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Article: ADAM: a robotic companion for enhanced quality of life in aging populations.

Mora, Alicia / Prados, Adrian / Mendez, Alberto / Espinoza, Gonzalo / Gonzalez, Pavel / Lopez, Blanca / Muñoz, Victor / Moreno, Luis / Garrido, Santiago / Barber, Ramon

Frontiers in neurorobotics

2024 Volume 18, Page(s) 1337608

Abstract: ... we present the ADAM robot, a new robot designed for domestic physical assistance. It mainly consists ... that require navigation and manipulation of the environment. Among ADAM's features are its modularity ...

Abstract	One of the major problems of today's society is the rapid aging of its population. Life expectancy is increasing, but the quality of life is not. Faced with the growing number of people who require cognitive or physical assistance, new technological tools are emerging to help them. In this article, we present the ADAM robot, a new robot designed for domestic physical assistance. It mainly consists of a mobile base, two arms with grippers and vision systems. All this allows the performance of physical tasks that require navigation and manipulation of the environment. Among ADAM's features are its modularity, its adaptability to indoor environments and its versatility to function as an experimental platform and for service applications. In addition, it is designed to work respecting the user's personal space and is collaborative, so it can learn from experiences taught by them. We present the design of the robot as well as examples of use in domestic environments both alone and in collaboration with other domestic platforms, demonstrating its potential.
Language	English
Publishing date	2024-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2453002-5
ISSN	1662-5218
ISSN	1662-5218
DOI	10.3389/fnbot.2024.1337608
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Article ; Online: Adam and the Ants

Betty Cortiñas-Lorenzo / Fernando Pérez-González

Entropy, Vol 22, Iss 1379, p

On the Influence of the Optimization Algorithm on the Detectability of DNN Watermarks

2020 Volume 1379

Abstract: ... the update direction given by Adam optimization strongly depends on the sign of a combination of columns ... that allows one to combine watermarking with Adam optimization with a minor impact on the detectability ...

Abstract	As training Deep Neural Networks (DNNs) becomes more expensive, the interest in protecting the ownership of the models with watermarking techniques increases. Uchida et al. proposed a digital watermarking algorithm that embeds the secret message into the model coefficients. However, despite its appeal, in this paper, we show that its efficacy can be compromised by the optimization algorithm being used. In particular, we found through a theoretical analysis that, as opposed to Stochastic Gradient Descent (SGD), the update direction given by Adam optimization strongly depends on the sign of a combination of columns of the projection matrix used for watermarking. Consequently, as observed in the empirical results, this makes the coefficients move in unison giving rise to heavily spiked weight distributions that can be easily detected by adversaries. As a way to solve this problem, we propose a new method called Block-Orthonormal Projections (BOP) that allows one to combine watermarking with Adam optimization with a minor impact on the detectability of the watermark and an increased robustness.
Keywords	watermarking ; deep neural networks ; optimization algorithms ; Adam ; stochastic gradient descent ; detectability ; Science ; Q ; Astrophysics ; QB460-466 ; Physics ; QC1-999
Subject code	510
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Adam and the Ants: On the Influence of the Optimization Algorithm on the Detectability of DNN Watermarks.

Cortiñas-Lorenzo, Betty / Pérez-González, Fernando

Entropy (Basel, Switzerland)

2020 Volume 22, Issue 12

Abstract	As training Deep Neural Networks (DNNs) becomes more expensive, the interest in protecting the ownership of the models with watermarking techniques increases. Uchida et al. proposed a digital watermarking algorithm that embeds the secret message into the model coefficients. However, despite its appeal, in this paper, we show that its efficacy can be compromised by the optimization algorithm being used. In particular, we found through a theoretical analysis that, as opposed to Stochastic Gradient Descent (SGD), the update direction given by Adam optimization strongly depends on the sign of a combination of columns of the projection matrix used for watermarking. Consequently, as observed in the empirical results, this makes the coefficients move in unison giving rise to heavily spiked weight distributions that can be easily detected by adversaries. As a way to solve this problem, we propose a new method called Block-Orthonormal Projections (BOP) that allows one to combine watermarking with Adam optimization with a minor impact on the detectability of the watermark and an increased robustness.
Language	English
Publishing date	2020-12-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e22121379
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Article ; Online: Alpha-1 Antitrypsin Reduces Disease Progression in a Mouse Model of Charcot-Marie-Tooth Type 1A: A Role for Decreased Inflammation and ADAM-17 Inhibition.

Zhukovsky, Nikolay / Silvano, Marianna / Filloux, Thierry / Gonzalez, Sergio / Krause, Karl-Heinz

International journal of molecular sciences

2022 Volume 23, Issue 13

Abstract: Charcot-Marie-Tooth disease type 1 (CMT1A) is a hereditary peripheral neuropathy for which there is no available therapy. Alpha-1 antitrypsin (AAT) is an abundant serine protease inhibitor with anti-inflammatory and immunomodulating properties. Here, we ... ...

Abstract	Charcot-Marie-Tooth disease type 1 (CMT1A) is a hereditary peripheral neuropathy for which there is no available therapy. Alpha-1 antitrypsin (AAT) is an abundant serine protease inhibitor with anti-inflammatory and immunomodulating properties. Here, we tested whether treatment with human AAT (hAAT) would have a therapeutic effect on CMT1A in a
MeSH term(s)	ADAM17 Protein/genetics ; Animals ; Charcot-Marie-Tooth Disease/drug therapy ; Charcot-Marie-Tooth Disease/genetics ; Charcot-Marie-Tooth Disease/metabolism ; Disease Models, Animal ; Disease Progression ; Inflammation/drug therapy ; Mice ; Mice, Transgenic ; Myelin Proteins/genetics ; alpha 1-Antitrypsin Deficiency
Chemical Substances	Myelin Proteins ; ADAM17 Protein (EC 3.4.24.86)
Language	English
Publishing date	2022-07-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23137405
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Article ; Online: Effectiveness of the application of an electronic medication management support system in patients with polypharmacy in general practice: a study protocol of cluster-randomised controlled trial (AdAM).

Müller, Beate S / Klaaßen-Mielke, Renate / Gonzalez-Gonzalez, Ana Isabel / Grandt, Daniel / Hammerschmidt, Reinhard / Köberlein-Neu, Juliane / Kellermann-Mühlhoff, Petra / Trampisch, Hans J / Beckmann, Till / Düvel, Lara / Surmann, Bastian / Flaig, Benno / Ihle, Peter / Söling, Sara / Grandt, Simone / Dinh, Truc Sophia / Piotrowski, Alexandra / Meyer, Ingo / Karbach, Ute /

Harder, Sebastian / Perera, Rafael / Glasziou, Paul / Pfaff, Holger / Greiner, Wolfgang / Gerlach, Ferdinand M / Timmesfeld, Nina / Muth, Christiane

BMJ open

2021 Volume 11, Issue 9, Page(s) e048191

Abstract: Introduction: Clinically complex patients often require multiple medications. Polypharmacy is associated with inappropriate prescriptions, which may lead to negative outcomes. Few effective tools are available to help physicians optimise patient ... ...

Abstract	Introduction: Clinically complex patients often require multiple medications. Polypharmacy is associated with inappropriate prescriptions, which may lead to negative outcomes. Few effective tools are available to help physicians optimise patient medication. This study assesses whether an electronic medication management support system (eMMa) reduces hospitalisation and mortality and improves prescription quality/safety in patients with polypharmacy. Methods and analysis: Planned design: pragmatic, parallel cluster-randomised controlled trial; general practices as randomisation unit; patients as analysis unit. As practice recruitment was poor, we included additional data to our primary endpoint analysis for practices and quarters from October 2017 to March 2021. Since randomisation was performed in waves, final study design corresponds to a stepped-wedge design with open cohort and step-length of one quarter. Scope: general practices, Westphalia-Lippe (Germany), caring for BARMER health fund-covered patients. Population: patients (≥18 years) with polypharmacy (≥5 prescriptions). Sample size: initially, 32 patients from each of 539 practices were required for each study arm (17 200 patients/arm), but only 688 practices were randomised after 2 years of recruitment. Design change ensures that 80% power is nonetheless achieved. Intervention: complex intervention eMMa. Follow-up: at least five quarters/cluster (practice). recruitment: practices recruited/randomised at different times; after follow-up, control group practices may access eMMa. Outcomes: primary endpoint is all-cause mortality and hospitalisation; secondary endpoints are number of potentially inappropriate medications, cause-specific hospitalisation preceded by high-risk prescribing and medication underuse. Statistical analysis: primary and secondary outcomes are measured quarterly at patient level. A generalised linear mixed-effect model and repeated patient measurements are used to consider patient clusters within practices. Time and intervention group are considered fixed factors; variation between practices and patients is fitted as random effects. Intention-to-treat principle is used to analyse primary and key secondary endpoints. Ethics and dissemination: Trial approved by Ethics Commission of North-Rhine Medical Association. Results will be disseminated through workshops, peer-reviewed publications, local and international conferences. Trial registration: NCT03430336. ClinicalTrials.gov (https://clinicaltrials.gov/ct2/show/NCT03430336).
MeSH term(s)	Electronics ; General Practice ; Humans ; Medication Therapy Management ; Polypharmacy ; Potentially Inappropriate Medication List ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2021-09-28
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2020-048191
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Conference proceedings: Wirksamkeit der ‚Anwendung für ein digital unterstütztes Arzneimitteltherapie-Management (AdAM)‘ – Studienprotokoll der cluster-randomisierten kontrollierten Studie

Müller, Beate Sigrid / González-González, Ana Isabel / Klaaßen-Mielke, Renate / Nguyen, Truc Sophia / Flaig, Benno / Meyer, Ingo / Ihle, Peter / Greiner, Wolfgang / Surmann, Bastian / Karbach, Ute / Pfaff, Holger / Söling, Sara / Köberlein-Neu, Juliane / Kellermann-Mühlhoff, Petra / Beckmann, Till / Düvel, Lara / Grandt, Daniel / Perera, Rafael / Harder, Sebastian /

Glasziou, Paul / Trampisch, Hans-Joachim / Timmesfeld, Nina / Muth, Christiane

2020 , Page(s) 20ebmS4–BS–05

Event/congress	21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin; Nützliche patientenrelevante Forschung; Basel, Schweiz; Deutsches Netzwerk Evidenzbasierte Medizin e.V.; 2020
Keywords	Medizin, Gesundheit
Publishing date	2020-02-12
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/20ebm127
Database	German Medical Science

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Conference proceedings: Wirksamkeit der ‚Anwendung für ein digital unterstütztes Arzneimitteltherapie-Management (AdAM)‘ – Studienprotokoll der Cluster-randomisierten kontrollierten Studie

Müller, Beate Sigrid / González-González, Ana Isabel / Klaaßen-Mielke, Renate / Nguyen, Truc Sophia / Flaig, Benno / Schubert, Ingrid / Ihle, Peter / Greiner, Wolfgang / Surmann, Bastian / Karbach, Ute / Pfaff, Holger / Söling, Sara / Köberlein-Neu, Juliane / Perera, Rafael / Harder, Sebastian / Glaziou, Paul / Trampisch, Hans-Joachim / Muth, Christiane

2019 , Page(s) P05–05

Event/congress	53. Kongress für Allgemeinmedizin und Familienmedizin; Erlangen; Deutsche Gesellschaft für Allgemeinmedizin und Familienmedizin; 2019
Keywords	Medizin, Gesundheit
Publishing date	2019-09-11
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/19degam152
Database	German Medical Science

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Article ; Online: Simulating Multi-Directional Narrowband Reflectance of the Earth’s Surface Using ADAM (A Surface Reflectance Database for ESA’s Earth Observation Missions)

Cédric Bacour / François-Marie Bréon / Louis Gonzalez / Ivan Price / Jan Peter Muller / Pascal Prunet / Anne Grete Straume

Remote Sensing, Vol 12, Iss 1679, p

2020 Volume 1679

Abstract: The ADAM (A Surface Reflectance Database for ESA’s Earth Observation Missions) product ... 0.1° spatial resolution for a typical year. ADAM aims to support the preparation of optical ... we describe (1) the methods used in the development of the gridded monthly ADAM climatologies (over land ...

Abstract	The ADAM (A Surface Reflectance Database for ESA’s Earth Observation Missions) product (a climatological database coupled to its companion calculation toolkit) enables users to simulate realistic hyperspectral and directional global Earth surface reflectances (i.e., top-of-canopy/bottom-of-atmosphere) over the 240–4000 nm spectral range (at 1-nm resolution) and in any illumination/observation geometry, at 0.1° × 0.1° spatial resolution for a typical year. ADAM aims to support the preparation of optical Earth observation missions as well as the design of operational processing chains for the retrieval of atmospheric parameters by characterizing the expected surface reflectance, accounting for its anisotropy. Firstly, we describe (1) the methods used in the development of the gridded monthly ADAM climatologies (over land surfaces: monthly means of normalized reflectances derived from MODIS observations in seven spectral bands for the year 2005; over oceans: monthly means over the 1999–2009 period of chlorophyll content from SeaWiFS and of wind speed from SeaWinds), and (2) the underlying modeling approaches of ADAM toolkit to simulate the spectro-directional variations of the reflectance depending on the assigned surface type. Secondly, we evaluate ADAM simulation performances over land surfaces. A comparison against POLDER multi-spectral/multi-directional measurements for year 2008 shows reliable simulation results with root mean square differences below 0.027 and R 2 values above 0.9 for most of the 14 land cover IGBP classes investigated, with no significant bias identified. Only for the “Snow and ice” class is the performance lower pointing to a limitation of climatological data to represent actual snow properties. An evaluation of the modeled reflectance in the specific backscatter direction against CALIPSO data reveals that ADAM tends to overestimate (underestimate) the so-called “hot-spot” by a factor of about 1.5 (1.5 to 2) for barren (vegetated) surfaces.
Keywords	hyperspectral reflectance ; bidirectional reflectance distribution function (BRDF) ; climatology database ; land and ocean surfaces ; MODIS ; SeaWinds ; Science ; Q
Subject code	333
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Simulating Multi-Directional Narrowband Reflectance of the Earth’s Surface Using ADAM (A Surface Reflectance Database for ESA’s Earth Observation Missions)

Bacour, Cédric / Bréon, François-Marie / Gonzalez, Louis / Price, Ivan / Muller, Jan Peter / Prunet, Pascal / Straume, Anne Grete

Remote Sensing. 2020 May 23, v. 12, no. 10

2020

Abstract	The ADAM (A Surface Reflectance Database for ESA’s Earth Observation Missions) product (a climatological database coupled to its companion calculation toolkit) enables users to simulate realistic hyperspectral and directional global Earth surface reflectances (i.e., top-of-canopy/bottom-of-atmosphere) over the 240–4000 nm spectral range (at 1-nm resolution) and in any illumination/observation geometry, at 0.1° × 0.1° spatial resolution for a typical year. ADAM aims to support the preparation of optical Earth observation missions as well as the design of operational processing chains for the retrieval of atmospheric parameters by characterizing the expected surface reflectance, accounting for its anisotropy. Firstly, we describe (1) the methods used in the development of the gridded monthly ADAM climatologies (over land surfaces: monthly means of normalized reflectances derived from MODIS observations in seven spectral bands for the year 2005; over oceans: monthly means over the 1999–2009 period of chlorophyll content from SeaWiFS and of wind speed from SeaWinds), and (2) the underlying modeling approaches of ADAM toolkit to simulate the spectro-directional variations of the reflectance depending on the assigned surface type. Secondly, we evaluate ADAM simulation performances over land surfaces. A comparison against POLDER multi-spectral/multi-directional measurements for year 2008 shows reliable simulation results with root mean square differences below 0.027 and R² values above 0.9 for most of the 14 land cover IGBP classes investigated, with no significant bias identified. Only for the “Snow and ice” class is the performance lower pointing to a limitation of climatological data to represent actual snow properties. An evaluation of the modeled reflectance in the specific backscatter direction against CALIPSO data reveals that ADAM tends to overestimate (underestimate) the so-called “hot-spot” by a factor of about 1.5 (1.5 to 2) for barren (vegetated) surfaces.
Keywords	anisotropy ; chlorophyll ; databases ; ice ; land cover ; lighting ; meteorological data ; models ; moderate resolution imaging spectroradiometer ; oceans ; reflectance ; remote sensing ; snow ; wind speed
Language	English
Dates of publication	2020-0523
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2513863-7
ISSN	2072-4292
ISSN	2072-4292
DOI	10.3390/rs12101679
Database	NAL-Catalogue (AGRICOLA)

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Article: Síndrome ADAM

González-Ramos, M / de Valencia, E L / García Delgado, C / Macías, M A

Boletin medico del Hospital Infantil de Mexico

1976 Volume 33, Issue 2, Page(s) 403–410

Abstract: We present six cases of ADAM syndrome, that we have been studying at the Unit of Clinical Genetics ... the different characteristics of ADAM syndrome: A-Amniotic, D-Deformation, A-Adhesions, M-Mutilation. ...

Title translation	ADAM syndrome.
Abstract	We present six cases of ADAM syndrome, that we have been studying at the Unit of Clinical Genetics of the Hospital Infantil de México. We wish to stress how it is possible using medical photography to appreciate the different characteristics of ADAM syndrome: A-Amniotic, D-Deformation, A-Adhesions, M-Mutilation.
MeSH term(s)	Abnormalities, Multiple ; Cleft Lip ; Cleft Palate ; Ectromelia ; Encephalocele ; Female ; Fingers/abnormalities ; Humans ; Infant ; Infant, Newborn ; Male ; Syndactyly ; Syndrome ; Tissue Adhesions ; Toes/abnormalities
Language	Spanish
Publishing date	1976-03
Publishing country	Mexico
Document type	English Abstract ; Journal Article
ZDB-ID	730519-9
ISSN	0539-6115 ; 1665-1146 ; 0539-6123
ISSN	0539-6115 ; 1665-1146 ; 0539-6123
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