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  1. Article: A convergent fragment coupling strategy to access quaternary stereogenic centers.

    Kerkovius, Jeff K / Wong, Alice R / Mak, Victor W / Reisman, Sarah E

    Chemical science

    2023  Volume 14, Issue 16, Page(s) 4397–4400

    Abstract: The formation of quaternary stereogenic ... ...

    Abstract The formation of quaternary stereogenic centers
    Language English
    Publishing date 2023-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d2sc07023e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Deep learning-assisted smartphone-based quantitative microscopy for label-free peripheral blood smear analysis.

    Huang, Bingxin / Kang, Lei / Tsang, Victor T C / Lo, Claudia T K / Wong, Terence T W

    Biomedical optics express

    2024  Volume 15, Issue 4, Page(s) 2636–2651

    Abstract: Hematologists evaluate alterations in blood cell enumeration and morphology to confirm peripheral blood smear findings through manual microscopic examination. However, routine peripheral blood smear analysis is both time-consuming and labor-intensive. ... ...

    Abstract Hematologists evaluate alterations in blood cell enumeration and morphology to confirm peripheral blood smear findings through manual microscopic examination. However, routine peripheral blood smear analysis is both time-consuming and labor-intensive. Here, we propose using smartphone-based autofluorescence microscopy (Smart-AM) for imaging label-free blood smears at subcellular resolution with automatic hematological analysis. Smart-AM enables rapid and label-free visualization of morphological features of normal and abnormal blood cells (including leukocytes, erythrocytes, and thrombocytes). Moreover, assisted with deep-learning algorithms, this technique can automatically detect and classify different leukocytes with high accuracy, and transform the autofluorescence images into virtual Giemsa-stained images which show clear cellular features. The proposed technique is portable, cost-effective, and user-friendly, making it significant for broad point-of-care applications.
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.511384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Children's Lived Experiences in Poverty in Hong Kong as a High-Income Asian Society.

    Cho, Esther Yin-Nei / Wong, Victor C W

    International journal of environmental research and public health

    2022  Volume 19, Issue 10

    Abstract: Child poverty situated in different socioeconomic and environmental contexts has long been a central concern for practitioners, researchers, and policy makers. However, concerned research studies are predominantly adult-centric, confined to specific ... ...

    Abstract Child poverty situated in different socioeconomic and environmental contexts has long been a central concern for practitioners, researchers, and policy makers. However, concerned research studies are predominantly adult-centric, confined to specific areas, or seldom found in Asian developed economies. Against the backdrop of this research gap, this study examines children's experiences of poverty in relation to economic and material aspects, social relationships and participation, and psychological and emotional wellbeing, and their ways of coping with the effects of poverty. Using a purposive sampling method, a total of 40 children participants aged 8-14 living in or near poverty were recruited for an individual interview. The study showed that children experienced a range of deprivations in relation to falling short of the resources, opportunities, and activities that are commanded by average young persons. Limited living space also stands out as a more severe problem that is difficult to cope with. The various coping strategies include small spending savvy tactics, parental buffering, compensation, and mental coping. Proximity to schools and NGOs can help children in poverty to cope with problems caused by deprivations in different aspects. Implications for research studies and practice for working with children in or near poverty are discussed accordingly.
    MeSH term(s) Adaptation, Psychological ; Adult ; Child ; Hong Kong ; Humans ; Income ; Poverty/psychology ; Societies
    Language English
    Publishing date 2022-05-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19106190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Children’s Lived Experiences in Poverty in Hong Kong as a High-Income Asian Society

    Esther Yin-Nei Cho / Victor C. W. Wong

    International Journal of Environmental Research and Public Health, Vol 19, Iss 6190, p

    2022  Volume 6190

    Abstract: Child poverty situated in different socioeconomic and environmental contexts has long been a central concern for practitioners, researchers, and policy makers. However, concerned research studies are predominantly adult-centric, confined to specific ... ...

    Abstract Child poverty situated in different socioeconomic and environmental contexts has long been a central concern for practitioners, researchers, and policy makers. However, concerned research studies are predominantly adult-centric, confined to specific areas, or seldom found in Asian developed economies. Against the backdrop of this research gap, this study examines children’s experiences of poverty in relation to economic and material aspects, social relationships and participation, and psychological and emotional wellbeing, and their ways of coping with the effects of poverty. Using a purposive sampling method, a total of 40 children participants aged 8–14 living in or near poverty were recruited for an individual interview. The study showed that children experienced a range of deprivations in relation to falling short of the resources, opportunities, and activities that are commanded by average young persons. Limited living space also stands out as a more severe problem that is difficult to cope with. The various coping strategies include small spending savvy tactics, parental buffering, compensation, and mental coping. Proximity to schools and NGOs can help children in poverty to cope with problems caused by deprivations in different aspects. Implications for research studies and practice for working with children in or near poverty are discussed accordingly.
    Keywords child poverty ; lived experiences ; deprivation ; social participation ; coping strategies ; Medicine ; R
    Subject code 360
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  5. Book: The Political economy of health care development and reforms in Hong Kong

    Wong, Victor C. W.

    (Social & political studies from Hong Kong)

    1999  

    Author's details Victor C. W. Wong
    Series title Social & political studies from Hong Kong
    Language English
    Size X, 325 S.
    Publisher Ashgate
    Publishing place Aldershot u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT011077914
    ISBN 1-84014-868-3 ; 978-1-84014-868-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1999 A 5336 order for loan Magazin

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  6. Article: The Use of a Non-Invasive Biomarker for Colorectal Cancer Screening: A Comparative Cost-Effectiveness Modeling Study.

    Wong, Martin C S / Huang, Junjie / Wong, Yuet-Yan / Ko, Samantha / Chan, Victor C W / Ng, Siew C / Chan, Francis K L

    Cancers

    2023  Volume 15, Issue 3

    Abstract: This study aimed to examine the cost-effectiveness of fecal biomarker M3 panel compared to fecal immunochemical test (FIT) and colonoscopy in an Asian population. In a hypothetical population of 100,000 persons aged 50 years who received FIT yearly, M3 ... ...

    Abstract This study aimed to examine the cost-effectiveness of fecal biomarker M3 panel compared to fecal immunochemical test (FIT) and colonoscopy in an Asian population. In a hypothetical population of 100,000 persons aged 50 years who received FIT yearly, M3 biomarker yearly, or colonoscopy every 10 years until the age of 75 years. Participants with positive FOBT or a result of "high risk" identified using the M3 biomarker are offered colonoscopy. We assumed surveillance colonoscopy is repeated every 3 years, and examined the treatment cost. A comparison of various outcome measures was conducted using Markov modelling. The incremental cost-effectiveness ratio (ICER) of FIT, M3 biomarker, and colonoscopy was USD108,176, USD133,485 and USD159,596, respectively. Comparing with FIT, the use of M3 biomarker could lead to significantly smaller total loss of cancer-related life-years (2783 vs. 5279); a higher number of CRC cases prevented (1622 vs. 146), a higher proportion of CRC cases prevented (50.2% vs. 4.5%), more life-years saved (2852 vs. 339), and cheaper total costs per life-year saved (USD212,553 vs. 773,894). The total costs per life-year saved is more affordable than that achieved by colonoscopy as a primary screening tool (USD212,553 vs. USD236,909). The findings show that M3 biomarkers may be more cost-effective than colonoscopy.
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15030633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Three-dimensional label-free histological imaging of whole organs by microtomy-assisted autofluorescence tomography.

    Zhang, Yan / Kang, Lei / Yu, Wentao / Tsang, Victor T C / Wong, Terence T W

    iScience

    2022  Volume 25, Issue 1, Page(s) 103721

    Abstract: Three-dimensional (3D) histology is vitally important to characterize disease-induced tissue heterogeneity at the individual cell level. However, it remains challenging for both high-throughput 3D imaging and volumetric reconstruction. Here we propose a ... ...

    Abstract Three-dimensional (3D) histology is vitally important to characterize disease-induced tissue heterogeneity at the individual cell level. However, it remains challenging for both high-throughput 3D imaging and volumetric reconstruction. Here we propose a label-free, cost-effective, and ready-to-use 3D histological imaging technique, termed microtomy-assisted autofluorescence tomography with ultraviolet excitation (MATE). With the combination of block-face imaging and serial microtome sectioning, MATE can achieve rapid and label-free imaging of paraffin-embedded whole organs at an acquisition speed of 1 cm
    Language English
    Publishing date 2022-01-01
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2021.103721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Inter-library loan at ZB MED

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  8. Article: Examining patient-reported late toxicity and its association with quality of life and unmet need for symptom management among nasopharyngeal cancer survivors: a cross-sectional survey.

    Tam, Victor C W / Ching, Jerry C F / Yip, Sindy S T / Kwong, Virginia H Y / Chan, Catherine P L / Wong, Kenneth C W / Lee, Shara W Y

    Frontiers in oncology

    2024  Volume 14, Page(s) 1378973

    Abstract: Introduction: Alongside the improved survival of nasopharyngeal cancer (NPC), late radiation toxicities are alarmingly hampering survivors' quality of life. A patient-reported symptom burden survey is lacking to address the unmet need for symptom ... ...

    Abstract Introduction: Alongside the improved survival of nasopharyngeal cancer (NPC), late radiation toxicities are alarmingly hampering survivors' quality of life. A patient-reported symptom burden survey is lacking to address the unmet need for symptom management among local NPC survivors.
    Methods: A single-center cross-sectional survey was conducted on 211 NPC survivors who had completed radiation therapy for three to 120 months. We employed the Chinese version M. D. Anderson Symptom Inventory - Head & Neck Module (MDASI-HN-C), Functional Assessment of Cancer Therapy - Head & Neck (FACT-HN-C), and a question extracted from the Cancer Survivors' Unmet Needs Measure (CaSUN).
    Results: Two hundred valid responses were collected. Participants suffered from at least four moderate to severe symptoms (mean = 4.84, SD = 4.99). The top five severe symptoms were dry mouth, mucus problems, difficulty swallowing or chewing, teeth or gum problems, and memory problems. MDASI-HN-C subscales were negatively correlated with the physical, emotional, functional, and HN-specific domains of the FACT-HN-C. The unmet need for symptom management was positively associated with symptom burden, either general symptoms (Adjusted odds ratio [OR
    Conclusion: Virtually all NPC survivors suffer from late toxicities, which interplay with survivors' perceptions intricately to affect their unmet needs for symptom management. Personalized supportive care strategies with regular assessments and stratifications are warranted.
    Language English
    Publishing date 2024-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1378973
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Rapid slide-free and non-destructive histological imaging using wide-field optical-sectioning microscopy.

    Zhang, Yan / Kang, Lei / Lo, Claudia T K / Tsang, Victor T C / Wong, Terence T W

    Biomedical optics express

    2022  Volume 13, Issue 5, Page(s) 2782–2796

    Abstract: Histopathology based on formalin-fixed and paraffin-embedded tissues has long been the gold standard for surgical margin assessment (SMA). However, routine pathological practice is lengthy and laborious, failing to guide surgeons intraoperatively. In ... ...

    Abstract Histopathology based on formalin-fixed and paraffin-embedded tissues has long been the gold standard for surgical margin assessment (SMA). However, routine pathological practice is lengthy and laborious, failing to guide surgeons intraoperatively. In this report, we propose a practical and low-cost histological imaging method with wide-field optical-sectioning microscopy (i.e., High-and-Low-frequency (HiLo) microscopy). HiLo can achieve rapid and non-destructive imaging of freshly-excised tissues at an extremely high acquisition speed of 5 cm
    Language English
    Publishing date 2022-04-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.454501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Systematic review on intentional non-medical fentanyl use among people who use drugs.

    Tsang, Vivian W L / Wong, James S H / Westenberg, Jean N / Ramadhan, Noor H / Fadakar, Hasti / Nikoo, Mohammadali / Li, Victor W / Mathew, Nick / Azar, Pouya / Jang, Kerry L / Krausz, Reinhard M

    Frontiers in psychiatry

    2024  Volume 15, Page(s) 1347678

    Abstract: Objectives: Fentanyl is a highly potent opioid and has, until recently, been considered an unwanted contaminant in the street drug supply among people who use drugs (PWUD). However, it has become a drug of choice for an increasing number of individuals. ...

    Abstract Objectives: Fentanyl is a highly potent opioid and has, until recently, been considered an unwanted contaminant in the street drug supply among people who use drugs (PWUD). However, it has become a drug of choice for an increasing number of individuals. This systematic review evaluated intentional non-medical fentanyl use among PWUD, specifically by summarizing demographic variance, reasons for use, and resulting patterns of use.
    Methods: The search strategy was developed with a combination of free text keywords and MeSH and non-MeSH keywords, and adapted with database-specific filters to Ovid MEDLINE, Embase, Web of Science, and PsychINFO. Studies included were human studies with intentional use of non-medical fentanyl or analogues in individuals older than 13. Only peer-reviewed original articles available in English were included.
    Results: The search resulted in 4437 studies after de-duplication, of which 132 were selected for full-text review. Out of 41 papers included, it was found that individuals who use fentanyl intentionally were more likely to be young, male, and White. They were also more likely to have experienced overdoses, and report injection drug use. There is evidence that fentanyl seeking behaviours are motivated by greater potency, delay of withdrawal, lower cost, and greater availability.
    Conclusions: Among PWUD, individuals who intentionally use fentanyl have severe substance use patterns, precarious living situations, and extensive overdose history. In response to the increasing number of individuals who use fentanyl, alternative treatment approaches need to be developed for more effective management of withdrawal and opioid use disorder.
    Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42021272111.
    Language English
    Publishing date 2024-02-13
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2024.1347678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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