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Article ; Online: Experimental study on the transporting and crushing effect of gas on coal powder during the develop stage of coal and gas outburst in roadway

Jie Cao / Qianting Hu / Linchao Dai / Xuelin Yang

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 16

Abstract: Abstract In recent years, coal and gas outburst disasters are still occurring and difficult to prevent, seriously endangering the safety of coal mine production. It is well known that the transporting and crushing of outburst coal is the main pathway of ... ...

Abstract	Abstract In recent years, coal and gas outburst disasters are still occurring and difficult to prevent, seriously endangering the safety of coal mine production. It is well known that the transporting and crushing of outburst coal is the main pathway of energy dissipation during the coal and gas outburst process. However, a consensus regarding how much gas involves in outburst and affects energy dissipation is still lacking. Quantitative study on the gas effect on migration and fragmentation characteristics of outburst coal in restricted roadway space can improve the energy model and guide the prevention and control of gas outburst. In this paper, an improved visual coal and gas outburst dynamic effect simulation experiment system was used to conduct outburst simulation experiments at different gas pressure conditions. The results showed that the movement of outburst coal in the roadway has experienced various flow patterns. In the initial stage of the outburst, under low gas pressure condition, the motion of the outburst coal was dominated by stratified flow. However, as the gas pressure increases, the initial acceleration increases, and the outburst coal mainly move forward rapidly in the form of plug flow. The average velocity at 0.3, 0.5, and 0.8 MPa gas pressure condition were 6.75, 22.22 and 35.81 m/s, respectively. Gas also has a crushing effect on outburst coal. With increasing gas pressure, the number of coal powder particles of the same mass increased significantly, and the range of the particle size distribution of the particles decreaed, and the median particle size decreased. As the gas pressure increases, the outburst intensity gradually increases, and the total energy involved in the outburst work also increases. However, the energy dissipation pathways are different. At 0.3 MPa, the energy dissipation is dominated by crushing energy, which is about six times the ejection energy. As the gas pressure increased to 0.8 MPa, the proportion of the ejection energy gradually increases to about twice that ...
Keywords	Medicine ; R ; Science ; Q
Subject code	660
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Experimental study on the transporting and crushing effect of gas on coal powder during the develop stage of coal and gas outburst in roadway.

Cao, Jie / Hu, Qianting / Dai, Linchao / Yang, Xuelin

Scientific reports

2023 Volume 13, Issue 1, Page(s) 18792

Abstract: In recent years, coal and gas outburst disasters are still occurring and difficult to prevent, seriously endangering the safety of coal mine production. It is well known that the transporting and crushing of outburst coal is the main pathway of energy ... ...

Abstract	In recent years, coal and gas outburst disasters are still occurring and difficult to prevent, seriously endangering the safety of coal mine production. It is well known that the transporting and crushing of outburst coal is the main pathway of energy dissipation during the coal and gas outburst process. However, a consensus regarding how much gas involves in outburst and affects energy dissipation is still lacking. Quantitative study on the gas effect on migration and fragmentation characteristics of outburst coal in restricted roadway space can improve the energy model and guide the prevention and control of gas outburst. In this paper, an improved visual coal and gas outburst dynamic effect simulation experiment system was used to conduct outburst simulation experiments at different gas pressure conditions. The results showed that the movement of outburst coal in the roadway has experienced various flow patterns. In the initial stage of the outburst, under low gas pressure condition, the motion of the outburst coal was dominated by stratified flow. However, as the gas pressure increases, the initial acceleration increases, and the outburst coal mainly move forward rapidly in the form of plug flow. The average velocity at 0.3, 0.5, and 0.8 MPa gas pressure condition were 6.75, 22.22 and 35.81 m/s, respectively. Gas also has a crushing effect on outburst coal. With increasing gas pressure, the number of coal powder particles of the same mass increased significantly, and the range of the particle size distribution of the particles decreaed, and the median particle size decreased. As the gas pressure increases, the outburst intensity gradually increases, and the total energy involved in the outburst work also increases. However, the energy dissipation pathways are different. At 0.3 MPa, the energy dissipation is dominated by crushing energy, which is about six times the ejection energy. As the gas pressure increased to 0.8 MPa, the proportion of the ejection energy gradually increases to about twice that of the crushing energy. Under the experimental conditions, 2.71-13.43% of the adsorbed gas involves in the outburst (AGIO) through rapid desorption, and the proportion increases with increasing gas pressure. This paper improves the energy model of coal and gas outburst, which is applicable to risk assessment and prevention of outburst disasters.
Language	English
Publishing date	2023-11-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-46023-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Methylene Blue Pretreatment Protects Against Repeated Neonatal Isoflurane Exposure-Induced Brain Injury and Memory Loss.

Wu, Chongyun / Deng, Qianting / Zhu, Ling / Liu, Timon Cheng-Yi / Duan, Rui / Yang, Luodan

Molecular neurobiology

2024

Abstract: Perioperative neurocognitive impairment (PND) is a common medical complication in the postoperative period. General anesthesia through volatile anesthetics poses a high risk of POCD. Moreover, the developing brain is especially vulnerable to anesthesia- ... ...

Abstract	Perioperative neurocognitive impairment (PND) is a common medical complication in the postoperative period. General anesthesia through volatile anesthetics poses a high risk of POCD. Moreover, the developing brain is especially vulnerable to anesthesia-induced neurotoxicity. Therefore, finding a practical approach to prevent or alleviate neonatal isoflurane (ISO) exposure-induced brain injury and cognitive decline is essential for reducing medical complications following major surgery during the early postnatal period. Using a repeated neonatal ISO exposure-induced PND rat model, we investigated the effects of methylene blue (MB) pretreatment on repeated neonatal isoflurane exposure-induced brain injury and memory loss. Intraperitoneal injection of low-dose MB (1 mg/kg) was conducted three times 24 h before each ISO exposure. The Barnes maze and novel objection test were conducted to assess learning and memory. Immunofluorescence staining, F-Jade C staining, TUNEL staining, and Western blot analysis were performed to determine mitochondrial fragmentation, neuronal injury, degeneration, and apoptosis. Evans blue extravasation assay, total antioxidant capacity assay, MDA assay kit, and related inflammatory assay kits were used to test blood-brain barrier (BBB) disruption, antioxidant capacity, and neuroinflammation. Behavioral tests revealed that MB pretreatment significantly ameliorated ISO exposure-induced cognitive deficits. In addition, MB pretreatment alleviates neuronal injury, apoptosis, and degeneration. Furthermore, the BBB integrity was preserved by MB pretreatment. Additional studies revealed that ISO-induced excessive mitochondrial fragmentation, oxidative stress, and neuroinflammation were significantly attenuated by MB pretreatment in the PND rat model. Our findings suggest that MB pretreatment alleviates ISO exposure-induced brain injury and memory loss for the first time, supporting MB pretreatment as a promising approach to protect the brain against neonatal ISO exposure-induced postoperative cognitive dysfunction.
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-024-03931-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Combining rigid and deformable groups to construct a robust birefringent crystal for compact polarization components.

Du, Zhipeng / Song, Xianyu / Liu, Wei / Wang, Ziyi / Sha, Hongyuan / Xu, Qianting / Zhou, Yang / Li, Yanqiang / Luo, Junhua / Zhao, Sangen

Science bulletin

2024

Abstract: There is a pressing demand for the development of novel birefringent crystals tailored for compact optical components, especially for crystals exhibiting large birefringence across a range of temperatures. This has commonly been achieved by introducing ... ...

Abstract	There is a pressing demand for the development of novel birefringent crystals tailored for compact optical components, especially for crystals exhibiting large birefringence across a range of temperatures. This has commonly been achieved by introducing various deformable groups with high polarizability anisotropy. In this study, we combined both rigid and deformable groups to synthesise a new birefringent crystal, Al
Language	English
Publishing date	2024-04-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2816140-3
ISSN	2095-9281 ; 2095-9273
ISSN (online)	2095-9281
ISSN	2095-9273
DOI	10.1016/j.scib.2024.04.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Circ_MAPK9 promotes STAT3 and LDHA expression by silencing miR-642b-3p and affects the progression of hepatocellular carcinoma

Kunyuan Wang / Qianting Lu / Yufeng Luo / Ganxiang Yu / Zhilei Wang / Jiaen Lin / Zhenlin Tan / Yueqiong Lao / Shiming Liu / Hui Yang

Biology Direct, Vol 19, Iss 1, Pp 1-

2024 Volume 14

Abstract: Abstract Background Aberrant expression and activation of circular RNAs (circRNAs) are closely associated with various cancers. The role of circ_MAPK9 (hsa_circ_0001566) in cancer progression remains unknown. This study aims to investigate the function, ... ...

Abstract	Abstract Background Aberrant expression and activation of circular RNAs (circRNAs) are closely associated with various cancers. The role of circ_MAPK9 (hsa_circ_0001566) in cancer progression remains unknown. This study aims to investigate the function, mechanism and clinical significance of circ_MAPK9 in hepatocellular carcinoma (HCC). Methods Circ_MAPK9 expression on the microarray of tumor from clinical HCC patients was detected by in situ hybridization (ISH). Circ_MAPK9 knockdown was achieved with siRNAs in SMMC-7721 and SK-Hep1 HCC cell lines. The biological function of circ_MAPK9 was verified in vitro by CCK8 test, colony formation assay, transwell assay, PI-Annexin V staining, and in vivo by xenograft tumor in nude mice. Fluorescent in situ hybridization (FISH), subcellular fractionation assay, a dual-luciferase reporter assay and rescue experiments were employed for further mechanistic investigation. Results The expression of circ_MAPK9 was significantly up-regulated in HCC tissues and cells, which was found to be associated with poor prognosis. Patients with high expression of circ_MAPK9 had a shorter overall survival and disease-free survival in comparison to those with low circ_MAPK9 expression. Functional assays showed that circ_MAPK9 knockdown suppressed cellular proliferation, migration, invasion and tumor growth in vivo, and promoted apoptosis in HCC cells. Moreover, we found that circ_MAPK9 knockdown could inhibit aerobic glycolysis by decreasing the production of adenosine triphosphate (ATP) and lactic acid, which was mediated by lactate dehydrogenase (LDHA). Mechanistically, circ_MAPK9 functioned as ceRNA via sponging miR-642b-3p and alleviated the inhibitory effect of miR-642b-3p on its target signal transducer and activator of transcription 3 (STAT3) and LDHA, thereby leading to STAT3 activation and LDHA expression. Conclusions Circ_MAPK9, as an oncogene, promotes HCC growth and metastasis through miR-642b-3p/STAT3-LDHA axis. Circ_MAPK9 could serve as a potential biomarker for HCC poor ...
Keywords	Hepatocellular carcinoma ; Circ_MAPK9 ; CeRNA ; Proliferation ; Metastasis ; Aerobic glycolysis ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Circ_MAPK9 promotes STAT3 and LDHA expression by silencing miR-642b-3p and affects the progression of hepatocellular carcinoma.

Wang, Kunyuan / Lu, Qianting / Luo, Yufeng / Yu, Ganxiang / Wang, Zhilei / Lin, Jiaen / Tan, Zhenlin / Lao, Yueqiong / Liu, Shiming / Yang, Hui

Biology direct

2024 Volume 19, Issue 1, Page(s) 4

Abstract: Background: Aberrant expression and activation of circular RNAs (circRNAs) are closely associated with various cancers. The role of circ_MAPK9 (hsa_circ_0001566) in cancer progression remains unknown. This study aims to investigate the function, ... ...

Abstract	Background: Aberrant expression and activation of circular RNAs (circRNAs) are closely associated with various cancers. The role of circ_MAPK9 (hsa_circ_0001566) in cancer progression remains unknown. This study aims to investigate the function, mechanism and clinical significance of circ_MAPK9 in hepatocellular carcinoma (HCC). Methods: Circ_MAPK9 expression on the microarray of tumor from clinical HCC patients was detected by in situ hybridization (ISH). Circ_MAPK9 knockdown was achieved with siRNAs in SMMC-7721 and SK-Hep1 HCC cell lines. The biological function of circ_MAPK9 was verified in vitro by CCK8 test, colony formation assay, transwell assay, PI-Annexin V staining, and in vivo by xenograft tumor in nude mice. Fluorescent in situ hybridization (FISH), subcellular fractionation assay, a dual-luciferase reporter assay and rescue experiments were employed for further mechanistic investigation. Results: The expression of circ_MAPK9 was significantly up-regulated in HCC tissues and cells, which was found to be associated with poor prognosis. Patients with high expression of circ_MAPK9 had a shorter overall survival and disease-free survival in comparison to those with low circ_MAPK9 expression. Functional assays showed that circ_MAPK9 knockdown suppressed cellular proliferation, migration, invasion and tumor growth in vivo, and promoted apoptosis in HCC cells. Moreover, we found that circ_MAPK9 knockdown could inhibit aerobic glycolysis by decreasing the production of adenosine triphosphate (ATP) and lactic acid, which was mediated by lactate dehydrogenase (LDHA). Mechanistically, circ_MAPK9 functioned as ceRNA via sponging miR-642b-3p and alleviated the inhibitory effect of miR-642b-3p on its target signal transducer and activator of transcription 3 (STAT3) and LDHA, thereby leading to STAT3 activation and LDHA expression. Conclusions: Circ_MAPK9, as an oncogene, promotes HCC growth and metastasis through miR-642b-3p/STAT3-LDHA axis. Circ_MAPK9 could serve as a potential biomarker for HCC poor prognosis and diagnosis.
MeSH term(s)	Animals ; Mice ; Humans ; Carcinoma, Hepatocellular/genetics ; STAT3 Transcription Factor/genetics ; In Situ Hybridization, Fluorescence ; Mice, Nude ; Liver Neoplasms/genetics ; Cell Proliferation ; MicroRNAs/genetics ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic
Chemical Substances	STAT3 Transcription Factor ; MicroRNAs ; STAT3 protein, human
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2221028-3
ISSN	1745-6150 ; 1745-6150
ISSN (online)	1745-6150
ISSN	1745-6150
DOI	10.1186/s13062-023-00442-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: LectoScape: A Highly Multiplexed Imaging Platform for Glycome Analysis and Biomedical Diagnosis.

Yang, Lujie / Yang, Qianting / Lin, Ling / Zhang, Chi / Dong, Lingkai / Gao, Xiang / Zhang, Zheng / Zeng, Chen / Wang, Peng George

Analytical chemistry

2024

Abstract: Glycosylation, a fundamental biological process, involves the attachment of glycans to proteins, lipids, and RNA, and it plays a crucial role in various biological pathways. It is of great significance to obtain the precise spatial distribution of ... ...

Abstract	Glycosylation, a fundamental biological process, involves the attachment of glycans to proteins, lipids, and RNA, and it plays a crucial role in various biological pathways. It is of great significance to obtain the precise spatial distribution of glycosylation modifications at the cellular and tissue levels. Here, we introduce LectoScape, an innovative method enabling detailed imaging of tissue glycomes with up to 1 μm resolution through image mass cytometry (IMC). This method utilizes 12 distinct, nonoverlapping lectins selected via microarray technology, enabling the multiplexed detection of a wide array of glycans. Furthermore, we developed an efficient labeling strategy for these lectins. Crucially, our approach facilitates the concurrent imaging of diverse glycan motifs, including N-glycan and O-glycan, surpassing the capabilities of existing technologies. Using LectoScape, we have successfully delineated unique glycan structures in various cell types, enhancing our understanding of the glycan distribution across human tissues. Our method has identified specific glycan markers, such as α2,3-sialylated Galβ1, 3GalNAc in O-glycan, and terminal GalNAc, as diagnostic indicators for cervical intraepithelial neoplasia. This highlights the potential of LectoScape in cancer diagnostics through the detection of abnormal glycosylation patterns.
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c04925
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Improvement of Oracle Bone Inscription Recognition Accuracy

Xuanming Fu / Zhengfeng Yang / Zhenbing Zeng / Yidan Zhang / Qianting Zhou

ISPRS International Journal of Geo-Information, Vol 11, Iss 45, p

A Deep Learning Perspective

2022 Volume 45

Abstract: Deep learning techniques have been successfully applied in handwriting recognition. Oracle bone inscriptions (OBI) are the earliest hieroglyphs in China and valuable resources for studying the etymology of Chinese characters. OBI are of important ... ...

Abstract	Deep learning techniques have been successfully applied in handwriting recognition. Oracle bone inscriptions (OBI) are the earliest hieroglyphs in China and valuable resources for studying the etymology of Chinese characters. OBI are of important historical and cultural value in China; thus, textual research surrounding the characters of OBI is a huge challenge for archaeologists. In this work, we built a dataset named OBI-100, which contains 100 classes of oracle bone inscriptions collected from two OBI dictionaries. The dataset includes more than 128,000 character samples related to the natural environment, humans, animals, plants, etc. In addition, we propose improved models based on three typical deep convolutional network structures to recognize the OBI-100 dataset. By modifying the parameters, adjusting the network structures, and adopting optimization strategies, we demonstrate experimentally that these models perform fairly well in OBI recognition. For the 100-category OBI classification task, the optimal model achieves an accuracy of 99.5%, which shows competitive performance compared with other state-of-the-art approaches. We hope that this work can provide a valuable tool for character recognition of OBI.
Keywords	cultural heritage ; oracle bone inscriptions ; deep learning ; CNN ; character recognition ; image classification ; Geography (General) ; G1-922
Subject code	006
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Construction of a risk model and deep learning network based on patients with active pulmonary tuberculosis and pulmonary inflammation.

Xu, Dechang / Zeng, Jiang / Xie, Fangfang / Yang, Qianting / Huang, Kaisong / Xiao, Wei / Zou, Houwen / Zhang, Huihua

Biomedical reports

2023 Volume 18, Issue 5, Page(s) 34

Abstract: Most patients with active pulmonary tuberculosis (TB) are difficult to be differentiated from pneumonia (PN), especially those with acid-fast bacillus smear-negative ( ... ...

Abstract	Most patients with active pulmonary tuberculosis (TB) are difficult to be differentiated from pneumonia (PN), especially those with acid-fast bacillus smear-negative (AFB
Language	English
Publishing date	2023-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2763624-0
ISSN	2049-9442 ; 2049-9434
ISSN (online)	2049-9442
ISSN	2049-9434
DOI	10.3892/br.2023.1616
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Microglia and Astrocytes in Alzheimer's Disease: Significance and Summary of Recent Advances.

Deng, Qianting / Wu, Chongyun / Parker, Emily / Liu, Timon Cheng-Yi / Duan, Rui / Yang, Luodan

Aging and disease

2023

Abstract: Alzheimer's disease, one of the most common forms of dementia, is characterized by a slow progression of cognitive impairment and neuronal loss. Currently, approved treatments for AD are hindered by various side effects and limited efficacy. Despite ... ...

Abstract	Alzheimer's disease, one of the most common forms of dementia, is characterized by a slow progression of cognitive impairment and neuronal loss. Currently, approved treatments for AD are hindered by various side effects and limited efficacy. Despite considerable research, practical treatments for AD have not been developed. Increasing evidence shows that glial cells, especially microglia and astrocytes, are essential in the initiation and progression of AD. During AD progression, activated resident microglia increases the ability of resting astrocytes to transform into reactive astrocytes, promoting neurodegeneration. Extensive clinical and molecular studies show the involvement of microglia and astrocyte-mediated neuroinflammation in AD pathology, indicating that microglia and astrocytes may be potential therapeutic targets for AD. This review will summarize the significant and recent advances of microglia and astrocytes in the pathogenesis of AD in three parts. First, we will review the typical pathological changes of AD and discuss microglia and astrocytes in terms of function and phenotypic changes. Second, we will describe microglia and astrocytes' physiological and pathological role in AD. These roles include the inflammatory response, "eat me" and "don't eat me" signals, Aβ seeding, propagation, clearance, synapse loss, synaptic pruning, remyelination, and demyelination. Last, we will review the pharmacological and non-pharmacological therapies targeting microglia and astrocytes in AD. We conclude that microglia and astrocytes are essential in the initiation and development of AD. Therefore, understanding the new role of microglia and astrocytes in AD progression is critical for future AD studies and clinical trials. Moreover, pharmacological, and non-pharmacological therapies targeting microglia and astrocytes, with specific studies investigating microglia and astrocyte-mediated neuronal damage and repair, may be a promising research direction for future studies regarding AD treatment and prevention.
Language	English
Publishing date	2023-09-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2625789-0
ISSN	2152-5250
ISSN	2152-5250
DOI	10.14336/AD.2023.0907
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