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Article ; Online: Molecular and cellular pruritus mechanisms in the host skin.

Li, Li / Li, Zhi-En / Mo, Yun-Li / Li, Wan-Yao / Li, Hui-Jing / Yan, Guang-Hai / Qin, Xiang-Zheng / Piao, Li-Hua

2024 Volume 136, Page(s) 104889

Abstract: Pruritus, also known as itching, is a complex sensation that involves the activation of specific physiological and cellular receptors. The skin is innervated with sensory nerves as well as some receptors for various sensations, and its immune system has ... ...

Abstract	Pruritus, also known as itching, is a complex sensation that involves the activation of specific physiological and cellular receptors. The skin is innervated with sensory nerves as well as some receptors for various sensations, and its immune system has prominent neurological connections. Sensory neurons have a considerable impact on the sensation of itching. However, immune cells also play a role in this process, as they release pruritogens. Disruption of the dermal barrier activates an immune response, initiating a series of chemical, physical, and cellular reactions. These reactions involve various cell types, including keratinocytes, as well as immune cells involved in innate and adaptive immunity. Collective activation of these immune responses confers protection against potential pathogens. Thus, understanding the molecular and cellular mechanisms that contribute to pruritus in host skin is crucial for the advancement of effective treatment approaches. This review provides a comprehensive analysis of the present knowledge concerning the molecular and cellular mechanisms underlying itching signaling in the skin. Additionally, this review explored the integration of these mechanisms with the broader context of itch mediators and the expression of their receptors in the skin.
MeSH term(s)	Humans ; Skin ; Pruritus/genetics ; Pruritus/metabolism ; Keratinocytes ; Sensory Receptor Cells/metabolism ; Signal Transduction
Language	English
Publishing date	2024-02-07
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	207655-x
ISSN	1096-0945 ; 0014-4800
ISSN (online)	1096-0945
ISSN	0014-4800
DOI	10.1016/j.yexmp.2024.104889
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Article ; Online: Typical clinical presentation of acute myocardial infarction and confusing coronary angiography: A case report and literature review of coronary embolism.

Yin, Mo-Qing / Fan, Li-Hua / Chen, Yun-Hu

Medicine

2023 Volume 102, Issue 19, Page(s) e33782

Abstract: Rationale: The purpose of this article is to discuss the characteristics, diagnosis, treatment, and outcomes of cases of multiple coronary embolism (CE) highly suspected to be caused by a dislodged aneurysm of the ventricular membranous septum (AVMS) ... ...

Abstract	Rationale: The purpose of this article is to discuss the characteristics, diagnosis, treatment, and outcomes of cases of multiple coronary embolism (CE) highly suspected to be caused by a dislodged aneurysm of the ventricular membranous septum (AVMS) thrombus. Patient concerns: A 35-year-old man was rushed to the Chest Pain Center of Taicang TCM Hospital Affiliated to Nanjing University of Chinese Medicine for sudden onset of chest pain. The patient had severe and persistent chest pain without relief, accompanied by sweating throughout the body. Diagnosis: An electrocardiogram showed ST-segment elevation in the inferior wall leads, and blood tests suggested elevated troponin I levels. The initial diagnosis was acute ST-segment elevation myocardial infarction. Emergency coronary angiography revealed complete occlusion of the first diagonal branch, thrombolysis in myocardial infarction grade 0 flow, and smooth remaining vessels. Complete occlusion of the left anterior descending artery unexpectedly occurred during interventional treatment. Postoperative cardiac ultrasonography revealed the presence of a thrombus within the AVMS and in the apical portion of the heart. The final diagnosis was a CE. Interventions: Intraoperatively, the diagonal branch occluded segment was dilated with a balloon and intracoronary administration of tirofiban and nitroglycerin. Postoperatively, antithrombotic therapy (aspirin, clopidogrel, and rivaroxaban) was administered. Outcomes: Ten days after admission, a repeat coronary angiography showed complete restoration of left anterior descending artery flow on its own, balloon dilation was again performed on the diagonal branch, and flow was restored to thrombolysis in myocardial infarction grade 1. Six months later, the intracardiac thrombus disappeared on repeat cardiac ultrasound. Lessons: AVMS is a potential source of embolism in patients with CE. CE has features that distinguish it from atherosclerosis, and a timely and correct diagnosis can help improve patient clinical outcomes.
MeSH term(s)	Male ; Humans ; Adult ; Coronary Angiography/adverse effects ; Myocardial Infarction/diagnosis ; Myocardial Infarction/etiology ; Coronary Artery Disease/complications ; Thrombosis/complications ; Embolism/complications ; Electrocardiography ; Arrhythmias, Cardiac/complications ; Chest Pain/complications
Language	English
Publishing date	2023-04-27
Publishing country	United States
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000033782
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: ABO blood groups and nosocomial infection.

Zhong, Xiao / Wang, Dong-Li / Xiao, Li-Hua / Mo, Lan-Fang / Luo, Xiao-Feng

Epidemiology and infection

2023 Volume 151, Page(s) e64

Abstract: The timely identification of the high-risk groups for nosocomial infections (NIs) plays a vital role in its prevention and control. Therefore, it is crucial to investigate whether the ABO blood group is a risk factor for NI. In this study, patients with ... ...

Abstract	The timely identification of the high-risk groups for nosocomial infections (NIs) plays a vital role in its prevention and control. Therefore, it is crucial to investigate whether the ABO blood group is a risk factor for NI. In this study, patients with NI and non-infection were matched by the propensity score matching method and a logistic regression model was used to analyse the matched datasets. The study found that patients with the B&AB blood group were susceptible to
MeSH term(s)	Humans ; ABO Blood-Group System ; Cross Infection/epidemiology ; Escherichia coli ; Pseudomonas aeruginosa ; Risk Factors ; Staphylococcus aureus
Chemical Substances	ABO Blood-Group System
Language	English
Publishing date	2023-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	632982-2
ISSN	1469-4409 ; 0950-2688
ISSN (online)	1469-4409
ISSN	0950-2688
DOI	10.1017/S0950268823000432
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Article ; Online: Iron(III) and BF

Li, Xue / Liao, Lin-Fen / Ding, Li-Yao / Chen, Chun-Hua / Liang, Cui / Mo, Dong-Liang

Organic letters

2024 Volume 26, Issue 15, Page(s) 3060–3064

Abstract: We described an iron(III) and ... ...

Abstract	We described an iron(III) and BF
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.4c00693
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Article: Causal relationship between nutritional assessment phenotypes and heart failure: A Mendelian randomization study.

Chen, Yun-Hu / Yin, Mo-Qing / Fan, Li-Hua / Jiang, Xue-Chun / Xu, Hong-Feng / Zhu, Xing-Yu / Zhang, Tao

Heliyon

2024 Volume 10, Issue 7, Page(s) e28619

Abstract: Introduction: Malnutrition is strongly associated with heart failure (HF); however, the causal link remains unclear. We used Mendelian randomization (MR) to infer causal associations between different nutritional assessment phenotypes and HF and to ... ...

Abstract	Introduction: Malnutrition is strongly associated with heart failure (HF); however, the causal link remains unclear. We used Mendelian randomization (MR) to infer causal associations between different nutritional assessment phenotypes and HF and to analyze whether these associations were mediated by common HF risk factors. Methods: Two-sample bidirectional MR was used to infer causal associations between nutritional assessment phenotypes and HF. Mutual influences between different nutritional assessment phenotypes and potential correlations were estimated using multivariate MR methods. Two-step MR was used to quantify the mediating effects of common HF risk factors on the causal associations. Results: Three phenotypes were positively associated with the development of HF: waist circumference (WC) (odds ratio [OR] = 1.74; 95% confidence interval [CI], 1.60-1.90; Conclusions: BMI, WC, and WBFM are potential risk factors for HF, and the correlation between WBFM and HF was significantly stronger than that between BMI and WC, and HF. EA, UWP, and TC are potential protective factors against HF. Common risk factors for HF mediate these causal pathways. Early identification of potential risk or protective factors for HF patients from the dimension of nutritional status is expected to further improve patient outcomes.
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e28619
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bibliometric analysis of traditional Chinese medicine research on heart failure in the 21st century based on the WOS database

Yun-Hu Chen / Mo-Qing Yin / Li-Hua Fan / Xue-Chun Jiang / Hong-Feng Xu / Tao Zhang / Xing-Yu Zhu

Heliyon, Vol 9, Iss 1, Pp e12770- (2023)

2023

Abstract: Introduction: Heart Failure (HF) is a key area of research in human medicine, and traditional Chinese medicine (TCM) is an important branch of this field. This study aimed to use bibliometric methods to sort out the trajectory of TCM research on HF in ... ...

Abstract	Introduction: Heart Failure (HF) is a key area of research in human medicine, and traditional Chinese medicine (TCM) is an important branch of this field. This study aimed to use bibliometric methods to sort out the trajectory of TCM research on HF in this century (2000–2022) from a high dimension and to analyze its characteristics, hotspots and frontiers. Methods: In this study, the search formula “TS=((''traditional Chinese medicine'') OR (''Chinese medicine'')) AND TS=(''heart failure'')'' was used to find relevant studies included in the Web of Science Core Collection from 2000 to 2022. Targeted literature records were analyzed and mapped using CiteSpace and VOSviewer. Results: The authors and collaborators of this study were still in the formation process, but several well-known scholars were included: YONG WANG, WEI WANG, etc. The main research institutions in this research area were Beijing Univ Chinese Med, China Acad Chinese Med Sc, etc. The main country of study was China. Current research hotspots and frontiers were Qili Qiangxin capsules, extracts (Tanshinone ⅡA, Panax ginseng, etc.), cardiac hypertrophy, ventricular remodeling, oxidative stress, signaling pathways, network pharmacology, etc. Influential journals that publish papers in this field were the Journal of Ethnopharmacology, Scientific Reports, Biomedicine & Pharmacotherapy, etc. The top 3 co-cited journals were Circulation, J ethnopharmacol, and J am coll cardiol. Conclusions: We analyzed valuable details in TCM research on HF in the 21st century, which may help researchers identify potential collaborators and partner institutions, hotspots, and frontiers in the field.
Keywords	Traditional Chinese medicine (TCM) ; Heart failure (HF) ; Bibliometrics ; Knowledge mapping ; Visual analysis ; Systematic review ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	001
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Bibliometric analysis of traditional Chinese medicine research on heart failure in the 21st century based on the WOS database.

Chen, Yun-Hu / Yin, Mo-Qing / Fan, Li-Hua / Jiang, Xue-Chun / Xu, Hong-Feng / Zhang, Tao / Zhu, Xing-Yu

Heliyon

2023 Volume 9, Issue 1, Page(s) e12770

Abstract	Introduction: Heart Failure (HF) is a key area of research in human medicine, and traditional Chinese medicine (TCM) is an important branch of this field. This study aimed to use bibliometric methods to sort out the trajectory of TCM research on HF in this century (2000-2022) from a high dimension and to analyze its characteristics, hotspots and frontiers. Methods: In this study, the search formula "TS=(("traditional Chinese medicine") OR ("Chinese medicine")) AND TS=("heart failure")" was used to find relevant studies included in the Web of Science Core Collection from 2000 to 2022. Targeted literature records were analyzed and mapped using CiteSpace and VOSviewer. Results: The authors and collaborators of this study were still in the formation process, but several well-known scholars were included: YONG WANG, WEI WANG, etc. The main research institutions in this research area were Beijing Univ Chinese Med, China Acad Chinese Med Sc, etc. The main country of study was China. Current research hotspots and frontiers were Qili Qiangxin capsules, extracts (Tanshinone ⅡA, Panax ginseng, etc.), cardiac hypertrophy, ventricular remodeling, oxidative stress, signaling pathways, network pharmacology, etc. Influential journals that publish papers in this field were the Journal of Ethnopharmacology, Scientific Reports, Biomedicine & Pharmacotherapy, etc. The top 3 co-cited journals were Circulation, J ethnopharmacol, and J am coll cardiol. Conclusions: We analyzed valuable details in TCM research on HF in the 21st century, which may help researchers identify potential collaborators and partner institutions, hotspots, and frontiers in the field.
Language	English
Publishing date	2023-01-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e12770
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Transcriptomics Reveals the Effect of Short-Term Freezing on the Signal Transduction and Metabolism of Grapevine.

Han, Xing / Li, Yi-Han / Yao, Mo-Han / Yao, Fei / Wang, Zhi-Lei / Wang, Hua / Li, Hua

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: Low temperature is an important factor limiting plant growth. Most cultivars ... ...

Abstract	Low temperature is an important factor limiting plant growth. Most cultivars of
MeSH term(s)	Freezing ; Gene Expression Profiling ; Gene Expression Regulation, Plant ; Plant Proteins/genetics ; Signal Transduction ; Transcriptome ; Vitis/genetics
Chemical Substances	Plant Proteins
Language	English
Publishing date	2023-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043884
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The transcription factor XBP1 in dendritic cells promotes the T

Yang, Gui / Zeng, Xian-Hai / Geng, Xiao-Rui / Liu, Jiang-Qi / Mo, Li-Hua / Luo, Xiang-Qian / Liu, Hua-Zhen / Zhang, Yuan-Yi / Yang, Li-Teng / Huang, Qin-Miao / Xiao, Xiao-Jun / Liu, Jie / Xu, Ling-Zhi / Liu, Da-Bo / Liu, Xiao-Yu / Liu, Zhi-Qiang / Yang, Ping-Chang

Science signaling

2023 Volume 16, Issue 791, Page(s) eabm9454

Abstract: Dendritic cells (DCs) that express T cell immunoglobulin domain molecule-4 (TIM4), a cell surface receptor for phosphatidylserine, induce T helper 2 ( ... ...

Abstract	Dendritic cells (DCs) that express T cell immunoglobulin domain molecule-4 (TIM4), a cell surface receptor for phosphatidylserine, induce T helper 2 (T
MeSH term(s)	Humans ; Interleukin-2/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Th2 Cells ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Hypersensitivity/genetics ; Hypersensitivity/metabolism ; Dendritic Cells/metabolism ; Particulate Matter/metabolism ; X-Box Binding Protein 1/genetics
Chemical Substances	Interleukin-2 ; Transcription Factors ; Membrane Proteins ; Particulate Matter ; XBP1 protein, human ; X-Box Binding Protein 1
Language	English
Publishing date	2023-06-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2417226-1
ISSN	1937-9145 ; 1945-0877
ISSN (online)	1937-9145
ISSN	1945-0877
DOI	10.1126/scisignal.abm9454
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Regulating ion affinity and dehydration of metal-organic framework sub-nanochannels for high-precision ion separation.

Mo, Ri-Jian / Chen, Shuang / Huang, Li-Qiu / Ding, Xin-Lei / Rafique, Saima / Xia, Xing-Hua / Li, Zhong-Qiu

Nature communications

2024 Volume 15, Issue 1, Page(s) 2145

Abstract: Membrane consisting of ordered sub-nanochannels has been pursued in ion separation technology to achieve applications including desalination, environment management, and energy conversion. However, high-precision ion separation has not yet been achieved ... ...

Abstract	Membrane consisting of ordered sub-nanochannels has been pursued in ion separation technology to achieve applications including desalination, environment management, and energy conversion. However, high-precision ion separation has not yet been achieved owing to the lack of deep understanding of ion transport mechanism in confined environments. Biological ion channels can conduct ions with ultrahigh permeability and selectivity, which is inseparable from the important role of channel size and "ion-channel" interaction. Here, inspired by the biological systems, we report the high-precision separation of monovalent and divalent cations in functionalized metal-organic framework (MOF) membranes (UiO-66-(X)
Language	English
Publishing date	2024-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-46378-6
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