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  1. Article ; Online: Supresión de angiotensina II en la infección por el virus SARS-CoV-2: una propuesta terapéutica.

    Lamas-Barreiro, José María / Alonso-Suárez, Mario / Fernández-Martín, Jorge Julián / Saavedra-Alonso, Jesus Angel

    Nefrologia

    2020  Volume 40, Issue 3, Page(s) 213–216

    Title translation Angiotensin II suppression in SARS-CoV-2 infection: a therapeutic approach.
    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Animals ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/enzymology ; Diabetes Complications/complications ; Humans ; Hypertension/complications ; Lisinopril/pharmacology ; Losartan/pharmacology ; Lung/enzymology ; Mice ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/enzymology ; Rats ; SARS-CoV-2 ; Virus Internalization
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Lisinopril (E7199S1YWR) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Ace2 protein, mouse (EC 3.4.17.23) ; Ace2 protein, rat (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Losartan (JMS50MPO89)
    Keywords covid19
    Language Spanish
    Publishing date 2020-04-30
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2837917-2
    ISSN 2013-2514 ; 2013-2514
    ISSN (online) 2013-2514
    ISSN 2013-2514
    DOI 10.1016/j.nefro.2020.04.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clear cell clusters in the kidney: a rare finding that should not be misdiagnosed as renal cell carcinoma.

    Ortiz-Rey, José-Antonio / Fachal, Carmen / Juaneda-Magdalena, Laura / Muñoz-Martín, Mónica / Repáraz-Andrade, Alfredo / Teijeira, Susana / Lamas-Barreiro, José-María / Almuster-Domínguez, Sheila / San Miguel-Fraile, Pilar / Gómez-de María, Carolina

    Virchows Archiv : an international journal of pathology

    2021  Volume 479, Issue 1, Page(s) 57–67

    Abstract: Clear cytoplasm is a major characteristic feature of most malignant renal neoplasms. Benign clear cells in the renal parenchyma, usually histiocytes, can occasionally be found, but they are infrequently of an epithelial nature. We report histological, ... ...

    Abstract Clear cytoplasm is a major characteristic feature of most malignant renal neoplasms. Benign clear cells in the renal parenchyma, usually histiocytes, can occasionally be found, but they are infrequently of an epithelial nature. We report histological, immunohistochemical, ultrastructural, and cytogenomic features of clear epithelial cell clusters incidentally found in four kidney specimens. Multiple microscopic clear cell clusters were present in the cortex, often in subcapsular location. They were composed of large epithelial cells with strikingly clear cytoplasm, without nuclear atypia, arranged in solid nests, and some tubules with narrow lumina. Immunohistochemically, they were positive for AE1AE3, PAX 8, EMA, kidney-specific cadherin, cytokeratin 7, E cadherin, and CD117, with focal immunoreactivity for CD10. Carbonic anhydrase IX, vimentin, and markers related to apoptosis and proliferation were negative. Ultrastructurally, the cytoplasms were enlarged and poor in organelles, showing ballooning degeneration. Array comparative genomic hybridization showed no chromosomal gains or losses. Clear cell clusters constitute a rare finding in the kidney and must be differentiated from benign lesions (ectopic adrenal tissue, osmotic tubulopathy, histiocytic clusters, renal adenomas) and renal cell carcinomas. Clear cell clusters appear to be generated from "endocrine-type" atrophic tubules whose cells are enlarged due to intracellular oedema. Immunohistochemistry shows a distal nephron phenotype with a limited expression of a proximal marker, CD10. Coexisting chronic renal disease or ischemic conditions seem to be related to the development of clear cell clusters. Pathological, ultrastructural, and cytogenomic features do not support a preneoplastic nature of this lesion, at least in the cases studied here.
    MeSH term(s) Aged ; Aged, 80 and over ; Biomarkers/analysis ; Carcinoma, Renal Cell/chemistry ; Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/ultrastructure ; Comparative Genomic Hybridization ; Diagnosis, Differential ; Diagnostic Errors ; Female ; Humans ; Immunohistochemistry ; Kidney/chemistry ; Kidney/pathology ; Kidney/ultrastructure ; Kidney Neoplasms/chemistry ; Kidney Neoplasms/pathology ; Kidney Neoplasms/ultrastructure ; Male ; Microscopy, Electron ; Middle Aged ; Phenotype ; Predictive Value of Tests
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-01-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-021-03018-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Supresión de angiotensia II en la infección por el virus SARS-CoV-2: una propuesta terapeútica

    María Lamas-Barreiro, José / Alonso-Suarez, Mario / Fernández-Martín, Jorge Julián / Saavedra-Alonso, Jesus Angel

    Nefrología

    Keywords covid19
    Publisher Elsevier
    Document type Article ; Online
    DOI 10.1016/j.nefro.2020.04.006
    Database COVID19

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  4. Article: Angiotensin II suppression in SARS-CoV-2 infection: a therapeutic approach

    Lamas-Barreiro, Jose Maria / Alonso-Suarez, Mario / Fernandez-Martin, Jorge Julian / Saavedra-Alonso, Jesus Angel

    Nefrologia

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #415117
    Database COVID19

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  5. Article ; Online: Angiotensin II suppression in SARS-CoV-2 infection

    Lamas-Barreiro, José María / Alonso-Suárez, Mario / Fernández-Martín, Jorge Julián / Saavedra-Alonso, Jesus Angel

    Nefrología (English Edition)

    a therapeutic approach

    2020  Volume 40, Issue 3, Page(s) 213–216

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2837917-2
    ISSN 2013-2514
    ISSN 2013-2514
    DOI 10.1016/j.nefroe.2020.06.014
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Supresión de angiotensina II en la infección por el virus SARS-CoV-2

    Lamas-Barreiro, José María / Alonso-Suárez, Mario / Fernández-Martín, Jorge Julián / Saavedra-Alonso, Jesus Angel

    Nefrología

    una propuesta terapéutica

    2020  Volume 40, Issue 3, Page(s) 213–216

    Keywords Nephrology ; covid19
    Language Spanish
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 632512-9
    ISSN 1989-2284 ; 0211-6995
    ISSN (online) 1989-2284
    ISSN 0211-6995
    DOI 10.1016/j.nefro.2020.04.006
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2773: Show issues Location:
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    Zs.MO 56: Show issues

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  7. Article: Supresión de angiotensina II en la infección por el virus SARS-CoV-2: una propuesta terapéutica./ Supresión de angiotensina II en la infección por el virus SARS-CoV-2: una propuesta terapéutica./ [Angiotensin II suppression in SARS-CoV-2 infection: a therapeutic approach]

    Lamas-Barreiro, José María / Alonso-Suárez, Mario / Fernández-Martín, Jorge Julián / Saavedra-Alonso, Jesus Angel

    Nefrologia

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32456945
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

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  8. Article ; Online: Angiotensin II suppression in SARS-CoV-2 infection

    José María Lamas-Barreiro / Mario Alonso-Suárez / Jorge Julián Fernández-Martín / Jesus Angel Saavedra-Alonso

    Nefrología (English Edition), Vol 40, Iss 3, Pp 213-

    a therapeutic approach

    2020  Volume 216

    Keywords Diseases of the genitourinary system. Urology ; RC870-923 ; covid19
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article ; Online: Supresión de angiotensina II en la infección por el virus SARS-CoV-2

    José María Lamas-Barreiro / Mario Alonso-Suárez / Jorge Julián Fernández-Martín / Jesus Angel Saavedra-Alonso

    Nefrología, Vol 40, Iss 3, Pp 213-

    una propuesta terapéutica

    2020  Volume 216

    Keywords Diseases of the genitourinary system. Urology ; RC870-923 ; covid19
    Language Spanish
    Publishing date 2020-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article: Fourier transform infrared spectroscopy-chemometric approach as a non-destructive olive cultivar tool for discriminating Portuguese monovarietal olive oils

    Lamas, Sandra / Rodrigues, Nuno / Fernandes, Isabel P. / Barreiro, Maria F. / Pereira, José A. / Peres, António M.

    European food research & technology. 2021 Oct., v. 247, no. 10

    2021  

    Abstract: Four Portuguese monovarietal olive oils (cvs. Cobrançosa, Madural, Santulhana and Verdeal Transmontana) were evaluated, totalizing 24 independent samples. Olive cultivar significantly influenced (P values < 0.05, one-way ANOVA) the oils’ physicochemical ... ...

    Abstract Four Portuguese monovarietal olive oils (cvs. Cobrançosa, Madural, Santulhana and Verdeal Transmontana) were evaluated, totalizing 24 independent samples. Olive cultivar significantly influenced (P values < 0.05, one-way ANOVA) the oils’ physicochemical and sensory attributes, fulfilling all oils the legal thresholds for extra-virgin classification. Oils from cv. Verdeal Transmontana had the highest oxidative stability (16.9 ± 1.0 h), whereas cvs. Cobrançosa and Santulhana oils have the highest total phenols content (204 ± 30 and 177 ± 33 mg GAE/kg, respectively). Concerning the sensory attributes, only cv. Santulhana oils fitted fruity greenly oils type, presenting, in general, significantly higher olfactory and gustatory intensities (P values < 0.05, one-way ANOVA), with a higher number of perceived sensory attributes (e.g., herbaceous sensations), compared to the other monovarietal oils. Free acidity, peroxide value, extinction coefficients, total phenols and oxidative stability allowed the unsupervised differentiation (principal component analysis, PCA) of the four monovarietal oils, and in a less extent, the sensory data. Fourier transform infrared (FTIR) spectroscopy-chemometric procedure was developed based on raw or transformed forms of the recorded spectra. Raw, 1st and 2nd derivative spectra allowed the unsupervised (PCA) and supervised (linear discriminant analysis, LDA) identification of the olive cultivar of the studied oils. In fact, FTIR-LDA models, based on the raw transmittance or on their 1st or 2nd derivatives, recorded at 5, 4 or 3 selected wavenumbers, respectively, allowed to correctly classify all oils (sensitivities greater than 99 ± 7% for the repeated K-fold-CV internal validation). Therefore, FTIR spectroscopy could be used as a fast, reliable, environmentally friendly and non-destructive olive cultivar-classification tool for monovarietal oils.
    Keywords Fourier transform infrared spectroscopy ; acidity ; cultivars ; discriminant analysis ; food research ; olives ; oxidative stability ; peroxide value ; principal component analysis ; taste ; technology ; transmittance
    Language English
    Dates of publication 2021-10
    Size p. 2473-2484.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 1359456-4
    ISSN 1431-4630 ; 1438-2377
    ISSN 1431-4630 ; 1438-2377
    DOI 10.1007/s00217-021-03809-8
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 792: Show issues

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