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Article ; Online: Systems Pharmacology Strategy for the Investigation of Action Mechanisms of Qin Herb Libanotis Buchtormensis (

Feng, Rundong / Wang, Lifang / Chai, Hu / Jiao, Jie / Zhang, Peng / Zheng, Xu / Liu, Haijing / Zhang, Wenjuan / Wu, Suli

Endocrine, metabolic & immune disorders drug targets

2023 Volume 24, Issue 1, Page(s) 142–152

Abstract: Introduction: Qin medicines are medicinal plants growing in habitat around the peak of Qinling ... one of the popular Qin herbs, which has been widely used for the treatment of various diseases ...

Abstract	Introduction: Qin medicines are medicinal plants growing in habitat around the peak of Qinling Mountain. Their unique curative effects on bone metabolic diseases and pain diseases have been favoured by the local people in clinical trials for thousands of years. Libanotis buchtormensis (Fisch.) DC. (LBD), is one of the popular Qin herbs, which has been widely used for the treatment of various diseases, such as osteoporosis, rheumatic, and cardiovascular diseases. However, due to the multiple compounds in LBD, the underlying molecular mechanisms of LBD remain unclear. Objective: This study aimed to systemically investigate the underlying mechanisms of LBD against bone diseases. Methods: In this study, a systems pharmacology platform included the potential active compound screening, target fishing, and network pharmacological analysis was employed to decipher the action mechanisms of LBD. Results: As a result, 12 potential active compounds and 108 targets were obtained. Furthermore, compound-target network and target-pathway network analysis showed that multi-components interacted with multi-targets and multi-pathways, i.e., MARK signalling pathway, mTORC1 signalling pathway, etc., involved in the regulation of the immune system and circulatory system. These results suggested the mechanisms of the therapeutic effects of LBD on various diseases through most compounds targeted by multiple targets. Conclusion: In conclusion, we successfully predicted the LBD bioactive compounds and potential targets, implying that LBD could be applied as a novel therapeutic herb in osteoporosis, rheumatic, and cardiovascular diseases. This work provides insight into the therapeutic mechanisms of LBD for treating various diseases.
MeSH term(s)	Humans ; Drugs, Chinese Herbal/pharmacology ; Medicine, Chinese Traditional/methods ; Network Pharmacology ; Cardiovascular Diseases/drug therapy ; Osteoporosis/drug therapy ; Molecular Docking Simulation
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2023-07-19
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2228325-0
ISSN	2212-3873 ; 1871-5303
ISSN (online)	2212-3873
ISSN	1871-5303
DOI	10.2174/1871530323666230720143415
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Article ; Online: Spatiotemporal characteristics of soil erosion in a typical watershed consisting of different landscape: A case study of the Qin River Basin.

Li, Yanyan / Rong, Tianqi / Qin, Mingzhou / Zhang, Pengyan / Yang, Dan / Liu, Zhenyue / Zhang, Ying / Zhu, Hui / Song, Meiling

PloS one

2022 Volume 17, Issue 10, Page(s) e0275470

Abstract: ... of soil erosion intensity among different geographic environmental factors. The Qin River Basin is a geographical ... Universal Soil Loss Equation model to analyze the spatiotemporal changes in the soil-erosion intensity in the Qin River Basin ... environmental factors and different land use types. Results show that the soil erosion modulus of Qin River Basin were ...

Abstract	Soil erosion has a severe impact on habitat and productivity. It is considered to be a major environmental threat prevalent in ecosystems. However, few researchers have studied the spatial distribution of soil erosion intensity among different geographic environmental factors. The Qin River Basin is a geographical unit consisting of mountains, hills, and plains with significant regional characteristics, and it has a basin area of 14,810.91 km2. This study uses the Geographical Information Systems, Revised Universal Soil Loss Equation model to analyze the spatiotemporal changes in the soil-erosion intensity in the Qin River Basin from 1990 to 2018. Different environmental factors of land use, slope and altitude on erosion intensities of 19 secondary land types were analyzed. It can better reflect the soil erosion under different environmental factors and different land use types. Results show that the soil erosion modulus of Qin River Basin were 10.25 t hm-2 a-1, and it belong to slight erosion from 1990 to 2018. Soil erosion intensity is greater in grassland and woodland than in cropland. The strongest soil erosion occurred in the sparse forestland, and the lowest was in beach land. Soil erosion was the highest for a slope of 15~25° and an altitude of 1200~1500 m. Rainfall and slope are important factors lead to soil erosion, indicating weak water and soil conservation implemented in these areas. Therefore, priority should be given to these geomorphic units to formulate and implement soil-erosion control and ecological restoration policies in the Qin River Basin. This study provides a good reference for preventing and controlling soil erosion in river basins.
MeSH term(s)	China ; Conservation of Natural Resources ; Ecosystem ; Environmental Monitoring/methods ; Rivers ; Soil ; Soil Erosion ; Water
Chemical Substances	Soil ; Water (059QF0KO0R)
Language	English
Publishing date	2022-10-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0275470
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Article ; Online: A four-component combination derived from Huang-Qin Decoction significantly enhances anticancer activity of irinotecan.

Xu, Dou-Dou / Hou, Xiao-Ying / Wang, Ou / Wang, Di / Li, Dan-Ting / Qin, Si-Yuan / Lv, Bo / Dai, Xiao-Min / Zhang, Zun-Jian / Wan, Jian-Bo / Xu, Feng-Guo

Chinese journal of natural medicines

2021 Volume 19, Issue 5, Page(s) 364–375

Abstract: Huang-Qin Decoction (HQD) is a classic prescription for diarrhea in Chinese medicine treatment ...

Abstract	Huang-Qin Decoction (HQD) is a classic prescription for diarrhea in Chinese medicine treatment. Recent studies have demonstrated that HQD and its modified formulation PHY906 could ameliorate irinotecan (CPT-11) induced gastrointestinal (GI) toxicity and enhance its anticancer therapeutic efficacy. Nevertheless, which constituents in HQD are effective is still unclear so far. The study aims to screen out the key bioactive components combination from HQD that could enhance the anticancer effect of CPT-11. First, the potential bioactive constituents were obtained through system pharmacology strategy. Then the bioactivity of each constituent was investigated synthetically from the aspects of NCM460 cell migration, TNF-α release of THP-1-derived macrophage and MTT assay in HCT116 cell. The contribution of each constituent in HQD was evaluated using the bioactive index E
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Apoptosis ; Cell Proliferation ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; HCT116 Cells ; Humans ; Irinotecan/pharmacology ; Scutellaria baicalensis/chemistry ; Xenograft Model Antitumor Assays
Chemical Substances	Antineoplastic Agents ; Drugs, Chinese Herbal ; Irinotecan (7673326042)
Language	English
Publishing date	2021-04-30
Publishing country	China
Document type	Journal Article
ZDB-ID	2192577-X
ISSN	1875-5364 ; 2095-6975 ; 1672-3651
ISSN (online)	1875-5364
ISSN	2095-6975 ; 1672-3651
DOI	10.1016/S1875-5364(21)60034-1
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Article ; Online: Sustainability assessment of small hydropower from an ESG perspective: A case study of the Qin-Ba Mountains, China.

Zhu, Jiwei / Zhang, Jianmei / Wu, Haojun / Yi, Xihan / Liu, Yu

Journal of environmental management

2023 Volume 350, Page(s) 119523

Abstract: ... From an Environmental, Social, and Governance (ESG) perspective and using three SHP stations (GXD, WZL, and SJB) in the Qin-Ba ...

Abstract	Small hydropower (SHP) has made significant contributions to economic and social development in rural and remote mountainous regions. However, the adverse ecological-environmental impacts resulting from the SHP sector and challenges in hydropower management have become major areas of concern. From an Environmental, Social, and Governance (ESG) perspective and using three SHP stations (GXD, WZL, and SJB) in the Qin-Ba Mountains as case studies, we constructed a sustainability assessment system comprising 18 indicators across three dimensions. The hesitant fuzzy linguistic term sets (HFLTSs) and cloud models were employed to determine the sustainability level of SHP by characterizing the hesitancy of the evaluator and the uncertainty of the evaluated data. (1) The ecological-environmental protection (E) dimension was assigned the greatest weight, followed by the dimensions of social responsibility contribution (S) and corporate governance management (G). The weights of certain indicators, including the water qualification rate, river morphology maintenance, guaranteed rate of instream flow, comprehensive utilization, and production safety standardization grade were relatively high, conforming to the current context of green development prioritization in which ecological-environmental protection is of the utmost importance. (2) The overall sustainability levels of all three SHP stations were "good", with the E-dimension contributing the most and the G-dimension contributing the least to the sustainability goal. (3) The GXD, WZL, and SJB stations were ranked first, second, and third, respectively, in terms of their sustainability scores. This study provides an innovative perspective for the sustainability assessment of SHP. The evaluation method can be generalized to encompass multi-attribute decision-making problems. The findings of this study can aid in addressing the shortcomings associated with SHP development and promote sustainability within the SHP industry.
MeSH term(s)	Conservation of Natural Resources ; Uncertainty ; Industry ; China ; Rivers
Language	English
Publishing date	2023-11-23
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2023.119523
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Article ; Online: Network pharmacological analysis to reveal the mechanism governing the effect of Qin Xi Tong on osteoarthritis and rheumatoid arthritis.

Lv, Yanyan / Zhang, Jie / Li, Chao / Wang, Li / Lei, Lei / Huang, Xiaoqiang

Clinical rheumatology

2023 Volume 42, Issue 8, Page(s) 2209–2222

Abstract: Introduction: Qin Xi Tong (QXT), produced by water extracts of Caulis Sinomenii, is clinically ...

Abstract	Introduction: Qin Xi Tong (QXT), produced by water extracts of Caulis Sinomenii, is clinically effective in the therapy of rheumatoid arthritis (RA). It is also a complementary agent for osteoarthritis (OA). This study aimed to screen the candidate targets and identify the potential mechanisms of QXT against RA and OA. Method: The active ingredients contained in QXT were queried from the TCMSP database. Their predicted targets were obtained through web-based databases, including TCMSP, BATMAN-TCM, CTD, and PharmMapper. The OA and RA targets were collected from the Genecards database and the GSE55235 dataset. Based on the DAVID database, GO and KEGG enrichment analyses of disease-drug common targets predicted potential signaling pathways for QXT. In addition, core targets were identified by mapping component-target-disease interaction networks with Cytoscape 3.9.1 and STRING. The Swissdock and Pymol tools further validate the predicted results. Results: A total of 161 genes were put forward as potential targets for treating RA and OA. These genes might be involved in joint inflammation, including the IL-17 signaling pathway, MAPK signaling pathway, and TNF signaling pathway. They also regulated the progression of joint injuries, such as apoptosis, Th17 cell differentiation, and osteoclast differentiation. In addition, we identified 12 core targets of QXT. Molecular docking results showed that QXT has a high affinity with these core targets. Conclusions: This study reveals the mechanism governing the effect of QXT on RA and OA, predicts the direct target, and provides new ideas for clinical treatment. Key Points • Our study reveals the underlying mechanism of QXT in the treatment of RA and OA. • Further research into the effects of compounds in QXT alone would be of interest.
MeSH term(s)	Humans ; Molecular Docking Simulation ; Osteoarthritis/drug therapy ; Arthritis, Rheumatoid/drug therapy ; Apoptosis ; Cell Differentiation ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Medicine, Chinese Traditional
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2023-05-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-023-06625-5
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Article: Network pharmacology analysis reveals neuroprotective effects of the Qin-Zhi-Zhu-Dan Formula in Alzheimer's disease.

Xu, Wenxiu / Ren, Beida / Zhang, Zehan / Chen, Congai / Xu, Tian / Liu, Shuling / Ma, Chongyang / Wang, Xueqian / Wang, Qingguo / Cheng, Fafeng

Frontiers in neuroscience

2022 Volume 16, Page(s) 943400

Abstract: ... neurodegenerative diseases. The Qin-Zhi-Zhu-Dan Formula (QZZD) is derived from a widely used Chinese patent drug-Qing-Kai ...

Abstract	There is yet no effective drug for Alzheimer's disease (AD) which is one of the world's most common neurodegenerative diseases. The Qin-Zhi-Zhu-Dan Formula (QZZD) is derived from a widely used Chinese patent drug-Qing-Kai-Ling Injection. It consists of
Language	English
Publishing date	2022-10-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2022.943400
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Article: Toxicological safety evaluation of Qin-Zhi-Zhu-Dan formula in rats during the treatment and recovery periods.

Xu, Wenxiu / Chen, Dan / Zhang, Zehan / Liu, Shuling / Chen, Congai / Sun, Chunyan / Ni, Wenchao / Kang, Xiangdong / Shang, Guojiao / Wang, Xueqian / Cheng, Fafeng / Wang, Qingguo

Frontiers in pharmacology

2022 Volume 13, Page(s) 987997

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-08-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.987997
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Article ; Online: Study on digital protection and innovative design of Qin opera costumes

Kaixuan Liu / Yuanyuan Gao / Jiaqi Zhang / Chun Zhu

Heritage Science, Vol 10, Iss 1, Pp 1-

2022 Volume 15

Abstract: Abstract Qin opera culture has a long history in China for thousands of years. It is the ancestor ... the protection and inheritance of traditional Qin opera culture is facing a new challenge and ... opportunity, its costume culture is the same. This paper analyzes the style and structure of Qin opera costumes, extracts ...

Abstract	Abstract Qin opera culture has a long history in China for thousands of years. It is the ancestor of Chinese opera. However, with the development of modern technology and the rise of new media, the protection and inheritance of traditional Qin opera culture is facing a new challenge and opportunity, its costume culture is the same. This paper analyzes the style and structure of Qin opera costumes, extracts the colors of the costumes, summarizes the costume patterns, and then uses the three-dimensional (3D) virtual visualization technology to virtually restore the Qin opera costume, and innovates the Qin opera costume. In this paper, twelve sets of traditional Qin opera costumes are virtually restored, and on this basis, the digital protection and innovative design of Qin opera series costumes are carried out, and all the restored costumes are displayed digitally in an all-round way. The combination of Qin opera costume and digital protection extends the application scope of virtual visualization technology and enriches the transmission mode of Qin opera costume. This study inherits and protects the traditional Qin opera costume culture better.
Keywords	Qin opera costumes ; Virtual visualization ; Innovative design ; Digital protection ; Fine Arts ; N ; Analytical chemistry ; QD71-142
Subject code	430
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
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Article ; Online: YdfD, a Lysis Protein of the Qin Prophage, Is a Specific Inhibitor of the IspG-Catalyzed Step in the MEP Pathway of

Lu, Zhifang / Wang, Biying / Qiu, Zhiyu / Zhang, Ruiling / Zheng, Jimin / Jia, Zongchao

International journal of molecular sciences

2022 Volume 23, Issue 3

Abstract: Bacterial cryptic prophage (defective prophage) genes are known to drastically influence host physiology, such as causing cell growth arrest or lysis, upon expression. Many phages encode lytic proteins to destroy the cell envelope. As natural antibiotics, ...

Abstract	Bacterial cryptic prophage (defective prophage) genes are known to drastically influence host physiology, such as causing cell growth arrest or lysis, upon expression. Many phages encode lytic proteins to destroy the cell envelope. As natural antibiotics, only a few lysis target proteins were identified.
MeSH term(s)	Biocatalysis ; Conserved Sequence ; Cysteine/chemistry ; Erythritol/analogs & derivatives ; Erythritol/metabolism ; Escherichia coli/metabolism ; Escherichia coli/ultrastructure ; Escherichia coli Proteins/metabolism ; Models, Biological ; Prophages/metabolism ; Protein Binding ; Protein Structure, Secondary ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Solutions ; Stress, Physiological ; Sugar Phosphates/metabolism ; Viral Proteins/chemistry ; Viral Proteins/metabolism
Chemical Substances	2-C-methylerythritol 4-phosphate ; Escherichia coli Proteins ; RNA, Messenger ; Solutions ; Sugar Phosphates ; Viral Proteins ; Cysteine (K848JZ4886) ; Erythritol (RA96B954X6)
Language	English
Publishing date	2022-01-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23031560
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Article ; Online: Huang Qin Decoction inhibits the initiation of experimental colitis associated carcinogenesis by controlling the PAD4 dependent NETs.

Pan, Zengfeng / Xie, Xuting / Chen, Yunliang / Pan, Simin / Wu, Zhiyun / Yang, Caiyi / Liang, Junjie / Zhang, Meilin / Wang, Qing / Chen, Jinyan / Zhou, Lian / Luo, Xia

Phytomedicine : international journal of phytotherapy and phytopharmacology

2022 Volume 107, Page(s) 154454

Abstract: ... Although Huang Qin Decoction (HQD) was found to be useful in treating UC and was used to gradually prevent and ... Conclusion: Huang Qin Decoction inhibits the initiation of colitis associated carcinogenesis by controlling ...

Abstract	Background: Colorectal cancer is associated with ulcerative colitis (UC). The infiltration of neutrophils is the main cause of DNA damage produced by inflammation in the intestinal epithelium. Under the action of peptidyl arginine deaminase 4 (PAD4), neutrophils dissociate chromatin and form neutrophil extracellular traps (NETs), which can aggravate tissue inflammation and encourage tumor development. Although Huang Qin Decoction (HQD) was found to be useful in treating UC and was used to gradually prevent and treat digestive tract cancers, the underlying reasons were unclear. Methods: To demonstrate HQD could inhibits the initiation of colitis associated carcinogenesis by controlling NETs related inflammation, we first performed an AOM/DSS-generated colitis-associated carcinogenesis model to assess the efficacy of HQD in reducing neutrophil infiltration and anti-tumor activity. Then, using network pharmacology research, we investigated the potential mechanisms underlying those medicinal effects, as demonstrated by the detection of NETs aggregation and PAD4 expression changes in the colon. Results: HQD substantially reduced the number of colon cancers and the expression of Ki67, restored the level of intestinal tight junction protein occludin and ZO-1, and relieved the intestinal inflammation caused by TNF-α, IL-1β. At the same time, it inhibited neutrophil infiltration in the colon and improved the immunosurveillance of CD8 Conclusion: Huang Qin Decoction inhibits the initiation of colitis associated carcinogenesis by controlling PAD4-dependent neutrophil extracellular traps.
MeSH term(s)	Animals ; Arginine/metabolism ; Carcinogenesis ; Chromatin/metabolism ; Colitis/chemically induced ; Colitis/complications ; Colitis/drug therapy ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Disease Models, Animal ; Extracellular Traps/metabolism ; Humans ; Inflammation/metabolism ; Ki-67 Antigen/metabolism ; Mice ; Mice, Inbred C57BL ; Occludin/metabolism ; Scutellaria baicalensis ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Chromatin ; Ki-67 Antigen ; Occludin ; Tumor Necrosis Factor-alpha ; Arginine (94ZLA3W45F)
Language	English
Publishing date	2022-09-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2022.154454
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