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Article ; Online: To Do Is Better: Prompt Surgery Is Indicated in COVID-19 Patients With Complicated Pneumatocele.

Castiglioni, Massimo / Pelosi, Giuseppe / Incarbone, Matteo

2021 Volume 113, Issue 4, Page(s) 1390

MeSH term(s)	COVID-19 ; Cysts/complications ; Humans ; Lung ; Pneumonia/complications ; SARS-CoV-2
Language	English
Publishing date	2021-05-08
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2021.04.070
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Book: Illicit drugs in the environment

Castiglioni, Sara

occurrence, analysis, and fate using mass spectrometry

(Wiley-Interscience series in mass spectrometry ; Wiley series on mass spectrometry)

2011

Author's details	ed. by Sara Castiglioni
Series title	Wiley-Interscience series in mass spectrometry Wiley series on mass spectrometry
Keywords	Rauschgift ; Umwelt ; Wasserverschmutzung ; Massenspektrometrie
Subject	Narkotisches Genussmittel ; Rauschdroge ; Rauschmittel ; Suchtgift ; Suchtmittel ; Psychoaktive Substanz ; Droge ; Drogen ; Rauschgifte ; Rauschdrogen ; Massenspektrographie ; Massenspektroskopie ; Wasser ; Gewässerbelastung ; Wasserverunreinigung ; Gewässerverschmutzung ; Gewässerverunreinigung ; Gewässer ; Wasserbelastung
Language	English
Size	XVII, 346 S. : graph. Darst., Kt.
Publisher	Wiley
Publishing place	Hoboken, NJ
Publishing country	United States
Document type	Book
HBZ-ID	HT016566783
ISBN	978-0-470-52954-6 ; 0-470-52954-7
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

In stock of ZB MED Bonn / Germany

Shelf mark	Loan status	Location
118/523	available for loan (reading room)	Freihandmagazin (U1)

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Article: Palliative Care for Patients with End-Stage, Non-Oncologic Diseases-A Retrospective Study in Three Public Palliative Care Departments in Northern Italy.

Romanò, Massimo / Oldani, Sabina / Reina, Valter / Sofia, Michele / Castiglioni, Claudia

Healthcare (Basel, Switzerland)

2022 Volume 10, Issue 6

Abstract: Patients with irreversible malignant and non-malignant diseases have comparable mortality rates, symptom burdens, and quality of life issues; however, non-cancer patients seldom receive palliative care (PC) or receive it late in their disease trajectory. ...

Abstract	Patients with irreversible malignant and non-malignant diseases have comparable mortality rates, symptom burdens, and quality of life issues; however, non-cancer patients seldom receive palliative care (PC) or receive it late in their disease trajectory. To explore the characteristics of non-cancer patients receiving PC in northern Italy, as well as the features and outcomes of their care, we retrospectively analyzed the charts of all non-cancer patients initiating PC regimens during 2019 in three publicly funded PC departments in Italy’s populous Lombardy region. We recorded the baseline variables (including data collected with the NECPAL CCOMS-ICO-derived questionnaire used since 2018 to evaluate all admissions to the region’s PC network), as well as treatment features (setting and duration) and outcomes (including time and setting of death). Of the 2043 patients admitted in 2019, only 12% (243 patients—131 females; mean age 83.5 years) had non-oncological primary diagnoses (mainly dementia [n = 78], heart disease [n = 55], and lung disease [n = 30]). All 243 had Karnofsky performance statuses ≤ 40% (10−20% in 64%); most (82%) were malnourished, 92% had ≥2 comorbidities, and 61% reported 2−3 severe symptoms (pain, dyspnea, and fatigue). Fifteen withdrew or were discharged from the study PCN; the other 228 remained in the PCN and died in hospice (n = 133), at home (n = 9), or after family-requested transfer to an emergency department (n = 1). Most deaths (172/228, 75%) occurred <3 weeks after PC initiation. These findings indicate that the PCN network we studied cares for few patients with life-limiting non-malignant diseases. Those admitted have advanced-stage illness, heavy symptom burdens, low performance statuses, and poor survival. Additional efforts are needed to improve PCN accessibility for non-cancer patients.
Language	English
Publishing date	2022-06-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare10061031
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Article ; Online: Optimization and Validation of a Method Based on QuEChERS Extraction and Gas Chromatographic-Mass Spectrometric Analysis for the Determination of Polycyclic Aromatic Hydrocarbons and Polychlorinated Biphenyls in Olive Fruits Irrigated with Treated Wastewaters

Maria Concetta Bruzzoniti / Luca Rivoira / Michele Castiglioni / Enrico Cagno / Ahmed Kettab / Donatella Fibbi / Massimo Del Bubba

Separations, Vol 9, Iss 82, p

2022 Volume 82

Abstract: ... with mass spectrometry detection. Extraction was optimized through a QuEChERS protocol, studying the effect ...

Abstract	The wastewater reuse is an important measure to face water shortage, thus improving the resilience of agricultural production chains. However, treated wastewater can contain residual organic micropollutants residues that may result in crop contamination. Among edible crops, olive is the most important agricultural product in the Mediterranean region. Methods to assess the contamination of organic micropollutants such as polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) in olives are poorly investigated. Given the complexity of olives, this study focused on the development and validation of a method for the simultaneous extraction of PAHs and PCBs from olives, and subsequent analysis by gas chromatography coupled with mass spectrometry detection. Extraction was optimized through a QuEChERS protocol, studying the effect of the extraction solvent (CH 2 Cl 2 , cyclohexane, CH 3 CN) and of the dispersive-solid phase extraction (d-SPE) sorbent (octadecyl silica, Florisil, primary secondary amine, Z-Sep) on the recovery of micropollutants. The best recoveries (94–122%, relative standard deviations below 5%) were obtained using CH 3 CN/H 2 O and a double purification step with Z-Sep and Florisil. The method developed for PAHs and PCBs, which showed good intra-day (<2.7%) and inter-day (<2.9%) precision and low matrix effect (\|ME\| < 14%), was applied to the analysis of olives grown by irrigation with reclaimed wastewaters.
Keywords	PAHs ; PCBs ; olives ; QuEChERS protocol ; gas chromatography ; mass spectrometry ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	660
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Palliative Care for Patients with End-Stage, Non-Oncologic Diseases—A Retrospective Study in Three Public Palliative Care Departments in Northern Italy

Massimo Romanò / Sabina Oldani / Valter Reina / Michele Sofia / Claudia Castiglioni

Healthcare, Vol 10, Iss 1031, p

2022 Volume 1031

Abstract	Patients with irreversible malignant and non-malignant diseases have comparable mortality rates, symptom burdens, and quality of life issues; however, non-cancer patients seldom receive palliative care (PC) or receive it late in their disease trajectory. To explore the characteristics of non-cancer patients receiving PC in northern Italy, as well as the features and outcomes of their care, we retrospectively analyzed the charts of all non-cancer patients initiating PC regimens during 2019 in three publicly funded PC departments in Italy’s populous Lombardy region. We recorded the baseline variables (including data collected with the NECPAL CCOMS-ICO-derived questionnaire used since 2018 to evaluate all admissions to the region’s PC network), as well as treatment features (setting and duration) and outcomes (including time and setting of death). Of the 2043 patients admitted in 2019, only 12% (243 patients—131 females; mean age 83.5 years) had non-oncological primary diagnoses (mainly dementia [ n = 78], heart disease [ n = 55], and lung disease [ n = 30]). All 243 had Karnofsky performance statuses ≤ 40% (10–20% in 64%); most (82%) were malnourished, 92% had ≥2 comorbidities, and 61% reported 2–3 severe symptoms (pain, dyspnea, and fatigue). Fifteen withdrew or were discharged from the study PCN; the other 228 remained in the PCN and died in hospice ( n = 133), at home ( n = 9), or after family-requested transfer to an emergency department ( n = 1). Most deaths (172/228, 75%) occurred <3 weeks after PC initiation. These findings indicate that the PCN network we studied cares for few patients with life-limiting non-malignant diseases. Those admitted have advanced-stage illness, heavy symptom burdens, low performance statuses, and poor survival. Additional efforts are needed to improve PCN accessibility for non-cancer patients.
Keywords	palliative care ; end-of-life care ; supportive care ; hospice ; non-cancer illness ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Experimental Design and Multiple Response Optimization for the Extraction and Quantitation of Thirty-Four Priority Organic Micropollutants in Tomatoes through the QuEChERS Approach

Luca Rivoira / Massimo Del Bubba / Giasmin Cecconi / Michele Castiglioni / Valentina Testa / Mattia Isola / Maria Concetta Bruzzoniti

Separations, Vol 10, Iss 174, p

2023 Volume 174

Abstract: ... with gas chromatography/mass spectrometry, for the simultaneous determination of 16 PAHs, 14 PCBs and 4 nitro-PAHs in three tomato cultivars ...

Abstract	The chemical contamination in fruit and vegetables represents a challenging analytical issue, with tomatoes deserving to be investigated as they are fundamental components of the Mediterranean diet. Polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs) and nitro-PAHs contamination is of serious concern, due to particulate deposition and to uptake from contaminated soils and water. However, time-consuming, non-simultaneous and/or non-eco-friendly extraction procedures are typically used to investigate organic contamination in tomatoes, with nitro-PAHs that have not yet been studied. Based on these premises, this work reports the development of a QuEChERS-based approach, coupled with gas chromatography/mass spectrometry, for the simultaneous determination of 16 PAHs, 14 PCBs and 4 nitro-PAHs in three tomato cultivars. The effect of dichloromethane, cyclohexane and acetone, as well as of four clean-up phases were studied through the advanced combination of full factorial experimental design and multiple response optimization approaches. The final protocol, based on cyclohexane extraction followed by a double purification step with primary secondary amine and octadecyl silica and a sulfuric acid oxidation, led to 60–120% recoveries (RSD% < 15%). Good repeatability (inter-day precision <15%) and negligible matrix effect (<16%) were confirmed and the protocol was applied to the analysis of real tomato samples purchased in a local market.
Keywords	tomatoes ; food contamination ; organic micropollutants ; PAH ; PCB ; nitro-PAH ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	540 ; 660
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Transcatheter Aortic Valve Implantation (TAVI) Planning with Dual-Layer Spectral CT Using Virtual Monoenergetic Image (VMI) Reconstructions and 20 mL of Contrast Media.

Fontana, Federico / Piacentino, Filippo / Gnesutta, Aroa / Macchi, Edoardo / Coppola, Andrea / Saccomanno, Angiola / Gatta, Tonia / Recaldini, Chiara / Minenna, Manuela / Tamborini, Claudio / Dossi, Filippo / Ascenti, Velio / Barbera, Simone / Cicero, Giuseppe / Carcano, Giulio / Ascenti, Giorgio / Castiglioni, Battistina / Venturini, Massimo

Journal of clinical medicine

2024 Volume 13, Issue 2

Abstract: Transcatheter aortic valve implantation (TAVI) is a less invasive alternative to surgical implantation and its implementation is progressively increasing worldwide. We routinely perform pre-procedural aortic angiography CT to assess aortic dimensions and ...

Abstract	Transcatheter aortic valve implantation (TAVI) is a less invasive alternative to surgical implantation and its implementation is progressively increasing worldwide. We routinely perform pre-procedural aortic angiography CT to assess aortic dimensions and vascular anatomy. This study aims to evaluate the image quality of CTA for TAVI planning using dual-layer spectral CT, with virtual monoenergetic image reconstructions at 40 keV. Thirty-one patients underwent a CTA protocol with the injection of 20 mL of contrast media. Image quality was assessed by measuring the mean density in Hounsfield Units (HU), the signal-to-noise ratio, and the contrast-to-noise ratio in VMI reconstructions. Additionally, a blinded subjective analysis was conducted by two observers. The results showed significant enhancement at all sampled vascular levels with a gradual decrease in HU from proximal to distal regions. Favourable subjective ratings were given for all parameters, with greater variability in the evaluation of iliac axes. A significant negative correlation (
Language	English
Publishing date	2024-01-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13020524
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Article ; Online: Characterization Techniques as Supporting Tools for the Interpretation of Biochar Adsorption Efficiency in Water Treatment: A Critical Review.

Castiglioni, Michele / Rivoira, Luca / Ingrando, Irene / Del Bubba, Massimo / Bruzzoniti, Maria Concetta

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 16

Abstract: Over the past decade, biochar (BC) has received significant attention in many environmental applications, including water purification, since it is available as a low-cost by-product of the energetic valorisation of biomass. Biochar has many intrinsic ... ...

Abstract	Over the past decade, biochar (BC) has received significant attention in many environmental applications, including water purification, since it is available as a low-cost by-product of the energetic valorisation of biomass. Biochar has many intrinsic characteristics, including its porous structure, which is similar to that of activated carbon (AC), which is the most widely used sorbent in water treatment. The physicochemical and performance characteristics of BCs are usually non-homogenously investigated, with several studies only evaluating limited parameters, depending on the individual perspective of the author. Within this review, we have taken an innovative approach to critically survey the methodologies that are generally used to characterize BCs and ACs to propose a comprehensive and ready-to-use database of protocols. Discussion about the parameters of chars that are usually correlated with adsorption performance in water purification is proposed, and we will also consider the physicochemical properties of pollutants (i.e., K
MeSH term(s)	Adsorption ; Charcoal/chemistry ; Humans ; Kinetics ; Water/chemistry ; Water Pollutants, Chemical/chemistry ; Water Purification/methods
Chemical Substances	Water Pollutants, Chemical ; biochar ; Water (059QF0KO0R) ; Charcoal (16291-96-6)
Language	English
Publishing date	2021-08-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26165063
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Article ; Online: Amino groups modified SBA-15 for dispersive-solid phase extraction in the analysis of micropollutants by QuEchERS approach.

Castiglioni, Michele / Onida, Barbara / Rivoira, Luca / Del Bubba, Massimo / Ronchetti, Silvia / Bruzzoniti, Maria Concetta

Journal of chromatography. A

2021 Volume 1645, Page(s) 462107

Abstract: In the analysis of contaminants in food products, sample preparation is performed by proper adsorbents, whose choice is crucial to eliminate matrix interference. In this work we modified SBA-15 adsorbents by functionalization with (3-aminopropyl)- ... ...

Abstract	In the analysis of contaminants in food products, sample preparation is performed by proper adsorbents, whose choice is crucial to eliminate matrix interference. In this work we modified SBA-15 adsorbents by functionalization with (3-aminopropyl)-triethoxysilane (SBA-15-APTES) and N-[3-(trimethoxysilyl)propyl]aniline (SBA-15-AN) aiming to use them for the first time in the clean-up step of a QuEChERS (quick, easy, cheap, effective, rugged and safe) extraction of micropollutants from strawberry, a sugar rich fruit. After physico-chemical characterization by nitrogen adsorption, infrared spectroscopy and thermogravimetric analysis, the adsorption capabilities of SBA-15 sorbents and possible interaction mechanisms were studied at different pH (2.1-8.5) for glucose, sucrose and fructose at concentrations characteristic of those found in strawberries. The performance of the two SBA-15 sorbents was compared with that of commercial PSA (primary secondary amine), usually proposed in QuEChERS protocols. Both SBA-15 materials exhibit up to 30% higher adsorption than PSA, suggesting their possible QuEChERS application. Synthesized SBA-15 adsorbents were hence used as innovative dispersive sorbents in the QuEChERS extractions of 13 PAHs and 14 PCBs from strawberry. For PCBs, SBA-15-AN provides better matrix removal than PSA and comparable extraction recoveries around 90%. For PAHs, the use of SBA-15-AN has the advantage of lower relative standard deviation (7%) than PSA (19%).
MeSH term(s)	Adsorption ; Environmental Pollutants/analysis ; Fragaria/chemistry ; Fruit/chemistry ; Polychlorinated Biphenyls/analysis ; Polycyclic Aromatic Hydrocarbons/analysis ; Silicon Dioxide/chemistry ; Solid Phase Extraction/methods
Chemical Substances	Environmental Pollutants ; Polycyclic Aromatic Hydrocarbons ; SBA-15 ; Silicon Dioxide (7631-86-9) ; Polychlorinated Biphenyls (DFC2HB4I0K)
Language	English
Publishing date	2021-03-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1171488-8
ISSN	1873-3778 ; 0021-9673
ISSN (online)	1873-3778
ISSN	0021-9673
DOI	10.1016/j.chroma.2021.462107
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Zs.A 813: Show issues

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Article ; Online: Lockdown and Psychosis: A Paranoid Delusion.

Nava, Roberto / Castiglioni, Michele / Don, Prasad Wisidagamage / Di Brita, Carmen / Colmegna, Fabrizia / Clerici, Massimo

The primary care companion for CNS disorders

2020 Volume 22, Issue 6

MeSH term(s)	Delusions ; Humans ; Psychotic Disorders/diagnosis ; Schizophrenia, Paranoid/diagnosis
Language	English
Publishing date	2020-11-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2675414-9
ISSN	2155-7780 ; 2155-7780
ISSN (online)	2155-7780
ISSN	2155-7780
DOI	10.4088/PCC.20l02741
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