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  1. Article ; Online: Observing Carbon-(k) Near Edge Structure for Various Polymers at High Spatial Resolution with Modern Scanning Transmission Electron Microscopy and Electron Energy Loss Spectroscopy Instrumentation.

    Williams, Robert E A

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue Supplement_1, Page(s) 412

    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozad067.194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The challenge of invasive mosquito vectors in the U.K. during 2016-2018: a summary of the surveillance and control of Aedes albopictus.

    Vaux, A G C / Dallimore, T / Cull, B / Schaffner, F / Strode, C / Pflüger, V / Murchie, A K / Rea, I / Newham, Z / Mcginley, L / Catton, M / Gillingham, E L / Medlock, J M

    Medical and veterinary entomology

    2019  Volume 33, Issue 4, Page(s) 443–452

    Abstract: ... dengue viruses. This paper considers the risk that Ae. aegypti and Ae. albopictus represent for the U.K. and ... albopictus into the U.K. via ground vehicular traffic, which can be expected to continue and increase ...

    Abstract Mosquito-borne diseases resulting from the expansion of two key vectors, Aedes aegypti and Aedes albopictus (Diptera: Culicidae), continue to challenge whole regions and continents around the globe. In recent years there have been human cases of disease associated with Chikungunya, dengue and Zika viruses. In Europe, the expansion of Ae. albopictus has resulted in local transmission of Chikungunya and dengue viruses. This paper considers the risk that Ae. aegypti and Ae. albopictus represent for the U.K. and details the results of mosquito surveillance activities. Surveillance was conducted at 34 points of entry, 12 sites serving vehicular traffic and two sites of used tyre importers. The most common native mosquito recorded was Culex pipiens s.l. (Diptera: Culicidae). The invasive mosquito Ae. albopictus was detected on three occasions in southern England (September 2016, July 2017 and July 2018) and subsequent control strategies were conducted. These latest surveillance results demonstrate ongoing incursions of Ae. albopictus into the U.K. via ground vehicular traffic, which can be expected to continue and increase as populations in nearby countries expand, particularly in France, which is the main source of ex-continental traffic.
    MeSH term(s) Aedes ; Animal Distribution ; Animals ; Chikungunya virus ; Dengue Virus ; Introduced Species ; Mosquito Control ; Mosquito Vectors ; United Kingdom
    Language English
    Publishing date 2019-07-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 286021-1
    ISSN 1365-2915 ; 0269-283X
    ISSN (online) 1365-2915
    ISSN 0269-283X
    DOI 10.1111/mve.12396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The challenge of invasive mosquito vectors in the U.K. during 2016–2018: a summary of the surveillance and control of Aedes albopictus

    Vaux, A. G. C / Catton, M / CULL, B / Dallimore, T / Gillingham, E. L / Mcginley, L / Medlock, J. M / Murchie, A. K / Newham, Z / Pflüger, V / Rea, I / Schaffner, F / Strode, C

    Medical and veterinary entomology. 2019 Dec., v. 33, no. 4

    2019  

    Abstract: ... dengue viruses. This paper considers the risk that Ae. aegypti and Ae. albopictus represent for the U.K. and ... albopictus into the U.K. via ground vehicular traffic, which can be expected to continue and increase ...

    Abstract Mosquito‐borne diseases resulting from the expansion of two key vectors, Aedes aegypti and Aedes albopictus (Diptera: Culicidae), continue to challenge whole regions and continents around the globe. In recent years there have been human cases of disease associated with Chikungunya, dengue and Zika viruses. In Europe, the expansion of Ae. albopictus has resulted in local transmission of Chikungunya and dengue viruses. This paper considers the risk that Ae. aegypti and Ae. albopictus represent for the U.K. and details the results of mosquito surveillance activities. Surveillance was conducted at 34 points of entry, 12 sites serving vehicular traffic and two sites of used tyre importers. The most common native mosquito recorded was Culex pipiens s.l. (Diptera: Culicidae). The invasive mosquito Ae. albopictus was detected on three occasions in southern England (September 2016, July 2017 and July 2018) and subsequent control strategies were conducted. These latest surveillance results demonstrate ongoing incursions of Ae. albopictus into the U.K. via ground vehicular traffic, which can be expected to continue and increase as populations in nearby countries expand, particularly in France, which is the main source of ex‐continental traffic.
    Keywords Aedes aegypti ; Aedes albopictus ; Culex pipiens ; dengue ; humans ; indigenous species ; insect vectors ; invasive species ; monitoring ; mosquito-borne diseases ; risk ; tires ; traffic ; viruses ; Zika virus ; England ; France
    Language English
    Dates of publication 2019-12
    Size p. 443-452.
    Publishing place Blackwell Publishing Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 286021-1
    ISSN 1365-2915 ; 0269-283X
    ISSN (online) 1365-2915
    ISSN 0269-283X
    DOI 10.1111/mve.12396
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: MARX, K.; ENGELS, F. Sobre a China. Brasília (DF)

    REA Editor

    Revista Espaço Acadêmico, Vol 16, Iss

    Edições Centelha Cultural, 2016 (216 p.)

    2016  Volume 184

    Abstract: Em jornal norte-americano de extraordinária influência naquele momento, o New York D Tribune, Marx e Engels publicaram em torno de 500 artigos – escritos no calor dos acontecimentos - dos quais aqui publicamos uma pequena antologia, apenas daqueles que ... ...

    Abstract Em jornal norte-americano de extraordinária influência naquele momento, o New York D Tribune, Marx e Engels publicaram em torno de 500 artigos – escritos no calor dos acontecimentos - dos quais aqui publicamos uma pequena antologia, apenas daqueles que tratam da China. Para além de jornalísticos, tais artigos discutem a política de saque das metrópoles do capital sobre países periféricos como a China, a geopolítica, as rebeliões camponesas chinesas e a lógica do sistema capitalista, em sua política de rapina internacional já naquele momento, século XIX.
    Keywords Marx ; Engels ; Marxismo ; Comunismo ; China ; Social sciences (General) ; H1-99
    Language Portuguese
    Publishing date 2016-09-01T00:00:00Z
    Publisher Universidade Estadual de Maringá
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: MARX, K.; ENGELS, F. Sobre a China. Brasília (DF)

    REA Editor

    Revista Espaço Acadêmico, Vol 16, Iss

    Edições Centelha Cultural, 2016 (216 p.)

    2016  Volume 184

    Abstract: Em jornal norte-americano de extraordinária influência naquele momento, o New York D Tribune, Marx e Engels publicaram em torno de 500 artigos – escritos no calor dos acontecimentos - dos quais aqui publicamos uma pequena antologia, apenas daqueles que ... ...

    Abstract Em jornal norte-americano de extraordinária influência naquele momento, o New York D Tribune, Marx e Engels publicaram em torno de 500 artigos – escritos no calor dos acontecimentos - dos quais aqui publicamos uma pequena antologia, apenas daqueles que tratam da China. Para além de jornalísticos, tais artigos discutem a política de saque das metrópoles do capital sobre países periféricos como a China, a geopolítica, as rebeliões camponesas chinesas e a lógica do sistema capitalista, em sua política de rapina internacional já naquele momento, século XIX.
    Keywords Marx ; Engels ; Marxismo ; Comunismo ; China ; Social sciences (General) ; H1-99
    Language Portuguese
    Publishing date 2016-09-01T00:00:00Z
    Publisher Universidade Estadual de Maringá
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Variant K of butyrylcholinesterase and types 1 and 2 of diabetes mellitus.

    Lepienski, L M / Alcântara, V M / Souza, R L R / Réa, R R / Chautard-Freire-Maia, E A

    Chemico-biological interactions

    2005  Volume 157-158, Page(s) 374–375

    MeSH term(s) Adolescent ; Age of Onset ; Alleles ; Butyrylcholinesterase/genetics ; Child ; Diabetes Mellitus, Type 1/enzymology ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 2/enzymology ; Diabetes Mellitus, Type 2/genetics ; Genetic Predisposition to Disease ; Genetic Variation/genetics ; Humans
    Chemical Substances Butyrylcholinesterase (EC 3.1.1.8)
    Language English
    Publishing date 2005-12-27
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 218799-1
    ISSN 1872-7786 ; 0009-2797
    ISSN (online) 1872-7786
    ISSN 0009-2797
    DOI 10.1016/j.cbi.2005.10.060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Variable K(+) channel subunit dysfunction in inherited mutations of KCNA1.

    Rea, Ruth / Spauschus, Alexander / Eunson, Louise H / Hanna, Michael G / Kullmann, Dimitri M

    The Journal of physiology

    2002  Volume 538, Issue Pt 1, Page(s) 5–23

    Abstract: Mutations of KCNA1, which codes for the K(+) channel subunit hKv1.1, are associated with the human ...

    Abstract Mutations of KCNA1, which codes for the K(+) channel subunit hKv1.1, are associated with the human autosomal dominant disease episodic ataxia type 1 (EA1). Five recently described mutations are associated with a broad range of phenotypes: neuromyotonia alone or with seizures, EA1 with seizures, or very drug-resistant EA1. Here we investigated the consequences of each mutation for channel assembly, trafficking, gating and permeation. We related data obtained from co-expression of mutant and wild-type hKv1.1 to the results of expressing mutant-wild-type fusion proteins, and combined electrophysiological recordings in Xenopus oocytes with a pharmacological discrimination of the contribution of mutant and wild-type subunits to channels expressed at the membrane. We also applied confocal laser scanning microscopy to measure the level of expression of either wild-type or mutant subunits tagged with green fluorescent protein (GFP). R417stop truncates most of the C-terminus and is associated with severe drug-resistant EA1. Electrophysiological and pharmacological measurements indicated that the mutation impairs both tetramerisation of R417stop with wild-type subunits, and membrane targeting of heterotetramers. This conclusion was supported by confocal laser scanning imaging of enhanced GFP (EGFP)-tagged hKv1.1 subunits. Co-expression of R417stop with wild-type hKv1.2 subunits yielded similar results to co-expression with wild-type hKv1.1. Mutations associated with typical EA1 (V404I) or with neuromyotonia alone (P244H) significantly affected neither tetramerisation nor trafficking, and only altered channel kinetics. Two other mutations associated with a severe phenotype (T226R, A242P) yielded an intermediate result. The phenotypic variability of KCNA1 mutations is reflected in a wide range of disorders of channel assembly, trafficking and kinetics.
    MeSH term(s) Animals ; Electrophysiology ; Female ; Fluorescence ; Humans ; Kinetics ; Kv1.1 Potassium Channel ; Kv1.2 Potassium Channel ; Models, Biological ; Mutation/physiology ; Oocytes ; Patch-Clamp Techniques ; Potassium Channel Blockers/pharmacology ; Potassium Channels/drug effects ; Potassium Channels/genetics ; Potassium Channels/physiology ; Potassium Channels, Voltage-Gated ; Protein Processing, Post-Translational ; Reference Values ; Tetraethylammonium/pharmacology ; Xenopus laevis
    Chemical Substances KCNA1 protein, human ; Kv1.2 Potassium Channel ; Potassium Channel Blockers ; Potassium Channels ; Potassium Channels, Voltage-Gated ; Kv1.1 Potassium Channel (147173-20-4) ; Tetraethylammonium (66-40-0)
    Language English
    Publishing date 2002-01-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/jphysiol.2001.013242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Variant K of butyrylcholinesterase and risk of early-onset type 1 diabetes mellitus in Euro-Brazilians.

    Lepienski, Luís M / Souza, Ricardo L R / Chautard-Freire-Maia, Eleidi A / Alcântara, Vânia M / Réa, Rosangela R

    Diabetes, obesity & metabolism

    2006  Volume 8, Issue 6, Page(s) 709–711

    MeSH term(s) Adult ; Age of Onset ; Butyrylcholinesterase/genetics ; Diabetes Mellitus, Type 1/genetics ; Female ; Genetic Predisposition to Disease ; Humans ; Linkage Disequilibrium ; Male
    Chemical Substances Butyrylcholinesterase (EC 3.1.1.8)
    Language English
    Publishing date 2006-11
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/j.1463-1326.2005.00559.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: AVP2, a sequence-divergent, K(+)-insensitive H(+)-translocating inorganic pyrophosphatase from Arabidopsis.

    Drozdowicz, Y M / Kissinger, J C / Rea, P A

    Plant physiology

    2000  Volume 123, Issue 1, Page(s) 353–362

    Abstract: ... from Arabidopsis, all characterized plant V-PPases share greater than 84% sequence identity and catalyze K ... accession no. AF182813), a sequence-divergent (36% identical) K(+)-insensitive, Ca(2+)-hypersensitive V ... Typified by AVP1 (V. Sarafian, Y. Kim, R.J. Poole, P.A. Rea [1992] Proc Natl Acad Sci USA 89: 1775-1779 ...

    Abstract Plant vacuolar H(+)-translocating inorganic pyrophosphatases (V-PPases; EC 3.6.1.1) have been considered to constitute a family of functionally and structurally monotonous intrinsic membrane proteins. Typified by AVP1 (V. Sarafian, Y. Kim, R.J. Poole, P.A. Rea [1992] Proc Natl Acad Sci USA 89: 1775-1779) from Arabidopsis, all characterized plant V-PPases share greater than 84% sequence identity and catalyze K(+)-stimulated H(+) translocation. Here we describe the molecular and biochemical characterization of AVP2 (accession no. AF182813), a sequence-divergent (36% identical) K(+)-insensitive, Ca(2+)-hypersensitive V-PPase active in both inorganic pyrophosphate hydrolysis and H(+) translocation. The differences between AVP2 and AVP1 provide the first indication that plant V-PPases from the same organism fall into two distinct categories. Phylogenetic analyses of these and other V-PPase sequences extend this principle by showing that AVP2, rather than being an isoform of AVP1, is but one representative of a novel category of AVP2-like (type II) V-PPases that coexist with AVP1-like (type I) V-PPases not only in plants, but also in apicomplexan protists such as the malarial parasite Plasmodium falciparum.
    MeSH term(s) Amino Acid Sequence ; Arabidopsis/enzymology ; Arabidopsis/genetics ; Ion Transport ; Molecular Sequence Data ; Phylogeny ; Potassium/metabolism ; Pyrophosphatases/chemistry ; Pyrophosphatases/genetics ; Pyrophosphatases/metabolism ; Sequence Homology, Amino Acid
    Chemical Substances Pyrophosphatases (EC 3.6.1.-) ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2000-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1104/pp.123.1.353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: 401(k) plan asset allocation, account balances, and loan activity.

    VanDerhei, J / Galer, R / Quick, C / Rea, J

    EBRI issue brief

    1999  , Issue 205, Page(s) 1–20

    Abstract: ... collaborating for the past two years to collect data on participants in 401(k) plans. This effort, known ... as the EBRI/ICI Participant-Directed Retirement Plan Data Collection Project, has obtained data for 401(k ... database appears to be broadly representative of the universe of 401(k) plans. Key findings include ...

    Abstract The Employee Benefit Research Institute (EBRI) and the Investment Company Institute (ICI) have been collaborating for the past two years to collect data on participants in 401(k) plans. This effort, known as the EBRI/ICI Participant-Directed Retirement Plan Data Collection Project, has obtained data for 401(k) plan participants from certain of EBRI and ICI sponsors and members serving as plan recordkeepers and administrators. The report includes 1996 information on 6.6 million active participants in 27,762 plans holding nearly $246 billion in assets. The data include demographic information, annual contributions, plan balances, asset allocation, and loans, and are currently the most comprehensive source of information on individual plan participants. In 1996, the first year for which data are ready for analysis, the EBRI/ICI database appears to be broadly representative of the universe of 401(k) plans. Key findings include: for all participants, 44.0 percent of the total plan balance is invested in equity funds, 19.1 percent in employer stock, 15.1 percent in guaranteed investment contracts (GICs), 7.8 percent in balanced funds, 6.8 percent in bond funds, 5.4 percent in money funds, 0.8 percent in other stable value funds, and 1.0 percent in other or unidentified investments. This allocation implies that over two-thirds of plan balances are invested directly or indirectly in equity securities. Asset allocation varies with age. For instance, on average, individuals in their twenties invested 76.8 percent of assets in equities and only 22.1 percent in fixed-income investments. By comparison, individuals in their sixties invested 53.2 percent of their assets in equities and 45.9 percent of assets in fixed-income investments. Investment options offered by 401(k) plans appear to influence asset allocation. For example, the addition of company stock substantially reduces the allocation to equity funds and the addition of GICs lowers allocations to bond and money funds. Employer contributions in the form of company stock affect participant allocation behavior. Participants in plans in which employer contributions are made in company stock appear to decrease allocations to equity funds and to increase the allocation of company stock in self-directed balances. The average account balance (net of plan loans) for all participants is $37,323. The balances, however, represent only amounts with current employers and do not include amounts remaining in the plans of prior employers. Nor do the balances indicate what savings would be in a "mature" 401(k) plan program. The average balances of older workers with long tenure at one employer indicate that a mature 401(k) plan program will produce substantial account balances. For example, individuals in their sixties with at least 30 years of tenure have average account balances in excess of $156,000; those in their fifties have balances in excess of $117,000.
    MeSH term(s) Data Collection ; Financing, Personal/statistics & numerical data ; Investments/statistics & numerical data ; Investments/trends ; Retirement/economics ; Retirement/trends ; Salaries and Fringe Benefits/statistics & numerical data ; United States
    Language English
    Publishing date 1999-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2568840-6
    ISSN 0887-137X
    ISSN 0887-137X
    DOI 10.2139/ssrn.1436935
    Database MEDical Literature Analysis and Retrieval System OnLINE

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