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  1. Article: Jin-Tian-Ge ameliorates ovariectomy-induced bone loss in rats and modulates osteoblastogenesis and osteoclastogenesis in vitro.

    Shen, Yi / Wang, Na / Zhang, Qi / Liu, Yuling / Wu, Qudi / He, Yuqiong / Wang, Yang / Wang, Xiaoyan / Zhao, Qiming / Zhang, Quanlong / Qin, Luping / Zhang, Qiaoyan

    Chinese medicine

    2022  Volume 17, Issue 1, Page(s) 78

    Abstract: ... for the treatment of osteoporosis and rheumatoid arthritis. Jin-Tian-Ge (JTG), the artificial tiger bone powder ...

    Abstract Background: Tiger bone, which had been one of the most famous traditional Chinese medicine for 2000 years, was originate from the skeleton of Panthera tigris L., and had the actions of anti-inflammatory, analgesic, immune-regulatory and promoting healing of bone fracture, and was used for the treatment of osteoporosis and rheumatoid arthritis. Jin-Tian-Ge (JTG), the artificial tiger bone powder, were prepared from skeletons of several farmed animals to substitute the natural tiger bone, and has been used for the treatment of osteoporosis in clinical practice. However, the characteristic and mechanism of action of JTG for the therapy of osteoporosis need to be further evidenced by using modern pharmacological methods. The aim of this work is to investigate the bone-protective effects of JTG, and explore the possible underlying mechanism.
    Methods: Ovariectomy (OVX) rats were orally administrated JTG or estradiol valerate (EV) for 12 weeks. We investigated the pharmacodynamic effects of JTG on anti-bone loss in OVX rats, and also investigated the role of JTG in promoting osteogenesis and inhibiting osteoclast differentiation.
    Results: JTG increased the bone mineral density (BMD), improved the bone microarchitecture and biomechanical properties in ovariectomized rast, whereas reversed the bone high turnover in OVX rats as evidenced by serum biochemical markers in OVX rats. JTG increased osteogenic differentiation of BMSCs in vitro, and up-regulated the expression of the key proteins of BMP and Wnt/β-catenin pathways. JTG also inhibited the osteoclastogenesis of BMM as evidenced by the alteration of the TRAP activity, F-actin construction and the expression of nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), c-Fos, Cathepsin K (Ctsk) and matrix metallopeptidase 9 (MMP9) of OCs induced with RANKL and LPS, reduced the expression and phosphorylation of NF-κB in OCs.
    Conclusions: JTG prevented bone loss in OVX rats and increased osteogenic differentiation of BMSCs through regulation of the BMP and Wnt/β-catenin pathway, inhibited osteoclastogenesis by suppressing the NF-κB pathway, suggesting that JTG had the potentials for prevention and treatment of osteoporosis by modulating formation and differentiation of osteoblast and osteoclast.
    Language English
    Publishing date 2022-10-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2260322-0
    ISSN 1749-8546
    ISSN 1749-8546
    DOI 10.1186/s13020-022-00627-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Herb-induced autoimmune-like hepatitis associated with Xiang-tian-guo (Swietenia macrophylla seeds): A case report and literature review.

    Shao, Yue-Ming / Zhang, Yu / Yin, Xin / Qin, Ting-Ting / Jin, Qing-Long / Wen, Xiao-Yu

    Medicine

    2021  Volume 100, Issue 2, Page(s) e24045

    Abstract: ... can be confusing.: Patient concerns: A 67-year-old woman taking xiang-tian-guo for 6 months was ... follow-up.: Lessons: We must to be vigilant about the safety of xiang-tian-guo as a herbal medicine ...

    Abstract Rationale: Drug-induced liver injury (DILI) has a relatively low incidence, whereas the incidence of herb-induced liver injury (HILI) is still under investigation. As a special type of DILI, the diagnosis of drug-induced autoimmune-like hepatitis presents a persistent challenge, because this condition has partial characteristics of both DILI and autoimmune hepatitis (AIH), such as a certain history of medication use and histology that similar is to AIH. Thus, the differential diagnosis between DILI and AIH can be confusing.
    Patient concerns: A 67-year-old woman taking xiang-tian-guo for 6 months was admitted to our hospital with a complaint of experiencing jaundice for 2 weeks.
    Diagnosis: A liver biopsy exhibited interface inflammation, foam cells, and "rosette" -like hepatocytes. She was diagnosed with herb-induced liver injury (hepatocellular and acute), a RUCAM score of 7 (probable), a severity for grade 4 liver injury, and accompanied autoimmune-like changes.
    Interventions: The patient was instructed to cease the administration of suspicious drugs. The patient also received liver protection and albumin transfusion.
    Outcomes: After 25 days of hospitalization, the patients aminotransferase levels returned to normal. No recurrence was observed after the administration of the treatments and a close follow-up.
    Lessons: We must to be vigilant about the safety of xiang-tian-guo as a herbal medicine. When faced with the difficulty of distinguishing between AIH and DILI, long-term follow-up observations for recurrence can aid clinicians in making a judgment.
    MeSH term(s) Aged ; Biopsy ; Chemical and Drug Induced Liver Injury/diagnosis ; Chemical and Drug Induced Liver Injury/etiology ; Diagnosis, Differential ; Drugs, Chinese Herbal/adverse effects ; Female ; Hepatitis, Autoimmune/diagnosis ; Humans ; Liver Function Tests ; Meliaceae/adverse effects
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2021-01-19
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000024045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Variations of Lateral Bedrock Erosion Rates Control Planation of Uplifting Folds in the Foreland of the Tian Shan, NW China

    Bufe, A. / Burbank, D. / Liu, L. / Bookhagen, B. / Qin, J. / Chen, J. / Li, T. / Thompson Jobe, J. / Yang, H.

    Journal of Geophysical Research

    2017  

    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Variations of Lateral Bedrock Erosion Rates Control Planation of Uplifting Folds in the Foreland of the Tian Shan, NW China

    A. Bufe / Douglas W. Burbank / Langtao Liu / Bodo Bookhagen / Jintang Qin / Jie Chen / Tao Li / Jessica A. Thompson Jobe / Huili Yang

    Journal of Geophysical Research

    2017  

    Publishing country de
    Document type Article ; Online
    DOI 10.1002/2016JF004099
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Variations of Lateral Bedrock Erosion Rates Control Planation of Uplifting Folds in the Foreland of the Tian Shan, NW China

    Bufe, Aaron / Burbank, Douglas W. / Liu, Langtao / Bookhagen, Bodo / Qin, Jintang / Chen, Jie / Li, Tao / Thompson Jobe, Jessica A. / Yang, Huili

    Journal of geophysical research. 2017 Dec., v. 122, no. 12

    2017  

    Abstract: ... in the foreland of the southwestern Tian Shan. A combination of field work, digital elevation model analysis, and ...

    Abstract Fluvial planation surfaces, such as straths, commonly serve as recorders of climatic and tectonic changes and are formed by the lateral erosion of rivers, a process that remains poorly understood. Here we present a study of kilometer‐wide, fluvially eroded, low‐relief surfaces on rapidly uplifting folds in the foreland of the southwestern Tian Shan. A combination of field work, digital elevation model analysis, and dating of fluvial deposits reveals that despite an arid climate and rapid average rock‐uplift rates of 1–3 mm/yr, rivers cut extensive (>1–2 km wide) surfaces with typical height variations of <6 m over periods of >2–6 kyr. The extent of this “beveling” varies in space and time, such that different beveling episodes affect individual structures. Between times of planation, beveled surfaces are abandoned, incised, and deformed across the folds. In a challenge to models that link strath cutting and abandonment primarily to changes in river incision rates, we demonstrate that lateral erosion rates of antecedent streams crossing the folds have to vary by more than 1 order of magnitude to explain the creation of beveled platforms in the past and their incision at the present day. These variations do not appear to covary with climate variability and might be caused by relatively small (much less than an order of magnitude) changes in sediment or water fluxes. It remains uncertain in which settings variations in lateral bedrock erosion rates predominate over changes in vertical erosion rates. Therefore, when studying fluvial planation and strath terraces, variability of both lateral and vertical erosion rates should be considered.
    Keywords arid zones ; bedrock ; digital elevation models ; geophysics ; research ; rivers ; sediments ; space and time ; tectonics ; China
    Language English
    Dates of publication 2017-12
    Size p. 2431-2467.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ISSN 2169-9003
    DOI 10.1002/2016JF004099
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Immunogenicity analysis following human immunodeficiency virus recombinant DNA and recombinant vaccinia virus Tian Tan prime-boost immunization.

    Liu, Cunxia / Du, Shouwen / Li, Chang / Wang, Yuhang / Wang, Maopeng / Li, Yi / Yin, Ronglan / Li, Xiao / Ren, Dayong / Qin, Yanqing / Ren, Jingqiang / Jin, Ningyi

    Science China. Life sciences

    2013  Volume 56, Issue 6, Page(s) 531–540

    Abstract: ... using combinations of recombinant DNA (pCCMp24) and recombinant attenuated vaccinia virus Tian Tan ...

    Abstract This study assessed and compared the immunogenicity of various immunization strategies in mice using combinations of recombinant DNA (pCCMp24) and recombinant attenuated vaccinia virus Tian Tan (rddVTT-CCMp24). Intramuscular immunization was performed on days 0 (prime) and 21 (boost). The immunogenicity of the vaccine schedules was determined by measuring human immunodeficiency virus (HIV)-specific binding antibody levels and cytokine (interleukin-2 and interleukin-4) concentrations in peripheral blood, analyzing lymphocyte proliferation capacity against HIV epitopes and CD4(+)/CD8(+) cell ratio, and monitoring interferon-gamma levels at different times post-immunization. The results showed that pCCMp24, rddVTT-CCMp24 and their prime-boost immunization induced humoral and cellular immune responses. The pCCMp24/rddVTT-CCMp24 immunization strategy increased CD8(+) T cells and induced more IFN-γ-secreting cells compared with single-shot rDNA. The prime-boost immunization strategy also induced the generation of cellular immunological memory to HIV epitope peptides. These results demonstrated that prime-boost immunization with rDNA and rddVTT-CCMp24 had a tendency to induce greater cellular immune response than single-shot vaccinations, especially IFN-γ response, providing a basis for further studies.
    MeSH term(s) Animals ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; CD4-CD8 Ratio ; Cell Proliferation ; DNA, Recombinant/immunology ; Enzyme-Linked Immunosorbent Assay ; Epitopes, T-Lymphocyte ; Female ; HIV/genetics ; HIV/immunology ; Humans ; Immunization/methods ; Immunization, Secondary/methods ; Interferon-gamma/immunology ; Interferon-gamma/metabolism ; Interleukin-2/blood ; Interleukin-2/immunology ; Interleukin-2/metabolism ; Interleukin-4/blood ; Interleukin-4/immunology ; Interleukin-4/metabolism ; Lymphocytes/cytology ; Lymphocytes/immunology ; Lymphocytes/metabolism ; Mice ; Mice, Inbred BALB C ; Recombination, Genetic ; Vaccinia virus/genetics ; Vaccinia virus/immunology ; Viral Vaccines/immunology
    Chemical Substances Antibodies, Viral ; DNA, Recombinant ; Epitopes, T-Lymphocyte ; Interleukin-2 ; Viral Vaccines ; Interleukin-4 (207137-56-2) ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2013-06
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1869-1889
    ISSN (online) 1869-1889
    DOI 10.1007/s11427-013-4484-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Characteristics of atmospheric dust deposited in snow on Urumqi Glacier No.1 of eastern Tian Shan, China: a comparison of measurements during Asian dust period with non-dust period].

    Dong, Zhi-Wen / Li, Zhong-Qin / Wang, Fei-Teng / Zhang, Ming-Jun

    Huan jing ke xue= Huanjing kexue

    2009  Volume 30, Issue 6, Page(s) 1818–1825

    Abstract: ... River in eastern Tian Shan, central Asia. An analysis of seasonal change of concentration ...

    Abstract Deposition of atmospheric dust was measured in the snow on Glacier No.1 at the headwater of Urumqi River in eastern Tian Shan, central Asia. An analysis of seasonal change of concentration of dust particles in the snow cover suggests that number concentration of dust particle is significantly high from April to June (439 x 10(3)/mL), which may be caused by Asian dust storm in spring. The comparison of mass-size distribution of dust particles between April to August shows an obvious change trend. The distribution of particles changes from single model (3-21 microm) in non-dust period before April, to bio-model (3-21 microm and 20-80 microm) during Asian dust period, and to single model (3-21 microm) after June in non-dust period again. Ca2+ concentration in the snow is also very high from April to June, while NH4+ and SO4(2-), as water-soluble constituents the concentration change is different from each other. Backward trajectory was also employed to examine the transport process of air mass in this region.
    MeSH term(s) Air Movements ; Air Pollutants/analysis ; Atmosphere/analysis ; China ; Dust ; Environmental Monitoring ; Ice Cover/chemistry ; Particle Size ; Seasons ; Snow/chemistry
    Chemical Substances Air Pollutants ; Dust
    Language Chinese
    Publishing date 2009-06-15
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 0250-3301
    ISSN 0250-3301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online: Remote Sensing Based Building Extraction II

    Tian, Jiaojiao / Yan, Qin / Awrangjeb, Mohammad / Kallfelz-Sirmacek, Beril / Demir, Nusret / Yan, Qin

    2023  

    Keywords Research & information: general ; Geography ; building extraction ; high-resolution remote-sensing image ; semantic edge detection ; semantic segmentation ; building footprint ; map vectorization ; convolutional neural network ; airborne LiDAR ; graph segmentation ; object primitive ; geometric feature ; road extraction ; high-resolution image ; hyperspectral image ; synthetic aperture radar (SAR) ; light detection and ranging (LiDAR) ; farmland range ; attention enhancement ; U-Net network improvement ; multi-source remote sensing image ; building model ; reconstruction ; half-space ; LiDAR data ; urban scale ; interactive segmentation network ; deep learning ; iterative training ; remote sensing images ; spatial attention ; global information awareness ; cross level information fusion ; dense matching ; convolutional neural networks ; end-to-end ; pyramid architecture ; building reconstruction ; LiDAR ; point clouds ; integer programming ; airborne Earth observation ; ultrahigh spatial resolution ; instance segmentation ; fully convolutional neural networks ; roofscape ; remote sensing building extraction ; building photovoltaic ; self-supervised learning ; n/a
    Language English
    Size 1 electronic resource (276 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030378287
    ISBN 9783036570655 ; 3036570659
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  9. Article ; Online: CIMBL55: a repository for maize drought resistance alleles.

    Tian, Tian / Qin, Feng

    Stress biology

    2023  Volume 3, Issue 1, Page(s) 13

    Abstract: Droughts threaten crop yields worldwide. Compared to other major staple cereal crops, maize (Zea mays) is especially sensitive to drought, which can cause dramatic fluctuations in its yield potential. Natural maize populations contain many superior ... ...

    Abstract Droughts threaten crop yields worldwide. Compared to other major staple cereal crops, maize (Zea mays) is especially sensitive to drought, which can cause dramatic fluctuations in its yield potential. Natural maize populations contain many superior alleles that can enhance drought resistance through complex regulatory mechanisms. We recently de novo assembled the genome of a prominent drought-resistant maize germplasm, CIMBL55, and systematically dissected the genetic basis for its drought resistance on the genome, transcriptome, and epigenome levels. These analyses revealed 65 favorable drought resistance alleles in CIMBL55. Subsequently, we genetically verified the functions of the drought resistance genes ZmABF4, ZmNAC075, and ZmRtn16 and unraveled the function of ZmRtn16 on a molecular level.
    Language English
    Publishing date 2023-05-19
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2731-0450
    ISSN (online) 2731-0450
    DOI 10.1007/s44154-023-00091-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Diffusely Enhancing Lesions on MRI in DPPX Antibody-Associated Encephalitis.

    Liu, Mao / Qin, Chuan / Tian, Dai-Shi

    JAMA neurology

    2024  

    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2023.5307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.191: Show issues Location:
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