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Article ; Online: CDNF and MANF regulate ER stress in a tissue-specific manner.

Pakarinen, Emmi / Lindholm, Päivi / Saarma, Mart / Lindahl, Maria

Cellular and molecular life sciences : CMLS

2022 Volume 79, Issue 2, Page(s) 124

Abstract: Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF) display cytoprotective effects in animal models of neurodegenerative diseases. These endoplasmic reticulum (ER)-resident proteins belong to the ... ...

Abstract	Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF) display cytoprotective effects in animal models of neurodegenerative diseases. These endoplasmic reticulum (ER)-resident proteins belong to the same protein family and function as ER stress regulators. The relationship between CDNF and MANF function, as well as their capability for functional compensation, is unknown. We aimed to investigate these questions by generating mice lacking both CDNF and MANF. Results showed that CDNF-deficient Manf
MeSH term(s)	Animals ; Dopaminergic Neurons/metabolism ; Dopaminergic Neurons/pathology ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum Stress ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nerve Growth Factors/metabolism ; Neurodegenerative Diseases/metabolism ; Unfolded Protein Response
Chemical Substances	MANF protein, mouse ; Nerve Growth Factors ; cdnf protein, mouse
Language	English
Publishing date	2022-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-022-04157-w
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Zs.A 195: Show issues

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Article ; Online: Longitudinal evolution of catheter-related bloodstream infections, kidney function and liver status in a nationwide adult intestinal failure cohort.

Pohju, Anne K / Hakkarainen, Antti I / Pakarinen, Mikko P / Sipponen, Taina M

Scandinavian journal of gastroenterology

2022 Volume 57, Issue 7, Page(s) 763–767

Abstract: ... significant median change occurred in estimated glomerular filtration rate (eGFR; -8.5 ml/min/1.73 m ...

Abstract	Objectives: The development of intestinal failure-related complications in Finnish adults is unknown. This study aimed to investigate the incidence of catheter-related bloodstream infections (CRBSI), and the longitudinal changes in biochemical liver and kidney tests in a nationwide cohort. Materials and methods: The search for Finnish adults with intestinal failure (IF) utilized a survey to Finnish health-care providers ( Results: In the nationwide cohort of 52 patients, the CRBSI incidence was 1.35/1000 catheter days. Seventy-three percent of CRBSI in a long-term catheter led to catheter replacement. During a median PS duration of 27.5 (interquartile range [IQR] 11.3-57.3) months, a statistically significant median change occurred in estimated glomerular filtration rate (eGFR; -8.5 ml/min/1.73 m Conclusions: Incidence of CRBSI, but not treatment strategies, in this nationwide adult IF population correspond well to those reported from specialized centers. Decreased kidney function and abnormal liver test results are frequent findings, and even more so over time, emphasizing the importance of regular monitoring.
MeSH term(s)	Adult ; Catheter-Related Infections/epidemiology ; Catheters/adverse effects ; Cross-Sectional Studies ; Humans ; Intestinal Failure ; Kidney ; Liver ; Parenteral Nutrition, Home/adverse effects ; Parenteral Nutrition, Home/methods ; Retrospective Studies ; Sepsis/complications
Language	English
Publishing date	2022-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	82042-8
ISSN	1502-7708 ; 0036-5521
ISSN (online)	1502-7708
ISSN	0036-5521
DOI	10.1080/00365521.2022.2039281
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Zs.A 567: Show issues

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Article ; Online: Vocal Cord Paralysis after Repair of Esophageal Atresia.

Koivusalo, A I / Suominen, J S / Nokso-Koivisto, J / Pakarinen, M P

European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie

2023 Volume 34, Issue 1, Page(s) 50–55

Abstract: Objective: Etiology of vocal cord paralysis (VCP) and laryngeal dysfunction may be congenital or surgical trauma of recurrent and superior laryngeal nerves. We assessed the incidence, risk factors, and morbidity of VCP after repair of esophageal ... ...

Abstract	Objective: Etiology of vocal cord paralysis (VCP) and laryngeal dysfunction may be congenital or surgical trauma of recurrent and superior laryngeal nerves. We assessed the incidence, risk factors, and morbidity of VCP after repair of esophageal atresia (EA). Methods: Medical records of 201 EA patients from 2000 to 2022 were reviewed for this retrospective study. Postrepair vocal cord examination (VCE) included awake nasolaryngeal fiberoscopy by otolaryngologist or laryngoscopy under spontaneous breathing anesthesia. Before 2017, postoperative VCE was performed in symptomatic patients only and routinely after 2017. Main results: Overall, VCE was performed on 79 (38%) patients (52 asymptomatic), whereas 122 asymptomatic patients underwent no VCE. VCP was diagnosed in 32 of 79 patients (right 12, left 10, and bilateral 10; symptomatic 25 and asymptomatic unilateral 7) corresponding with extrapolated overall VCP incidence of 16 to 24% among 201 patients including asymptomatic ones. Ten patients (bilateral VCP 8 and left VCP 2) required tracheostomy. Of 10 patients with bilateral VCP, three underwent laryngotracheal expansion surgery (left VC lateralization in one and laryngoplasty in two with acquired subglottic stenosis), three remained tracheostomy dependent, three were off tracheostomy, and one died of complications after redo esophageal reconstruction. All patients with unilateral VCP managed without tracheostomy. Cervical dissection or ostomy formation was a major risk factor of VCP. Conclusion: Repair of EA is associated with a considerable risk of VCP and associated morbidity. Cervical EA surgery significantly increased the risk of VCP. Bilateral VCP may eventually require laryngotracheal expansion surgery.
MeSH term(s)	Humans ; Vocal Cord Paralysis/epidemiology ; Vocal Cord Paralysis/etiology ; Vocal Cord Paralysis/diagnosis ; Esophageal Atresia/surgery ; Esophageal Atresia/complications ; Retrospective Studies ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Incidence
Language	English
Publishing date	2023-09-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1065043-x
ISSN	1439-359X ; 0939-7248 ; 0939-6764 ; 0930-7249
ISSN (online)	1439-359X
ISSN	0939-7248 ; 0939-6764 ; 0930-7249
DOI	10.1055/s-0043-1774370
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Zs.A 3140: Show issues

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Article ; Online: Intestinal failure in Finland: prevalence and characteristics of an adult patient population.

Pohju, Anne K / Pakarinen, Mikko P / Sipponen, Taina M

European journal of gastroenterology & hepatology

2021 Volume 33, Issue 12, Page(s) 1505–1510

Abstract: Objectives: Details of intestinal failure in the Finnish adult population are unknown. This study aimed to specify the intestinal failure prevalence and to clinically characterize the patient population in Finland.: Methods: All Finnish healthcare ... ...

Abstract	Objectives: Details of intestinal failure in the Finnish adult population are unknown. This study aimed to specify the intestinal failure prevalence and to clinically characterize the patient population in Finland. Methods: All Finnish healthcare units with the potential of providing parenteral support received an electronic survey to report whether they had patient(s) aged ≥18 years on long-term (≥120 days) parenteral support due to intestinal failure. Patient details came from patient records. IBM SPSS v.25 was used to analyze descriptive statistics. Results: Of the 74 patients, 52 were included after confirming parenteral support indication from the records. The adult intestinal failure prevalence for 2017 was 11.7 per million, 95% confidence interval: 8.9-15.3. Most patients were women (69%), and the median age was 62 (45-72) years. Short bowel syndrome was the most frequent intestinal failure mechanism (73%), and surgical complication the most frequent underlying diagnosis (29%). Of patients, 66% represented the clinical classification category parenteral nutrition 1 or parenteral nutrition 2. Median Charlson Comorbidity Index was one (0-2.8); hypertension (37%) and diabetes (23%) were the most frequent comorbidities. Patients received seven (3.5-7) parenteral support infusions weekly, and eight patients (15%) were on fluids and electrolytes only. The median duration of parenteral support was 27.5 (11.3-57.3) months. Ten patients ceased parenteral support during 2017 after a median of 20.0 (9.0-40.3) parenteral support months. Eight weaned off parenteral support, one ran out of catheter sites, and one died. Conclusion: Prevalence and patient characteristics of adult intestinal failure in Finland are similar to those in other Western countries.
MeSH term(s)	Aged ; Female ; Finland/epidemiology ; Humans ; Intestinal Diseases/diagnosis ; Intestinal Diseases/epidemiology ; Intestinal Diseases/therapy ; Male ; Middle Aged ; Parenteral Nutrition/adverse effects ; Prevalence ; Retrospective Studies ; Short Bowel Syndrome
Language	English
Publishing date	2021-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0000000000002082
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Zs.A 2932: Show issues

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Article ; Online: Bacterial translocation markers and toll-like receptors in biliary atresia following successful portoenterostomy.

Godbole, Nimish / Kyrönlahti, Antti / Hukkinen, Maria / Pihlajoki, Marjut / Heikinheimo, Markku / Pakarinen, Mikko P

Acta paediatrica (Oslo, Norway : 1992)

2023 Volume 112, Issue 10, Page(s) 2210–2217

Abstract: Aim: The gut-liver axis may contribute to pathophysiology of cholestatic liver disorders like biliary atresia (BA) by bacterial translocation (BT). Toll-like receptors (TLR) are pattern recognition receptors known to activate innate immunity and ... ...

Abstract	Aim: The gut-liver axis may contribute to pathophysiology of cholestatic liver disorders like biliary atresia (BA) by bacterial translocation (BT). Toll-like receptors (TLR) are pattern recognition receptors known to activate innate immunity and secretion of inflammatory cytokines. Herein, we examined BT-associated biomarkers and TLRs in relation to liver injury after successful portoenterostomy (SPE) in BA. Methods: Serum levels of lipopolysaccharide-binding protein (LBP), CD14, LAL, TNF-α, IL-6 and FABP2 along with liver expression of TLRs (TLR1, TLR4, TLR7 and TLR9), LBP and CD14 were measured during median 4.9 (1.7-10.6) years follow-up after SPE in 45 BA patients. Results: Serum LBP, CD14, TNF-α and IL-6 all increased after SPE whereas LAL and FABP-2 remained unchanged. Serum LBP correlated positively with CD14 and markers of hepatocyte injury and cholestasis, but not with Metavir fibrosis stage, transcriptional markers for fibrosis (ACTA2) or ductular reaction. Serum CD14 concentration was significantly higher in patients with portal hypertension than without. While liver expression of TLR4 and LBP remained low, TLR7 and TLR1 showed marked BA-specific increases, and TLR7 correlated with Metavir fibrosis stage and ACTA2. Conclusion: BT does not seem to play a significant role in liver injury after SPE in our series of BA patients.
MeSH term(s)	Child ; Humans ; Bacterial Translocation ; Biliary Atresia/surgery ; Portoenterostomy, Hepatic/methods ; Toll-Like Receptors/blood ; Biomarkers ; Tumor Necrosis Factor-alpha
Chemical Substances	Toll-Like Receptors ; Biomarkers ; lipopolysaccharide-binding protein ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2023-07-05
Publishing country	Norway
Document type	Journal Article
ZDB-ID	203487-6
ISSN	1651-2227 ; 0365-1436 ; 0803-5253
ISSN (online)	1651-2227
ISSN	0365-1436 ; 0803-5253
DOI	10.1111/apa.16893
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Article ; Online: A Retrospective Study of Long-Term Outcomes in 16 ABO-Incompatible Deceased Donor Pediatric Liver Transplants from a National Transplant Center at Helsinki University Hospital, Finland, 1987-2022.

Jahnukainen, Timo / Sareneva, Inna / Lauronen, Jouni / Ylinen, Elisa / Tainio, Juuso / Nordin, Arno / Hukkinen, Maria / Pakarinen, Mikko P / Jalanko, Hannu

Annals of transplantation

2024 Volume 29, Page(s) e941929

Abstract: BACKGROUND The use of ABO-incompatible liver transplants (ABO-ILTs) from deceased donors has become more common due to the shortage of available donor livers and increased transplant waiting times. This retrospective study from a national transplant ... ...

Abstract	BACKGROUND The use of ABO-incompatible liver transplants (ABO-ILTs) from deceased donors has become more common due to the shortage of available donor livers and increased transplant waiting times. This retrospective study from a national transplant center at Helsinki University Hospital, Finland, aimed to assess the long-term outcomes of ABO-incompatible deceased donor pediatric liver transplants between 1987 and 2022. MATERIAL AND METHODS Sixteen (9.5%) of the 169 pediatric liver transplantations were ABO-ILTs. The median age at transplantation was 5.0 (0.5-15.4) years. Reasons for ABO-ILTs were acute liver failure (18.75%), malignancy (12.5%), small body size and long waiting time (25%), and other reasons (43.75%). The median post-transplant follow-up time was 147 (0.72-353) months. Patient and graft survival and occurrence of surgical complications were compared to ABO-identical transplants, and anti-ABO antibody titers were analyzed. RESULTS The 1-, 3-, and 5-year patient survivals were comparable between the ABO-I and ABO-compatible groups, being 81.3%, 73.9%, and 73.9% (ABO-I) and 87.5%, 82.5%, 77.9% (ABO-compatible), respectively. Three patients with ABO-ILTs died of sepsis and multiorgan failure during the first 3 months after transplantation. The occurrence of biliary complications and early vascular thrombosis (<30 days after transplantation) did not differ significantly between recipients with an ABO-ILT vs ABO-compatible liver graft. CONCLUSIONS The findings from this study support findings from previous studies that outcomes after ABO-incompatible liver transplants in children were comparable to outcomes from ABO-identical liver transplants.
MeSH term(s)	Child ; Humans ; Child, Preschool ; Adolescent ; Liver Transplantation/methods ; Retrospective Studies ; Finland ; Blood Group Incompatibility ; ABO Blood-Group System ; Hospitals ; Graft Survival ; Graft Rejection ; Living Donors
Chemical Substances	ABO Blood-Group System
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484710-3
ISSN	2329-0358 ; 1425-9524
ISSN (online)	2329-0358
ISSN	1425-9524
DOI	10.12659/AOT.941929
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Zs.A 5093: Show issues

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Article ; Online: Mobile-CEA - A Novel Surveillance Method for Patients with Colorectal Cancer.

Pakarinen, Sakari / Varpe, Pirita / Carpelan, Anu / Koivisto, Mari / Huhtinen, Heikki

Cancer control : journal of the Moffitt Cancer Center

2022 Volume 29, Page(s) 10732748221102780

Abstract: Objective: The follow-up of the increasing number of cancer survivors threatens to overload the health care system. While short message system (SMS)-based communication is widely used in other areas of the health care system, there are no studies of its ...

Abstract	Objective: The follow-up of the increasing number of cancer survivors threatens to overload the health care system. While short message system (SMS)-based communication is widely used in other areas of the health care system, there are no studies of its appliance in cancer surveillance. The aim of the current study was to analyze the acceptability, convenience and impact of a novel mobile phone messaging -based system (Mobile-CEA) on health personnel contacts in patients with colorectal cancer (CRC) during 2 years of follow-up. Methods: The follow-up data of 52 curatively treated patients with CRC (22 Mobile-CEA-, 30 standard surveillance) was collected retrospectively from the electronic archives. Mobile-CEA patient satisfaction was measured by a tailored non-validated questionnaire. Health personnel satisfaction was assessed by personal interviews. Results: Mobile-CEA surveillance group had less health personnel contacts than the standard surveillance group: median 3 (min 0-max 7) vs 5 (min 4-max 7) and 77.2% of the Mobile-CEA group had less than 4 contacts (minimum with the standard surveillance) to health personnel. There were no recurrences in either group. Mobile-CEA patients were satisfied with this novel follow-up method. Health personnel considered it as a practical and safe tool in CRC surveillance. Conclusion: Mobile-CEA surveillance seems to be a promising and effective follow-up method for curatively treated patients with CRC. Further studies and experiences are needed.
MeSH term(s)	Cell Phone ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/therapy ; Health Services ; Humans ; Retrospective Studies ; Text Messaging
Language	English
Publishing date	2022-06-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1328503-8
ISSN	1526-2359 ; 1073-2748
ISSN (online)	1526-2359
ISSN	1073-2748
DOI	10.1177/10732748221102780
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Zs.A 4467: Show issues

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Article ; Online: Infant liver biochemistry is different than current laboratory accepted norms.

Kolho, Kaija-Leena / Lahtiharju, Tapio / Merras-Salmio, Laura / Pakarinen, Mikko P / Knip, Mikael

European journal of pediatrics

2023 Volume 182, Issue 12, Page(s) 5707–5711

Abstract: The purpose is to study liver biochemistry in a well-defined cohort of term infants. The methods include healthy term infants (n = 619) provided blood samples at 3 and 6 months of age when participating to the DIABIMMUNE study. The infants were followed ... ...

Abstract	The purpose is to study liver biochemistry in a well-defined cohort of term infants. The methods include healthy term infants (n = 619) provided blood samples at 3 and 6 months of age when participating to the DIABIMMUNE study. The infants were followed up at clinical study visits 3, 6, 12, 18, 24, and 36 months the participation rate being 88.6% at the end of follow-up, while none disclosed any signs of a liver disease. The serum levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), total bilirubin (BIL), and conjugated bilirubin (BIL-conj) were determined using Siemens Atellica CH 930 analyzers. The results are at 3 months of age, the upper 90% CI for ALT, AST, ALP, GGT, BIL, and BIL-conj were higher than the current upper reference limits in our accredited hospital laboratory. At 6 months, the upper 90% CIs for ALT had declined but was still higher than the cut-offs for a raised value. The upper 90% CI for AST remained as high as at 3 months, whereas ALP, BIL-conj, and GGT had decreased close to the current cut-offs. The type of feeding was associated with the levels of liver biochemistry. Exclusively or partially breastfed infants showed higher ALT, AST, BIL, and BIL-conj values at 3 months than formula-fed. Breastfed infants had higher AST, Bil, and Bil-conj values also at 6 months. Conclusion: We encourage setting appropriate reference ranges for liver biochemistry for the first year of life and to note the type of feeding. What is Known: • Healthy infants may show higher values of liver biochemistry during their first year of life than in later life. • It has been speculated that type of feeding may play a role in liver biochemistry levels among infants. What is New: • In a cohort of healthy infants, several analytes of liver biochemistry were higher than the currently used upper reference limits at 3 and 6 months of age, and exclusively or partially breastfed infants showed higher values than formula-fed. • The findings address the importance of setting appropriate reference ranges for liver biochemistry for the first year of life.
MeSH term(s)	Infant ; Female ; Humans ; Liver ; Bilirubin ; Liver Diseases ; Alkaline Phosphatase ; gamma-Glutamyltransferase ; Aspartate Aminotransferases ; Alanine Transaminase
Chemical Substances	Bilirubin (RFM9X3LJ49) ; Alkaline Phosphatase (EC 3.1.3.1) ; gamma-Glutamyltransferase (EC 2.3.2.2) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2)
Language	English
Publishing date	2023-10-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-023-05248-x
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Article ; Online: Cutoffs and Characteristics of Abnormal Bowel Dilatation in Pediatric Short Bowel Syndrome.

Nieminen, Oona / Hukkinen, Maria / Kivisaari, Reetta / Mutanen, Annika / Merras-Salmio, Laura / Pakarinen, Mikko P

Journal of pediatric gastroenterology and nutrition

2023 Volume 77, Issue 6, Page(s) 720–725

Abstract: ... 183%, and 23% higher in SBS patients compared to controls ( P < 0.01 for all). The maximal DDR and ... with SBDR ( r = 0.586, P < 0.01). Patients with maximal DDR less than 1.5, which was also the 99th ... percentile for controls, were 2.5-fold more likely to wean off PN ( P = 0.005), whereas SBDR and CDR were not ...

Abstract	Objectives: Although excessive intestinal dilatation associates with worsened outcomes in pediatric short bowel syndrome (SBS), little is known about the natural history and definition of pathological dilatation. We addressed fore-, mid-, and hind-gut dilatation in children with SBS, who had not undergone autologous intestinal reconstructive (AIR) surgery, in relation to controls. Methods: SBS children without history of AIR surgery (n = 59) and age-matched controls without any disclosed intestinal pathology (n = 140) were included. Maximum diameter of duodenum, small bowel (SB), and colon were measured in each intestinal contrast series during 2002 to 2020 and expressed as diameter ratio (DR) to L5 vertebrae height. Predictive ability of DR for weaning off parenteral nutrition (PN) was analyzed with Cox proportional hazards regression models using multiple cutoffs. Results: Duodenum (DDR), SB (SBDR), and colon (CDR) DR were 53%, 183%, and 23% higher in SBS patients compared to controls ( P < 0.01 for all). The maximal DDR and SBDR measured during follow-up is associated with current PN dependence and young age. DDR correlated with SBDR ( r = 0.586, P < 0.01). Patients with maximal DDR less than 1.5, which was also the 99th percentile for controls, were 2.5-fold more likely to wean off PN ( P = 0.005), whereas SBDR and CDR were not predictive for PN duration. Conclusions: All segments of remaining bowel, especially SB, dilate above normal levels in children with SBS. In SBS children without AIR surgery, PN dependence and young age is associated with duodenal and small intestinal dilatation, while duodenal dilatation also predicted prolonged PN.
MeSH term(s)	Humans ; Child ; Short Bowel Syndrome/complications ; Dilatation ; Retrospective Studies ; Intestine, Small/surgery ; Intestine, Small/pathology ; Intestines/pathology ; Intestinal Diseases/complications
Language	English
Publishing date	2023-09-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0000000000003934
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Zs.A 1728: Show issues

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Article ; Online: Impact of selective reporting of wound cultures on microbiology reports and antimicrobial-drug use on a wound-care ward in Finland: a retrospective cohort study.

Torvikoski, Jukka A / Lehtola, Laura K / Ahava, Maarit J / Pakarinen, Laura M / Tissari, Päivi J / Pätäri-Sampo, Anu S

EBioMedicine

2024 Volume 100, Page(s) 104992

Abstract: ... 0.35, p < 0.001). The post-intervention group demonstrated lower frequencies of antimicrobial ... treatment 7 d after wound culture collection, 82% pre-intervention vs 58% post-intervention (OR 0.31, p < 0 ... 001), and antimicrobial escalation, 42% vs 20% (OR 0.35, p < 0.001) respectively. Length ...

Abstract	Background: Selective reporting is a promising tool for antimicrobial stewardship, but in wound cultures, its effects on the use of antimicrobials are unknown. Our HUS Diagnostic Center Bacteriology laboratory refined its selective reporting protocol for wound cultures during 2017-2018. In this study we aimed to show our protocol's impact on the frequency of antimicrobial escalation. Methods: We performed a retrospective cohort study of patients in the wound-care ward of a primary-care hospital in Helsinki, Finland, from 2014 to 2016 (pre-intervention) and from 2019 to April 2021 (post-intervention). With the inclusion criterion being wound-culture collection, this provided us with 299 patients, of which 152 were in the pre-intervention group, and 147 were post-intervention. We collected the data from medical records and compared the pre-intervention- with the post-intervention group in terms of patient profiles, microbiology reports, antimicrobial treatment, and treatment outcomes. Findings: In the pre-intervention group 40% of the patients were male and 60% female and in the post-intervention group 49% and 51% respectively. The frequency of AST reported had decreased from 63% in the pre-intervention group to 37% post-intervention (OR 0.35, p < 0.001). The post-intervention group demonstrated lower frequencies of antimicrobial treatment 7 d after wound culture collection, 82% pre-intervention vs 58% post-intervention (OR 0.31, p < 0.001), and antimicrobial escalation, 42% vs 20% (OR 0.35, p < 0.001) respectively. Length of hospital stay, and all-cause mortality were similar between the groups. Interpretation: Selective reporting of wound cultures appears an effective and safe measure to reduce the use of antimicrobials. Funding: HUS Diagnostic Center.
MeSH term(s)	Humans ; Male ; Female ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Retrospective Studies ; Finland/epidemiology ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/therapeutic use ; Hospitals
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents
Language	English
Publishing date	2024-02-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2024.104992
Database	MEDical Literature Analysis and Retrieval System OnLINE

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