stock of ZB MED Bonn / Germany

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  9. Article ; Online: A Collaborative Emergency Medicine and Radiology Pulmonary Nodule Program: Identification of Associated Efficacy and Outcomes.

    Jiang, Lynn G / Cahill, Meghan / Chansakul, Aisara / Steel, Peter A D / Sullivan, Deirdre / Pua, Bradley B

    Journal of the American College of Radiology : JACR

    2023  Volume 20, Issue 8, Page(s) 796–803

    Abstract: Purpose: Incidental radiologic findings are commonplace, but the episodic nature of emergency department (ED) care makes it challenging to ensure that patients obtain appropriate follow-up. Rates of follow-up range from 30% to 77%, with some studies ... ...

    Abstract Purpose: Incidental radiologic findings are commonplace, but the episodic nature of emergency department (ED) care makes it challenging to ensure that patients obtain appropriate follow-up. Rates of follow-up range from 30% to 77%, with some studies demonstrating that more than 30% have no follow-up at all. The aim of this study is to describe and analyze the outcomes of a collaborative emergency medicine and radiology initiative to establish a formal workflow for the follow-up of pulmonary nodules identified during ED care.
    Methods: A retrospective analysis was performed of patients referred to the pulmonary nodule program (PNP). Patients were divided into two categories: those with follow-up and those who do not have post-ED follow-up. The primary outcome was determining follow-up rates and outcomes, including patients referred for biopsy. The characteristics of patients who completed follow-up compared with those lost to follow-up were also examined.
    Results: A total of 574 patients were referred to the PNP. Initial follow-up was established in 390 (69.1%); 30.8% were considered lost to follow-up, and more than half of these patients did not respond to initial contact. There were minimal differences in characteristics between patients in these two categories. Of the 259 patients who completed PNP follow-up, 26 were referred for biopsy (13%).
    Conclusions: The PNP provided effective transitions of care and potentially improved patient health care. Strategies to further enhance follow-up adherence will provide iterative improvement of the program. The PNP provides an implementation framework for post-ED pulmonary nodule follow-up in other health care systems and can be modified for use with other incidental diagnostic findings.
    MeSH term(s) Humans ; Retrospective Studies ; Radiography ; Multiple Pulmonary Nodules/diagnostic imaging ; Radiology ; Tomography, X-Ray Computed ; Emergency Service, Hospital
    Language English
    Publishing date 2023-07-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2274861-1
    ISSN 1558-349X ; 1546-1440
    ISSN (online) 1558-349X
    ISSN 1546-1440
    DOI 10.1016/j.jacr.2023.04.020
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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: Abnormal respiratory progenitors in fibrotic lung injury.

    Xie, Ting / Lynn, Heather / Parks, William C / Stripp, Barry / Chen, Peter / Jiang, Dianhua / Noble, Paul W

    Stem cell research & therapy

    2022  Volume 13, Issue 1, Page(s) 64

    Abstract: Recent advances in single-cell RNA sequencing (scRNA-seq) and epithelium lineage labeling have yielded identification of multiple abnormal epithelial progenitor populations during alveolar type 2 (ATII) cell differentiation into alveolar type 1 (ATI) ... ...

    Abstract Recent advances in single-cell RNA sequencing (scRNA-seq) and epithelium lineage labeling have yielded identification of multiple abnormal epithelial progenitor populations during alveolar type 2 (ATII) cell differentiation into alveolar type 1 (ATI) cells during regenerative lung post-fibrotic injury. These abnormal cells include basaloid/basal-like cells, ATII transition cells, and persistent epithelial progenitors (PEPs). These cells occurred and accumulated during the regeneration of distal airway and alveoli in response to both chronic and acute pulmonary injury. Among the alveolar epithelial progenitors, PEPs express a distinct Krt8
    MeSH term(s) Alveolar Epithelial Cells ; Epithelial Cells ; Humans ; Lung ; Lung Injury ; Pulmonary Alveoli
    Language English
    Publishing date 2022-02-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2548671-8
    ISSN 1757-6512 ; 1757-6512
    ISSN (online) 1757-6512
    ISSN 1757-6512
    DOI 10.1186/s13287-022-02737-y
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