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Article ; Online: Immune-mediated Necrotizing Myopathy in a Patient with Microscopic Polyangiitis: A Case Report.

Umemoto, Daichi / Kanzawa, Yohei / Nakamura, Tomoko / Nishino, Ichizo / Mizuki, Shimpei / Ohnishi, Jun / Nakajima, Takahiro / Ishimaru, Naoto / Kinami, Saori

Internal medicine (Tokyo, Japan)

2023

Abstract: We herein report a case of immune-mediated necrotizing myopathy (IMNM) in a patient with microscopic polyangiitis (MPA). A 77-year-old Japanese woman presented with a 2-day history of proximal muscle weakness and myalgia, with elevated serum creatinine ... ...

Abstract	We herein report a case of immune-mediated necrotizing myopathy (IMNM) in a patient with microscopic polyangiitis (MPA). A 77-year-old Japanese woman presented with a 2-day history of proximal muscle weakness and myalgia, with elevated serum creatinine kinase (CK) levels. Findings of a muscle biopsy were compatible with IMNM; however, anti-SRP and anti-HMGCR antibodies were negative. She also had peripheral neuropathy with elevated serum MPO-ANCA titers, leading to a diagnosis of MPA. IMNM can be a pathological result of MPA muscle involvement.
Language	English
Publishing date	2023-10-06
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.2583-23
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Article: Joint Space Width, but not Osteophyte Thickness, is a Reliable Indicator of Degeneration of Lateral Knee Joint Cartilage.

Matsumoto, Kazu / Ishimaru, Daichi / Ogawa, Hiroyasu / Akiyama, Haruhiko

Acta orthopaedica Belgica

2020 Volume 85, Issue 4, Page(s) 494–501

Abstract: In this histologically controlled in vitro study, we evaluated the validity of plain radiography for the assessment of lateral knee joint cartilage degeneration (25 specimens). We examined the correlation between histological grade and radiography ... ...

Abstract	In this histologically controlled in vitro study, we evaluated the validity of plain radiography for the assessment of lateral knee joint cartilage degeneration (25 specimens). We examined the correlation between histological grade and radiography findings along with patient demographics. Our study indicated that the Mankin score had a significant inverse correlation with middle joint space width (JSW r=-0.19,P=0.02), but not with inner and outer JSW (inner : r=-0.11,P=0.10, outer : r=-0.14,P=0.06) under a non-weight bearing condition. The Mankin score had a significant inverse correlation with middle and outer JSW (middle : r=-0.17,P=0.04, outer : r=-0.14,P=0.04), but not with inner JSW (inner : r=-0.15,P=0.06) under valgus stress. There was no significant correlation between the Mankin score and osteophyte thickness (r=0.004,P=0.76). We also examined the correlation with patient demographics. We found that only the preoperative femorotibial angle had a significant inverse correlation with the Mankin score. These results indicate that JSW, but not osteophyte thickness, is reliable for evaluating lateral femoral cartilage degeneration.
MeSH term(s)	Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Knee ; Cartilage, Articular/diagnostic imaging ; Cartilage, Articular/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Osteoarthritis, Knee/diagnostic imaging ; Osteoarthritis, Knee/physiopathology ; Osteophyte/diagnostic imaging ; Osteophyte/physiopathology ; Prospective Studies ; Radiography
Language	English
Publishing date	2020-05-06
Publishing country	Belgium
Document type	Journal Article
ZDB-ID	210367-9
ISSN	0001-6462 ; 1784-407X
ISSN	0001-6462 ; 1784-407X
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Zs.A 37: Show issues

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Article: A Case of an Insufficiency Fracture of the Medial Proximal Tibia Secondary to Osteomalacia Associated with Long-Term Saccharated Ferric Oxide Administration.

Ishimaru, Daichi / Sumi, Hiroshi

Case reports in orthopedics

2017 Volume 2017, Page(s) 1675654

Abstract: This article presents a case of insufficiency fracture of medial proximal tibia caused by long-term administration of saccharated ferric oxide (SFO) in a 77-year-old female. In this case, 2-year administration of SFO for iron deficit anemia induced ... ...

Abstract	This article presents a case of insufficiency fracture of medial proximal tibia caused by long-term administration of saccharated ferric oxide (SFO) in a 77-year-old female. In this case, 2-year administration of SFO for iron deficit anemia induced hypophosphatemic osteomalacia and finally resulted in an insufficiency fracture of medial proximal tibia. Hypophosphatemia and pain due to the insufficiency fracture were recovered promptly by withdrawing SFO administration and rest. This case represented varus deformity of the knee associated with osteoarthritis, which may also cause the insufficiency fracture of medial proximal tibia in addition to osteomalacia due to long-term administration of SFO. Long-term SFO administration should be avoided because of a definitive risk of osteomalacia and fragile fracture.
Language	English
Publishing date	2017-07-04
Publishing country	United States
Document type	Case Reports
ZDB-ID	2684648-2
ISSN	2090-6757 ; 2090-6749
ISSN (online)	2090-6757
ISSN	2090-6749
DOI	10.1155/2017/1675654
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Article ; Online: Glucose emission spectra through mid-infrared passive spectroscopic imaging of the wrist for non-invasive glucose sensing.

Kitazaki, Tomoya / Morimoto, Yusuke / Yamashita, So / Anabuki, Daichi / Tahara, Shiori / Nishiyama, Akira / Wada, Kenji / Ishimaru, Ichiro

Scientific reports

2022 Volume 12, Issue 1, Page(s) 20558

Abstract: Non-invasive blood glucose sensing can be achieved using mid-infrared spectroscopy, although no practical device based on this method has yet been developed. Here, we propose mid-infrared passive spectroscopic imaging for glucose measurements from a ... ...

Abstract	Non-invasive blood glucose sensing can be achieved using mid-infrared spectroscopy, although no practical device based on this method has yet been developed. Here, we propose mid-infrared passive spectroscopic imaging for glucose measurements from a distance. Spectroscopic imaging of thermal radiation from the human body enabled, for the first time in the world, the detection of glucose-induced luminescence from a distance. In addition, glucose emission spectra of the wrist acquired at regular intervals up to 60 min showed that there was a strong correlation between the glucose emission intensity and blood glucose level measured using an invasive sensor. Thus, the new technology proposed here is expected to be applied to real-time monitoring of diabetic patients to detect hypoglycemic attacks during sleep and to detect hyperglycemia in a population. Moreover, this technology could lead to innovations that would make it possible to remotely measure a variety of substances.
MeSH term(s)	Humans ; Wrist ; Glucose ; Blood Glucose ; Wrist Joint ; Spectrophotometry, Infrared
Chemical Substances	Glucose (IY9XDZ35W2) ; Blood Glucose
Language	English
Publishing date	2022-11-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-25161-x
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Article ; Online: Modified Extension Block Technique for Bony Mallet Injury of the Hallux.

Kawashima, Kenji / Shinozaki, Masato / Tsugita, Masanori / Ishimaru, Daichi / Akiyama, Haruhiko

The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons

2019 Volume 58, Issue 3, Page(s) 596–598

Abstract: Bony mallet injury of the hallux is uncommon. In the few reports of this injury, authors have described surgical treatments such as closed reduction with percutaneous pinning and open surgical fixation with Kirschner wires or a suture anchor. However, ... ...

Abstract	Bony mallet injury of the hallux is uncommon. In the few reports of this injury, authors have described surgical treatments such as closed reduction with percutaneous pinning and open surgical fixation with Kirschner wires or a suture anchor. However, the appropriate surgical management for this injury remains controversial. In this article, we describe a case of bony mallet injury of the hallux repaired with the modified extension block techniqueusing 3 Kirschner wires. This method is an effective and simple treatment to allow anatomic reduction of the displaced articular fracture fragment without incision, residual hardware, or the complications associated with open surgical treatment.
MeSH term(s)	Adult ; Bone Wires ; Fracture Fixation, Internal/methods ; Fractures, Avulsion/diagnostic imaging ; Fractures, Avulsion/surgery ; Hallux/diagnostic imaging ; Hallux/injuries ; Hallux/surgery ; Humans ; Imaging, Three-Dimensional ; Male ; Toe Phalanges/diagnostic imaging ; Toe Phalanges/injuries ; Toe Phalanges/surgery ; Tomography, X-Ray Computed
Language	English
Publishing date	2019-02-08
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1146972-9
ISSN	1542-2224 ; 1067-2516
ISSN (online)	1542-2224
ISSN	1067-2516
DOI	10.1053/j.jfas.2018.09.018
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Zs.A 1468: Show issues

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Article ; Online: Correlation between mutated genes and forearm deformity in patients with multiple osteochondroma.

Matsumoto, Kazu / Ishimaru, Daichi / Ogawa, Hiroyasu / Komura, Shingo / Shimizu, Katsuji / Akiyama, Haruhiko

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

2020 Volume 26, Issue 3, Page(s) 483–486

Abstract: Backgrounds: Exostosin-1 (EXT1) and exostosin-2 (EXT2) cause multiple osteochondromas (MO). In this study, we investigated the correlation between forearm deformity and mutant EXTs in Japanese families with MO.: Methods: We evaluated 112 patients in ... ...

Abstract	Backgrounds: Exostosin-1 (EXT1) and exostosin-2 (EXT2) cause multiple osteochondromas (MO). In this study, we investigated the correlation between forearm deformity and mutant EXTs in Japanese families with MO. Methods: We evaluated 112 patients in 71 families with MO. Genomic DNA was isolated from peripheral blood leucocytes. Of these, 28 patients were selected and underwent radiography for their forearms since they had gross forearm deformities. We measured the radial articular angle (RAA), ulna variance (UV), carpal slip (CS), and percentage of radial bowing (%RB) to compare between patients with mutant EXT1 or EXT2 and those with missense or other mutations using Student's t-test. Results: Twenty-two (78.6%) and 6 (11.4%) out of 28 patients had mutations in EXT1 and EXT2, respectively. Nine (32.1%) and 19 (67.9%) of the 28 patients had missense and other mutations, respectively. The mean age of patients with EXT1 and EXT2 were 25.9 ± 20.3 and 33.5 ± 25.4 years, respectively and those with missense mutation and other mutations were 28.7 ± 27.0 and 24.6 ± 17.0 years, respectively. There were no significant differences in RAA, UV, and RB between patients harbouring mutant EXT1 or EXT2 (RAA, 40.1 ± 8.7 and 31.5 ± 13.9°; UV, -2.7 ± 5.7 and -3.1 ± 3.7 mm; %RB, 8.6 ± 1.5 and 8.3 ± 2.0%). CS was significantly greater in patients with mutant EXT1 than that in those with mutant EXT2 (EXT1, 44.1 ± 16.8%; EXT2, 18.6 ± 14.0%). There were no significant differences in RAA, UV, CS and %RB between patients with missense and other mutations. Conclusions: Patients with mutant EXT1 displayed greater CS than patients with mutant EXT2, indicating that patients with MO harbouring EXT1 mutations sustain more severe ulnar drift deformities than those with EXT2 mutations.
MeSH term(s)	Adult ; Exostoses, Multiple Hereditary/diagnostic imaging ; Exostoses, Multiple Hereditary/genetics ; Forearm/diagnostic imaging ; Humans ; Leg ; Musculoskeletal Diseases ; Mutation
Language	English
Publishing date	2020-07-04
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1314243-4
ISSN	1436-2023 ; 0949-2658
ISSN (online)	1436-2023
ISSN	0949-2658
DOI	10.1016/j.jos.2020.05.012
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Zs.A 4484: Show issues

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Article: Black Colouration of the Knee Articular Cartilage after Spontaneously Recurrent Haemarthrosis.

Matsumoto, Kazu / Ishimaru, Daichi / Ogawa, Hiroyasu / Akiyama, Haruhiko

Case reports in orthopedics

2016 Volume 2016, Page(s) 1238392

Abstract: Mild discolouration of the articular cartilage is known to gradually occur during aging. However, pathological tissue pigmentation is occasionally induced under several specific conditions. In the present case, we performed total knee replacement in a ... ...

Abstract	Mild discolouration of the articular cartilage is known to gradually occur during aging. However, pathological tissue pigmentation is occasionally induced under several specific conditions. In the present case, we performed total knee replacement in a patient with recurrent haemarthrosis. However, during the operation, we observed severe black colouration of the knee articular cartilage, due to the deposition of hemosiderin and lipofuscin. To our knowledge, this is the first report of severe cartilage pigmentation, due to hemosiderin and lipofuscin deposition in articular cartilage.
Language	English
Publishing date	2016-05-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2684648-2
ISSN	2090-6757 ; 2090-6749
ISSN (online)	2090-6757
ISSN	2090-6749
DOI	10.1155/2016/1238392
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Article: Reconstruction of a malignant soft tissue tumor around the elbow joint using a frozen autograft treated with liquid nitrogen, in combination with a free anterolateral thigh flap: A report of two cases.

Hirakawa, Akihiro / Nagano, Akihito / Komura, Shingo / Ishimaru, Daichi / Kawashima, Kenji / Akiyama, Haruhiko

Case reports in plastic surgery & hand surgery

2018 Volume 5, Issue 1, Page(s) 80–86

Abstract: We present two cases of malignant soft tissue tumor around the elbow joint treated ... ...

Abstract	We present two cases of malignant soft tissue tumor around the elbow joint treated with
Language	English
Publishing date	2018-11-08
Publishing country	United States
Document type	Case Reports
ISSN	2332-0885
ISSN	2332-0885
DOI	10.1080/23320885.2018.1539911
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Article: Suprascapular Nerve Entrapment Caused by Protrusion of an Intraosseous Ganglion of the Glenoid into the Spinoglenoid Notch: A Rare Cause of Posterior Shoulder Pain.

Ishimaru, Daichi / Nagano, Akihito / Terabayashi, Nobuo / Nishimoto, Yutaka / Akiyama, Haruhiko

Case reports in orthopedics

2017 Volume 2017, Page(s) 1704697

Abstract: We describe a case of suprascapular nerve entrapment caused by protrusion of an intraosseous ganglion of the glenoid into the spinoglenoid notch. A 47-year-old man with left shoulder pain developed an intraosseous cyst in the left glenoid, which came ... ...

Abstract	We describe a case of suprascapular nerve entrapment caused by protrusion of an intraosseous ganglion of the glenoid into the spinoglenoid notch. A 47-year-old man with left shoulder pain developed an intraosseous cyst in the left glenoid, which came into contact with the suprascapular nerve. The area at which the patient experienced spontaneous shoulder pain was innervated by the suprascapular nerve, and 1% xylocaine injection into the spinoglenoid notch under ultrasonographic guidance relieved the pain. Therefore, we concluded that the protrusion of an intraosseous cyst of the glenoid into the spinoglenoid notch was a cause of the pain, and performed curettage. Consequently, the shoulder pain was resolved promptly without suprascapular nerve complications, and the cyst was histologically diagnosed as an intraosseous ganglion. This case demonstrated that the intraosseous ganglion of the glenoid was a benign lesion but could be a cause of suprascapular nerve entrapment syndrome. Curettage is a useful treatment option for a ganglion inside bone and very close to the suprascapular nerve.
Language	English
Publishing date	2017-05-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	2684648-2
ISSN	2090-6757 ; 2090-6749
ISSN (online)	2090-6757
ISSN	2090-6749
DOI	10.1155/2017/1704697
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Article ; Online: Primary bone sarcomas in patients over 40 years of age: A retrospective study using data from the Bone Tumor Registry of Japan.

Nagano, Akihito / Ishimaru, Daichi / Nishimoto, Yutaka / Akiyama, Haruhiko / Kawai, Akira

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

2017 Volume 22, Issue 4, Page(s) 749–754

Abstract: Background: Optimal treatments of patients aged >40 years with osteosarcoma and Ewing sarcoma and of patients with other types of bone sarcoma have not yet been established.: Methods: The clinical characteristics of 746 patients with primary bone ... ...

Abstract	Background: Optimal treatments of patients aged >40 years with osteosarcoma and Ewing sarcoma and of patients with other types of bone sarcoma have not yet been established. Methods: The clinical characteristics of 746 patients with primary bone sarcomas aged >40 years listed in the nationwide tumor registry (Bone and Soft Tissue Tumor Registry of Japan) were investigated. Patients with Ewing sarcoma, conventional chondrosarcoma, multiple myeloma, and malignant lymphoma were excluded. The effects of adjuvant chemotherapy were determined by comparing outcomes in patients aged 40-70 years with non-metastatic high grade bone tumors who received surgery plus chemotherapy with those who underwent surgery alone. Results: Axial site tumors (38.6%) and distant metastasis at presentation (21.4%) were frequent in patients aged >40 years with primary bone sarcomas. Chemotherapy was administered to 407 (54.6%) patients. Their 5-year overall survival (OS) and progression free survival (PFS) rates were 47.6% and 39.8%, respectively. Multivariate analysis showed that distant metastases at presentation, histological high grade, and radiation therapy were significantly correlated with both OS and PFS. Age and tumor size were also significantly correlated with OS. Patients aged 40-70 years who underwent surgery plus chemotherapy and those who underwent surgery alone had 5-year OS rates of 69.3% and 63.2%, respectively (p = 0.092), and 5-year PFS rates of 55.4% and 50.7%, respectively (p = 0.63). Conclusions: Bone sarcoma patients aged >40 years had distinct clinical features and a poor prognosis. Chemotherapy did not improve OS or PFS in patients aged 40-70 years.
Language	English
Publishing date	2017-07
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1314243-4
ISSN	1436-2023 ; 0949-2658
ISSN (online)	1436-2023
ISSN	0949-2658
DOI	10.1016/j.jos.2017.03.008
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