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Article ; Online: Optimal patient selection for maze procedure in patients undergoing mitral valve disease.

Masuda, Tomoaki / Aoki, Atsushi / Omoto, Tadashi / Maruta, Kazuto

2024 Volume 19, Issue 1, Page(s) 190

Abstract: Objectives: Although risk factors for unsuccessful Maze procedure have been demonstrated, an appropriate patient selection is still controversial. In our institute, Maze procedure is indicated for those whom normal sinus rhythm (NSR) was reestablished ... ...

Abstract	Objectives: Although risk factors for unsuccessful Maze procedure have been demonstrated, an appropriate patient selection is still controversial. In our institute, Maze procedure is indicated for those whom normal sinus rhythm (NSR) was reestablished by intraoperative direct cardioversion (DC) after ventricular unloading by total cardiopulmonary bypass. The purpose of this study was to evaluate the effectiveness of our indication criteria for Maze procedure in patients with mitral valve disease. Methods: Between October 2012 and October 2021, MAZE was indicated in 55 patients in whom normal sinus rhythm (NSR) was reestablished by intraoperative direct current cardioversion (DC). Three endpoints and predictors were examined: disappearance of atrial fibrillation (AF), NSR, and A-wave detection. Results: Restoration of NSR by intraoperative DC was confirmed in 43 patients, and these patients underwent MAZE. AF disappeared in 39 patients (90.7%), and F-wave ≥ 0.1 mV was a significant predictive factor (odds ratio (OR) 20.99, 95% CI 1.22-1079.06). NSR was reestablished in 36 patients (83.7%), and F-wave ≥ 0.1 mV (odds ratio 15.62, 95% CI 1.62-359.86) + AF history ≤ 3 years (OR 8.30, 95% CI 1.09-177.04) were significant predictors. A-wave detection was confirmed in 26 patients (60.5%), and left atrial diameter ≤ 55 mm was a significant predictor (OR 5.22, 95% CI 1.28-24.79). Conclusions: Intraoperative DC after ventricular unloading resulted effective patient selection for concomitant Maze procedure. F-wave and AF history were predictive factor of electrical restoration of AF, and left atrial diameter was predictive factor of restoration of atrial function.
MeSH term(s)	Humans ; Mitral Valve/surgery ; Maze Procedure ; Mitral Valve Insufficiency ; Patient Selection ; Mitral Valve Stenosis/surgery ; Treatment Outcome ; Heart Valve Diseases/complications ; Atrial Fibrillation/diagnosis ; Catheter Ablation/methods
Language	English
Publishing date	2024-04-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-024-02766-z
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Article: Factors Influencing on the Aneurysm Sac Shrinkage after Endovascular Abdominal Aortic Aneurysm Repair by the Analysis of the Patients with the Aneurysm Sac Shrinkage and Expansion.

Aoki, Atsushi / Maruta, Kazuto / Masuda, Tomoaki / Omoto, Tadashi

Annals of vascular diseases

2023 Volume 16, Issue 4, Page(s) 245–252

Abstract: Objectives: ...

Abstract	Objectives:
Language	English
Publishing date	2023-09-28
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2394256-3
ISSN	1881-6428 ; 1881-641X
ISSN (online)	1881-6428
ISSN	1881-641X
DOI	10.3400/avd.oa.23-00065
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Article: Procedure and Aortic Remodeling Effects of Entry Closure with Stentgraft for Type B Aortic Dissection: Comparison between the Patients with Narrow True Lumen and Those with Aneurysmal Dilated False Lumen.

Aoki, Atsushi / Maruta, Kazuto / Masuda, Tomoaki / Omoto, Tadashi

Annals of vascular diseases

2022 Volume 15, Issue 3, Page(s) 175–185

Abstract: ... ...

Abstract	Objectives
Language	English
Publishing date	2022-07-13
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2394256-3
ISSN	1881-6428 ; 1881-641X
ISSN (online)	1881-6428
ISSN	1881-641X
DOI	10.3400/avd.oa.22-00089
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Article ; Online: Operative Timing and Feasibility of Mitral Valve Repair in Active Infective Endocarditis.

Omoto, Tadashi / Aoki, Atsushi / Maruta, Kazuto / Masuda, Tomoaki

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia

2022 Volume 29, Issue 1, Page(s) 23–28

Abstract: Purpose: We studied the association between operative timing and the feasibility of mitral valve (MV) repair in active infective endocarditis (IE).: Methods: Forty-nine active IE patients who underwent MV operation were classified according to ... ...

Abstract	Purpose: We studied the association between operative timing and the feasibility of mitral valve (MV) repair in active infective endocarditis (IE). Methods: Forty-nine active IE patients who underwent MV operation were classified according to operative timing: within 48 hours (Term I: n = 7), between 3 and 14 days (Term II: n = 22), and ≥15 days (Term III: n = 20). Patient profiles, operative outcomes, and feasibility of MV repair were evaluated. Complexity score and severity score were used to define the feasibility of MV repair depending on the extent of infected lesion and technical difficulties. Results: There were no differences in basic profile in the three groups. Rate of major complications was higher in Term I (86%) than II (41%, p = 0.031) and III (25%, p = 0.005). In-hospital mortality was also higher in Term I (43%) than II (9%, p = 0.039) and III (5%, p = 0.015). The three groups did not differ by feasibility of MV repair calculated by the two-score system or by frequency of MV repair (I: 57%, II: 59%, and III: 55%). Conclusions: Morbidity and mortality were high in urgent cases. Feasibility of MV repair is associated with the extent of infected lesion and technical difficulties, and not with operative timing.
MeSH term(s)	Humans ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Feasibility Studies ; Heart Valve Prosthesis Implantation/adverse effects ; Treatment Outcome ; Endocarditis, Bacterial/complications ; Endocarditis/diagnostic imaging ; Endocarditis/surgery ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/surgery ; Mitral Valve Insufficiency/etiology
Language	English
Publishing date	2022-11-03
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2019756-1
ISSN	2186-1005 ; 1341-1098
ISSN (online)	2186-1005
ISSN	1341-1098
DOI	10.5761/atcs.oa.22-00135
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Zs.A 5253: Show issues

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Article ; Online: Recent Advances in Drug Therapy for Parkinson's Disease.

Murakami, Hidetomo / Shiraishi, Tomotaka / Umehara, Tadashi / Omoto, Shusaku / Iguchi, Yasuyuki

Internal medicine (Tokyo, Japan)

2022 Volume 62, Issue 1, Page(s) 33–42

Abstract: Parkinson's disease (PD) is a neurodegenerative disease manifesting with motor and non-motor symptoms. Current treatment mainly relies on medication as a symptomatic therapy modulating neurotransmitters. Dopamine replacement therapy has been established, ...

Abstract	Parkinson's disease (PD) is a neurodegenerative disease manifesting with motor and non-motor symptoms. Current treatment mainly relies on medication as a symptomatic therapy modulating neurotransmitters. Dopamine replacement therapy has been established, and levodopa is the gold standard for treatment of PD. However, the emergence of motor complications, such as a wearing-off phenomenon, is a clinical problem. Both primary symptoms and motor complications have been targets for the development of treatments for PD. Recent progression in the management of motor complications is supported by newly developed agents and advances in device and formulation technology to deliver drugs continuously. Elucidation of the pathophysiology of PD and the development of disease-modifying therapy that affects the underlying fundamental pathophysiology of the disease are also progressing. In this review, we introduce current knowledge on developments concerning medications for patients with PD.
MeSH term(s)	Humans ; Parkinson Disease/drug therapy ; Antiparkinson Agents/therapeutic use ; Neurodegenerative Diseases/drug therapy ; Levodopa/therapeutic use
Chemical Substances	Antiparkinson Agents ; Levodopa (46627O600J)
Language	English
Publishing date	2022-02-01
Publishing country	Japan
Document type	Review ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.8940-21
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Zs.A 240: Show issues

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Article ; Online: Clinical impact of the right ventricular impairment in patients following transcatheter aortic valve replacement.

Higuchi, Satoshi / Mochizuki, Yasuhide / Omoto, Tadashi / Matsumoto, Hidenari / Masuda, Tomoaki / Maruta, Kazuto / Aoki, Atsushi / Shinke, Toshiro

Scientific reports

2024 Volume 14, Issue 1, Page(s) 1776

Abstract: The right ventricular (RV) impairment can predict clinical adverse events in patients following transcatheter aortic valve replacement (TAVR) for severe aortic stenosis (AS). Limited reports have compared impact of the left ventricular (LV) and RV ... ...

Abstract	The right ventricular (RV) impairment can predict clinical adverse events in patients following transcatheter aortic valve replacement (TAVR) for severe aortic stenosis (AS). Limited reports have compared impact of the left ventricular (LV) and RV disorders. This retrospective study evaluated two-year major adverse cardiac and cerebrovascular events (MACCE) in patients following TAVR for severe AS. RV sphericity index was calculated as the ratio between RV mid-ventricular and longitudinal diameters during the end-diastolic phase. Of 239 patients, 2-year MACCE were observed in 34 (14%). LV ejection fraction was 58 ± 11%. Tricuspid annular plane systolic excursion (TAPSE) and RV sphericity index were 20 ± 3 mm and 0.36 (0.31-0.39). Although the univariate Cox regression analysis demonstrated that both LV and RV parameters predicted the outcomes, LV parameters no longer predicted them after adjustment. Lower TAPSE (adjusted hazard ratio per 1 mm, 0.84; 95% confidence interval, 0.75-0.93) and higher RV sphericity index (adjusted hazard ratio per 0.1, 1.94; 95% confidence interval, 1.17-3.22) were adverse clinical predictors. In conclusion, the RV structural and functional disorders predict two-year MACCE, whereas the LV parameters do not. Impact of LV impairment can be attenuated after development of RV disorders.
MeSH term(s)	Humans ; Transcatheter Aortic Valve Replacement/adverse effects ; Retrospective Studies ; Ventricular Function, Left ; Stroke Volume ; Ventricular Dysfunction, Left/etiology ; Aortic Valve Stenosis
Language	English
Publishing date	2024-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52242-w
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Article ; Online: Rapid eye movement sleep behavior disorder is associated with decreased quality of life and stigma in people with Parkinson's disease.

Ozawa, Masakazu / Murakami, Hidetomo / Shiraishi, Tomotaka / Umehara, Tadashi / Omoto, Shusaku / Iguchi, Yasuyuki

Acta neurologica Belgica

2023 Volume 123, Issue 3, Page(s) 1073–1079

Abstract: Background: Individuals with Parkinson's disease (PD) may present with rapid eye movement sleep behavior disorder (RBD). We therefore investigated the association between RBD and quality of life (QOL) in people with PD.: Methods: Individuals with PD ... ...

Abstract	Background: Individuals with Parkinson's disease (PD) may present with rapid eye movement sleep behavior disorder (RBD). We therefore investigated the association between RBD and quality of life (QOL) in people with PD. Methods: Individuals with PD and a Mini-Mental State Examination score ≥ 24 were divided into two groups using the RBD screening questionnaire (RBDSQ): those with an RBDSQ score ≥ 5 were assigned to the "probable RBD" (pRBD) group, and those with a score < 5 to the "non-pRBD" group. Participants were then evaluated for motor symptoms (Movement Disorder Society-Unified Parkinson's Disease Rating Scale part III and modified Hoehn and Yahr Scale), cognitive functions (Montreal Cognitive Assessment and Frontal Assessment Battery [FAB]), anhedonia (Snaith-Hamilton Pleasure Scale), and QOL (Parkinson's Disease Questionnaire [PDQ]-39 total and subscores for mobility, activities of daily living, emotional well-being, stigma, social support, cognition, communication, and bodily discomfort). Each measure was compared between the two groups (Mann-Whitney U test/χ Results: Ninety-three individuals with PD were recruited (mean ± standard deviation age, 67.0 ± 10.6 years). The pRBD group exhibited a longer disease duration (P = 0.006), worse FAB (P = 0.015) and PDQ-39 total (P = 0.032) scores. RBDSQ scores correlated with higher scores in the PDQ-39 stigma domain (B = 2.44, P = 0.033). Conclusion: RBD is associated with worse QOL and stigma in people with PD. The RBDSQ is a useful tool for the prediction of such disturbances in QOL.
MeSH term(s)	Humans ; Middle Aged ; Aged ; Parkinson Disease/complications ; Parkinson Disease/psychology ; Quality of Life ; REM Sleep Behavior Disorder/etiology ; REM Sleep Behavior Disorder/diagnosis ; Activities of Daily Living ; Surveys and Questionnaires
Language	English
Publishing date	2023-03-21
Publishing country	Italy
Document type	Journal Article
ZDB-ID	127315-2
ISSN	2240-2993 ; 0300-9009
ISSN (online)	2240-2993
ISSN	0300-9009
DOI	10.1007/s13760-023-02213-1
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Article ; Online: Midterm Outcomes of Endovascular Abdominal Aortic Aneurysm Repair with Prevention of type 2 Endoleak by Intraoperative Aortic Side Branch Coil Embolization.

Aoki, Atsushi / Maruta, Kazuto / Omoto, Tadashi / Masuda, Tomoaki

Annals of vascular surgery

2021 Volume 78, Page(s) 180–189

Abstract: Objective: The midterm results of endovascular abdominal aortic aneurysm repair (EVAR) with aortic side branch coil embolization during EVAR was evaluated.: Methods: Our center began coil embolization for all patent inferior mesenteric artery (IMA) ... ...

Abstract	Objective: The midterm results of endovascular abdominal aortic aneurysm repair (EVAR) with aortic side branch coil embolization during EVAR was evaluated. Methods: Our center began coil embolization for all patent inferior mesenteric artery (IMA) and lumbar artery (LA) with an inner diameter more than 2.0 mm during EVAR since June 2015. When four or more LA were patent, coil embolization for LA with inner diameter 2.0 mm or less was done. EVAR without aortic side branches coil embolization was performed for 59 patients prior to June 2015 (control group) and 79 patients underwent EVAR with coil embolization during EVAR (coil group). The success rate of coil embolization for IMA and LA was evaluated in coil group. The frequency of type 2 endoleak (T2EL), freedom from aneurysm sac expansion (5 mm or more) rate and the rate of the aneurysm sac shrinkage (10 mm or more) were compared between the coil and control groups. Additionally, multiple logistic regression analysis for all patients was conducted to analyze whether IMA patency and the number of patent lumbar artery at the end of EVAR were the risk factors of the aneurysm sac expansion of 5 mm or more. Results: The success rate of IMA coil embolization was 96.4% and that of LA was 74.5%. Compared to the control group, the frequency of T2EL was significantly lower in coil group at 7 days (1.3% vs. 60.4%, P <0.0001) and at 6 months (2.1% vs 38.2%, P <0.0001) after EVAR. The freedom from aneurysm sac expansion rate was significantly better in the coil group at 5 years (100% in coil group and 65.2% in control group, P = 0.002). The rate of aneurysm sac shrinkage was significantly better in coil group (15.5% vs. 2.0% at 1 year, 42.8% vs. 6.3% at 2 years and 53.4% vs. 17.8% at 3 years, p = 0.0007). The risk of aneurysm sac expansion of 5 mm or more was estimated to be 11 times greater when the IMA was patent, and 4.9 times greater when 3 or more LAs were patent at the end of EVAR. Conclusion: When IMA was occluded and the number of patent LA became 2 or less by aortic side branch coil embolization during EVAR, favorable mid-term results were safely obtained and good long-term result could be expected with EVAR.
MeSH term(s)	Aged ; Aged, 80 and over ; Aortic Aneurysm, Abdominal/diagnostic imaging ; Aortic Aneurysm, Abdominal/physiopathology ; Aortic Aneurysm, Abdominal/surgery ; Blood Vessel Prosthesis Implantation/adverse effects ; Case-Control Studies ; Embolization, Therapeutic/adverse effects ; Embolization, Therapeutic/instrumentation ; Endoleak/diagnostic imaging ; Endoleak/etiology ; Endoleak/prevention & control ; Endovascular Procedures/adverse effects ; Female ; Humans ; Lumbar Vertebrae/blood supply ; Male ; Mesenteric Artery, Inferior/diagnostic imaging ; Mesenteric Artery, Inferior/physiopathology ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2021-09-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1027366-9
ISSN	1615-5947 ; 0890-5096
ISSN (online)	1615-5947
ISSN	0890-5096
DOI	10.1016/j.avsg.2021.06.037
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Zs.A 2882: Show issues

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Article ; Online: Polypoidal choroidal vasculopathy in a patient with DMPK-associated myotonic dystrophy.

Iida, Yuka / Hayashi, Takaaki / Tokuhisa, Teruaki / Mizobuchi, Kei / Omoto, Shusaku / Nakano, Tadashi

Documenta ophthalmologica. Advances in ophthalmology

2022 Volume 144, Issue 3, Page(s) 217–226

Abstract: Background: Myotonic dystrophy type 1 (DM1) is an autosomal dominant genetic disorder that affects multiple organs, including the muscle and eye, caused by a CTG triplet expansion of the 3' untranslated region (UTR) of the DMPK gene. Cataracts and ... ...

Abstract	Background: Myotonic dystrophy type 1 (DM1) is an autosomal dominant genetic disorder that affects multiple organs, including the muscle and eye, caused by a CTG triplet expansion of the 3' untranslated region (UTR) of the DMPK gene. Cataracts and retinal degeneration are major eye complications in patients with DM1. We reported the case of a Japanese patient with DM1 who exhibited submacular hemorrhage unilaterally, rarely complicating DM1. Case report: A 56-year-old woman presented with loss of visual acuity in the left eye (LE). The patient was diagnosed with DM1, who carried expanded CTG repeats (1100) of the 3' UTR of DMPK. Her corrected visual acuities were 20/100 and 20/2000 in the right eye (RE) and LE, respectively. Cataracts were observed in both eyes. Fundoscopy and angiography revealed submacular hemorrhage in the LE due to polypoidal choroidal vasculopathy (PCV, also known as aneurysmal type 1 neovascularization). The patient underwent intravitreal injections of an anti-vascular endothelial growth factor drug and sulfur hexafluoride gas in the LE. Full-field electroretinography was performed, showing that the rod and standard-flash responses were reduced to 50% and below 10% in the RE and LE, whereas the cone and 30-Hz flicker responses were reduced to 40-50% and 15-20% in the RE and LE, respectively, compared with the controls. Multifocal electroretinography revealed that the overall responses were extinguished in the LE and considerably attenuated in the RE. Conclusions: This is the first patient with DM1 complicated with PCV. Widespread retinal dysfunction may be associated with expanded CTG repeats, which is significantly longer than the mean repeat number of patients with DM1.
MeSH term(s)	Cataract/complications ; Electroretinography ; Eye Diseases/complications ; Female ; Humans ; Intravitreal Injections ; Middle Aged ; Myotonic Dystrophy/complications ; Myotonic Dystrophy/diagnosis ; Myotonic Dystrophy/genetics ; Myotonin-Protein Kinase/genetics ; Retinal Hemorrhage/diagnosis ; Retinal Hemorrhage/etiology
Chemical Substances	DMPK protein, human ; Myotonin-Protein Kinase (EC 2.7.11.1)
Language	English
Publishing date	2022-03-13
Publishing country	Netherlands
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	212594-8
ISSN	1573-2622 ; 0012-4486
ISSN (online)	1573-2622
ISSN	0012-4486
DOI	10.1007/s10633-022-09867-x
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Article ; Online: Peripheral immune profile in drug-naïve dementia with Lewy bodies.

Umehara, Tadashi / Mimori, Masahiro / Kokubu, Tatsushi / Ozawa, Masakazu / Shiraishi, Tomotaka / Sato, Takeo / Onda, Asako / Matsuno, Hiromasa / Omoto, Shusaku / Sengoku, Renpei / Murakami, Hidetomo / Oka, Hisayoshi / Iguchi, Yasuyuki

Journal of neurology

2024

Abstract: Background: Accumulating evidence suggests that peripheral inflammation is associated with the pathogenesis of Parkinson's disease (PD). We examined peripheral immune profiles and their association with clinical characteristics in patients with DLB and ... ...

Abstract	Background: Accumulating evidence suggests that peripheral inflammation is associated with the pathogenesis of Parkinson's disease (PD). We examined peripheral immune profiles and their association with clinical characteristics in patients with DLB and compared these with values in patients with PD. Methods: We analyzed peripheral blood from 93 participants (drug-naïve DLB, 31; drug-naïve PD, 31; controls, 31). Absolute leukocyte counts, absolute counts of leukocyte subpopulations, and peripheral blood inflammatory indices such as neutrophil-to-lymphocyte ratio were examined. Associations with clinical characteristics, cardiac sympathetic denervation, and striatal Results: Patients with DLB had lower absolute lymphocyte and basophil counts than did age-matched controls (both; p < 0.005). Higher basophil counts were marginally associated with higher global cognition (p = 0.054) and were significantly associated with milder motor severity (p = 0.020) and higher striatal Conclusions: As in patients with PD, the peripheral immune profile is altered in patients with DLB. Some peripheral immune cell counts and inflammatory indices reflect the degree of disease progression. These findings may deepen our knowledge on the role of peripheral inflammation in the pathogenesis of DLB.
Language	English
Publishing date	2024-04-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-024-12336-x
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