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Article ; Online: What About This IDEA: The PROSPECT That Occult Malignant Lesions May Explain Local Recurrences in Very Early Breast Cancer?

Mann, G Bruce / Rose, Allison K / Zdenkowski, Nick

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2024 , Page(s) JCO2302729

Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Letter
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.23.02729
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Article ; Online: Precision dentistry.

Kaur, N / Mishra, G / Parihar, V / Sharma, S S / Tyro, K D / Mann, S K

British dental journal

2023 Volume 234, Issue 4, Page(s) 197

Language	English
Publishing date	2023-02-24
Publishing country	England
Document type	Letter
ZDB-ID	218090-x
ISSN	1476-5373 ; 0007-0610
ISSN (online)	1476-5373
ISSN	0007-0610
DOI	10.1038/s41415-023-5586-2
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Article ; Online: Asymmetric Synthesis of α-Chloroamides via Photoenzymatic Hydroalkylation of Olefins.

Liu, Yi / Bender, Sophie G / Sorigue, Damien / Diaz, Daniel J / Ellington, Andrew D / Mann, Greg / Allmendinger, Simon / Hyster, Todd K

Journal of the American Chemical Society

2024 Volume 146, Issue 11, Page(s) 7191–7197

Abstract: Photoenzymatic intermolecular hydroalkylations of olefins are highly enantioselective for chiral centers formed during radical termination but poorly selective for centers set in the C-C bond-forming event. Here, we report the evolution of a flavin- ... ...

Abstract	Photoenzymatic intermolecular hydroalkylations of olefins are highly enantioselective for chiral centers formed during radical termination but poorly selective for centers set in the C-C bond-forming event. Here, we report the evolution of a flavin-dependent "ene"-reductase to catalyze the coupling of α,α-dichloroamides with alkenes to afford α-chloroamides in good yield with excellent chemo- and stereoselectivity. These products can serve as linchpins in the synthesis of pharmaceutically valuable motifs. Mechanistic studies indicate that radical formation occurs by exciting a charge-transfer complex templated by the protein. Precise control over the orientation of molecules within the charge-transfer complex potentially accounts for the observed stereoselectivity. The work expands the types of motifs that can be prepared using photoenzymatic catalysis.
MeSH term(s)	Alkenes ; Catalysis
Chemical Substances	Alkenes
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.4c00927
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Article: Neoadjuvant chemotherapy in non-metastatic breast cancer: The surgeon's perspective.

Ofri, A / Elstner, K / Mann, G B / Kumar, S / Warrier, S

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland

2023 Volume 21, Issue 6, Page(s) 356–360

Abstract: Breast cancer is the most common non-skin cancer in Australia, affecting 1 in 7 women by the age of 85 years. Current management of early breast cancer is becoming increasingly variable and complex. The typical range of treatments include some ... ...

Abstract	Breast cancer is the most common non-skin cancer in Australia, affecting 1 in 7 women by the age of 85 years. Current management of early breast cancer is becoming increasingly variable and complex. The typical range of treatments include some combination of surgery, chemotherapy and targeted therapy, immunotherapy, radiotherapy, and endocrine therapy. Neoadjuvant chemotherapy (NACT) in carefully selected patients can facilitate increased rates of breast conservation therapy, and when successful, offers improved cosmesis due to less extensive resection of tissue. A neoadjuvant approach also provides biological insight into a patient's tumour, prognostication based on a patient's response to therapy, as well as enabling their treating oncologist to personalise adjuvant strategies based on the presence or absence of residual cancer at surgery. Neoadjuvant chemotherapy has become an integral element in the provision of breast conserving surgery to selected early-stage breast cancer patients. Appreciating the indications and understanding the likely outcomes from NACT in select situations, can result in significant improvements in patient tailored care.
MeSH term(s)	Humans ; Female ; Aged, 80 and over ; Breast Neoplasms/drug therapy ; Breast Neoplasms/surgery ; Neoadjuvant Therapy ; Surgeons ; Chemotherapy, Adjuvant
Language	English
Publishing date	2023-04-21
Publishing country	Scotland
Document type	Journal Article ; Review
ZDB-ID	2102927-1
ISSN	1479-666X
ISSN	1479-666X
DOI	10.1016/j.surge.2023.04.001
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Article ; Online: Community resilience in a rural food system: documenting pathways to nutrition solutions.

Mann, G / Cafer, A / Kaiser, K / Gordon, K

Public health

2020 Volume 186, Page(s) 157–163

Abstract: Objective: To describe and determine the barriers and facilitators to food-related health behaviors of residents in a rural Mississippi Delta community.: Study design: Descriptive study of qualitative interviews.: Methods: A non-random sample of ... ...

Abstract	Objective: To describe and determine the barriers and facilitators to food-related health behaviors of residents in a rural Mississippi Delta community. Study design: Descriptive study of qualitative interviews. Methods: A non-random sample of 34 low-income, food-insecure adults residing in a rural Mississippi Delta community were interviewed using fuzzy cognitive mapping, a mixed methods approach. Results: Participants strongly emphasized the time restraints they faced in both procuring and preparing foods, due to substantial travel time required to procure groceries. Participants also identified key facilitators to healthy eating behaviors, including seasonal produce stands, foraging, fishing, home provisioning, and access to the local food pantry. These barriers and facilitators are highly interconnected with other influential factors including poverty, lack of health care, unemployment, and faith-based support systems. Conclusions: While the connection between low food access and poor eating habits is well researched, this novel mixed-method approach details two important elements missing from the literature: (1) other factors often overlooked that mitigate or exacerbate this relationship and (2) the dynamic nature of the relationships between these factors, poor eating habits, and health. Additionally, this research examines these relationships in an underrepresented rural minority population where resources needed to mitigate poor health are often much more limited. Findings from this study are critical to health and food policy in Mississippi and more generally, rural communities.
MeSH term(s)	Adult ; Diet, Healthy ; Feeding Behavior/psychology ; Food Insecurity ; Food Supply/statistics & numerical data ; Humans ; Mississippi ; Poverty ; Qualitative Research ; Rural Population/statistics & numerical data
Language	English
Publishing date	2020-08-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	427333-3
ISSN	1476-5616 ; 0033-3506
ISSN (online)	1476-5616
ISSN	0033-3506
DOI	10.1016/j.puhe.2020.06.041
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Article ; Online: Acute Dissociation and Ketamine's Antidepressant and Anti-Suicidal Ideation Effects in a Midazolam-Controlled Trial.

Sajid, Sumra / Galfalvy, Hanga C / Keilp, John G / Burke, Ainsley K / Mann, J John / Grunebaum, Michael F

The international journal of neuropsychopharmacology

2024 Volume 27, Issue 4

Abstract: Objective: We sought to explore relationships of acute dissociative effects of intravenous ketamine with change in depression and suicidal ideation and with plasma metabolite levels in a randomized, midazolam-controlled trial.: Methods: Data from a ... ...

Abstract	Objective: We sought to explore relationships of acute dissociative effects of intravenous ketamine with change in depression and suicidal ideation and with plasma metabolite levels in a randomized, midazolam-controlled trial. Methods: Data from a completed trial in suicidal, depressed participants (n = 40) randomly assigned to ketamine was used to examine relationships between ketamine treatment-emergent dissociative and psychotomimetic symptoms with pre/post-infusion changes in suicidal ideation and depression severity. Nonparametric correlational statistics were used. These methods were also used to explore associations between dissociative or psychotomimetic symptoms and blood levels of ketamine and metabolites in a subset of participants (n = 28) who provided blood samples immediately post-infusion. Results: Neither acute dissociative nor psychotomimetic effects of ketamine were associated with changes in suicidal ideation or depressive symptoms from pre- to post-infusion. Norketamine had a trend-level, moderate inverse correlation with dissociative symptoms on Day 1 post-injection (P = .064; P =.013 removing 1 outlier). Dehydronorketamine correlated with Clinician-Administered Dissociative States Scale scores at 40 minutes (P = .034), 230 minutes (P = .014), and Day 1 (P = .012). Conclusion: We did not find evidence that ketamine's acute, transient dissociative, or psychotomimetic effects are associated with its antidepressant or anti-suicidal ideation actions. The correlation of higher plasma norketamine with lower dissociative symptoms on Day 1 post-treatment suggests dissociation may be more an effect of the parent drug.
MeSH term(s)	Humans ; Ketamine/administration & dosage ; Ketamine/blood ; Ketamine/pharmacology ; Ketamine/analogs & derivatives ; Suicidal Ideation ; Male ; Adult ; Midazolam/administration & dosage ; Midazolam/pharmacology ; Midazolam/blood ; Female ; Antidepressive Agents/blood ; Antidepressive Agents/administration & dosage ; Antidepressive Agents/pharmacology ; Dissociative Disorders/chemically induced ; Dissociative Disorders/blood ; Middle Aged ; Young Adult ; Double-Blind Method
Chemical Substances	Ketamine (690G0D6V8H) ; Midazolam (R60L0SM5BC) ; Antidepressive Agents ; norketamine (XQY6JVF94X)
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1440129-0
ISSN	1469-5111 ; 1461-1457
ISSN (online)	1469-5111
ISSN	1461-1457
DOI	10.1093/ijnp/pyae017
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Article ; Online: The complex impact of COVID-19 on cancer outcomes in Australia.

Canfell, Karen / Chiam, Karen / Nickson, Carolyn / Mann, G Bruce

The Medical journal of Australia

2023 Volume 219, Issue 9, Page(s) 402–404

MeSH term(s)	Humans ; COVID-19 ; Neoplasms/epidemiology ; Neoplasms/therapy ; SARS-CoV-2 ; Australia/epidemiology
Language	English
Publishing date	2023-10-18
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186082-3
ISSN	1326-5377 ; 0025-729X
ISSN (online)	1326-5377
ISSN	0025-729X
DOI	10.5694/mja2.52125
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Article ; Online: A conceptual model for changes in finger photoplethysmograph signals caused by hand posture and isothermic regulation.

Keogh, C / Drummond, G B / Bates, A / Mann, J / Arvind, D K

Physiological measurement

2022 Volume 43, Issue 1

Abstract: ... ...

Abstract	Objective
MeSH term(s)	Fingers/physiology ; Hand/physiology ; Heart Rate ; Humans ; Photoplethysmography/methods ; Posture/physiology
Language	English
Publishing date	2022-02-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1149545-5
ISSN	1361-6579 ; 0967-3334
ISSN (online)	1361-6579
ISSN	0967-3334
DOI	10.1088/1361-6579/ac482e
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Article ; Online: Influence of Process Parameters on the Kinetics of the Micelle-to-Vesicle Transition and Ripening of Polystyrene-Block-Polyacrylic Acid.

Mann, Jil / Mayer, Julian K / Garnweitner, Georg / Schilde, Carsten

Polymers

2023 Volume 15, Issue 7

Abstract: Due to their ability to self-assemble into complex structures, block copolymers are of great interest for use in a wide range of future applications, such as self-healing materials. Therefore, it is important to understand the mechanisms of their ... ...

Abstract	Due to their ability to self-assemble into complex structures, block copolymers are of great interest for use in a wide range of future applications, such as self-healing materials. Therefore, it is important to understand the mechanisms of their structure formation. In particular, the process engineering of the formation and transition of the polymer structures is required for ensuring reproducibility and scalability, but this has received little attention in the literature. In this article, the influence of the addition rate of the selective solvent on the homogeneity of self-assembled vesicles of polystyrene-block-polyacrylic acid is demonstrated, as well as the influence of the reaction time and the mixing intensity on the morphology of the polymer structures. For example, it was demonstrated that the higher the mixing intensity, the faster the transition from micelle to vesicle. The experimental results are further supported by CFD simulations, which visually and graphically show an increase in shear rate and narrower shear rate distributions at higher stirring rates. Furthermore, it was demonstrated that the vesicle size is not only kinetically determined, since flow forces above a critical size lead to the deformation and fission of the vesicles.
Language	English
Publishing date	2023-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym15071695
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Article ; Online: Budd-Chiari Syndrome-A Single Center Experience From the United Kingdom.

Mann, J P / Ikram, F / Modin, L / Kelgeri, C / Sharif, K / Olliff, S / McGuirk, S / Gupte, G L

Journal of pediatric gastroenterology and nutrition

2023 Volume 77, Issue 4, Page(s) 455–459

Abstract: Pediatric Budd-Chiari syndrome (BCS) is a rare cause of portal hypertension and liver disease in Europe and North America. In order to understand the long-term effect of radiological intervention on BCS we performed a single center retrospective review. ... ...

Abstract	Pediatric Budd-Chiari syndrome (BCS) is a rare cause of portal hypertension and liver disease in Europe and North America. In order to understand the long-term effect of radiological intervention on BCS we performed a single center retrospective review. Fourteen cases were identified; 6 of 14 (43%) had a congenital thrombophilia with many having multiple prothrombotic mutations. Two were managed with medical anticoagulation alone and two required super-urgent transplant for acute liver failure. The remaining 10 of 14 (71%) underwent radiological intervention: 1 of 14 thrombolysis, 5 of 14 angioplasty, and 4 of 14 transjugular intrahepatic portosystemic shunt (TIPS). Six of 14 (43%) patients required repeat radiological intervention (1 angioplasty, 5 TIPS) but none required surgical shunts or liver transplantation for chronic liver disease. The time between diagnosis and treatment did not predict the need for repeat radiological intervention. These data show that radiological intervention can be highly effective, and reduces the need for surgery, though it requires specialist multidisciplinary teams for monitoring.
MeSH term(s)	Humans ; Child ; Budd-Chiari Syndrome/diagnosis ; Budd-Chiari Syndrome/therapy ; Portasystemic Shunt, Transjugular Intrahepatic ; Retrospective Studies ; Angioplasty ; United Kingdom ; Treatment Outcome
Language	English
Publishing date	2023-06-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0000000000003860
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