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  1. Article ; Online: Letter to the editor: "The human gut microbiome in critical illness: Disruptions, consequences, and therapeutic frontiers".

    Evans, Tess / Litton, Edward

    Journal of critical care

    2024  Volume 82, Page(s) 154768

    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Letter
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2024.154768
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2152: Show issues Location:
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  2. Article ; Online: Probiotics and sepsis: separating the signal from the noise.

    Litton, Edward / Currie, Andrew / Raby, Edward

    Intensive care medicine

    2021  Volume 47, Issue 8, Page(s) 924–925

    MeSH term(s) Humans ; Infant, Newborn ; Infant, Premature ; Probiotics ; Sepsis/therapy
    Language English
    Publishing date 2021-05-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-021-06427-w
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  3. Article: Characteristics and outcomes of patients admitted to regional and rural intensive care units in Australia.

    Secombe, Paul / Brown, Alex / Bailey, Michael / Litton, Edward / Pilcher, David

    Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

    2023  Volume 22, Issue 4, Page(s) 335–343

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2023-10-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2401976-8
    ISSN 1441-2772
    ISSN 1441-2772
    DOI 10.51893/2020.4.OA6
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  4. Article ; Online: Molecular Methodologies for Improved Polymicrobial Sepsis Diagnosis.

    Doualeh, Mariam / Payne, Matthew / Litton, Edward / Raby, Edward / Currie, Andrew

    International journal of molecular sciences

    2022  Volume 23, Issue 9

    Abstract: Polymicrobial sepsis is associated with worse patient outcomes than monomicrobial sepsis. Routinely used culture-dependent microbiological diagnostic techniques have low sensitivity, often leading to missed identification of all causative organisms. To ... ...

    Abstract Polymicrobial sepsis is associated with worse patient outcomes than monomicrobial sepsis. Routinely used culture-dependent microbiological diagnostic techniques have low sensitivity, often leading to missed identification of all causative organisms. To overcome these limitations, culture-independent methods incorporating advanced molecular technologies have recently been explored. However, contamination, assay inhibition and interference from host DNA are issues that must be addressed before these methods can be relied on for routine clinical use. While the host component of the complex sepsis host-pathogen interplay is well described, less is known about the pathogen's role, including pathogen-pathogen interactions in polymicrobial sepsis. This review highlights the clinical significance of polymicrobial sepsis and addresses how promising alternative molecular microbiology methods can be improved to detect polymicrobial infections. It also discusses how the application of shotgun metagenomics can be used to uncover pathogen/pathogen interactions in polymicrobial sepsis cases and their potential role in the clinical course of this condition.
    MeSH term(s) Coinfection/diagnosis ; Coinfection/microbiology ; Humans ; Metagenomics ; Sepsis/diagnosis ; Sepsis/microbiology
    Language English
    Publishing date 2022-04-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23094484
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  5. Article: Lower gut dysbiosis and mortality in acute critical illness: a systematic review and meta-analysis.

    Evans, Tess / Ali, Umar / Anderton, Ryan / Raby, Edward / Manning, Laurens / Litton, Edward

    Intensive care medicine experimental

    2023  Volume 11, Issue 1, Page(s) 6

    Abstract: Background: The human gastrointestinal tract harbours a complex multi-kingdom community known as the microbiome. Dysbiosis refers to its disruption and is reportedly extreme in acute critical illness yet its clinical implications are unresolved. The ... ...

    Abstract Background: The human gastrointestinal tract harbours a complex multi-kingdom community known as the microbiome. Dysbiosis refers to its disruption and is reportedly extreme in acute critical illness yet its clinical implications are unresolved. The review systematically evaluates the association between gut dysbiosis and clinical outcomes of patients early in critical illness.
    Methods: Following PRISMA guidelines, a prospectively registered search was undertaken of MEDLINE and Cochrane databases for observational studies undertaking metagenomic sequencing of the lower gastrointestinal tract of critically ill adults and children within 72 h of admission. Eligible studies reported an alpha diversity metric and one or more of the primary outcome, in-hospital mortality, or secondary clinical outcomes. After aggregate data were requested, meta-analysis was performed for four studies with in-hospital mortality stratified to high or low Shannon index.
    Results: The search identified 26 studies for systematic review and 4 had suitable data for meta-analysis. No effect of alpha diversity was seen on in-hospital mortality after binary transformation of Shannon index (odds ratio 0.52, CI 0.12-4.98, I
    Conclusions: There is a paucity of large, rigorous observational studies in this population. Globally, alpha diversity was dynamically reduced in early ICU admission in adults and children and was not associated with in-hospital mortality. The abundance of taxa such as Enterococcus spp. appears to offer greater predictive capacity for important clinical and ecological outcomes.
    Language English
    Publishing date 2023-02-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2740385-3
    ISSN 2197-425X
    ISSN 2197-425X
    DOI 10.1186/s40635-022-00486-z
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  6. Article: The IRONMAN trial: a protocol for a multicentre randomised placebo-controlled trial of intravenous iron in intensive care unit patients with anaemia.

    Litton, Edward

    Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

    2015  Volume 17, Issue 2, Page(s) 144–145

    MeSH term(s) Anemia/drug therapy ; Critical Care ; Ferric Compounds/therapeutic use ; Hematinics/therapeutic use ; Humans
    Chemical Substances Ferric Compounds ; Hematinics
    Language English
    Publishing date 2015-06
    Publishing country Australia
    Document type Comment ; Letter
    ZDB-ID 2401976-8
    ISSN 1441-2772
    ISSN 1441-2772
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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Iron Deficiency and Cardiac Surgery.

    Litton, Edward / Shah, Akshay

    Journal of cardiothoracic and vascular anesthesia

    2019  Volume 33, Issue 8, Page(s) 2151–2152

    MeSH term(s) Anemia, Iron-Deficiency ; Blood Transfusion ; Cardiac Surgical Procedures ; Elective Surgical Procedures ; Humans
    Language English
    Publishing date 2019-03-29
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2019.03.050
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    Zs.MO 31: Show issues

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  8. Article ; Online: Reducing Respiratory Complications After Cardiac Surgery.

    Allan, Peter A / Litton, Edward

    Journal of cardiothoracic and vascular anesthesia

    2019  Volume 34, Issue 1, Page(s) 166–167

    MeSH term(s) Cannula ; Cardiac Surgical Procedures ; Humans ; Hypoxia ; Respiration Disorders
    Language English
    Publishing date 2019-07-15
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2019.07.120
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  9. Article ; Online: Prophylactic, Postoperative, Noninvasive Ventilation After Thoracoabdominal Surgery.

    Litton, Edward / Law, Timothy

    Journal of cardiothoracic and vascular anesthesia

    2019  Volume 33, Issue 6, Page(s) 1646–1647

    MeSH term(s) Humans ; Noninvasive Ventilation ; Pilot Projects ; Postoperative Period ; Respiratory Insufficiency
    Language English
    Publishing date 2019-01-17
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2019.01.034
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  10. Article ; Online: Molecular Methodologies for Improved Polymicrobial Sepsis Diagnosis

    Mariam Doualeh / Matthew Payne / Edward Litton / Edward Raby / Andrew Currie

    International Journal of Molecular Sciences, Vol 23, Iss 4484, p

    2022  Volume 4484

    Abstract: Polymicrobial sepsis is associated with worse patient outcomes than monomicrobial sepsis. Routinely used culture-dependent microbiological diagnostic techniques have low sensitivity, often leading to missed identification of all causative organisms. To ... ...

    Abstract Polymicrobial sepsis is associated with worse patient outcomes than monomicrobial sepsis. Routinely used culture-dependent microbiological diagnostic techniques have low sensitivity, often leading to missed identification of all causative organisms. To overcome these limitations, culture-independent methods incorporating advanced molecular technologies have recently been explored. However, contamination, assay inhibition and interference from host DNA are issues that must be addressed before these methods can be relied on for routine clinical use. While the host component of the complex sepsis host–pathogen interplay is well described, less is known about the pathogen’s role, including pathogen–pathogen interactions in polymicrobial sepsis. This review highlights the clinical significance of polymicrobial sepsis and addresses how promising alternative molecular microbiology methods can be improved to detect polymicrobial infections. It also discusses how the application of shotgun metagenomics can be used to uncover pathogen/pathogen interactions in polymicrobial sepsis cases and their potential role in the clinical course of this condition.
    Keywords polymicrobial sepsis ; molecular diagnostics ; PCR ; pathogen interactions ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 630
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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