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  1. Article ; Online: Endoscopic Repair of Anterior Skull Base Cerebrospinal Fluid Leaks is Successful in Frail Patients.

    Eide, Jacob G / Kshirsagar, Rijul S / Wen, Chris / Qatanani, Anas / Harris, Jacob / Sellers, Lauren / Abello, Eric H / Douglas, Jennifer E / Palmer, James N / Adappa, Nithin D / Kuan, Edward C

    The Laryngoscope

    2024  

    Abstract: Objective: Surgical frailty estimates a patient's ability to withstand the physiologic stress of an intervention. There is limited data regarding the impact of frailty on endoscopic cerebrospinal fluid (CSF) leak repair.: Methods: Patients undergoing ...

    Abstract Objective: Surgical frailty estimates a patient's ability to withstand the physiologic stress of an intervention. There is limited data regarding the impact of frailty on endoscopic cerebrospinal fluid (CSF) leak repair.
    Methods: Patients undergoing CSF leak repair at two tertiary academic skull base programs were retrospectively reviewed. Demographic, treatment, and postoperative outcomes data were recorded. Frailty was calculated using validated indices, including the American Society of Anesthesiologists (ASA) classification, Charlson Comorbidity Index (CCI), and the Modified 5-Item Frailty Index (mFI-5). Outcomes included 30-day medical and surgical complications and readmission.
    Results: A total of 185 patients were included with 128 (69.2%) female patients and average age of 54 ± 14 years. The average body mass index was 34.6 ± 8.5. The most common identified etiology was idiopathic intracranial hypertension (IIH) in 64 patients (34.6%). A total of 125 patients (68%) underwent perioperative lumbar drain placement (primarily to measure intracranial pressures and diagnose IIH). Most patients were ASA class 3 (48.6%) with mean CCI 2.14 ± 2.23 and mFI-5 0.97 ± 0.90. Three patients had postoperative CSF leaks, with an overall repair success rate of 98.4%. There was no association between increased frailty and 30-day medical outcomes, surgical outcomes, or readmission (all p > 0.05).
    Conclusions: Endoscopic CSF leak repair in a frail population, including lumbar drain placement and bed rest, was not associated with an increased rate of complications. Previous data suggests increased complications in open craniotomy procedures in patients with significant comorbidities. This study suggests that the endoscopic approach to CSF leak repair is well tolerated in the frail population.
    Level of evidence: IV Laryngoscope, 2024.
    Language English
    Publishing date 2024-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.31440
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  2. Article ; Online: A Practical Guide to Address Harassment and Bullying in Cardiology.

    Bravo-Jaimes, Katia / Costello, Briana T / Reza, Nosheen / Sanghavi, Monika / Tamirisa, Kamala P / Mehta, Laxmi S / Mamas, Mamas A / Taub, Cynthia C / Volgman, Annabelle Santos / Mieres, Jennifer H / Ijioma, Nkechinyere N / Douglas, Pamela S / Hayes, Sharonne N / Bullock-Palmer, Renée P

    JACC. Case reports

    2023  Volume 22, Page(s) 101988

    Language English
    Publishing date 2023-09-20
    Publishing country Netherlands
    Document type Editorial
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2023.101988
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  3. Article ; Online: Disruption of an ant-plant mutualism shapes interactions between lions and their primary prey.

    Kamaru, Douglas N / Palmer, Todd M / Riginos, Corinna / Ford, Adam T / Belnap, Jayne / Chira, Robert M / Githaiga, John M / Gituku, Benard C / Hays, Brandon R / Kavwele, Cyrus M / Kibungei, Alfred K / Lamb, Clayton T / Maiyo, Nelly J / Milligan, Patrick D / Mutisya, Samuel / Ng'weno, Caroline C / Ogutu, Michael / Pietrek, Alejandro G / Wildt, Brendon T /
    Goheen, Jacob R

    Science (New York, N.Y.)

    2024  Volume 383, Issue 6681, Page(s) 433–438

    Abstract: Mutualisms often define ecosystems, but they are susceptible to human activities. Combining experiments, animal tracking, and mortality investigations, we show that the invasive big-headed ant ( ...

    Abstract Mutualisms often define ecosystems, but they are susceptible to human activities. Combining experiments, animal tracking, and mortality investigations, we show that the invasive big-headed ant (
    MeSH term(s) Animals ; Ants/physiology ; Elephants ; Equidae ; Lions ; Myrmecophytes ; Symbiosis ; Food Chain ; Buffaloes
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adg1464
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  4. Article: A Novel Preclinical Murine Model to Monitor Inflammatory Breast Cancer Tumor Growth and Lymphovascular Invasion.

    Rickard, Ashlyn G / Sannareddy, Dorababu S / Bennion, Alexandra / Patel, Pranalee / Sauer, Scott J / Rouse, Douglas C / Bouchal, Samantha / Liu, Harrison / Dewhirst, Mark W / Palmer, Gregory M / Devi, Gayathri R

    Cancers

    2023  Volume 15, Issue 8

    Abstract: Inflammatory breast cancer (IBC), an understudied and lethal breast cancer, is often misdiagnosed due to its unique presentation of diffuse tumor cell clusters in the skin and dermal lymphatics. Here, we describe a window chamber technique in combination ...

    Abstract Inflammatory breast cancer (IBC), an understudied and lethal breast cancer, is often misdiagnosed due to its unique presentation of diffuse tumor cell clusters in the skin and dermal lymphatics. Here, we describe a window chamber technique in combination with a novel transgenic mouse model that has red fluorescent lymphatics (ProxTom RFP Nu/Nu) to simulate IBC clinicopathological hallmarks. Various breast cancer cells stably transfected to express green or red fluorescent reporters were transplanted into mice bearing dorsal skinfold window chambers. Intravital fluorescence microscopy and the in vivo imaging system (IVIS) were used to serially quantify local tumor growth, motility, length density of lymph and blood vessels, and degree of tumor cell lymphatic invasion over 0-140 h. This short-term, longitudinal imaging time frame in studying transient or dynamic events of diffuse and collectively migrating tumor cells in the local environment and quantitative analysis of the tumor area, motility, and vessel characteristics can be expanded to investigate other cancer cell types exhibiting lymphovascular invasion, a key step in metastatic dissemination. It was found that these models were able to effectively track tumor cluster migration and dissemination, which is a hallmark of IBC clinically, and was recapitulated in these mouse models.
    Language English
    Publishing date 2023-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15082261
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  5. Article ; Online: COVID-19-Related Employment Disruptions and Increased Financial Burden Among Survivors of Adolescent and Young Adult Cancer.

    Waters, Austin R / Kaddas, Heydon K / van Thiel Berghuijs, Karely M / Vaca Lopez, Perla L / Warner, Echo L / Ou, Judy Y / Ramsay, Joemy M / Palmer, Alexandra / Ray, Nicole / Tsukamoto, Tomoko / Fair, Douglas B / Lewis, Mark A / Linder, Lauri / Gill, David / Kirchhoff, Anne C

    Journal of adolescent and young adult oncology

    2023  Volume 12, Issue 5, Page(s) 744–751

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Young Adult ; Adolescent ; Financial Stress/epidemiology ; Pandemics ; COVID-19/epidemiology ; Neoplasms/therapy ; Survivors ; Employment
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2607978-1
    ISSN 2156-535X ; 2156-5333
    ISSN (online) 2156-535X
    ISSN 2156-5333
    DOI 10.1089/jayao.2022.0099
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  6. Article: Clinical and technical factors in endoscopic skull base surgery associated with reconstructive success.

    Abiri, A / Bitner, B F / Nguyen, T V / Pang, J C / Roman, K M / Vasudev, M / Chung, D D / Tripathi, S H / Harris, J C / Kosaraju, N / Shih, R M / Ko, M / Miller, J E / Douglas, J E / Lee, D J / Eide, J G / Kshirsagar, R S / Phillips, K M / Sedaghat, A R /
    Bergsneider, M / Wang, M B / Palmer, J N / Adappa, N D / Hsu, F P K / Kuan, E C

    Rhinology

    2024  

    Abstract: Background: In this study, we identified key discrete clinical and technical factors that may correlate with primary reconstructive success in endoscopic skull base surgery (ESBS).: Methods: ESBS cases with intraoperative cerebrospinal fluid (CSF) ... ...

    Abstract Background: In this study, we identified key discrete clinical and technical factors that may correlate with primary reconstructive success in endoscopic skull base surgery (ESBS).
    Methods: ESBS cases with intraoperative cerebrospinal fluid (CSF) leaks at four tertiary academic rhinology programs were retrospectively reviewed. Logistic regression identified factors associated with surgical outcomes by defect subsite (anterior cranial fossa [ACF], suprasellar [SS], purely sellar, posterior cranial fossa [PCF]).
    Results: Of 706 patients (50.4% female), 61.9% had pituitary adenomas, 73.4% had sellar or SS defects, and 20.5% had high-flow intraoperative CSF leaks. The postoperative CSF leak rate was 7.8%. Larger defect size predicted ACF postoperative leaks; use of rigid reconstruction and older age protected against sellar postoperative leaks; and use of dural sealants compared to fibrin glue protected against PCF postoperative leaks. SS postoperative leaks occurred less frequently with the use of dural onlay. Body-mass index, intraoperative CSF leak flow rate, and the use of lumbar drain were not significantly associated with postoperative CSF leak. Meningitis was associated with larger tumors in ACF defects, nondissolvable nasal packing in SS defects, and high-flow intraoperative leaks in PCF defects. Sinus infections were more common in sellar defects with synthetic grafts and nondissolvable nasal packing.
    Conclusions: Depending on defect subsite, reconstructive success following ESBS may be influenced by factors, such as age, defect size, and the use of rigid reconstruction, dural onlay, and tissue sealants.
    Language English
    Publishing date 2024-01-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80336-4
    ISSN 0300-0729
    ISSN 0300-0729
    DOI 10.4193/Rhin23.267
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  7. Article ; Online: Addressing spiritual distress in pediatric oncology.

    Dolan, J Gregory / Hill, Douglas L / Palmer, Laura / Feudtner, Chris

    Pediatric blood & cancer

    2022  Volume 69, Issue 3, Page(s) e29552

    MeSH term(s) Child ; Humans ; Medical Oncology ; Neoplasms/therapy ; Spirituality
    Language English
    Publishing date 2022-01-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.29552
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  8. Article ; Online: Publisher Correction: A T cell resilience model associated with response to immunotherapy in multiple tumor types.

    Zhang, Yu / Vu, Trang / Palmer, Douglas C / Kishton, Rigel J / Gong, Lanqi / Huang, Jiao / Nguyen, Thanh / Chen, Zuojia / Smith, Cari / Livák, Ferenc / Paul, Rohit / Day, Chi-Ping / Wu, Chuan / Merlino, Glenn / Aldape, Kenneth / Guan, Xin-Yuan / Jiang, Peng

    Nature medicine

    2022  Volume 28, Issue 10, Page(s) 2219

    Language English
    Publishing date 2022-08-11
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-022-01997-8
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  9. Article ; Online: Evaluating Tumor Hypoxia Radiosensitization Via Electron Paramagnetic Resonance Oxygen Imaging (EPROI).

    Rickard, Ashlyn G / Mowery, Yvonne M / Bassil, Alex / Rouse, Douglas C / Williams, Nerissa T / Charity, Theresa / Belloni, Rafaela / Crouch, Brian / Ramanujam, Nimmi / Stevenson, Daniel / Castillo, Rico / Blocker, Stephanie / Epel, Boris / Kotecha, Mrignayani / Palmer, Gregory M

    Molecular imaging and biology

    2023  

    Abstract: Purpose: Tumor hypoxia contributes to aggressive phenotypes and diminished therapeutic responses to radiation therapy (RT) with hypoxic tissue being 3-fold less radiosensitive than normoxic tissue. A major challenge in implementing hypoxic ... ...

    Abstract Purpose: Tumor hypoxia contributes to aggressive phenotypes and diminished therapeutic responses to radiation therapy (RT) with hypoxic tissue being 3-fold less radiosensitive than normoxic tissue. A major challenge in implementing hypoxic radiosensitizers is the lack of a high-resolution imaging modality that directly quantifies tissue-oxygen. The electron paramagnetic resonance oxygen-imager (EPROI) was used to quantify tumor oxygenation in two murine tumor models: E0771 syngeneic transplant breast cancers and primary p53/MCA soft tissue sarcomas, with the latter autochthonous model better recapitulating the tumor microenvironment in human malignancies. We hypothesized that tumor hypoxia differs between these models. We also aimed to quantify the absolute change in tumor hypoxia induced by the mitochondrial inhibitor papaverine (PPV) and its effect on RT response.
    Procedures: Tumor oxygenation was characterized in E0771 and primary p53/MCA sarcomas via EPROI, with the former model also being quantified indirectly via diffuse reflectance spectroscopy (DRS). After confirming PPV's effect on hypoxic fraction (via EPROI), we compared the effect of 0 versus 2 mg/kg PPV prior to 20 Gy on tumor growth delay and survival.
    Results: Hypoxic sarcomas were more radioresistant than normoxic sarcomas (p=0.0057, 2-way ANOVA), and high baseline hypoxic fraction was a significant (p=0.0063, Cox Regression Model) hazard in survivability regardless of treatment. Pre-treatment with PPV before RT did not radiosensitize tumors in the sarcoma or E0771 model. In the sarcoma model, EPROI successfully identified baseline hypoxic tumors. DRS quantification of total hemoglobin, saturated hemoglobin, changes in mitochondrial potential and glucose uptake showed no significant difference in E0771 tumors pre- and post-PPV.
    Conclusion: EPROI provides 3D high-resolution pO
    Language English
    Publishing date 2023-09-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2079160-4
    ISSN 1860-2002 ; 1536-1632
    ISSN (online) 1860-2002
    ISSN 1536-1632
    DOI 10.1007/s11307-023-01855-0
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  10. Article ; Online: Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2.

    Hernandez Cordero, Ana I / Gonzales, Natalia M / Parker, Clarissa C / Sokoloff, Greta / Vandenbergh, David J / Cheng, Riyan / Abney, Mark / Skol, Andrew / Douglas, Alex / Palmer, Abraham A / Gregory, Jennifer S / Lionikas, Arimantas

    American journal of human genetics

    2020  Volume 106, Issue 1, Page(s) 138

    Language English
    Publishing date 2020-02-03
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 219384-x
    ISSN 1537-6605 ; 0002-9297
    ISSN (online) 1537-6605
    ISSN 0002-9297
    DOI 10.1016/j.ajhg.2019.12.008
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