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  1. Article ; Online: Rationality of irrationality: preference catering or shaping?

    Ling, Xiaoxu / Yan, Siyuan

    Journal of medical ethics

    2023  Volume 49, Issue 11, Page(s) 759–760

    Language English
    Publishing date 2023-08-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 194927-5
    ISSN 1473-4257 ; 0306-6800
    ISSN (online) 1473-4257
    ISSN 0306-6800
    DOI 10.1136/jme-2023-109339
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1163: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Two undescribed compounds from

    Ma, Siyuan / Ge, Li / Lu, Hongyu / Yan, Jianhua / Yang, Kedi

    Natural product research

    2024  , Page(s) 1–8

    Abstract: A new naphtho- ...

    Abstract A new naphtho-
    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2024.2334325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Highly efficient deep-blue emitting CsPbBr

    Zhang, Xue / Cui, Yanyu / Ye, Siyuan / Lin, Zhuohan / Li, Yan

    Journal of colloid and interface science

    2024  Volume 668, Page(s) 68–76

    Abstract: Two-dimensional (2D) ... ...

    Abstract Two-dimensional (2D) CsPbBr
    Language English
    Publishing date 2024-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2024.03.202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 71/707: Show issues

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  4. Article ; Online: Let's be fair. What about an AI editor?

    Ling, Xiaoxu / Yan, Siyuan

    Accountability in research

    2023  , Page(s) 1–2

    Abstract: Much of the current attention on artificial intelligence (AI)-based natural language processing (NLP) systems has focused on research ethics and integrity but neglects their roles in the editorial and peer-reviewing process. We argue that the academic ... ...

    Abstract Much of the current attention on artificial intelligence (AI)-based natural language processing (NLP) systems has focused on research ethics and integrity but neglects their roles in the editorial and peer-reviewing process. We argue that the academic community needs to develop and apply a consistent end-to-end policy on the ethics and integrity of NLP in academic publishing: standards such as drafting requirements and disclosure criteria imposed on potential contributors should be consistently applied to the editorial and peer review process in academic publications.
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2069334-5
    ISSN 1545-5815 ; 0898-9621
    ISSN (online) 1545-5815
    ISSN 0898-9621
    DOI 10.1080/08989621.2023.2223997
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Coexistence and transformation from urban industrial land to green space in decentralization of megacities

    Gege Yan / Siyuan Wang

    Ecological Indicators, Vol 156, Iss , Pp 111120- (2023)

    A case study of Daxing District, Beijing, China

    2023  

    Abstract: Decentralization is essential for the sustainable socio-economic development of megacities. In the context of the decentralization of noncapital functions in Beijing, the renewal of inefficient urban industrial land (UIL) into urban green space (UGS) is ... ...

    Abstract Decentralization is essential for the sustainable socio-economic development of megacities. In the context of the decentralization of noncapital functions in Beijing, the renewal of inefficient urban industrial land (UIL) into urban green space (UGS) is an important way to improve the quality of the city. This paper analyzes the urban industrial land use efficiency (UILUE) and its urban green space suitability (UGSS) of 865 study units in Daxing District, Beijing, and combines bivariate spatial autocorrelation with cluster analysis. The results show that (1) the distribution of UIL in Daxing District is “dense in the north and sparse in the south”, and UILUE shows a spatial pattern of “high in the west and low in the east”, with a high-efficiency area of 985.85 ha, accounting for 12.06 % of the study area, and a low-efficiency area of 507.77 ha, accounting for 6.21 % of the study area. (2) Among the existing UIL, the high suitable area is 1106.46 ha, accounting for 13.57 % of the study area, and the low suitable area is 439 ha, accounting for 5.38 % of the study area. (3) Through bivariate spatial autocorrelation analysis, four types of UIL were identified, among which the low–high cluster area had the greatest potential for land conversion, with 175 study units and an area of 1335.22 ha, accounting for 16.28 % of the study area. Finally, this paper proposes recommendations for the renewal and utilization of UIL in Daxing District to provide guidance and suggestions for the decentralization of other megacities in the world.
    Keywords Decentralization ; UILUE ; UGSS ; Bivariate spatial autocorrelation ; Daxing district ; Ecology ; QH540-549.5
    Subject code 710
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  6. Article ; Online: Linc01116 Silencing Inhibits the Proliferation and Invasion, Promotes Apoptosis of Chordoma Cells via Regulating the Expression of Mir-9-5p/Pkg1.

    Liu, Junqi / Qi, Yan / Hou, Siyuan / Zhang, Siyuan / Wang, Zhenlin

    Current molecular medicine

    2023  

    Abstract: Background: Long intergenic non-protein coding RNA 1116 (LINC01116) plays a carcinogenic role in a variety of cancers. The study aims to investigate the roles of LINC01116 and hsa-miR-9-5p (miR-9-5p) and fathom their interaction in chordoma.: Method: ...

    Abstract Background: Long intergenic non-protein coding RNA 1116 (LINC01116) plays a carcinogenic role in a variety of cancers. The study aims to investigate the roles of LINC01116 and hsa-miR-9-5p (miR-9-5p) and fathom their interaction in chordoma.
    Method: The predicted binding sites between miR-9-5p with LINC01116 and phosphoglycerate kinase 1 (PGK1) by starBase were confirmed through dual-luciferase reporter assay. The behaviors of chordoma cells undergoing transfection with siLINC01116 or miR-9-5p inhibitor were determined by Cell Counting Kit-8 (CCK-8), colony formation, Transwell, and flow cytometry assays. The glucose consumption, lactate production, and adenosine triphosphate (ATP) production of chordoma cells were examined with specific kits. Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot were performed to determine relevant gene expressions in chordoma cells.
    Results: Silencing of LINC01116 facilitated the apoptosis and expressions of Bcl-2- associated X (Bax), cleaved caspase-3 (C caspase-3) and miR-9-5p while repressing the cell cycle, viability, proliferation, invasion, glucose consumption, lactate production, ATP production, and expressions of PGK1 and Bcl-2. Meanwhile, LINC01116 sponged miR-9-5p, which could target PGK1. Moreover, the miR-9-5p inhibitor acted contrarily and reversed the role of siLINC01116 in chordoma cells. Besides, LINC01116 downregulation facilitated apoptosis and attenuated the proliferation and invasion of chordoma cells as well as PGK1 expression by upregulating miR-9-5p expression.
    Conclusion: LINC01116/miR-9-5p plays a regulatory role in the progression of chordoma cells and is a potential biomarker for chordoma.
    Language English
    Publishing date 2023-07-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2064873-X
    ISSN 1875-5666 ; 1566-5240
    ISSN (online) 1875-5666
    ISSN 1566-5240
    DOI 10.2174/1566524023666230719121758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5580: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Cathodoluminescence and tip-plasmon resonance of Bi2Te3 triangular nanostructures.

    Yan, Qigeng / Wang, Siyuan / Guan, Kuiwen / Guan, Xiaojin / He, Lei

    PloS one

    2024  Volume 19, Issue 1, Page(s) e0291251

    Abstract: Bi2Te3, as a topological insulator, is able to support plasmonic emission in the visible spectral range. Thin Bi2Te3 flakes can be exfoliated directly from a Bi2Te3 crystal, and the shape of Bi2Te3 flakes can be further modified by focused ion beam ... ...

    Abstract Bi2Te3, as a topological insulator, is able to support plasmonic emission in the visible spectral range. Thin Bi2Te3 flakes can be exfoliated directly from a Bi2Te3 crystal, and the shape of Bi2Te3 flakes can be further modified by focused ion beam milling. Therefore, we have designed a Bi2Te3 triangular antenna with distinct tip angles for the application of plasmonic resonance. The plasmonic emission of the Bi2Te3 triangular antenna is excited and investigated by cathodoluminescence in the scanning electron microscope. Enhanced tip plasmons have been observed from distinct tips with angles of 20º, 36º, 54º, 70º, and 90º, respectively. Due to the confinement of geometric boundaries for oscillating charges, the resonant peak position of tip plasmon with a smaller angle has a blue shift. Moreover, the dependence of plasmonic behavior on the excitation position has been discovered as well. This research provides a unique approach to fabricate Bi2Te3 nanostructures and manipulate the corresponding plasmonic properties.
    MeSH term(s) Surface Plasmon Resonance ; Nanostructures/chemistry ; Vibration
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0291251
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  8. Article ; Online: Novel aromatic moieties-modified poly(glycidyl amine)s with potent siRNA delivery and cancer treatment effect.

    Shuai, Qi / Xie, Wanxuan / Chen, Siyuan / Su, Huahui / Yan, Yunfeng

    Journal of materials chemistry. B

    2024  Volume 12, Issue 12, Page(s) 3115–3128

    Abstract: The development of safe and effective delivery systems is critical for the clinical applications of siRNA-based therapeutics. Polymer-based vectors have garnered significant attention owing to their structural flexibility and functional tunability. ... ...

    Abstract The development of safe and effective delivery systems is critical for the clinical applications of siRNA-based therapeutics. Polymer-based vectors have garnered significant attention owing to their structural flexibility and functional tunability. Polyethyleneimine (PEI) has been extensively studied for nucleic acid delivery; nevertheless, its high cytotoxicity has posed challenges for clinical applications. In this study, we have reported poly(glycidyl amine) (PGAm), a linear PEI analogue, demonstrating remarkable siRNA delivery efficacy and improved biocompatibility. By introducing three aromatic moieties (tyrosine,
    MeSH term(s) Humans ; Animals ; Mice ; HeLa Cells ; RNA, Small Interfering/metabolism ; Cell Line, Tumor ; Amines ; Polymers ; Neoplasms
    Chemical Substances RNA, Small Interfering ; Amines ; Polymers
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d3tb02876c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The efficacy of furmonertinib in untreated advanced NSCLC patients with sensitive EGFR mutations in a real-world setting: a single institutional experience.

    Yan, Ningning / Guo, Sanxing / Huang, Siyuan / Zhang, Huixian / Li, Xingya

    Frontiers in oncology

    2024  Volume 14, Page(s) 1331128

    Abstract: Background: Furmonertinib is the standard treatment option in the first-line setting for advanced non-small cell lung cancer (NSCLC) with sensitive epidermal growth factor receptor (EGFR) mutations in China. However, there are limited real-world data ... ...

    Abstract Background: Furmonertinib is the standard treatment option in the first-line setting for advanced non-small cell lung cancer (NSCLC) with sensitive epidermal growth factor receptor (EGFR) mutations in China. However, there are limited real-world data available.
    Methods: We conducted a retrospective study at a single center, analyzing a cohort of 73 NSCLC patients who tested positive for EGFR mutations and were treated with furmonertinib as their initial therapy between August 2022 and December 2023. The primary endpoint was progression-free survival (PFS), with secondary endpoints including objective response rate (ORR), overall survival (OS), and safety profile.
    Results: The median observation period was 9 months (95% confidence interval [CI], 8.0-20.0). The median PFS was 19.5 months (95% CI, 14.6-24.4). OS data were not yet mature. Univariate analysis showed no significant correlation between PFS and factors such as Eastern Cooperative Oncology Group performance status (ECOG PS) score, presence of brain or liver metastases, sex, age, EGFR mutation status, or number of metastatic sites. However, multivariate analysis indicated a potential trend toward extended PFS in patients younger than 65 years (p = 0.053, 95% CI, 0.10-1.02), although the p-value was only marginally significant. The most common adverse events were diarrhea (24%), anemia (36%), and liver injury (32%); however, only four cases experienced severe adverse events.
    Conclusion: In a real-world setting, furmonertinib appears to be a favorable treatment option for EGFR-mutated patients. The manageable nature of adverse events further supports its use in clinical practice.
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1331128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Land degradation neutrality assessment and factors influencing it in China's arid and semiarid regions.

    Feng, Siyuan / Zhao, Wenwu / Yan, Jinming / Xia, Fangzhou / Pereira, Paulo

    The Science of the total environment

    2024  Volume 925, Page(s) 171735

    Abstract: The ecosystems in China's arid and semiarid regions are notably fragile and experiencing dramatic land degradation. At the 12th Conference of the Parties (COP12) to the United Nations Convention to Combat Desertification (UNCCD) in October 2015, a ... ...

    Abstract The ecosystems in China's arid and semiarid regions are notably fragile and experiencing dramatic land degradation. At the 12th Conference of the Parties (COP12) to the United Nations Convention to Combat Desertification (UNCCD) in October 2015, a definition for land degradation neutrality (LDN) was proposed and subsequently integrated into the Sustainable Development Goals (SDGs). Research on LDN has developed in terms of conceptual framework constructions, quantitative assessments, and empirical studies. However, LDN and its drivers must be clarified in China's arid and semiarid regions since some representative processes have yet to be fully considered in the assessment. Here, we develop an LDN indicator system specialised for the area, assess their LDN status, and determine the impacts of human activities and climate change on LDN. Our research aims to refine the LDN indicator system tailored for China's arid and semiarid regions by incorporating the trends of wind and water erosion. We also identify the influence of human activity and climate change on LDN, which provides insightful strategies for ecological restoration and sustainable development in drylands with climate-sensitive ecosystems. The results show that: (1) In 2020, more than half of areas of China's arid and semiarid regions achieved LDN, with more pronounced success in the southeastern areas compared to the central regions. (2) For LDN drivers, elevation shows negligible influence on LDN, whereas increased temperature promotes LDN achievement. Conversely, factors like vapour pressure deficit and v-direction wind speed hinder it. In conclusion, China's arid and semiarid regions achieved LDN, and the dominant factor that substantially influences LDN varies across geographical zones, with higher wind speeds and elevated GDP levels generally obstructing LDN in most areas.
    Language English
    Publishing date 2024-03-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.171735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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