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  1. Article: A case of meropenem-induced liver injury and jaundice.

    Cheung, Szeya / Bulovic, Jennifer / Pillai, Ajish / Manoj, Trehan / Neeraj, Katriyar

    Journal of community hospital internal medicine perspectives

    2021  Volume 11, Issue 1, Page(s) 143–144

    Abstract: This report describes what we believe is the first reported case of clinically significant cholestasis and acute liver injury within three days of meropenem therapy. An 83-year-old Hispanic female was admitted for sepsis of unknown origin and was started ...

    Abstract This report describes what we believe is the first reported case of clinically significant cholestasis and acute liver injury within three days of meropenem therapy. An 83-year-old Hispanic female was admitted for sepsis of unknown origin and was started on intravenous meropenem. Three days following initiation of the antibiotic, the patient developed mixed hepatocellular and cholestatic liver injury with jaundice and pruritus. Possible causes of cholestasis were excluded after extensive investigations. A drug-induced liver injury was suspected and meropenem was discontinued. Following discontinuation of meropenem, the patient demonstrated symptomatic and laboratory improvements, and her liver enzymes and bilirubin levels were normalized.
    Language English
    Publishing date 2021-01-26
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2616884-4
    ISSN 2000-9666
    ISSN 2000-9666
    DOI 10.1080/20009666.2020.1845929
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A case of meropenem-induced liver injury and jaundice

    Szeya Cheung / Jennifer Bulovic / Ajish Pillai / Trehan Manoj / Katriyar Neeraj

    Journal of Community Hospital Internal Medicine Perspectives, Vol 11, Iss 1, Pp 143-

    2021  Volume 144

    Abstract: This report describes what we believe is the first reported case of clinically significant cholestasis and acute liver injury within three days of meropenem therapy. An 83-year-old Hispanic female was admitted for sepsis of unknown origin and was started ...

    Abstract This report describes what we believe is the first reported case of clinically significant cholestasis and acute liver injury within three days of meropenem therapy. An 83-year-old Hispanic female was admitted for sepsis of unknown origin and was started on intravenous meropenem. Three days following initiation of the antibiotic, the patient developed mixed hepatocellular and cholestatic liver injury with jaundice and pruritus. Possible causes of cholestasis were excluded after extensive investigations. A drug-induced liver injury was suspected and meropenem was discontinued. Following discontinuation of meropenem, the patient demonstrated symptomatic and laboratory improvements, and her liver enzymes and bilirubin levels were normalized.
    Keywords drug-induced liver injury ; antibiotic-induced liver injury ; antibiotic-induced jaundice ; meropenem-induced cholestatic jaundice ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  3. Article: Kwashiorkor on the south shore.

    Arcieri, Samuel T / Cheung, Szeya / Belkin, Alexander / Pillai, Ajish / Gupta, Ravi

    Journal of community hospital internal medicine perspectives

    2021  Volume 11, Issue 4, Page(s) 528–530

    Abstract: Kwashiorkor syndrome is a form of severe protein-energy malnutrition characterized by protein deficiency and bilateral extremity swelling. Worldwide, most affected regions include Southeast Asia, South Africa and Central America; it is rare in developed ... ...

    Abstract Kwashiorkor syndrome is a form of severe protein-energy malnutrition characterized by protein deficiency and bilateral extremity swelling. Worldwide, most affected regions include Southeast Asia, South Africa and Central America; it is rare in developed countries such as the USA. We report a case of profound kwashiorkor in a 38-year-old male with an underlying psychiatric disorder and restricted diet who presented with extensive abdominal distention and systemic findings indicative of protein malnutrition.
    Language English
    Publishing date 2021-06-21
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2616884-4
    ISSN 2000-9666
    ISSN 2000-9666
    DOI 10.1080/20009666.2021.1933718
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Recurrent Acute Pancreatitis in a Patient with COVID-19 Infection.

    Cheung, Szeya / Delgado Fuentes, Alain / Fetterman, Alan D

    The American journal of case reports

    2020  Volume 21, Page(s) e927076

    Abstract: BACKGROUND The novel COVID-19 disease has infected more than 2 million people worldwide, causing more than 120 000 deaths. While the disease is known to primarily affect the respiratory system, gastrointestinal manifestations can also occur. However, ... ...

    Abstract BACKGROUND The novel COVID-19 disease has infected more than 2 million people worldwide, causing more than 120 000 deaths. While the disease is known to primarily affect the respiratory system, gastrointestinal manifestations can also occur. However, little is known about the development of acute pancreatitis in COVID-19. The present report highlights a patient with no precipitating risk factors for pancreatitis who presented with recurring acute pancreatitis following the diagnosis of SARS-CoV-2 infection. CASE REPORT An otherwise healthy 38-year-old man presented to the Emergency Department (ED) with fever and epigastric pain. Laboratory testing revealed a lipase level of 10 255 ukat/L. An abdominal ultrasound showed no gallstones. After ruling out the possible causes of acute pancreatitis, a diagnosis of idiopathic acute pancreatitis was made. He received conservative management and was discharged home after being medically stabilized. Of note, the patient tested positive for SARS-CoV-2 infection at a local testing center 1 week prior to presenting to the ED. One week following the discharge, the patient returned with recurrent severe epigastric pain. Laboratory testing showed a lipase level of 20 320 ukat/L. An abdominal CT revealed acute pancreatitis. Further workups, including abdominal ultrasound, hepatitis serology, and immunoglobulin G for autoimmune pancreatitis, were unrevealing. Repeated SARS-CoV-2 testing produced positive results. CONCLUSIONS The temporal relationship between clinical presentation of acute pancreatitis and SARS-CoV-2 infection in this patient with no precipitating risk factors for pancreatitis suggests COVID-19-associated acute pancreatitis. Our review of the literature found a handful of reported cases of acute pancreatitis in patients with coexisting SARS-CoV-2 infection, and this report presents the first presumptive case of COVID-19-associated recurring acute pancreatitis.
    MeSH term(s) Adult ; Betacoronavirus ; COVID-19 ; Cholangiopancreatography, Magnetic Resonance/methods ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Humans ; Male ; Pancreatitis/complications ; Pancreatitis/diagnosis ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Recurrence ; SARS-CoV-2 ; Tomography, X-Ray Computed/methods
    Keywords covid19
    Language English
    Publishing date 2020-08-24
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.927076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Kwashiorkor on the south shore

    Samuel T. Arcieri / Szeya Cheung / Alexander Belkin / Ajish Pillai / Ravi Gupta

    Journal of Community Hospital Internal Medicine Perspectives, Vol 11, Iss 4, Pp 528-

    2021  Volume 530

    Abstract: Kwashiorkor syndrome is a form of severe protein-energy malnutrition characterized by protein deficiency and bilateral extremity swelling. Worldwide, most affected regions include Southeast Asia, South Africa and Central America; it is rare in developed ... ...

    Abstract Kwashiorkor syndrome is a form of severe protein-energy malnutrition characterized by protein deficiency and bilateral extremity swelling. Worldwide, most affected regions include Southeast Asia, South Africa and Central America; it is rare in developed countries such as the USA. We report a case of profound kwashiorkor in a 38-year-old male with an underlying psychiatric disorder and restricted diet who presented with extensive abdominal distention and systemic findings indicative of protein malnutrition.
    Keywords kwashiorkor syndrome ; severe malnutrition ; protein deficiency ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  6. Article: Recurrent Acute Pancreatitis in a Patient with COVID-19 Infection

    Cheung, Szeya / Delgado Fuentes, Alain / Fetterman, Alan D

    Am J Case Rep

    Abstract: BACKGROUND The novel COVID-19 disease has infected more than 2 million people worldwide, causing more than 120 000 deaths. While the disease is known to primarily affect the respiratory system, gastrointestinal manifestations can also occur. However, ... ...

    Abstract BACKGROUND The novel COVID-19 disease has infected more than 2 million people worldwide, causing more than 120 000 deaths. While the disease is known to primarily affect the respiratory system, gastrointestinal manifestations can also occur. However, little is known about the development of acute pancreatitis in COVID-19. The present report highlights a patient with no precipitating risk factors for pancreatitis who presented with recurring acute pancreatitis following the diagnosis of SARS-CoV-2 infection. CASE REPORT An otherwise healthy 38-year-old man presented to the Emergency Department (ED) with fever and epigastric pain. Laboratory testing revealed a lipase level of 10 255 ukat/L. An abdominal ultrasound showed no gallstones. After ruling out the possible causes of acute pancreatitis, a diagnosis of idiopathic acute pancreatitis was made. He received conservative management and was discharged home after being medically stabilized. Of note, the patient tested positive for SARS-CoV-2 infection at a local testing center 1 week prior to presenting to the ED. One week following the discharge, the patient returned with recurrent severe epigastric pain. Laboratory testing showed a lipase level of 20 320 ukat/L. An abdominal CT revealed acute pancreatitis. Further workups, including abdominal ultrasound, hepatitis serology, and immunoglobulin G for autoimmune pancreatitis, were unrevealing. Repeated SARS-CoV-2 testing produced positive results. CONCLUSIONS The temporal relationship between clinical presentation of acute pancreatitis and SARS-CoV-2 infection in this patient with no precipitating risk factors for pancreatitis suggests COVID-19-associated acute pancreatitis. Our review of the literature found a handful of reported cases of acute pancreatitis in patients with coexisting SARS-CoV-2 infection, and this report presents the first presumptive case of COVID-19-associated recurring acute pancreatitis.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #729775
    Database COVID19

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    Inter-library loan at ZB MED

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  7. Article ; Online: Superior Mesenteric Artery Thrombosis and Acute Intestinal Ischemia as a Consequence of COVID-19 Infection.

    Cheung, Szeya / Quiwa, Joseph C / Pillai, Ajish / Onwu, Chuks / Tharayil, Zubin J / Gupta, Ravi

    The American journal of case reports

    2020  Volume 21, Page(s) e925753

    Abstract: BACKGROUND The novel COVID-19 disease caused by the SARS-CoV-2 virus is a highly infectious disease that originated in Wuhan, China, and has rapidly spread throughout the world. In addition to respiratory complications, the virus has also been implicated ...

    Abstract BACKGROUND The novel COVID-19 disease caused by the SARS-CoV-2 virus is a highly infectious disease that originated in Wuhan, China, and has rapidly spread throughout the world. In addition to respiratory complications, the virus has also been implicated in damage to other organ systems as well as coagulopathy. The present report describes the first presumptive case of COVID-19-associated acute superior mesenteric artery thrombosis and acute intestinal ischemia. CASE REPORT A 55-year old man presented to the emergency department with nausea, generalized abdominal pain and diarrhea; he denied having a fever or any respiratory symptoms. Computed tomography (CT) of the abdomen and pelvis revealed bilateral pulmonary ground-glass opacities. He tested positive for SARS-CoV-2, and was treated with hydroxychloroquine, azithromycin and ceftriaxone, and was discharged home after five days of inpatient treatment. One week later, the patient returned with recurrent nausea, vomiting and worsening diffuse abdominal pain. A CT scan of the abdomen showed a 1.6-cm clot, causing high grade narrowing of the proximal superior mesenteric artery and bowel ischemia. The patient emergently underwent exploratory laparotomy, thromboembolectomy and resection of the ischemic small bowel. A post-operative complete hypercoagulable workup was unrevealing. CONCLUSIONS Despite the absence of respiratory symptoms, patients infected with SARS-CoV-2 may show atypical presentations, such as gastrointestinal symptoms. Clinicians managing patients with suspected or confirmed SARS-CoV-2 infection during the COVID-19 pandemic should monitor these patients for potential complications that may arise from this disease.
    MeSH term(s) Abdominal Pain/etiology ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Diarrhea/etiology ; Embolectomy ; Humans ; Infarction/diagnosis ; Infarction/surgery ; Infarction/virology ; Intestines/blood supply ; Intestines/diagnostic imaging ; Intestines/surgery ; Ischemia/diagnostic imaging ; Ischemia/surgery ; Ischemia/virology ; Male ; Mesenteric Artery, Superior/diagnostic imaging ; Mesenteric Artery, Superior/surgery ; Mesenteric Vascular Occlusion/diagnostic imaging ; Mesenteric Vascular Occlusion/surgery ; Mesenteric Vascular Occlusion/virology ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2 ; Thrombectomy ; Thrombosis/diagnostic imaging ; Thrombosis/surgery ; Thrombosis/virology ; Tomography, X-Ray Computed
    Keywords covid19
    Language English
    Publishing date 2020-07-29
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.925753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Superior Mesenteric Artery Thrombosis and Acute Intestinal Ischemia as a Consequence of COVID-19 Infection

    Cheung, Szeya / Quiwa, Joseph C / Pillai, Ajish / Onwu, Chuks / Tharayil, Zubin J / Gupta, Ravi

    Am J Case Rep

    Abstract: BACKGROUND The novel COVID-19 disease caused by the SARS-CoV-2 virus is a highly infectious disease that originated in Wuhan, China, and has rapidly spread throughout the world. In addition to respiratory complications, the virus has also been implicated ...

    Abstract BACKGROUND The novel COVID-19 disease caused by the SARS-CoV-2 virus is a highly infectious disease that originated in Wuhan, China, and has rapidly spread throughout the world. In addition to respiratory complications, the virus has also been implicated in damage to other organ systems as well as coagulopathy. The present report describes the first presumptive case of COVID-19-associated acute superior mesenteric artery thrombosis and acute intestinal ischemia. CASE REPORT A 55-year old man presented to the emergency department with nausea, generalized abdominal pain and diarrhea; he denied having a fever or any respiratory symptoms. Computed tomography (CT) of the abdomen and pelvis revealed bilateral pulmonary ground-glass opacities. He tested positive for SARS-CoV-2, and was treated with hydroxychloroquine, azithromycin and ceftriaxone, and was discharged home after five days of inpatient treatment. One week later, the patient returned with recurrent nausea, vomiting and worsening diffuse abdominal pain. A CT scan of the abdomen showed a 1.6-cm clot, causing high grade narrowing of the proximal superior mesenteric artery and bowel ischemia. The patient emergently underwent exploratory laparotomy, thromboembolectomy and resection of the ischemic small bowel. A post-operative complete hypercoagulable workup was unrevealing. CONCLUSIONS Despite the absence of respiratory symptoms, patients infected with SARS-CoV-2 may show atypical presentations, such as gastrointestinal symptoms. Clinicians managing patients with suspected or confirmed SARS-CoV-2 infection during the COVID-19 pandemic should monitor these patients for potential complications that may arise from this disease.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #690362
    Database COVID19

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    Inter-library loan at ZB MED

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