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  1. Book: Chang jian bing Zhong yi te se zhen liao

    Liang, Huazi

    2000  

    Title translation Characteristic diagnosis and treatment of common diseases with traditional Chinese medicine.
    Author's details zhu bian Liang Huazi
    MeSH term(s) Medicine, Chinese Traditional ; Diagnosis ; Drug Therapy
    Keywords China
    Language Chinese
    Size 2, 351 p.
    Edition Di 1 ban.
    Publisher Jin dun chu ban she
    Publishing place Beijing
    Document type Book
    ISBN 9787508210834 ; 7508210832
    Database Catalogue of the US National Library of Medicine (NLM)

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  2. Article ; Online: Noninvasive Characterization of Metabolic Changes in Ischemic Stroke Using Z-spectrum-fitted Multiparametric Chemical Exchange Saturation Transfer-weighted Magnetic Resonance Imaging.

    Wang, Zhen-Xiong / Wei, Xin-Hua / Cai, Ke-Jia / Zhu, Wen-Zhen / Su, Chang-Liang

    Current medical science

    2023  Volume 43, Issue 5, Page(s) 970–978

    Abstract: Objective: This study aimed to noninvasively characterize the metabolic alterations ... can comprehensively detect metabolic alterations in ischemic brain tissues. ...

    Abstract Objective: This study aimed to noninvasively characterize the metabolic alterations in ischemic brain tissues using Z-spectrum-fitted multiparametric chemical exchange saturation transfer-weighted magnetic resonance imaging (CEST-MRI).
    Methods: Three sets of Z-spectrum data with saturation power (B
    Results: Ischemic lesions showed increased APT
    Conclusion: The Z-spectrum-fitted multiparametric CEST-MRI can comprehensively detect metabolic alterations in ischemic brain tissues.
    Language English
    Publishing date 2023-09-11
    Publishing country China
    Document type Journal Article
    ZDB-ID 2931065-9
    ISSN 2523-899X ; 2096-5230
    ISSN (online) 2523-899X
    ISSN 2096-5230
    DOI 10.1007/s11596-023-2785-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Association between reversal agents (sugammadex vs. neostigmine) for neuromuscular block and postoperative pulmonary complications: A retrospective analysis.

    Ren, Aolin / Fan, Meihan / Gu, Zhen / Liang, Xiao / Xu, Liuhang / Liu, Chengjun / Wang, Dutian / Chang, Hanxuan / Zhu, Minmin

    British journal of clinical pharmacology

    2024  

    Abstract: Aims: Residual neuromuscular blockade has been linked to pulmonary complications in the postoperative period. This study aimed to determine whether sugammadex was associated with a lower risk of postoperative pulmonary complications (PPCs) compared with ...

    Abstract Aims: Residual neuromuscular blockade has been linked to pulmonary complications in the postoperative period. This study aimed to determine whether sugammadex was associated with a lower risk of postoperative pulmonary complications (PPCs) compared with neostigmine.
    Methods: This retrospective cohort study was conducted in a tertiary academic medical center. Patients ≥18 year of age undergoing noncardiac surgical procedures with general anesthesia and mechanical ventilation were enrolled between January 2019 and September 2021. We identified all patients receiving rocuronium and reversal with neostigmine or sugammadex via electronic medical record review. The primary endpoint was a composite of PPCs (including pneumonia, atelectasis, respiratory failure, pulmonary embolism, pleural effusion, or pneumothorax). The incidence of PPCs was compared using propensity score analysis.
    Results: A total of 1786 patients were included in this study. Among these patients, 976 (54.6%) received neostigmine, and 810 (45.4%) received sugammadex. In the whole sample, PPCs occurred in 81 (4.54%) subjects (7.04% sugammadex vs. 2.46% neostigmine). Baseline covariates were well balanced between groups after overlap weighting. Patients in the sugammadex group had similar risk (overlap weighting OR: 0.75; 95% CI: 0.40 to 1.41) compared to neostigmine. The sensitivity analysis showed consistent results. In subgroup analysis, the interaction P-value for the reversal agents stratified by surgery duration was 0.011.
    Conclusion: There was no significant difference in the rate of PPCs when the neuromuscular blockade was reversed with sugammadex compared to neostigmine. Patients undergoing prolonged surgery may benefit from sugammadex, which needs to be further investigated.
    Language English
    Publishing date 2024-04-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.16056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: An Unusual Cause of Macroscopic T-Wave Alternans in a Patient With Acute Promyelocytic Leukemia.

    Liang, Zhen-Hua / Zhao, Yun-Tao / Zhou, Yi-Chang

    JAMA internal medicine

    2021  Volume 181, Issue 7, Page(s) 985–987

    MeSH term(s) Arrhythmias, Cardiac/physiopathology ; Electrocardiography ; Humans ; Leukemia, Promyelocytic, Acute/physiopathology ; Male ; Middle Aged
    Language English
    Publishing date 2021-05-17
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2021.1631
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Self-similar chiral organic molecular cages.

    Wang, Zhen / Zhang, Qing-Pu / Guo, Fei / Ma, Hui / Liang, Zi-Hui / Yi, Chang-Hai / Zhang, Chun / Chen, Chuan-Feng

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 670

    Abstract: The endeavor to enhance utility of organic molecular cages involves the evolution of them into higher-level chiral superstructures with self-similar, presenting a meaningful yet challenging. In this work, 2D tri-bladed propeller-shaped triphenylbenzene ... ...

    Abstract The endeavor to enhance utility of organic molecular cages involves the evolution of them into higher-level chiral superstructures with self-similar, presenting a meaningful yet challenging. In this work, 2D tri-bladed propeller-shaped triphenylbenzene serves as building blocks to synthesize a racemic 3D tri-bladed propeller-shaped helical molecular cage. This cage, in turn, acts as a building block for a pair of higher-level 3D tri-bladed chiral helical molecular cages, featuring multilayer sandwich structures and displaying elegant characteristics with self-similarity in discrete superstructures at different levels. The evolutionary procession of higher-level cages reveals intramolecular self-shielding effects and exclusive chiral narcissistic self-sorting behaviors. Enantiomers higher-level cages can be interconverted by introducing an excess of corresponding chiral cyclohexanediamine. In the solid state, higher-level cages self-assemble into supramolecular architectures of L-helical or D-helical nanofibers, achieving the scale transformation of chiral characteristics from chiral atoms to microscopic and then to mesoscopic levels.
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-44922-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: DCAF1-targeting microRNA-3175 activates Nrf2 signaling and inhibits dexamethasone-induced oxidative injury in human osteoblasts.

    Chen, Jing / Liang, Jin-Qian / Zhen, Yun-Fang / Chang, Lei / Zhou, Zhen-Tao / Shen, Xiong-Jie

    Cell death & disease

    2021  Volume 12, Issue 11, Page(s) 1024

    Abstract: Activation of nuclear-factor-E2-related factor 2 (Nrf2) signaling can protect human osteoblasts from dexamethasone-induced oxidative injury. DDB1 and CUL4 associated factor 1 (DCAF1) is a novel ubiquitin E3 ligase for Nrf2 protein degradation. We ... ...

    Abstract Activation of nuclear-factor-E2-related factor 2 (Nrf2) signaling can protect human osteoblasts from dexamethasone-induced oxidative injury. DDB1 and CUL4 associated factor 1 (DCAF1) is a novel ubiquitin E3 ligase for Nrf2 protein degradation. We identified a novel DCAF1-targeting miRNA, miR-3175. RNA pull-down, Argonaute 2 RNA-immunoprecipitation, and RNA fluorescent in situ hybridization results confirmed a direct binding between miR-3175 and DCAF1 mRNA in primary human osteoblasts. DCAF1 3'-untranslated region luciferase activity and its expression were significantly decreased after miR-3175 overexpression but were augmented with miR-3175 inhibition in human osteoblasts and hFOB1.19 osteoblastic cells. miR-3175 overexpression activated Nrf2 signaling, causing Nrf2 protein stabilization, antioxidant response (ARE) activity increase, and transcription activation of Nrf2-dependent genes in human osteoblasts and hFOB1.19 cells. Furthermore, dexamethasone-induced oxidative injury and apoptosis were largely attenuated by miR-3175 overexpression in human osteoblasts and hFOB1.19 cells. Importantly, shRNA-induced silencing or CRISPR/Cas9-mediated Nrf2 knockout abolished miR-3175 overexpression-induced osteoblast cytoprotection against dexamethasone. Conversely, DFAC1 knockout, by the CRISPR/Cas9 method, activated the Nrf2 cascade and inhibited dexamethasone-induced cytotoxicity in hFOB1.19 cells. Importantly, miR-3175 expression was decreased in necrotic femoral head tissues of dexamethasone-taking patients, where DCAF1 mRNA was upregulated. Together, silencing DCAF1 by miR-3175 activated Nrf2 signaling to inhibit dexamethasone-induced oxidative injury and apoptosis in human osteoblasts.
    MeSH term(s) Apoptosis/genetics ; Case-Control Studies ; Dexamethasone/pharmacology ; Femur Head/drug effects ; Femur Head/metabolism ; Femur Head/pathology ; Gene Knockout Techniques ; Gene Silencing ; HEK293 Cells ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Necrosis ; Osteoblasts/drug effects ; Osteoblasts/metabolism ; Oxidative Stress/drug effects ; Protein Binding ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; RNA, Messenger/genetics ; Reactive Oxygen Species/metabolism ; Signal Transduction/genetics ; Transfection ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
    Chemical Substances MIRN3175 microRNA, human ; MicroRNAs ; NF-E2-Related Factor 2 ; NFE2L2 protein, human ; RNA, Messenger ; Reactive Oxygen Species ; Dexamethasone (7S5I7G3JQL) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; DCAF1 protein, human (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2021-10-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-021-04300-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Letter to the Editor: Can Sural Fasciocutaneous Flaps Be Effective in Patients Older Than 65?

    Das De, Soumen / Liang, Zhen Chang

    Clinical orthopaedics and related research

    2020  Volume 478, Issue 7, Page(s) 1699–1700

    MeSH term(s) Humans ; Soft Tissue Injuries ; Surgical Flaps
    Keywords covid19
    Language English
    Publishing date 2020-06-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1097/CORR.0000000000001332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Antagonistic Activity and Mechanism of

    Yi, Yan-Jie / Yin, Ya-Nan / Yang, Ying-Ao / Liang, Yu-Qian / Shan, You-Tian / Zhang, Chang-Fu / Zhang, Yu-Rong / Liang, Zhen-Pu

    Phytopathology

    2022  , Page(s) PHYTO04220118R

    Abstract: Wheat powdery mildew caused ... ...

    Abstract Wheat powdery mildew caused by
    Language English
    Publishing date 2022-11-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208889-7
    ISSN 1943-7684 ; 0031-949X
    ISSN (online) 1943-7684
    ISSN 0031-949X
    DOI 10.1094/PHYTO-04-22-0118-R
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Ent-eudesmane sesquiterpenoids from the Chinese liverwort Chiloscyphus polyanthus.

    Zhu, Ming-Zhu / Li, Yi / Zhou, Jin-Chuan / Lv, Dong-Xue / Fu, Xiao-Jie / Liang, Zhen / Yuan, Shuang-Zhi / Han, Jing-Jing / Zhang, Jiao-Zhen / Xu, Ze-Jun / Chang, Wen-Qiang / Lou, Hong-Xiang

    Phytochemistry

    2023  Volume 214, Page(s) 113796

    Abstract: Seven previously undescribed ent-eudesmane sesquiterpenoids (1-7), as well as seven known analogs (8-14), were isolated from the Chinese liverwort Chiloscyphus polyanthus var. rivularis. Their structures were established based on comprehensive ... ...

    Abstract - Seven previously undescribed ent-eudesmane sesquiterpenoids (1-7), as well as seven known analogs (8-14), were isolated from the Chinese liverwort Chiloscyphus polyanthus var. rivularis. Their structures were established based on comprehensive spectroscopy analysis, electronic circular dichroism calculations, as well as biosynthetic considerations. The cytotoxicity against HepG2 (Human hepatocellular carcinomas) cancer cell line, and antifungal activity against Candida albicans SC5314 of all isolated ent-eudesmane sesquiterpenoids were preliminarily tested, results showed that the tested compounds did not display obvious cytotoxicity and antifungal activities under the tested concentration.
    MeSH term(s) Antifungal Agents/pharmacology ; Antifungal Agents/chemistry ; China ; Hepatophyta/chemistry ; Molecular Structure ; Sesquiterpenes/chemistry ; Sesquiterpenes, Eudesmane/pharmacology ; Sesquiterpenes, Eudesmane/chemistry ; Hep G2 Cells/drug effects ; Humans ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology
    Chemical Substances Antifungal Agents ; eudesmane (473-11-0) ; Sesquiterpenes ; Sesquiterpenes, Eudesmane ; Antineoplastic Agents
    Language English
    Publishing date 2023-07-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2023.113796
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Real-time monitoring of abnormal mitochondrial viscosity in glioblastoma with a novel mitochondria-targeting fluorescent probe.

    Zhang, Qing / Liu, Wei / Jiang, Ling / He, Yan-Jun / Wu, Chang-Jian / Ren, Shen-Zhen / Wang, Bao-Zhong / Liu, Li / Zhu, Hai-Liang / Wang, Zhong-Chang

    The Analyst

    2024  

    Abstract: Glioblastoma is the most fatal and insidious malignancy, due to the existence of the blood-brain barrier (BBB) and the high invasiveness of tumor cells. Abnormal mitochondrial viscosity has been identified as a key feature of malignancies. Therefore, ... ...

    Abstract Glioblastoma is the most fatal and insidious malignancy, due to the existence of the blood-brain barrier (BBB) and the high invasiveness of tumor cells. Abnormal mitochondrial viscosity has been identified as a key feature of malignancies. Therefore, this study reports on a novel fluorescent probe for mitochondrial viscosity, called ZVGQ, which is based on the twisted intramolecular charge transfer (TICT) effect. The probe uses 3-dicyanomethyl-1,5,5-trimethylcyclohexene as an electron donor moiety and molecular rotor, and triphenylphosphine (TPP) cation as an electron acceptor and mitochondrial targeting group. ZVGQ is highly selective, pH and time stable, and exhibits rapid viscosity responsiveness.
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/d4an00226a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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