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Book ; Online: Impfung gegen humane Papillomviren (HPV)

Lohse, Tina / Jacke, Christian Olaf / Wild, Frank

eine Analyse der Arzneimittelverordnungsdaten in der PKV - 2006 bis 2016

(WIP-Analyse ; 2019, 1)

2019

Institution	Wissenschaftliches Institut der PKV
Author's details	Tina Lohse, Christian O. Jacke, Frank Wild ; WIP, Wissenschaftliches Institut der PKV
Series title	WIP-Analyse ; 2019, 1
Collection
Language	German
Size	1 Online-Ressource (16 Seiten), Diagramme
Publisher	WIP - Wissenschaftliches Institut der PKV
Publishing place	Köln
Publishing country	Germany
Document type	Book ; Online
Note	Open Access
HBZ-ID	HT020282266
ISBN	9783981826944 ; 3981826949
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Increasing Transparency for Consumers Showing Probabilities of Virtual Items in Loot Boxes in Digital Games

Philipp Christian Lohse

International Journal of Social Sciences and Economic Review, Vol 2, Iss

2023 Volume 3

Abstract: Purpose of the study: This study is motivated by the increasing public discussions about loot boxes. There are similarities between loot boxes and gambling. Digital games often cross the line between skill-based games and gambling. Methodology: The ... ...

Abstract	Purpose of the study: This study is motivated by the increasing public discussions about loot boxes. There are similarities between loot boxes and gambling. Digital games often cross the line between skill-based games and gambling. Methodology: The presented data in this study is based on an online survey from July 2019 in Germany, Hungary, South Africa, Thailand, the United Kingdom, and the United States of America. Main Findings: This paper discusses the public acceptance of a possible loot box regulation. Often, the probabilities of items inside loot boxes are not shown. This paper discusses the acceptance of mandatory showing of loot box probabilities and finds that there is a major agreement to the possible increase of transparency. Research limitations: The presented data only applies to Germany, Hungary, South Africa, Thailand, the UK, and the USA in July 2019. Findings from this study cannot be transferred to other countries. There might be further regional differences in other countries. Further research of consumer preferences for possible regulations can help in determining useful regulations for digital games with loot boxes. Novelty/Originality of this study: Knowledge in this research field is still limited. There are yet adequate studies that explore consumer preferences concerning game design. This applies especially for the field of consumer preferences concerning the showing of probabilities of virtual items inside loot boxes.
Keywords	Freemium ; Digital ; Gaming ; Survey ; Transparency ; Loot Box ; Economics as a science ; HB71-74 ; Social sciences (General) ; H1-99
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Editorial Office International Journal of Social Sciences and Economic Review
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Marangoni Instability of a Drop in a Stably Stratified Liquid.

Li, Yanshen / Diddens, Christian / Prosperetti, Andrea / Lohse, Detlef

Physical review letters

2021 Volume 126, Issue 12, Page(s) 124502

Abstract: Marangoni instabilities can emerge when a liquid interface is subjected to a concentration or temperature gradient. It is generally believed that for these instabilities bulk effects like buoyancy are negligible compared to interfacial forces, especially ...

Abstract	Marangoni instabilities can emerge when a liquid interface is subjected to a concentration or temperature gradient. It is generally believed that for these instabilities bulk effects like buoyancy are negligible compared to interfacial forces, especially on small scales. Consequently, the effect of a stable stratification on the Marangoni instability has hitherto been ignored. Here, however, we show that they can matter. We report, for an immiscible drop immersed in a stably stratified ethanol-water mixture, a new type of oscillatory solutal Marangoni instability that is triggered once the stratification has reached a critical value. We experimentally explore the parameter space spanned by the stratification strength and the drop size and theoretically explain the observed crossover from levitating to bouncing by balancing the advection and diffusion around the drop. Finally, the effect of the stable stratification on the Marangoni instability is surprisingly strongly amplified in confined geometries, leading to an earlier onset.
Language	English
Publishing date	2021-03-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.126.124502
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Management of Thermal Injuries in Donkeys: A Case Report.

Lohse, Jorge / Pietrantoni, Pierpaolo / Tummers, Christian

Animals : an open access journal from MDPI

2020 Volume 10, Issue 11

Abstract: Burn injuries are uncommon in large animals and there are no reports of these injuries in donkeys. Burns cause local and systemic effects. Extensive thermal injuries can be challenging to manage and the extent of the burn surface affected will directly ... ...

Abstract	Burn injuries are uncommon in large animals and there are no reports of these injuries in donkeys. Burns cause local and systemic effects. Extensive thermal injuries can be challenging to manage and the extent of the burn surface affected will directly impact the severity of the illness and the prognosis. Burns are classified according to the depth of injury into four categories, from first-degree burns, and the least affect to fourth-degree burns, which are the more severely affected patients. This case report describes the medical management of four donkeys that sustained various degrees of external burn injuries during the wildland-urban interface fire in Valparaiso, Chile. The donkeys were treated topically for several weeks and closely monitor for inadequate nutritional intake. Water based topical medications are preferred in burn cases because they can be easily applied and removed without interfering with wound healing. Of note, the caloric demands of these cases can be achieved by increasing the amount of grain, adding fat (i.e., vegetable oil), and free-choice alfalfa hay. All donkeys recovered and were retired to an animal shelter.
Language	English
Publishing date	2020-11-17
Publishing country	Switzerland
Document type	Case Reports
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani10112131
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Behavioral factors predict all-cause mortality in female coronary patients and healthy controls over 26 years - a prospective secondary analysis of the Stockholm Female Coronary Risk Study.

Deter, Hans-Christian / Meister, Reinhard / Leineweber, Constanze / Kecklund, Göran / Lohse, Lukas / Orth-Gomér, Kristina

PloS one

2022 Volume 17, Issue 12, Page(s) e0277028

Abstract: Objective: The prognosis of coronary artery disease (CAD) is related to its severity and cardiovascular risk factors in both sexes. In women, social isolation, marital stress, sedentary lifestyle and depression predicted CAD progression and outcome ... ...

Abstract	Objective: The prognosis of coronary artery disease (CAD) is related to its severity and cardiovascular risk factors in both sexes. In women, social isolation, marital stress, sedentary lifestyle and depression predicted CAD progression and outcome within 3 to 5 years. We hypothesised that these behavioral factors would still be associated with all-cause mortality in female patients after 26 years. Methods: We examined 292 patients with CAD and 300 healthy controls (mean age of 56 ± 7 y) within the Fem-Cor-Risk-Study at baseline. Their cardiac, behavioral, and psychosocial risk profiles, exercise, smoking, and dietary habits were assessed using standardized procedures. Physiological characteristics included a full lipid profile, the coagulation cascade and autonomic dysfunction (heart rate variability, HRV). A new exploratory analysis using machine-learning algorithms compared the effects of social and behavioral mechanisms with standard risk factors. Results: All-cause mortality records were completed in 286 (97.9%) patients and 299 (99.7%) healthy women. During a median follow-up of 26 years, 158 (55.2%) patients and 101 (33.9%) matched healthy controls died. The annualized mortality rate was 2.1% and 1.3%, respectively. After controlling for all available confounders, behavioral predictors of survival in patients were social integration (HR 0.99, 95% CI 0.99-1.0) and physical activity (HR 0.54, 95% CI 0.37-0.79). Smoking acted as a predictor of all-cause mortality (HR 1.56, 95% CI 1.03-2.36). Among healthy women, moderate physical activity (HR 0.42, 95% CI 0.24-0.74) and complete HRV recordings (≥50%) were found to be significant predictors of survival. Conclusions: CAD patients with adequate social integration, who do not smoke and are physically active, have a favorable long-term prognosis. The exact survival times confirm that behavioral risk factors are associated with all-cause mortality in female CAD patients and healthy controls.
MeSH term(s)	Humans ; Female ; Middle Aged ; Prospective Studies ; Social Isolation ; Exercise
Language	English
Publishing date	2022-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0277028
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Reduced Steroid Synthesis in the Follicular Fluid of MTHFR 677TT Mutation Carriers: Effects of Increased Folic Acid Administration.

Pavlik, Roman / Hecht, Stephanie / Noss, Ulrich / Soldin, Offie P / Mendu, Rao D / Soldin, Steven J / Lohse, Peter / Thaler, Christian J

Geburtshilfe und Frauenheilkunde

2022 Volume 82, Issue 10, Page(s) 1074–1081

Abstract: ... ...

Abstract	Objective
Language	English
Publishing date	2022-09-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80111-2
ISSN	1438-8804 ; 0016-5751 ; 1615-3359
ISSN (online)	1438-8804
ISSN	0016-5751 ; 1615-3359
DOI	10.1055/a-1791-9358
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Article ; Online: Management of Thermal Injuries in Donkeys

Jorge Lohse / Pierpaolo Pietrantoni / Christian Tummers

Animals, Vol 10, Iss 2131, p

A Case Report

2020 Volume 2131

Abstract	Burn injuries are uncommon in large animals and there are no reports of these injuries in donkeys. Burns cause local and systemic effects. Extensive thermal injuries can be challenging to manage and the extent of the burn surface affected will directly impact the severity of the illness and the prognosis. Burns are classified according to the depth of injury into four categories, from first-degree burns, and the least affect to fourth-degree burns, which are the more severely affected patients. This case report describes the medical management of four donkeys that sustained various degrees of external burn injuries during the wildland–urban interface fire in Valparaiso, Chile. The donkeys were treated topically for several weeks and closely monitor for inadequate nutritional intake. Water based topical medications are preferred in burn cases because they can be easily applied and removed without interfering with wound healing. Of note, the caloric demands of these cases can be achieved by increasing the amount of grain, adding fat (i.e., vegetable oil), and free-choice alfalfa hay. All donkeys recovered and were retired to an animal shelter.
Keywords	donkeys ; thermal injurie ; burns ; fire ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Breath-by-breath comparison of a novel percutaneous phrenic nerve stimulation approach with mechanical ventilation in juvenile pigs: a pilot study.

Deininger, Matthias Manfred / Ziles, Dmitrij / Borleis, Annegret / Seemann, Teresa / Erlenkoetter, Fabian / Bleilevens, Christian / Lohse, Arnhold / Benner, Carl-Friedrich / Leonhardt, Steffen / Walter, Marian / Breuer, Thomas

Scientific reports

2024 Volume 14, Issue 1, Page(s) 10252

Abstract: About one in three critically ill patients requires mechanical ventilation (MV). Prolonged MV, however, results in diaphragmatic weakness, which itself is associated with delayed weaning and increased mortality. Inducing active diaphragmatic contraction ... ...

Abstract	About one in three critically ill patients requires mechanical ventilation (MV). Prolonged MV, however, results in diaphragmatic weakness, which itself is associated with delayed weaning and increased mortality. Inducing active diaphragmatic contraction via electrical phrenic nerve stimulation (PNS) not only provides the potential to reduce diaphragmatic muscular atrophy but also generates physiological-like ventilation and therefore offers a promising alternative to MV. Reasons why PNS is not yet used in critical care medicine are high procedural invasiveness, insufficient evidence, and lack of side-by-side comparison to MV. This study aims to establish a minimal-invasive percutaneous, bilateral electrode placement approach for sole PNS breathing and thereby enable, for the first time, a breath-by-breath comparison to MV. Six juvenile German Landrace pigs received general anesthesia and orotracheal intubation. Following the novel ultrasound-guided, landmark-based, 4-step approach, two echogenic needles per phrenic nerve were successfully placed. Stimulation effectiveness was evaluated measuring tidal volume, diaphragmatic thickening and tomographic electrical impedance in a breath-by-breath comparison to MV. Following sufficient bilateral phrenic nerve stimulation in all pigs, PNS breaths showed a 2.2-fold increase in diaphragmatic thickening. It induced tidal volumes in the lung-protective range by negative pressure inspiration and improved dorso-caudal regional ventilation in contrast to MV. Our study demonstrated the feasibility of a novel ultrasound-guided, percutaneous phrenic nerve stimulation approach, which generated sufficient tidal volumes and showed more resemblance to physiological breathing than MV in a breath-by-breath comparison.
MeSH term(s)	Animals ; Phrenic Nerve/physiology ; Respiration, Artificial/methods ; Swine ; Pilot Projects ; Diaphragm/innervation ; Diaphragm/physiology ; Tidal Volume ; Electric Stimulation Therapy/methods ; Transcutaneous Electric Nerve Stimulation/methods ; Electric Stimulation/methods
Language	English
Publishing date	2024-05-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comparative Study
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-61103-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Identification of novel snoRNA-based biomarkers for clear cell renal cell carcinoma from urine-derived extracellular vesicles.

Grützmann, Konrad / Salomo, Karsten / Krüger, Alexander / Lohse-Fischer, Andrea / Erdmann, Kati / Seifert, Michael / Baretton, Gustavo / Aust, Daniela / William, Doreen / Schröck, Evelin / Thomas, Christian / Füssel, Susanne

Biology direct

2024 Volume 19, Issue 1, Page(s) 38

Abstract: Background: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of RCC with high rates of metastasis. Targeted therapies such as tyrosine kinase and checkpoint inhibitors have improved treatment success, but therapy-related side effects ... ...

Abstract	Background: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of RCC with high rates of metastasis. Targeted therapies such as tyrosine kinase and checkpoint inhibitors have improved treatment success, but therapy-related side effects and tumor recurrence remain a challenge. As a result, ccRCC still have a high mortality rate. Early detection before metastasis has great potential to improve outcomes, but no suitable biomarker specific for ccRCC is available so far. Therefore, molecular biomarkers derived from body fluids have been investigated over the past decade. Among them, RNAs from urine-derived extracellular vesicles (EVs) are very promising. Methods: RNA was extracted from urine-derived EVs from a cohort of 78 subjects (54 ccRCC patients, 24 urolithiasis controls). RNA-seq was performed on the discovery cohort, a subset of the whole cohort (47 ccRCC, 16 urolithiasis). Reads were then mapped to the genome, and expression was quantified based on 100 nt long contiguous genomic regions. Cluster analysis and differential region expression analysis were performed with adjustment for age and gender. The candidate biomarkers were validated by qPCR in the entire cohort. Receiver operating characteristic, area under the curve and odds ratios were used to evaluate the diagnostic potential of the models. Results: An initial cluster analysis of RNA-seq expression data showed separation by the subjects' gender, but not by tumor status. Therefore, the following analyses were done, adjusting for gender and age. The regions differentially expressed between ccRCC and urolithiasis patients mainly overlapped with small nucleolar RNAs (snoRNAs). The differential expression of four snoRNAs (SNORD99, SNORD22, SNORD26, SNORA50C) was validated by quantitative PCR. Confounder-adjusted regression models were then used to classify the validation cohort into ccRCC and tumor-free subjects. Corresponding accuracies ranged from 0.654 to 0.744. Models combining multiple genes and the risk factors obesity and hypertension showed improved diagnostic performance with an accuracy of up to 0.811 for SNORD99 and SNORA50C (p = 0.0091). Conclusions: Our study uncovered four previously unrecognized snoRNA biomarkers from urine-derived EVs, advancing the search for a robust, easy-to-use ccRCC screening method.
MeSH term(s)	Humans ; Carcinoma, Renal Cell/urine ; Carcinoma, Renal Cell/genetics ; Extracellular Vesicles/genetics ; Extracellular Vesicles/metabolism ; Biomarkers, Tumor/urine ; Biomarkers, Tumor/genetics ; Female ; Male ; Middle Aged ; Kidney Neoplasms/urine ; Kidney Neoplasms/genetics ; Aged ; RNA, Small Nucleolar/genetics ; Cohort Studies ; Adult
Chemical Substances	Biomarkers, Tumor ; RNA, Small Nucleolar
Language	English
Publishing date	2024-05-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2221028-3
ISSN	1745-6150 ; 1745-6150
ISSN (online)	1745-6150
ISSN	1745-6150
DOI	10.1186/s13062-024-00467-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online ; Thesis: Der Einfluss von HIF-1α und metabolischen Interaktionen auf Histoplasma capsulatum Infektionen in Alveolarmakrophagen

Lohse, Björn [Verfasser] / Rupp, Jan [Akademischer Betreuer] / Sadik, Christian [Akademischer Betreuer]

2021

Author's details	Björn Lohse ; Akademische Betreuer: Jan Rupp, Christian Sadik
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Zentrale Hochschulbibliothek Lübeck
Publishing place	Lübeck
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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