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  1. Book ; Thesis: A comprehensive study to decipher the impact of simulated microgravity on human induced pluripotent stem cell-derived cardiomyocytes

    Acharya, Aviseka

    2021  

    Author's details vorgeelgt von Aviseka Acharya aus Narisho, Odisha, Indien
    Language English
    Size 141 Seiten, Illustrationen, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2021
    Note Zusammenfassung in deutscher und englischer Sprache
    HBZ-ID HT020975505
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 D 461 order for loan Magazin

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  2. Book ; Online: Bridging Two Worlds

    Acharya, Amitav / Acharya, Amitav / Bell, Daniel A / Bhargava, Rajeev / Yan, Xuetong

    Comparing Classical Political Thought and Statecraft in India and China

    2023  

    Keywords Politics & government ; foreign policies; China; India
    Language English
    Size 1 electronic resource (335 pages)
    Publisher University of California Press
    Document type Book ; Online
    Note English
    HBZ-ID HT030379738
    ISBN 9780520390980 ; 0520390989
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Development and application of SEM/EDS in biological, biomedical & nanotechnological research

    Acharya, Aniruddha

    2023  

    Abstract: This comprehensive review discusses the development of scanning electron microscopy and the application of this technology in different fields such as biology, nanobiotechnology and biomedical science. Besides being a tool for high resolution imaging of ... ...

    Abstract This comprehensive review discusses the development of scanning electron microscopy and the application of this technology in different fields such as biology, nanobiotechnology and biomedical science. Besides being a tool for high resolution imaging of surface or topography, the technology is coupled with analytical techniques such as energy dispersive spectroscopy for elemental mapping. Since the commercialization of the technology, it has developed manifold and currently very high-resolution nano scale imaging is possible by this technology. The development of FIB-SEM has allowed three-dimensional imaging of materials while the development of cryostage allows imaging of hydrated biological samples. Though variable pressure or environmental SEM can be used for imaging hydrated samples, they cannot capture a high-resolution image. SBEM and ATUM-SEM has automated the sampling process while improved and more powerful software along with user-friendly computer interface has made image analysis faster and more reliable. This review presents one of the most widely used analytical techniques used across the globe for scientific investigation. The power and potential of SEM is expanding with the development of accessory technology.

    Comment: 32 pages, 5 figures, 1 table, unpublished work
    Keywords Quantitative Biology - Quantitative Methods
    Subject code 600
    Publishing date 2023-11-01
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Article ; Online: A comprehensive review of machine learning techniques for multi-omics data integration: challenges and applications in precision oncology.

    Acharya, Debabrata / Mukhopadhyay, Anirban

    Briefings in functional genomics

    2024  

    Abstract: Multi-omics data play a crucial role in precision medicine, mainly to understand the diverse biological interaction between different omics. Machine learning approaches have been extensively employed in this context over the years. This review aims to ... ...

    Abstract Multi-omics data play a crucial role in precision medicine, mainly to understand the diverse biological interaction between different omics. Machine learning approaches have been extensively employed in this context over the years. This review aims to comprehensively summarize and categorize these advancements, focusing on the integration of multi-omics data, which includes genomics, transcriptomics, proteomics and metabolomics, alongside clinical data. We discuss various machine learning techniques and computational methodologies used for integrating distinct omics datasets and provide valuable insights into their application. The review emphasizes both the challenges and opportunities present in multi-omics data integration, precision medicine and patient stratification, offering practical recommendations for method selection in various scenarios. Recent advances in deep learning and network-based approaches are also explored, highlighting their potential to harmonize diverse biological information layers. Additionally, we present a roadmap for the integration of multi-omics data in precision oncology, outlining the advantages, challenges and implementation difficulties. Hence this review offers a thorough overview of current literature, providing researchers with insights into machine learning techniques for patient stratification, particularly in precision oncology. Contact:  anirban@klyuniv.ac.in.
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2540916-5
    ISSN 2041-2657 ; 2041-2649 ; 2041-2647
    ISSN (online) 2041-2657
    ISSN 2041-2649 ; 2041-2647
    DOI 10.1093/bfgp/elae013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6076: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Real-World Vaccine Research and Clinical Practice.

    Kumar, Anika / Acharya, Nisha R

    JAMA ophthalmology

    2024  

    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2024.1049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ul I Zs.26: Show issues Location:
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  6. Article ; Online: Soil fertility mapping of a cultivated area in Resunga Municipality, Gulmi, Nepal.

    Ghimire, Prabin / Shrestha, Santosh / Acharya, Ashok / Wagle, Aayushma / Acharya, Tri Dev

    PloS one

    2024  Volume 19, Issue 1, Page(s) e0292181

    Abstract: Soil fertility maps are crucial for sustainable soil and land use management system for predicting soil health status. However, many regions of Nepal lack updated or reliable soil fertility maps. This study aimed to develop the soil fertility map of ... ...

    Abstract Soil fertility maps are crucial for sustainable soil and land use management system for predicting soil health status. However, many regions of Nepal lack updated or reliable soil fertility maps. This study aimed to develop the soil fertility map of agricultural areas in Resunga Municipality, Gulmi district of Nepal using the geographical information system (GIS) technique. A total of 57 composite geo-referenced soil samples from the depth (0-20 cm) were taken from the agricultural land of an area of 52 km2. Soil samples were analyzed for their texture, pH, organic matter, total nitrogen, available phosphorous, available potassium, available boron, and available zinc. These parameters were modelled to develop a soil quality index (SQI). Using the kriging tool, obtained parameters were interpolated and digital maps were produced along with soil quality and nutrient indices. The result showed that the study area lies within the fair (0.4 to 0.6) and good (0.6 to 0.8) range of SQI representing 96% and 3% respectively. Soil organic matter and nitrogen showed moderate variability exhibiting a low status in 95% and 86% of the total study area. Phosphorous and potassium showed medium status in 88% and 75% of the study area, respectively. Zinc was low and boron status was medium in most of the area. To maintain soil fertility is by improving the rate of exogenous application of fertilizers and manures. The application of micronutrients like boron and zinc is highly recommended in the study area along with organic manures. The soil fertility map can be used as a baseline for soil and land use management in Resunga Municipality. We recommend further studies to validate the map and assess the factors affecting soil fertility in this region. Soil fertility maps provide researchers, farmers, students, and land use planners with easier decision-making tools for sustainable crop production systems and land use management systems.
    MeSH term(s) Humans ; Soil ; Nepal ; Boron ; Agriculture ; Nitrogen/analysis ; Potassium ; Zinc
    Chemical Substances Soil ; Boron (N9E3X5056Q) ; Nitrogen (N762921K75) ; Potassium (RWP5GA015D) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0292181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Antioxidative and Antibacterial Hydro-Ethanolic Fraction from an Asian Edible Mushroom Lentinus sajor-caju (Agaricomycetes) Suppresses Inflammatory Responses by Downregulating COX-2 and iNOS Expression.

    Naskar, Arghya / Dasgupta, Adhiraj / Basak, Gouri / Acharya, Krishnendu

    International journal of medicinal mushrooms

    2024  Volume 26, Issue 1, Page(s) 1–15

    Abstract: Mushrooms are prevalently important sources of pharmaceutically active metabolites. Various mushroom species belonging to the Lentinus genus are recognized for their nutritional and therapeutic properties. One such species is L. sajor-caju, which is ... ...

    Abstract Mushrooms are prevalently important sources of pharmaceutically active metabolites. Various mushroom species belonging to the Lentinus genus are recognized for their nutritional and therapeutic properties. One such species is L. sajor-caju, which is renowned in Southeast Asian nations for its culinary value. The primary goal of this study is to investigate the potential medicinal properties of L. sajor-caju, specifically its antioxidant, antibacterial, and anti-inflammatory effects. A hydroethanolic extract was formulated using dried basidiocarps, which exhibited a high phenolic content of approximately 14% and a flavonoid content of approximately 2.7%. The extract demonstrated significant antioxidant potential in in vitro reactions. The extract is sufficiently capable of scavenging free radicals (DPPH and ABTS) and chelate Fe2+ with EC50 values spanning from 186 to 390 μg/mL. In addition, considerable antimicrobial activity against tested pathogenic microorganisms was observed, as indicated by low MIC50 values (256-358 μg/mL). Moreover, the fraction was found to prevent heat-induced protein denaturation which signifies its anti-inflammatory potential. When tested on the RAW 264.7 cell line, reduction in the nitrite production, and downregulation of COX-2 and iNOS mRNA expression was observed which are the key regulator of inflammatory signalling systems. The study, therefore, recommends the use of L. sajor-caju in the medical and pharmaceutical industries for the benefit of humanity.
    MeSH term(s) Agaricales/chemistry ; Anti-Bacterial Agents ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Basidiomycota ; Cyclooxygenase 2/genetics ; Ethanol ; Lentinula ; Animals ; Mice ; RAW 264.7 Cells
    Chemical Substances Anti-Bacterial Agents ; Anti-Inflammatory Agents ; Antioxidants ; Cyclooxygenase 2 (EC 1.14.99.1) ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2108803-2
    ISSN 1940-4344 ; 1521-9437
    ISSN (online) 1940-4344
    ISSN 1521-9437
    DOI 10.1615/IntJMedMushrooms.2023051138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7482: Show issues

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  8. Article ; Online: P-ring: The conserved nature of phosphorus enriched cells in seedling roots of distantly related species.

    Acharya, Aniruddha / Pesacreta, Thomas C

    Plant signaling & behavior

    2023  Volume 18, Issue 1, Page(s) 2217389

    Abstract: Plants require sunlight, carbon dioxide, water and mineral ions for their growth and development. Roots in vascular plants sequester water and ions from soil and transport them to the aboveground parts of the plant. Due to heterogeneous nature of soil, ... ...

    Abstract Plants require sunlight, carbon dioxide, water and mineral ions for their growth and development. Roots in vascular plants sequester water and ions from soil and transport them to the aboveground parts of the plant. Due to heterogeneous nature of soil, roots have evolved several regulatory barriers from molecular to organismic level that selectively allows certain ions to enter the vascular tissues for transport according to the physiological and metabolic demands of plant cell. Current literature profusely elaborates about apoplastic barriers, but the possibility of the existence of a symplastic regulation through phosphorous-enriched cells has not been mentioned. Recent investigations on native ion distribution in seedling roots of several species (
    MeSH term(s) Seedlings/metabolism ; Phosphorus/metabolism ; Biological Transport ; Plant Roots/metabolism ; Water/metabolism ; Soil
    Chemical Substances Phosphorus (27YLU75U4W) ; Water (059QF0KO0R) ; Soil
    Language English
    Publishing date 2023-06-18
    Publishing country United States
    Document type Journal Article
    ISSN 1559-2324
    ISSN (online) 1559-2324
    DOI 10.1080/15592324.2023.2217389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Engineering Plastic Eating Enzymes Using Structural Biology.

    Barclay, Amelia / Acharya, K Ravi

    Biomolecules

    2023  Volume 13, Issue 9

    Abstract: Plastic pollution has emerged as a significant environmental concern in recent years and has prompted the exploration of innovative biotechnological solutions to mitigate plastic's negative impact. The discovery of enzymes capable of degrading specific ... ...

    Abstract Plastic pollution has emerged as a significant environmental concern in recent years and has prompted the exploration of innovative biotechnological solutions to mitigate plastic's negative impact. The discovery of enzymes capable of degrading specific types of plastics holds promise as a potential solution. However, challenges with efficiency, industrial scalability, and the diverse range of the plastic waste in question, have hindered their widespread application. Structural biology provides valuable insights into the intricate interactions between enzymes and plastic materials at an atomic level, and a deeper understanding of their underlying mechanisms is essential to harness their potential to address the mounting plastic waste crisis. This review article examines the current biochemical and biophysical methods that may facilitate the development of enzymes capable of degrading polyethylene terephthalate (PET), one of the most extensively used plastics. It also discusses the challenges that must be addressed before substantial advancements can be achieved in using these enzymes as a solution to the plastic pollution problem.
    Language English
    Publishing date 2023-09-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13091407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Energy inequality and air pollution nexus in India.

    Roy, Arindam / Acharya, Prasenjit

    The Science of the total environment

    2023  Volume 876, Page(s) 162805

    Abstract: Energy usage, inequality, and their impacts are deeply intertwined, especially in India. Every year, cooking using biomass-based solid fuel usage causes death to tens of thousands of Indians, specifically, economically unprivileged people. Solid fuel ... ...

    Abstract Energy usage, inequality, and their impacts are deeply intertwined, especially in India. Every year, cooking using biomass-based solid fuel usage causes death to tens of thousands of Indians, specifically, economically unprivileged people. Solid fuel burning has been known as one of the prominent sources of ambient PM
    Language English
    Publishing date 2023-03-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.162805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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