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  1. Article: [Epilepsy in Children].

    Oguni, Hirokazu

    Brain and nerve = Shinkei kenkyu no shinpo

    2023  Volume 75, Issue 4, Page(s) 297–301

    Abstract: Childhood epilepsy is characterized by specific epilepsy syndromes that occur during each developmental age. These "age-dependent" epilepsy syndromes are clinically categorized into a self-limited epilepsy group with good prognosis and high prevalence ... ...

    Abstract Childhood epilepsy is characterized by specific epilepsy syndromes that occur during each developmental age. These "age-dependent" epilepsy syndromes are clinically categorized into a self-limited epilepsy group with good prognosis and high prevalence rate and a pharmacoresistant epilepsy group with poor prognosis despite low prevalence rates. Many children develop pharmacoresistant epilepsy beginning in early infancy and progress to developmental epileptic encephalopathy, which is associated with intellectual, behavioral, and/or motor disabilities. These children do not show remission in epilepsy and are transitioned to the adult service and require comprehensive medical care.
    MeSH term(s) Adult ; Child ; Humans ; Epilepsy/epidemiology ; Epileptic Syndromes ; Prevalence ; Electroencephalography
    Language Japanese
    Publishing date 2023-04-10
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416202328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 398: Show issues Location:
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  2. Article ; Online: A reappraisal of interictal EEG characteristics in self-limited epilepsy with autonomic seizures, formerly known as Panayiotopoulos syndrome or early-onset benign occipital epilepsy.

    Oguni, Hirokazu

    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society

    2023  Volume 47, Page(s) 18–24

    Abstract: Purpose: In the 2022 New International Classification of Epilepsy Syndromes, self-limited epilepsy with autonomic seizures (SeLEAS), formerly known as Panayiotopoulos syndrome is recognized as an electroclinical syndrome that is clinically characterized ...

    Abstract Purpose: In the 2022 New International Classification of Epilepsy Syndromes, self-limited epilepsy with autonomic seizures (SeLEAS), formerly known as Panayiotopoulos syndrome is recognized as an electroclinical syndrome that is clinically characterized by autonomic seizures and electroencephalographically by multifocal EEG foci. EEG studies were reviewed herein and the suitability of the EEG definition to characterize SeLEAS was assessed.
    Methods and results: The EEG findings of SeLEAS studies published to date were reviewed and typical sites of EEG foci and their evolutionary changes with age were analyzed. Although previous studies investigated the details of interictal EEG characteristics in a sufficient number of SeLEAS cases, there were few systematically analyzing cross sectional and longitudinal EEG changes except one study. Despite these limited evidence, I propose the following practical and useful EEG definition. The interictal EEG characteristics of SeLEAS are multifocal EEG foci with age-dependent predominant locations; occipital (O) at 2-5 years old, and occipital and frontopolar (synchronous and independent O and Fp spikes) at 4-7 years old and centro-parieto-temporal (CPT) at 6-10 years old. O EEG foci evolve to multifocal EEG foci with a O-Fp or CPT predominance with age and disappear by 12∼16 years old. O-Fp EEG foci may further evolve to generalized spike-wave complexes and rarely to spike-wave activated in sleep. In rare cases, the EEGs do not have epileptic EEG foci.
    Conclusion: Interictal EEG foci in SeLAES may have different EEG patterns in terms of location and the mode of appearance depending on the age at which EEG is recorded. O-Fp EEG foci may be a specific EEG pattern indicating a diagnosis of SeLEAS.
    MeSH term(s) Humans ; Child, Preschool ; Child ; Adolescent ; Cross-Sectional Studies ; Epilepsies, Partial/diagnosis ; Epilepsy/diagnosis ; Seizures/diagnosis ; Electroencephalography
    Language English
    Publishing date 2023-08-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1397146-3
    ISSN 1532-2130 ; 1090-3798
    ISSN (online) 1532-2130
    ISSN 1090-3798
    DOI 10.1016/j.ejpn.2023.08.004
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    Zs.A 4867: Show issues Location:
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  3. Article ; Online: Epilepsy with myoclonic-atonic seizures, also known as Doose syndrome: Modification of the diagnostic criteria.

    Oguni, Hirokazu

    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society

    2021  Volume 36, Page(s) 37–50

    Abstract: Purpose: The aim of this review is to propose the updated diagnostic criteria of epilepsy with myoclonic-atonic seizures (EMAS), which is a recent subject of genetic studies. Although EMAS has been well known as Doose syndrome, it is often difficult to ... ...

    Abstract Purpose: The aim of this review is to propose the updated diagnostic criteria of epilepsy with myoclonic-atonic seizures (EMAS), which is a recent subject of genetic studies. Although EMAS has been well known as Doose syndrome, it is often difficult to diagnose due to a lack of consensus regarding some of the inclusion criteria. Along with progress in molecular genetic study on the syndrome, it becomes important to recruit electroclinical homogeneous EMAS patients, hence the validity of the clinical criteria should be verified based on recent clinical researches. At present, the most updated ILAE diagnostic manual of EMAS includes: (1) normal development and cognition before the onset of epilepsy; (2) onset of epilepsy between 6 months and 6 years of age (peak: 2-4 years); (3) myoclonic-atonic seizures (MAS) are mandatory (4) presence of generalized spike-wave discharges at 2-3 Hz without persistent focal spike discharges; and (5) exclusion of other myoclonic epilepsy syndromes. In the criteria, we should emphasize that the age at onset of MAS is between 2-5 years in (2), presence of myoclonic-atonic, atonic or myoclonic-flexor seizures (MASs) causing drop attacks associated with generalized spike-wave discharges is mandatory in (3), and epileptic spasms causing drop attacks must be excluded in (5). In the modified criteria, I propose that EMAS is redesignated as genetic generalized epilepsy with MASs, consistent with the familial genetic study conducted by Doose and the recent identification of candidate genes. It should also be noted that EMASs evolves to transient or long-lasting epileptic encephalopathy.
    MeSH term(s) Child ; Child, Preschool ; Electroencephalography ; Epilepsies, Myoclonic/diagnosis ; Epilepsies, Myoclonic/genetics ; Epilepsy ; Epilepsy, Generalized ; Humans ; Infant ; Seizures/etiology ; Seizures/genetics
    Language English
    Publishing date 2021-12-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1397146-3
    ISSN 1532-2130 ; 1090-3798
    ISSN (online) 1532-2130
    ISSN 1090-3798
    DOI 10.1016/j.ejpn.2021.11.009
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  4. Article: Wearable EEG Device for Continuous Spike-Wave in Sleep.

    Oguni, Hirokazu

    Pediatric neurology briefs

    2020  Volume 34, Page(s) 10

    Abstract: Investigators from the Hospital Dona Estefânia, Escola Superior de Tecnologias e Saúde de Lisboa and Centro Hospitalar Psiquiátrico de Lisboa investigated 38 patients with continuous spike-wave of sleep (CSWS) syndrome. ...

    Abstract Investigators from the Hospital Dona Estefânia, Escola Superior de Tecnologias e Saúde de Lisboa and Centro Hospitalar Psiquiátrico de Lisboa investigated 38 patients with continuous spike-wave of sleep (CSWS) syndrome.
    Language English
    Publishing date 2020-12-02
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 1043-3155
    ISSN 1043-3155
    DOI 10.15844/pedneurbriefs-34-10
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  5. Article ; Online: Differentiating non-epileptic seizures from epileptic seizures in Glut1 deficiency syndrome.

    Ito, Yasushi / Nakatsukasa, Hidetsugu / Toyoma, Yuriko / Nagata, Satoru / Oguni, Hirokazu

    Developmental medicine and child neurology

    2024  

    Abstract: Aim: To investigate the clinical characteristics of non-epileptic seizures due to transient brain dysfunction caused by energy deficiency after prolonged fasting or exercise in individuals with glucose transporter type 1 deficiency syndrome (Glut1DS), ... ...

    Abstract Aim: To investigate the clinical characteristics of non-epileptic seizures due to transient brain dysfunction caused by energy deficiency after prolonged fasting or exercise in individuals with glucose transporter type 1 deficiency syndrome (Glut1DS), and then elucidate further the seizure features to distinguish non-epileptic seizures from epileptic seizures.
    Method: This retrospective case-control study included 57 non-epileptic seizures and 23 epileptic seizures (control group) in 14 individuals (11 males, three females; aged 5-44 years, median = 20 years) with Glut1DS, all with a heterozygous pathogenic SLC2A1 mutation.
    Results: Non-epileptic seizures were classified as paroxysmal altered consciousness (n = 8), movement disorders (n = 35) (eye-head movements, ataxia, spasticity, weakness, involuntary movement), dysaesthesia (n = 8), and vomiting (n = 6) at the peak ages at onset of 5 to 10 years. Ketogenic diet therapy was effective in 33 of 43 (77%) non-epileptic seizures. Providing supplementary food before high-impact exercise or during attacks prevented or mitigated non-epileptic seizures in some individuals. Glut1DS-associated non-epileptic seizures are fundamentally situation-related seizures with specific provoking and ameliorating factors. Non-epileptic seizures can be distinguished from epileptic seizures by the absence of complete consciousness loss and rapid postictal recovery despite prolonged seizures.
    Interpretation: Non-epileptic seizures are not well recognized but require different therapeutic approaches compared to epileptic seizures. Awareness of the differentiation of non-epileptic seizures from epileptic seizures is essential when performing preventive or therapeutic decision-making for acute exacerbation seizures.
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 80369-8
    ISSN 1469-8749 ; 0012-1622
    ISSN (online) 1469-8749
    ISSN 0012-1622
    DOI 10.1111/dmcn.15942
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  6. Article ; Online: Endogenous panophthalmitis after colonoscopy.

    Yamamoto, Yukichika / Oguni, Kohei / Hagiya, Hideharu / Otuska, Fumio

    Internal and emergency medicine

    2023  Volume 19, Issue 1, Page(s) 241–242

    MeSH term(s) Humans ; Panophthalmitis/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Colonoscopy/adverse effects
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-07-10
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-023-03368-8
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  7. Article ; Online: Splenomegaly in silent endocarditis.

    Ishida, T / Hagiya, H / Yamamoto, Y / Oguni, K / Otsuka, F

    QJM : monthly journal of the Association of Physicians

    2022  Volume 115, Issue 9, Page(s) 615–616

    MeSH term(s) Endocarditis/complications ; Endocarditis/diagnostic imaging ; Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/diagnostic imaging ; Humans ; Splenomegaly/diagnostic imaging ; Splenomegaly/etiology
    Language English
    Publishing date 2022-08-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcac150
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  8. Article: [Epileptology and pediatric neurology].

    Oguni, H

    No to hattatsu. Brain and development

    2013  Volume 45, Issue 1, Page(s) 2

    MeSH term(s) Child ; Epilepsy/epidemiology ; Humans ; Pediatrics
    Language Japanese
    Publishing date 2013-01
    Publishing country Japan
    Document type Editorial
    ZDB-ID 605615-5
    ISSN 1884-7668 ; 0029-0831
    ISSN (online) 1884-7668
    ISSN 0029-0831
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  9. Article: [Clinical characteristics of Rasmussen encephalitis with special reference to Japanese experience].

    Oguni, H

    No to hattatsu. Brain and development

    2013  Volume 45, Issue 2, Page(s) 106–109

    MeSH term(s) Adolescent ; Adult ; Age of Onset ; Child ; Child, Preschool ; Encephalitis/immunology ; Encephalitis/therapy ; Epilepsia Partialis Continua/immunology ; Epilepsia Partialis Continua/therapy ; Female ; Humans ; Immunotherapy/methods ; Infant ; Japan ; Male ; Treatment Outcome ; Young Adult
    Language Japanese
    Publishing date 2013-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 605615-5
    ISSN 1884-7668 ; 0029-0831
    ISSN (online) 1884-7668
    ISSN 0029-0831
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  10. Article: Glass transition on the development of a hydrogen-bond network in nano-channel ice, and subsequent phase transitions of the ordering of hydrogen atom positions within the network in [Co(H(2)bim)(3)](TMA)·20H(2)O.

    Watanabe, Keisuke / Oguni, Masaharu / Tadokoro, Makoto / Oohata, Yûki / Nakamura, Ryouhei

    Journal of physics. Condensed matter : an Institute of Physics journal

    2006  Volume 18, Issue 37, Page(s) 8427–8436

    Abstract: Low-temperature thermal properties of crystalline [Co(H(2)bim)(3)](TMA)·20H(2)O were studied ... by adiabatic calorimetry, where H(2)bim is 2,2'-biimidazole, TMA is 1,3,5-benzene tricarboxylic acid, and 20H(2 ... to the periodicity of the hydrogen-bond network. The transition entropy was evaluated to be 0.65 J K(-1)(H(2)O-mol ...

    Abstract Low-temperature thermal properties of crystalline [Co(H(2)bim)(3)](TMA)·20H(2)O were studied by adiabatic calorimetry, where H(2)bim is 2,2'-biimidazole, TMA is 1,3,5-benzene tricarboxylic acid, and 20H(2)O represents the water forming nano-channel in the crystal. A glass transition was observed at T(g) = 107 K. It was discussed as a freezing-in phenomenon of a small number of water molecules remaining partially disordered in their positional arrangement. The possibility that some defects really remain in the hydrogen-bond network of channel water was mentioned. Two subsequent phase transitions were observed at 54.8 and 59 K. These were interpreted as being of a (super-structural commensurate)-incommensurate-(normal commensurate) type in the heating direction with respect to the hydrogen-atom positions as referred to the periodicity of the hydrogen-bond network. The transition entropy was evaluated to be 0.65 J K(-1)(H(2)O-mol)(-1) as a total of the two, indicating that the disorder of the hydrogen atoms is present only in part of the water molecules of the channel. Based on the fact that the excess heat capacity due to the equilibrium phase transition is observed down to 35-40 K, the relaxation time for the rearrangement of the hydrogen-atom positions was assumed at the longest to be 1 ks at 35 K. This indicates that the activation energy of the rearrangement amounts to at most 13 kJ mol(-1) and that the transfer of Bjerrum defects is attributed to the rearrangement.
    Language English
    Publishing date 2006-09-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472968-4
    ISSN 1361-648X ; 0953-8984
    ISSN (online) 1361-648X
    ISSN 0953-8984
    DOI 10.1088/0953-8984/18/37/003
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